MEDVi vs TrimRx vs PlexusDx: Costs, Plans & Support

Last updated: September 22, 2026

Written by: Jay Hastings, CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance.

This article is part of the PlexusDx Education Hub — evidence-based guidance on GLP-1 therapies and weight-management care. Browse all Peptides & GLP-1 education

Editorial note: PlexusDx publishes this editorial review and offers one of the programs discussed. PlexusDx is not affiliated with MEDVi and has no commercial relationship with the companies named in this article; there are no affiliate links. Information is based on the sources and dates shown.

As of September 22, 2026, MEDVi's compounded semaglutide injection is $179 for the first month for new patients and $299 per refill as displayed on its program page; its ongoing month-to-month rate for compounded tirzepatide injection is $399, verified September 22, 2026. TrimRx's pricing is rendered by script and could not be read from its site, so every TrimRx price is unknown; its own blog says its prices vary by dose, and we could not verify any figure. PlexusDx publishes flat month-to-month prices: Semaglutide Injection $189/mo and Tirzepatide Injection $289/mo, the same at every dose, with no membership fee.

Three-provider decision summary

All three are cash-pay telehealth programs for compounded GLP-1 medication. Prescriptions are issued by licensed providers in each company's network, and the medication is prepared by state-licensed compounding pharmacies. Compounded semaglutide and tirzepatide are not FDA-approved and are not the same as Wegovy®, Ozempic®, Zepbound®, or Mounjaro®; the FDA's statement on unapproved GLP-1 drugs explains the distinction. None of that changes between the three; what changes is price visibility, dose pricing, and terms.

MEDVi publishes a semaglutide first-month and refill price, bundles dietitian visits and coaching, and offers a compounded tablet plus a branded route. TrimRx publishes no readable price and, by its own description, prices by dose. PlexusDx publishes every tier on the product page, charges one price across all doses, and bills nothing until the provider approves. If you only want the MEDVi numbers, the owner article is MEDVi Cost: Semaglutide, Tirzepatide, Membership, and Plan Prices.

Same-medication pricing and upfront payment

The table compares the same medication and route across the three programs on a month-to-month basis. Unknown means the official page did not expose a figure; it does not mean free or cheap. PlexusDx's 3- and 6-month commitment tiers appear separately below the table because they are not month-to-month rates.

PlexusDx publishes this comparison and offers one of the programs discussed. Information is based on the sources and dates shown.

Checked September 22, 2026 on MEDVi's program page, TrimRx's site, and PlexusDx product pages. MEDVi's semaglutide refill rate is as displayed and its tirzepatide ongoing rate was verified September 22, 2026; confirm both in its official offer. Neither MEDVi nor TrimRx publishes its billing-cycle length, so each charge is one billing cycle, not necessarily a calendar month.

On upfront payment: MEDVi bills per cycle, and MEDVi offers 3-, 6- and 12-month bundles; their rates appear in its signup flow and are not published here. TrimRx's plan structure could not be read. PlexusDx month-to-month plans are billed one cycle at a time. Its commitment tiers are advertised per-month rates on a 3- or 6-month commitment: Semaglutide Injection $169/mo on 3 months ($507 commitment total) or $149/mo on 6 months ($894); Tirzepatide Injection $269/mo on 3 months ($807) or $249/mo on 6 months ($1,494). The payment schedule and any refund terms for a multi-month plan are shown at checkout.

Introductory versus recurring charges

MEDVi's model has a step: $179 for the first month, then $299 per refill. For a new patient on semaglutide injection, that is $777 over 3 cycles, $1,674 over 6, and $3,468 over 12, assuming the first cycle at $179 and every later cycle at $299. Refill-only, 12 cycles at $299 is $3,588. On tirzepatide injection at MEDVi's ongoing $399 rate, verified September 22, 2026, refill-only totals are $1,197 over 3 cycles, $2,394 over 6, and $4,788 over 12; a new-patient tirzepatide total is not computed because MEDVi shows its tirzepatide first-month offer after the questionnaire. Budget on the refill rate, not the first month.

TrimRx's introductory structure, if any, could not be verified. PlexusDx has no step: $189/mo for semaglutide injection is $567 over 3 cycles, $1,134 over 6, and $2,268 over 12 month-to-month. Tirzepatide Injection at $289/mo is $867, $1,734, and $3,468 over the same spans. Compare MEDVi's 12-cycle new-patient semaglutide total of $3,468 with PlexusDx's 12-cycle tirzepatide total of $3,468 and you can see why the medication, not just the brand, has to match before a price comparison means anything. Like for like on tirzepatide at the ongoing month-to-month rates, PlexusDx Tirzepatide Injection at $289/mo is $110 a month less than MEDVi's $399/mo, or $3,468 versus $4,788 over 12 billing cycles.

Dose pricing and support

Dose pricing is the sharpest difference. MEDVi states "same fair price at every dose." PlexusDx states that your monthly price is flat across every dose level for the compound and changes only with your commitment tier. TrimRx's own blog says its price depends on dose, which means a clinician-directed dose change can change your bill; confirm the exact schedule with TrimRx before you enroll.

On support, MEDVi's program page lists physician review, a personalized plan, 1:1 guidance, a metabolic report, free dietitian visits and care coaching, unlimited 24/7 support, free shipping, and HSA/FSA acceptance. TrimRx's public pages did not let us verify its support inclusions. PlexusDx includes the provider visit, prescription, medication, and shipping in one price, with care through an independent network of U.S.-licensed clinicians on a state-licensed telehealth platform; it does not include dietitian visits. Five states require a scheduled video consultation on PlexusDx, and your provider advises if that applies.

On reputation, publicly posted reviews on third-party sites describe a range of experiences with MEDVi and TrimRx, positive and negative, and we do not reduce them to a score. Our MEDVi customer reviews roundup states its sources and limits; treat any single review thread as one account, not a verdict.

Cancellation and commitment

MEDVi's policy, read September 22, 2026: cancel anytime with at least 72 hours' notice before the next billing date; a full refund only within the first 72 hours without services or on medical disqualification; no refund for the month in which you cancel; multi-month plans refundable only for months with no medication shipped; consult fees non-refundable; prescription medication not returnable. TrimRx's refund and cancellation terms could not be read from its site and are unknown. PlexusDx month-to-month plans can be cancelled anytime with no fees, and $0 is charged until your provider approves the prescription. The refund terms for a PlexusDx multi-month commitment are shown at checkout.

Which provider fits each priority?

If bundled coaching and dietitian access matter most, MEDVi publishes the broadest support list, and it is the only one of the three with a compounded tablet and a branded route. You will pay a higher refill rate than the first month ($299 on semaglutide injection, and an ongoing $399 on tirzepatide injection, verified September 22, 2026), and MEDVi shows its tirzepatide first-month offer after the questionnaire.

If you are set on TrimRx for another reason, go in with the questions its site does not answer: the exact price at your starting dose and at the next dose, the billing cycle, and the refund terms. Its self-described dose-based pricing is the item most likely to surprise you later.

If a published, flat price that does not move with dose is your priority, PlexusDx fits: $189/mo for Semaglutide Injection or $289/mo for Tirzepatide Injection month-to-month, all-inclusive, no membership, cancel anytime. The head-to-head with MEDVi is on MEDVi vs PlexusDx: Compare GLP-1 Prices, Plans, and Support, and all current plans are on the PlexusDx weight-management collection. Whichever program you choose, the decision to start, change, or stop a GLP-1 medication belongs to your treating clinician.

A note on genetics (optional)

PlexusDx offers compounded semaglutide and tirzepatide through its Weight Management Protocols. Separately, and only if it interests you, the GLP-1 & Peptide Pathways Genetic Test ($298) analyzes 14 pathways, 49 peptides, 150+ genetic insights, including variants in FTO, MC4R and TCF7L2 that relate to appetite and glucose-handling pathways. It does not predict how you will respond to any medication and does not tell you which drug, dose or provider is right for you; it is context for a conversation with your clinician. Test before you invest, and treat genetics as a guide, not a guarantee.

This article is educational. PlexusDx is not affiliated with MEDVi and has no commercial relationship with the companies discussed. PlexusDx offers compounded semaglutide and tirzepatide through its own Weight Management Protocols; this article compares approaches in the GLP-1 telehealth space. The GLP-1 & Peptide Pathways Genetic Test analyzes how your genes influence peptide-related biological pathways. It does not predict response to any specific medication and does not recommend, prescribe, or determine which peptides you should use. Consult a qualified healthcare provider before beginning any peptide protocol. Compounded semaglutide and tirzepatide are not FDA-approved drug products; they are prepared by state-licensed compounding pharmacies under federal compounding rules and are not the same as Wegovy®, Ozempic®, Zepbound® or Mounjaro®. Zepbound® and Mounjaro® are registered trademarks of Eli Lilly and Company; Wegovy® and Ozempic® are registered trademarks of Novo Nordisk A/S. PlexusDx is not affiliated with or endorsed by either company.

Frequently Asked Questions

How much does TrimRx charge for semaglutide or tirzepatide?

We could not read a price from TrimRx's site on September 22, 2026 because its pricing is rendered by script, so every TrimRx figure is unknown. TrimRx's own blog says its price depends on the dose you are prescribed, which means the number can change when your clinician changes your dose. Confirm the exact rate at your starting dose and the next dose directly with TrimRx before enrolling.

Does MEDVi or TrimRx raise the price when the dose changes?

MEDVi states it charges the same price at every dose. TrimRx's own blog says its price depends on dose, so a clinician-directed change can change your bill; confirm the schedule before enrolling. PlexusDx states that its monthly price is flat across every dose level for the compound and changes only with the commitment tier you choose.

What is MEDVi's semaglutide cost over a year?

For a new patient paying $179 for the first cycle and $299 for each later refill, as displayed September 22, 2026, 12 billing cycles come to $3,468. Refill-only, 12 cycles at $299 is $3,588. MEDVi does not publish its billing-cycle length, so these are 12 cycles rather than a calendar year. Confirm both figures in MEDVi's official offer.

Is PlexusDx cheaper than MEDVi and TrimRx?

On ongoing month-to-month rates, PlexusDx's $189 per month is below MEDVi's $299 semaglutide refill rate as displayed September 22, 2026, and PlexusDx's $289 Tirzepatide Injection is below MEDVi's ongoing $399 tirzepatide rate, verified the same day, $110 a month less on either compound; TrimRx's rates are unknown, so no comparison with TrimRx is possible. PlexusDx's advantages are specific: one flat price across doses, no membership fee, and $0 until provider approval. MEDVi includes dietitian visits and coaching that PlexusDx does not.

Are the medications from these three providers FDA-approved?

No. All three dispense compounded semaglutide or tirzepatide prepared by state-licensed compounding pharmacies for an individual prescription. Compounded products are not FDA-approved and are not the same as Wegovy, Ozempic, Zepbound, or Mounjaro. A licensed pharmacy or prescriber is not FDA approval, and brand clinical-trial results do not establish identical outcomes for compounded formulations.

Sources and dates checked

• MEDVi program page (glp1.medvi.org), read September 22, 2026
• MEDVi start page (start.medvi.org), read September 22, 2026
• MEDVi cancellation and refund policy, read September 22, 2026
• TrimRx website and blog (trimrx.com), read September 22, 2026; pricing not readable
• PlexusDx Semaglutide Injection product page, read September 22, 2026
• PlexusDx Tirzepatide Injection product page, read September 22, 2026
• FDA: FDA's concerns with unapproved GLP-1 drugs used for weight loss

This article is part of the PlexusDx Education Hub. Browse all Peptides & GLP-1 education

Medical and Editorial Standards

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. Sources and the dates they were checked are listed at the end of the article.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services, and offers compounded GLP-1 programs through its Weight Management Protocols. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.