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Bottle of Methylene Blue capsules with a blue label on a white background
Infographic showing 3 easy steps to order medication online with a doctor on a phone screen.

Methylene Blue Protocol

Compounded Methylene Blue via licensed providers. Capsule form, flat monthly price, your provider in your corner.

Care from a licensed provider in your corner — async intake, no waiting room

Compounded Methylene Blue shipped discreetly to your door — pharmacy-grade capsule

Single flat monthly price at $149 — no commitment tiers, no dosing ladder

Optional genetics layer to refine your protocol — 17 Longevity insights including FOXO3, $99 post-enrollment

One price covers provider, prescription, medication, and shipping. No membership.

$149/mo — All-Inclusive
Your monthly price doesn't change as your dose changes. Same price every dose level.
Coming Soon

This protocol is launching soon. Check back shortly.

THE BENEFITS

What Methylene Blue actually does for you.

WHAT CHANGES

Methylene Blue gives your mitochondria a detour around damage.

Your cells produce energy in the mitochondrial electron chain. With age and stress, parts of the chain wear down. Damaged chains mean foggy focus, mental fatigue, slower thinking. Methylene Blue acts as an electron carrier that bypasses the damage.

WHAT YOU'LL FEEL

Show up to your day differently

Sharper focus through long days. Steadier mental energy by mid-afternoon. A mind that bounces back instead of fading by 3pm.

HOW LONG IT TAKES

Real results take real time

Methylene Blue builds week over week. Most people feel sharper focus within two to four weeks. Mental energy and cognitive stamina keep compounding through week twelve. Your provider checks in every month and adjusts your plan as you go.

WHY IT WORKS FOR YOU

Built around your biology, not someone else's average

Methylene Blue response varies by genetics. The optional Precision Peptide Genetic Test analyzes 17 Longevity insights including FOXO3 so your protocol gets shaped around your body.

PEER-REVIEWED RESEARCH

1891

Methylene Blue has been used in medicine since 1891 and acts as a mitochondrial electron carrier — accepting electrons in the mitochondrial respiratory chain to support cellular ATP production. Source: Tucker et al., Translational Psychiatry, 2018.

Compounded medications are not FDA-approved or evaluated for safety, effectiveness, or quality. PlexusDx coordinates care; licensed providers evaluate and prescribe when clinically appropriate; partner pharmacies dispense and label medications.

READY?

Feel the difference your provider designs around you.

Coming Soon

This protocol is launching soon. Check back shortly.

Overview

Compounded Methylene Blue is a mitochondrial cofactor prescribed by licensed providers as a pharmacy-grade capsule. Provider-determined dosing cadence. One monthly price covers your provider visit, prescription, medication, and shipping — $149 per month flat, no commitment tiers. No membership fee. Eligible adults in 46 states.

  • Provider-determined capsule dosing — once or twice daily per provider cadence
  • Methylene Blue mechanism — mitochondrial electron carrier, supports cellular energy production and oxidative stress response
  • $149 per month flat all-inclusive — covers consult, prescription, compounded medication, shipping
  • Real medical authority — licensed providers in your state, no AI prescriptions
  • 17 Longevity genetic insights including FOXO3 — optional Precision Peptide Genetic Test, $99 as an add-on after your first month

The optional Precision Peptide Genetic Test analyzes 17 Longevity insights including FOXO3 — the most-studied longevity gene, linked to centenarian populations and cellular repair capacity — with crossover into Energy Metabolism, Tissue Repair, and Cognition pathways. Drawn from a 150+ insight panel across 14 pathways. Available for $99 as an add-on after your first month of treatment.

Why trust PlexusDx

Compliance

503A pharmacy-grade medication

Your compounded Methylene Blue is prepared by a licensed 503A compounding pharmacy for your prescription — not mass-manufactured.

Coverage

Licensed providers in all 50 states

Available in all 50 states. Five states require a scheduled video consultation — your provider advises.

Privacy

HIPAA-compliant platform

Protected under HIPAA. Never sold or shared without your consent. Results delivered securely through the PlexusDx Results Portal.

Pricing

One transparent price

All-inclusive. Your dose may need to go up. Your price won't.

Telehealth across the US — see state availability below

Pricing

What you pay

$149 /mo

All-inclusive. No membership. Cancel anytime.

Async provider intake Rx issuance Compounded Methylene Blue Direct shipping

Provider-determined dosing

Your provider reviews your intake and selects your starting protocol — dose and cadence guidance. This protocol is currently available in 46 states. We're unable to ship Methylene Blue Capsule to Arkansas, Indiana, Minnesota, and South Carolina at this time.

WHAT HAPPENS NEXT

After you order

What happens once your intake is in.

Same day

LICENSED REVIEW

Provider review & prescription

A licensed US provider reviews your intake, selects the compound, and writes your prescription.

3–5 business days

503A COMPOUNDING

Pharmacy ships your medication

Your compounded Methylene Blue ships from a US 503A pharmacy prepared specifically for your prescription. A 503A pharmacy is a state-licensed compounding facility regulated by FDA and state boards of pharmacy that prepares medications individually for a specific patient based on a valid prescription. Dosing schedule included.

Every month

CARE THAT CONTINUES

Ongoing provider care

Unlimited provider messaging, dose adjustments, and clinical check-ins.

Anytime

FLEXIBILITY

Cancel anytime, no fees

Cancel anytime — no fees, no contracts. Your provider reviews each refill.

OUR COMMITMENT

Nothing is charged until your provider approves your prescription. Cancel anytime, no fees.

EVERYTHING INCLUDED

What's included

Your provider, your pharmacy, your direct-to-door shipping — everything in your monthly Methylene Blue Protocol protocol.

PROVIDER

Licensed, async

Licensed providers in all 50 states. Most patients reviewed within one business day.

PHARMACY

503A compounded

Pharmacy-grade Methylene Blue prepared for your provider-selected dose and cadence.

SHIPPING

Direct-to-door

Cold-chain packed. Ships from U.S. partner pharmacy.

ALL-INCLUSIVE

One all-inclusive price

Provider, prescription, medication, and shipping — in one monthly charge. No membership.

WHAT YOU WON'T PAY
Membership fee
Consult charge
Hidden fees
REFILLS

Provider-reviewed

Each refill re-authorized by your provider. Not auto-shipped.

MONITORING

Monthly check-ins

Provider check-ins to assess response and adjust formulation as needed.

FLEXIBILITY

Cancel anytime

No long-term contract. Pause or stop between refills.

Optional add-on
Available post-enrollment

The optional Precision Peptide Genetic Test analyzes 17 Longevity insights including FOXO3 — the most-studied longevity gene, linked to centenarian populations and cellular repair capacity — drawn from a 150+ insight panel across 14 pathways. Available for $99 as an add-on after your first month of treatment.

17
Pathway insights
150+
Total panel
14
Pathways
$99
Add-on
Featured SNP
FOXO3
the most-studied longevity gene, linked to centenarian populations and cellular repair capacity
Explore the Genetic Test → $99 · one-time · available after your first month of treatment

CLINICAL FIT CHECK

Is this protocol right for you?

We lead with safety considerations first. If any exclusion applies to you, stop here and speak with your primary care provider before starting intake.

SAFETY EXCLUSIONS

Skip this protocol if…

MALIGNANCY HISTORY

Active or recent cancer diagnosis

PREGNANCY STATUS

Pregnant, breastfeeding, or planning pregnancy

ORGAN DISEASE

Severe hepatic, renal, or cardiovascular disease

KNOWN ALLERGY

G6PD deficiency, serotonergic medication use, or hypersensitivity to methylene blue

ELIGIBLE

You're a fit if…

ENERGY & MENTAL CLARITY

Adults seeking support for cellular energy, mental clarity, or focus

CLINICAL OVERSIGHT

Want licensed provider oversight across all 50 states

PRICING TRANSPARENCY

Want one all-inclusive price with no hidden fees

DATA-GUIDED CARE

You prefer clinical decisions informed by your personal health data

PROVIDER VERDICT

Your licensed provider confirms final eligibility during intake review. No medication ships without their sign-off.

Built differently

What makes PlexusDx different

Five things every shopper deserves before they sign up.

THE DIFFERENTIATOR

Genetics-informed care from a complete precision health platform

17 Longevity insights via the Precision Peptide Genetic Test — across 14 pathways, 49 peptides. The only telehealth peptide protocol with a genetic testing layer.

TRANSPARENCY

Radically transparent

Every dose level and every price published.

PRICING

All-inclusive

One price for intake, Rx, medication, shipping.

CLINICAL

Async clinical oversight

No in-person visits. Available in all 50 states.

NO GATE

No membership gate

Your first dollar goes toward care, not a subscription.

Clinical details

Clinical details

How this compound works and what lab work is involved.

Compound spec

Class

Mitochondrial cofactor

cellular energy and antioxidant cofactor

Route

Subcutaneous injection

provider-determined cadence

Half-life

Provider-set

cadence depends on dose and tolerance

Compounded by

503A pharmacy

licensed US partner

How it works

About this compound

Methylene Blue is a phenothiazine derivative that functions as an alternative electron carrier in the mitochondrial respiratory chain, bypassing damaged Complex I/III and supporting NAD+/NADH redox balance. It crosses the blood-brain barrier and has documented neuroprotective and metabolic effects across diverse cellular systems.

Your provider determines your Methylene Blue dose and daily cadence during intake review. Methylene Blue is delivered as a compounded pharmacy-grade capsule at $149 per month flat, all clinically supervised.

See how PlexusDx customers describe their precision health journey — read Customer Stories.

Why it matters

Aging response varies by genetics. The optional Precision Peptide Genetic Test analyzes 17 Longevity insights including FOXO3 — the most-studied longevity gene, linked to centenarian populations and cellular repair capacity. Available for $99 as an add-on after your first month of treatment.

Lab requirements
No blood work required at intake. Blood testing is available at patient election and may be recommended by your provider based on your individual health history. At-home blood collection is available through Red Drop Dx — no clinic visit required.
NOT REQUIRED
Compare Compounds

How this compound compares

Compound
Mechanism
Route
Starts at
NAD+
Coenzyme / cellular energy
Multi-route
$179/mo
Sermorelin
GHRH analog
Injection / oral
$155/mo
MIC B12
Lipotropic cofactor
Injection
$129/mo
Glutathione
Endogenous antioxidant
Multi-route
$129/mo
You're viewingMethylene Blue
Mitochondrial cofactor
Capsule
$149/mo
GHK-Cu Rx
Copper-binding tripeptide
Topical cream
$169/mo
Lipo C
Lipotropic + antioxidant injection
Injection
$199/mo
PT-141
Melanocortin receptor agonist
Injection
$219/mo

If your provider determines a different compound is the better clinical fit, they'll initiate the switch — no fees, no resubscription, billing adjusts automatically.

Methylene Blue Protocol — FAQ

Answers before you start

Straight answers on pricing, formulation, and what's included — pulled from the questions Longevity patients ask most.

PRICING

How does Methylene Blue pricing work?

Methylene Blue is priced at a single flat rate — $149/month, all-inclusive — covering async provider consultation, prescription, compounded subcutaneous Methylene Blue, and shipping. Monthly billing only at launch, no commitment tiers, no membership fee. The Precision Peptide Genetic Test is an optional $99 add-on after your first month, not bundled into the protocol price.

INCLUSIONS

What's included in every monthly charge?

Every monthly charge includes async provider consultation and intake review, your prescription written by a licensed provider in your state, compounded subcutaneous Methylene Blue from a state-licensed 503A pharmacy, and free discreet shipping in all 50 states. Refills are provider-reviewed and authorized through your portal — no separate re-intake required unless your dose or cadence changes.

TITRATION

Can my provider adjust my Methylene Blue dose?

Yes. Your provider determines your dose during intake review based on your clinical goals, tolerance, and preference. Methylene Blue is dosed within a single formulation tier — your provider can adjust the exact dose (typically 0.5–2 mg/kg) and cadence based on your response. Billing stays at $149/month — titration within the tier does not trigger a price change.

MECHANISM

What is Methylene Blue and how does it support mitochondrial and cognitive pathways?

Methylene Blue is a mitochondrial cofactor — a synthetic phenothiazine compound that can serve as an alternative electron carrier in the mitochondrial electron transport chain, supporting cellular energy production and acting as a redox-active modulator of oxidative stress. Compounded subcutaneous Methylene Blue is intended to support cellular mitochondrial resilience and pathways relevant to cognitive function and brain energy metabolism.

GENETICS

Do I need my Precision Peptide Genetic Test before starting?

No — the Precision Peptide Genetic Test is optional and available as a $99 add-on after your first month of treatment. Your provider can prescribe Methylene Blue based on standard intake without genetic data. The test analyzes 14 pathways, 49 peptides, and 150+ genetic insights — including 17 Longevity insights with FOXO3 plus crossover into 6 Cognition insights and 4 Brain Health insights particularly relevant to mitochondrial cofactor protocols — providing additional context that may inform long-term protocol adjustments.

FLEXIBILITY

What if I need a different formulation, tier, or compound?

Methylene Blue is offered in a single subcutaneous formulation — your provider sets dose and cadence based on response. If your provider recommends a different longevity compound (NAD+, Sermorelin, MIC B12, Glutathione, or others), they can switch your prescription and your billing updates to reflect the new compound. No fees to switch.

─── READY TO START

Start your Methylene Blue protocol today

Three reasons to start your longevity protocol with PlexusDx.

ENROLL TODAY
Ready to Start Your Methylene Blue Protocol?

Order your Methylene Blue protocol today. Gain access to 17 Longevity genetic insights post-enrollment, including FOXO3 plus 6 Cognition and 4 Brain Health insights particularly relevant to mitochondrial cofactor protocols. Make informed decisions supported by clinical oversight and your unique biology.

Coming Soon
~60 second intake · $0 until Rx approved
TRANSPARENCY
Every formulation, every price
Published before you enroll. No intake required to see prices.
Radically transparent
ALL-INCLUSIVE
One price, all-in
Intake, Rx, medication, and shipping — one monthly price.
No surprise billing
GENETICS-INFORMED
Your biology, your care
150+ insights across 14 pathways, available post-enrollment for $99.
The only telehealth layer
Important Information
Compounded medications are not approved by the FDA or reviewed for quality, safety, or efficacy.

Novo Nordisk, Inc. is the only United States company with FDA-approved products containing semaglutide, identified under the trade names Rybelsus®, Ozempic®, and Wegovy®.

Lilly USA LLC is the only United States company with FDA-approved products containing tirzepatide, identified under the trade names Zepbound® and Mounjaro®.

The Precision Peptide Genetic Test analyzes how your genes influence peptide-related biological pathways. It does not recommend, prescribe, or determine which peptides you should use. Consult a qualified healthcare provider before beginning any peptide protocol.