Optimal Diet & Weight Loss Genetic Test
See how your DNA shapes weight loss, appetite, metabolism, and the way you respond to food and exercise, and turn those insights into a plan you can act on.
Genetic Tests are a one-time purchase
The Optimal Diet & Weight Loss Genetic Test turns one cheek swab into 292 DNA insights across 147 genes, covering weight loss and appetite, the way you handle carbs and fats, your nutrient needs, and how your body responds to exercise.
What your DNA reveals in this test
Weight loss & body composition
How your genes may shape weight loss and regain, where you store fat, and your balance of muscle and fat. A practical starting point for setting realistic goals with your provider.
Appetite, cravings & blood sugar
How your genes may shape hunger, fullness, snacking, and the way you handle sugar and carbs. Helpful context for understanding the patterns behind your eating.
Macronutrients & diet type
How your genes may shape your response to carbs, fats, and protein, and which eating patterns may suit you, so food choices can be personal instead of generic.
Vitamins & minerals
How well your body absorbs and uses key vitamins and minerals like folate, vitamin D, and iron, which shapes how you respond to foods and supplements. The well-known MTHFR gene sits here.
Fitness & exercise response
How your genes may shape endurance, power, and how your body responds to training, so you can match your workouts to your biology.
Recovery, injury & metabolism
How your genes may shape muscle recovery, tendon and ligament resilience, and how your body handles fats after exercise. Context, not a diagnosis.
What this test covers
This test analyzes your DNA across the Diet & Nutrition, Weight & Body Fat, and Fitness & Injury reports: 292 markers across 86 traits, grouped into the six areas below.
Weight loss & body composition
How your genes may shape weight loss and regain, where your body stores fat, and your balance of muscle and fat. This area includes the well-known FTO gene, along with MC4R and PPARG for body weight and fat-storage tendencies.
Appetite, cravings & blood sugar
How your genes may shape hunger, fullness, snacking, and the way your body handles sugar and carbs. This area includes LEPR for satiety signaling, TCF7L2 for blood sugar response, and ADIPOQ for appetite and fat balance.
Macronutrients & diet type
How your genes may shape the way you respond to carbs, fats, and protein, and which eating patterns may suit you. This area includes APOA2 and FABP2 for fat sensitivity and FADS1 for how you process dietary fats.
Vitamins & minerals
How well your body absorbs and uses key vitamins and minerals, which shapes how you respond to foods and supplements. The well-known MTHFR gene sits here for folate, alongside VDR for vitamin D and HFE for iron.
Fitness & exercise response
How your genes may shape endurance, power, and how your body responds to training. This area includes the well-studied ACTN3 power-and-speed gene, PPARGC1A for endurance, and ADRB2 for training response.
Recovery, injury & metabolism
How your genes may shape muscle recovery, tendon and ligament resilience, and how your body handles fats after exercise. This area includes COL5A1 for tendon and collagen, COMT for stress and recovery, and UCP1 for energy metabolism.
You do not have to act on all of it. Pick one or two areas, talk them over with your doctor, and build from there. This test shows genetic tendencies, not a diagnosis. It does not diagnose, treat, or predict obesity or any condition, and it does not guarantee any specific weight or fitness outcome.
From kit to results in four steps
Order your kit
We ship your DNA collection kit to your door for free, in discreet packaging.
Register and swab at home
Register your kit online with the included instructions, then take a quick, painless cheek swab. No needles, no clinic visit.
Mail it back
Seal your sample in the prepaid return envelope and drop it in the mail. Our CLIA-certified lab analyzes your DNA on the Illumina Global Screening Array.
Get your reports
In about 2 to 4 weeks, your reports and personalized guidance appear in your PlexusDx Results Portal.
Everything included with your test
Three genetic reports
Your Diet & Nutrition, Weight & Body Fat, and Fitness & Injury reports, delivered together in your PlexusDx Results Portal.
An at-home swab kit
The cheek swab, collection vial, and a prepaid return envelope, with free shipping both ways.
Plain-English insights
Your results in clear language, with discussion points for you and your provider, not raw genetic data.
One swab, 292 markers
A single cheek swab covers all 292 markers across the three reports. Your DNA does not change, so you test once.
The reports inside this test
Each one is a full PlexusDx genetic report. Explore what they cover.
Diet & Nutrition Genetic Report
How your genes may shape the way you process vitamins, minerals, fats, and carbs, with diet-type and supplement context to personalize your nutrition.
View reportWeight & Body Fat Genetic Report
How your genes may shape appetite, fat storage, blood sugar response, and how your body loses weight and keeps it off.
View reportFitness & Injury Genetic Report
How your genes may shape endurance, power, training response, muscle recovery, and tendon and ligament resilience.
View reportAll your reports live in one place: your PlexusDx Results Portal, alongside any other PlexusDx tests and reports you own. One login, your whole genetic picture.
PlexusDx tests and reports are for wellness and educational purposes only and are not intended to diagnose, treat, cure, or prevent any disease. Results are delivered through the PlexusDx Results Portal.
One cheek swab unlocks 292 DNA insights across weight, diet, and fitness.