Metabolism & Thyroid Health Genetic Test
See how your DNA shapes thyroid function, metabolism, weight, and energy, and turn those insights into a plan you can act on.
Genetic Tests are a one-time purchase
The Metabolism and Thyroid Health Genetic Test turns one cheek swab into 420+ DNA insights across 194 genes, covering thyroid hormone activity, metabolism and blood sugar, weight and appetite, your nutrient needs, hormones, and how your body makes energy.
What your DNA reveals in this test
Thyroid & metabolic rate
How your genes may shape thyroid hormone activity, including the T4-to-T3 conversion that helps set your metabolic pace. Useful context for understanding your energy and metabolism.
Weight, appetite & blood sugar
How your genes may shape hunger, fullness, fat storage, and the way you handle sugar and carbs. Helpful context for the patterns behind your eating and weight.
Vitamins & minerals
How well your body absorbs and uses key vitamins and minerals like folate, vitamin D, and iron, which shapes how you respond to foods and supplements. The well-known MTHFR gene sits here.
Macronutrients & diet response
How your genes may shape your response to carbs, fats, and protein, and which eating patterns may suit you, so food choices can be personal instead of generic.
Hormones & reproductive health
How your genes may shape estrogen, progesterone, and testosterone balance and fertility-related pathways, for context you can review with your provider.
Energy, fitness & recovery
How your genes may shape mitochondrial energy production, endurance and power, and how your body recovers from exercise. Context, not a diagnosis.
What this test covers
This test analyzes your DNA across the Diet & Nutrition, Weight & Body Fat, Fitness & Injury, and Hormone & Fertility reports: 424 markers across 96 traits, grouped into the six areas below.
Thyroid & metabolic rate
How your genes may shape thyroid hormone activity and the metabolic pace it sets. This area includes DIO2 and DIO1, the enzymes that convert T4 into the active T3 your cells use, along with TSHR for thyroid signaling.
Weight, appetite & blood sugar
How your genes may shape hunger, fullness, fat storage, and the way your body handles sugar and carbs. This area includes the well-known FTO gene, MC4R for appetite, and TCF7L2 for blood sugar response.
Vitamins & minerals
How well your body absorbs and uses key vitamins and minerals, which shapes how you respond to foods and supplements. The well-known MTHFR gene sits here for folate, alongside VDR for vitamin D and HFE for iron.
Macronutrients & diet response
How your genes may shape the way you respond to carbs, fats, and protein, and which eating patterns may suit you. This area includes APOA2 for fat sensitivity, CPT1B for fat-to-energy use, and FADS1 for processing dietary fats.
Hormones & reproductive health
How your genes may shape estrogen, progesterone, and testosterone balance, along with fertility-related pathways. This area includes SHBG for free testosterone, CYP19A1 for estrogen production, and COMT for estrogen processing.
Energy, fitness & recovery
How your genes may shape mitochondrial energy production, endurance versus power, and how your body recovers. This area includes PPARGC1A for mitochondrial energy, the well-studied ACTN3 power gene, and COL5A1 for tendon resilience.
You do not have to act on all of it. Pick one or two areas, talk them over with your doctor, and build from there. This test shows genetic tendencies, not a diagnosis. It does not diagnose, treat, or predict any thyroid, metabolic, or reproductive condition, and it does not guarantee any specific outcome.
From kit to results in four steps
Order your kit
We ship your DNA collection kit to your door for free, in discreet packaging.
Register and swab at home
Register your kit online with the included instructions, then take a quick, painless cheek swab. No needles, no clinic visit.
Mail it back
Seal your sample in the prepaid return envelope and drop it in the mail. Our CLIA-certified lab analyzes your DNA on the Illumina Global Screening Array.
Get your reports
In about 2 to 4 weeks, your reports and personalized guidance appear in your PlexusDx Results Portal.
Everything included with your test
Four genetic reports
Your Diet & Nutrition, Weight & Body Fat, Fitness & Injury, and Hormone & Fertility reports, delivered together in your PlexusDx Results Portal.
An at-home swab kit
The cheek swab, collection vial, and a prepaid return envelope, with free shipping both ways.
Plain-English insights
Your results in clear language, with discussion points for you and your provider, not raw genetic data.
One swab, 424 insights
A single cheek swab covers all 424 insights across your reports. Your DNA does not change, so you test once.
The reports inside this test
Each one is a full PlexusDx genetic report. Explore what they cover.
Diet & Nutrition Genetic Report
How your genes may shape the way you process vitamins, minerals, fats, and carbs, with diet-type and supplement context to personalize your nutrition.
View reportWeight & Body Fat Genetic Report
How your genes may shape appetite, fat storage, blood sugar response, and how your body loses weight and keeps it off.
View reportFitness & Injury Genetic Report
How your genes may shape endurance, power, training response, muscle recovery, and how your body makes energy.
View reportHormone & Fertility Genetic Report (Men's or Women's)
How your genes may shape thyroid hormone activity, estrogen, progesterone, and testosterone balance, and fertility-related pathways. You receive the report matched to your biological sex.
View reportAll your reports live in one place: your PlexusDx Results Portal, alongside any other PlexusDx tests and reports you own. One login, your whole genetic picture.
PlexusDx tests and reports are for wellness and educational purposes only and are not intended to diagnose, treat, cure, or prevent any disease. Results are delivered through the PlexusDx Results Portal.
One cheek swab unlocks 424 DNA insights across thyroid, metabolism, and hormones.