HSA | FSA CARDS ARE NOW ACCEPTED

Metabolism & Thyroid Health Genetic Test
Metabolism & Thyroid Health Genetic Test
Metabolism & Thyroid Health Genetic Test
Metabolism & Thyroid Health Genetic Test
Metabolism & Thyroid Health Genetic Test

Metabolism & Thyroid Health Genetic Test

$298.00

350+ Genetic Traits. 4 Comprehensive Reports. 1 Swab.

  • Thyroid & Hormone Report: understand your genetics related to thyroid function, metabolism, and key hormones.
  • Diet & Nutrition Report: insights on dietary response, nutrient metabolism, macros, micronutrient and mineral needs.
  • Weight & Body Fat Report: discover how your body handles hunger, cravings, snacking, overeating, blood sugar, weight regain, fat distribution
  • Fitness & Injury Report: understand your genetics related to endurance, strength response, recovery, lean mass, metabolic rate, motivation
  • Personalized Diets, Meal Plans, and Supplement Recommendations: custom solutions based on your unique genes and biology, with only the specific nutrients you need.

Comprehensive DNA reports including Hormones, Belly Fat, Metabolic, and Thyroid Health

Discover a personalized path to metabolic wellness with the Precision Metabolism & Thyroid Health Genetic Test. This comprehensive test reveals unique genetic insights into metabolism, hormones, and thyroid health, offering tailored strategies for weight management, blood sugar control, and hormonal balance. With evidence-based recommendations for supplements, diet, and lifestyle, it empowers you to achieve a balanced, energized life.

Pay using HSA/FSA with flex Select Flex at checkout to pay for your HSA/FSA eligible items

Use the Power of Genetics to 
Take Control of Your Metabolism and Thyroid Health

With countless wellness options, finding what truly works for your body can be overwhelming. Precision Wellness Tests provide a personalized roadmap by analyzing how your unique genetics impact key health areas. These insights empower you to make informed decisions aligned with your goals—because health isn’t just about the genetic cards you’re dealt; it’s how you play them.

350+ DNA reports including Hormones, Weight Loss, Metabolic, and Thyroid Health

Unlock a personalized approach to metabolic wellness with the Precision Metabolism and Thyroid Health Genetic Test. This test reveals unique genetic insights into metabolic health, guiding you with tailored strategies to support balanced weight, blood sugar, and overall metabolic function. By examining the genetics behind hormone levels, it provides recommendations to help you achieve optimal hormonal balance. The test also focuses on thyroid health, identifying genetic markers that influence thyroid function and hormone regulation, with personalized tips to support a healthy thyroid. Additionally, it uncovers genetic factors related to body weight and fat distribution, providing strategies for effective weight management. With insights into how your genetics impact blood sugar control, you’ll receive targeted recommendations for maintaining stable levels. This comprehensive test empowers you with the knowledge to optimize metabolism, hormones, and thyroid health for a balanced, energized life.

Your Precision Metabolism and Thyroid Health Genetic Test comes with evidence-based, actionable, and personalized supplement, diet, and lifestyle recommendations.

  • WHAT YOU GET: 350+ personalized genetic reports and recommendations related to Hormones, Diet, Nutrition, Weight Loss, Thyroid Health and much more
  • WHY PRECISION HEALTH? Precision Health tailors wellness solutions targeting areas like Metabolic Rate, Visceral Fat, Weight Regain, Underactive Thyroid and more based on your unique DNA
  • HOW DOES IT WORK? Once you've opened your kit, register by following the instructions inside. Then, collect your sample and mail it back to us using the prepaid return mailer.
  • ACTIONABLE REPORTS: Practical reports for improving your overall wellness, including insights for TSH, FSH, Prolactin, Insulin, SHBG, Supplements, Diet and Lifestyle Recommendations
  • TARGETED INSIGHTS: Tailor your diet, supplements, and lifestyle to your genetic makeup for optimal health and performance.
  • PERSONALIZED RECOMMENDATIONS: Discover personalized diet, supplement, and lifestyle recommendations tailored to your DNA, all evidence-based and backed by 20,000+ clinical trials.
  • ADVANCED DNA TESTING: Get comprehensive reports with personalized diet, supplement, and lifestyle recommendations to achieve your health goals. Analysis of over 200 million genetic variants.
  • YOUR PRIVACY MATTERS: Your privacy is our priority. We use HIPAA compliant security and advanced encryption, ensuring your personal information is always protected.

    • One test for the rest of your life

    Personalized, actionable advice

    Achieve your health goals faster

    Optimize your diet, vitamins, and lifestyle

    Make Targeted Changes Based on Your DNA

    With personalized dietary, supplement, and lifestyle suggestions, you will understand why specific health recommendations are right for your body and tailored to meet your current health needs. Our recommendations are crafted based on your genetic profile because there is no such thing as one-size-fits-all.

    50 %
    of adults in the U.S. have at least one chronic health condition, many of which are impacted by genetic factors.1
    80 %
    of Americans have nutrient deficiencies, which can impact everything from cognitive function to immunity and metabolic health.2
    25 %
    of U.S. adults are affected by mental health conditions, where genetic predispositions play a key role in conditions such as anxiety, depression, and stress management.3

    How It Works

    Discover lifelong insights from one test.

    Order

    Select your test and purchase directly online. 3-5 days later, your kit will arrive at your door.

    Swab

    Follow the instructions included in your kit to ensure you collect an effective sample.

    Results

    Send your completed DNA specimen back and receive your personalized results.

    From Sofa to Science

    Experience the convenience of Precision Wellness right from your home. Just follow the simple steps included with your kit, and soon your detailed report will arrive at your doorstep.

    Your Kit Contains:

    1x INSTRUCTIONS & REGISTRATION CODE
    1x CHEEK SWAB & TRANSPORT TUBE
    1x BIOHAZARD BAG
    1x PREPAID RETURN MAILER

    Metabolism & Thyroid Health Genetic Test

    The following questions are specific to PlexusDx Metabolism & Thyroid Health Genetic Test

    What is the PlexusDx Metabolism & Thyroid Health Genetic Test and what reports does it include?

    The PlexusDx Metabolism and Thyroid Health Genetic Test is an at-home DNA test that uses one cheek swab to deliver insights from more than 350 genetic traits across four comprehensive reports, helping you personalize strategies for metabolism, weight management, and energy. It includes a Thyroid and Hormone report focused on genetic tendencies related to thyroid function, metabolism, and key hormones, a Diet and Nutrition report covering dietary response, macronutrient handling, nutrient metabolism, and vitamin and mineral needs, a Weight and Body Fat report that explores drivers such as hunger, cravings, snacking, overeating, blood sugar patterns, weight regain tendency, and fat distribution, and a Fitness and Injury report addressing endurance and strength response, recovery, lean mass potential, metabolic rate, and motivation, along with personalized diet guidance, meal plans, and supplement recommendations tailored to your genes and focused only on the nutrients most relevant to you.

    What is included in the Hormone & Fertility Health genetic report?

    Hormones shape how you feel day to day, including energy, mood, sleep, metabolism, skin, and reproductive health. The PlexusDx Hormone and Fertility Health panel turns your DNA into practical guidance across hormone balance, cycle symptoms, thyroid function, and fertility-related traits. It helps you understand baseline tendencies and personalize nutrition, lifestyle, and clinician conversations when needed.

    1) Core hormone pathways

    This section focuses on how your body produces, uses, and clears key hormones.

    • Estrogen: Genetic patterns tied to estrogen balance can influence cycle regularity, mood shifts, skin changes, and how your body processes estrogen over time.
    • Progesterone: Progesterone supports cycle comfort, sleep quality, calm mood signaling, and early pregnancy support. Genetics may influence luteal phase symptoms.
    • Testosterone: Testosterone influences muscle mass, libido, motivation, and energy in all sexes. Genetics can affect androgen sensitivity and how strongly lifestyle impacts levels and effects.

    2) Thyroid and metabolic regulation

    Thyroid hormones help control metabolism, temperature regulation, energy, and mental clarity.

    • Thyroid: This section evaluates genetic tendencies tied to thyroid signaling, helping guide strategies around nutrition, sleep, stress management, and symptom tracking.

    3) Cycle symptoms and hormone sensitivity

    Some people have normal labs but still experience significant symptoms. Genetics can help identify sensitivity patterns.

    • PMS: Genetic influences tied to irritability, cravings, sleep disruption, bloating, and fatigue.
    • PMDD: Susceptibility patterns linked to stronger mood and anxiety changes around the cycle, supporting better planning, tracking, and professional support when needed.
    • Hot flashes: Genetics related to temperature regulation and transition symptoms, useful for perimenopause and menopause planning.

    4) Fertility and reproductive health traits

    This section looks at tendencies related to reproductive health and pregnancy readiness.

    • Infertility: Susceptibility patterns that may help identify areas to monitor and discuss with a clinician.
    • Uterine fibroids: Genetics linked to fibroid susceptibility to support symptom awareness and screening decisions.
    • Pregnancy: Genetic factors that may influence pregnancy-related tendencies and physiological response to pregnancy demands.

      These insights do not diagnose any condition.

    What you get from this panel

    Use this report to:

    • Understand hormone balance tendencies across estrogen, progesterone, and testosterone
    • Personalize energy, mood, and metabolism support using thyroid genetics
    • Make sense of cycle symptoms with insights on PMS, PMDD, and hot flashes
    • Get proactive reproductive health insights related to infertility, uterine fibroids, and pregnancy
    What is included in the Diet & Nutrition genetic report?

    Most nutrition advice is one-size-fits-all. Your body is not. The PlexusDx Diet & Nutrition panel turns your DNA into practical guidance on how you may respond to foods, macronutrients, and key nutrients so you can make smarter choices for energy, body composition, heart health, digestion, and long-term wellness.

    Macronutrients and diet-style fit

    Your genes can influence which eating patterns may suit you best, including:

    • Carbohydrates and higher-carb patterns
    • Fats and lipid metabolism
    • Higher-protein patterns for satiety and lean mass support
    • Keto-style approaches tied to fat-based fueling and lipid handling
    • Mediterranean-style eating for sustainable cardiometabolic support

    Heart and metabolic health signals

    This panel includes genetic insights related to:

    • Cholesterol and triglycerides and how strongly diet may affect them
    • Adiponectin tied to insulin sensitivity and metabolic flexibility
    • Homocysteine patterns linked to nutrient status and cardiometabolic health

    Digestion and food tolerance

    Genetics can provide a smarter starting point for gut comfort, including:

    • FODMAP-related patterns that may guide food choices for bloating or irregularity
    • Microbiome-related tendencies that may influence diet response

    Micronutrients and performance nutrients

    Your needs can vary. This panel helps you prioritize:

    • Vitamins: A, C, D, K, folate, B12, B6, riboflavin, biotin
    • Minerals: magnesium, zinc, selenium, iron, copper, manganese, calcium, sodium, phosphate, molybdenum
    • Choline for brain function and liver fat handling
    • CoQ10, creatine, carnitine, lycopene for energy and performance support

    Lifestyle nutrition insights

    You also get guidance for:

    • Caffeine sensitivity and metabolism speed for sleep and energy balance
    • Antioxidant response and likely benefit from antioxidant-rich foods

    What you get from this panel

    Use this report to choose a diet style that better fits your biology, prioritize the nutrients most likely to matter for you, support heart and metabolic health with targeted decisions, and reduce trial and error so you can eat and supplement with more confidence.

    What is included in the Weight & Body Fat genetic report?

    Weight loss is not only about calories. Genetics can influence appetite signals, cravings, blood sugar response, and fat storage patterns. The PlexusDx Weight & Body Fat panel helps you understand your biggest drivers so you can build a plan that fits your biology.

    Appetite, cravings, and eating behavior

    This section looks at tendencies related to:

    • Hunger and fullness signals
    • Snacking and between-meal cravings
    • Overeating and response to highly palatable foods
    • Emotional eating during stress, low mood, or fatigue
    • Sweet cravings and reward response to sugary foods

    These insights can guide practical tactics like higher-protein meals, smarter meal timing, fiber targets, and trigger-food planning.

    Blood sugar and weight-loss resistance

    Blood sugar stability can shape hunger, energy, and progress. This section includes genetics related to:

    • Glucose control and blood sugar swings that may drive cravings or crashes
    • Weight-loss response, including when macros, timing, activity, or recovery may matter more
    • Weight regain tendencies after dieting

    Fat storage and body composition

    Not all weight is the same. This section covers tendencies related to:

    • Fat distribution patterns
    • Sensitivity to dietary fat intake
    • Muscle mass maintenance and development, which can affect metabolism and glucose control
    • Baseline body weight patterns, including BMI and obesity-related risk tendencies

    Nutrition levers tied to body fat outcomes

    This panel also highlights genetics connected to:

    • Fiber response for fullness, blood sugar balance, and weight control
    • Response to monounsaturated and saturated fats for satiety and metabolic support

    What you get from this panel

    Use this report to:

    • Identify likely blockers like hunger, snacking, sugar cravings, overeating, and emotional eating
    • Choose strategies that improve consistency and reduce cravings
    • Support steadier energy with better blood sugar control
    • Eat and train more effectively based on fat distribution and muscle tendencies
    • Reduce the risk of weight regain with a plan you can maintain
    What is included in the Fitness & Injury genetic report?

    The best workout plan is one your body can recover from, adapt to, and stick with. The PlexusDx Fitness & Injury panel uses your DNA to help you train smarter for better performance, improved body composition, stronger recovery, and fewer setbacks.

    Performance potential

    Your genetics can offer clues about the training mix you may respond to best, including:

    • Endurance capacity, including aerobic efficiency and oxygen delivery
    • Endurance versus power tendencies to guide steady-state and high-intensity work
    • Strength and resistance training response, including muscle and grip strength markers
    • Explosive power traits that may support sprinting, jumping, HIIT, and strength-focused goals
    • Lean body mass potential that can influence how quickly you see visible changes

    Recovery and resilience

    Progress depends on recovery. This section covers tendencies related to:

    • Recovery speed and ideal training frequency
    • Muscle soreness and damage response to help set volume and intensity
    • Pain sensitivity and how training may feel day to day
    • Stress response, since stress can slow recovery and raise injury risk
    • Motivation and activity drive to shape a plan you can maintain

    Metabolism and body composition

    Training affects more than fitness. This panel includes genetics linked to:

    • Resting metabolic rate and baseline calorie burn
    • How strongly exercise may support fat loss for you
    • Glucose response and insulin sensitivity changes with training
    • Lipid response, including triglycerides and HDL cholesterol
    • Blood pressure tendencies that can inform training and recovery priorities

    Injury risk and durability

    This section highlights genetics related to staying durable, including:

    • Tendon strength and tolerance to repetitive load
    • Collagen and soft-tissue injury susceptibility to support smarter progression and warmups
    • Concussion-related considerations for contact or higher-risk activities

    What you get from this panel

    Use this report to:

    • Choose a training style that fits you, whether endurance, strength, power, or a blend
    • Plan recovery so you train consistently without burnout
    • Support fat loss and metabolic health with the right cardio and strength balance
    • Reduce injury risk with smarter progression and connective-tissue support
    • Build a routine you are more likely to sustain based on motivation and stress patterns

    Orders

    Find questions related to ordering.

    Does my doctor need to order these tests?

    No. You can order the test directly.

    Can I order these tests for someone else?

    Yes. You can purchase a test for another person. They will need to activate their test kit on our website upon receipt. For minors, parental or guardian consent is required for activation.

    Once someone has successfully responded to PGx registration questions, PlexusDx's Clinician Network will order your test for you.

    How long does it take to receive my results?

    Once we receive your sample at the lab, it takes approximately 10-14 business days to complete the review and analysis for PGx tests and 2-4 weeks for NGx tests.

    Can I use FSA/HSA to cover these tests?

    Yes, the cost of each test is typically reimbursable through both Flexible Spending Accounts (FSA) and Health Savings Accounts (HSA).

    What is Flex and what is their relationship with PlexusDx?

    PlexusDx has partnered with Flex to allow you to use your Health Savings Account (HSA) or Flexible Spending Account (FSA). This means you can now use your HSA or FSA debit card to buy health and wellness tests with pre-tax dollars, resulting in net savings of 30-40%, depending on your tax bracket.

    How do I pay with my HSA or FSA card?

    To use your HSA or FSA debit card, add products to your cart as usual. At checkout, select "Flex | Pay with HSA/FSA" as your payment option, enter your HSA or FSA debit card, and complete your checkout as usual. If you don't see "Flex | Pay with HSA/FSA," you may be in Shop Pay. Select "checkout as guest" to view more payment options.

    What if I don't have my HSA/FSA card available?

    If you don't have your HSA or FSA card handy, still select "Flex | Pay with HSA/FSA" as your payment method. Enter your credit card information and Flex will email you an itemized receipt to submit for reimbursement.

    Why can't I see Flex as a payment method?

    The key here is to make sure you are logged out of Shop Pay. One of the easiest ways to do this is to go through checkout in an incognito window.

    Why is my HSA/FSA card being declined?

    HSA/FSA cards are debit cards, and the most common reason for declines is insufficient funds. Reach out to your HSA/FSA administrator to confirm your balance.

    I submitted my Flex itemized receipt for reimbursement and my FSA requires more information.
    Please forward us the request from your FSA, and we will work with the Flex team to issue you a new receipt.
    Help! I didn't receive an email from Flex with my itemized receipt and/or letter of medical necessity. What should I do?

    Please check your spam folder, as sometimes emails from notifications@withflex.com may be automatically filtered as spam by some email service providers. If you still can't find it, please email support@withflex.com and let them know the email address associated with your order.

    I would like to use multiple HSA/FSA cards to pay for an item. Can I do that?

    No, unfortunately, this isn't a supported feature right now. If there are insufficient funds in a single HSA or FSA account, you can instead enter a credit card on the Flex checkout page. You will receive an itemized receipt and/or Letter of Medical Necessity from Flex, which you can submit for reimbursement.

    Is sales tax covered by HSA/FSA funds, or is it treated separately?

    Sales tax for eligible items is also covered by HSA/FSA funds. If the customer has a split cart, the tax will be divided among the cards based on the items.

    My HSA/FSA Claim was denied. What should I do?

    We strongly recommend checking with your HSA/FSA provider to see if a purchase is eligible prior to completing the purchase. However, if you believe your claim has been wrongly denied, please send over any response from your HSA/FSA provider to us so we can share it with Flex and receive guidance on the next best steps to take. Please note that employer-sponsored FSAs can determine what products are eligible beyond the IRS's guidelines, so it's extremely important to check prior to purchase.

    Can a customer purchase a product now and apply for FSA reimbursement in the next calendar year?

    The ability to apply for FSA reimbursement in a future calendar year depends on the policy of the specific FSA provider. Most FSA administrators require that the purchase be made during the time of coverage. For example, if the FSA coverage is for 2025, all purchases typically need to be made and/or submitted for reimbursement within that coverage period. However, some administrators may have more flexible rules regarding the timing of when the expense occurred. We recommend that customers review their plan policy to confirm the details. Note: Health Savings Accounts (HSAs) are different and generally allow for reimbursement at any time, even in future years.

    Can old (non-Flex) customers use their order confirmation email to apply for HSA/FSA reimbursement?

    Unfortunately, for purchases made without using Flex in the checkout to receive an itemized receipt, it may be difficult to apply for reimbursement. For Health Savings Accounts (HSAs), consumers can use an itemized receipt for reimbursement anytime after they have made the purchase, even if it is many years later. For Flexible Spending Accounts (FSAs), most accounts require that the purchase was made in the calendar year during which the consumer had the FSA, as FSAs typically do not roll over. Some FSAs offer a buffer window, allowing customers additional time to submit receipts for expenses incurred during the previous calendar year.

    Can I speak to a live person?

    Customer Support is available 9am – 5pm EST Monday – Friday.

    877-760-2333

    support@tests.plexusdx.com

    Reporting & Results

    Below are common questions about the test results and reports.

    What is covered by the Precision Wellness Test reports?

    The PlexusDx Precision Wellness Tests cover over 1000 genetic reports related to your overall health. Here is a small sample...

    How you process macronutrients: 

    • Dietary protein
    • Dietary fats
    • Carbohydrates

    Choosing the right types of dietary fat:

    • Saturated fat
    • Omega-3
    • Unsaturated fat

    Getting enough vitamins:

    • Vitamin B6
    • Vitamin E
    • Vitamin D
    • Vitamin B12
    • Folate
    • Vitamin B2
    • Vitamin C
    • Vitamin A
    • Vitamin K

    Getting enough minerals:

    • Zinc
    • Magnesium
    • Iron
    • Potassium
    • Selenium
    • Calcium

    Improving your eating habits:

    • Tendency to overeat
    • Sugar cravings
    • Snacking 
    What steps should I take after getting my test results?

    Receiving your results marks a significant moment in your health journey. They serve as an insightful tool in managing your healthcare effectively. Should you have any inquiries about your results or if you're interested in obtaining clinical advice, please don't hesitate to contact us at results@plexusdx.com.

    Additionally, every client who completes our tests has the opportunity to be connected with either a Clinical Pharmacist or Registered Dietitian through the PlexusDx Network upon request.

    Does this test provide ancestry information?

    This DNA test doesn't offer ancestry details. It focuses solely on how your genes affect your response to specific medications.

    Can this test predict my disease risk?

    This DNA test isn't designed to assess your likelihood of developing diseases, including cancer.

    Privacy

    Below are questions about how we are committed to protecting your privacy and information.

    How does PlexusDx handle my DNA sample?

    Your genetic data is utilized solely for report processing, with no storage or use beyond this requirement. Rest assured, we promptly discard your sample after processing is complete.

    Will you share my data with my insurance or employer?

    No. Your data is for you, and you only.