Leverage the Power of Genetics to Take Control of Your Hormone and Reproductive Health

With countless wellness options, finding what truly works for your body can be overwhelming. Precision Wellness Tests provide a personalized roadmap by analyzing how your unique genetics impact key health areas. These insights empower you to make informed decisions aligned with your goals—because health isn’t just about the genetic cards you’re dealt; it’s how you play them.

85+ DNA reports including Thyroid, Hormones, Sexual and Reproductive Health

The Precision Hormone, Thyroid, and Reproductive Health Genetic Test offers an in-depth, personalized approach to understanding the genetic factors that influence your hormonal and reproductive wellness. This comprehensive test covers critical areas affecting hormone balance and reproductive health, equipping you with targeted insights and strategies to support fertility, metabolic health, and optimal hormonal function. By examining genes that influence metabolism, weight, and blood sugar, the test provides actionable recommendations to promote a stable metabolic profile essential for reproductive health. It also addresses genetic predispositions to hormonal imbalances, offering tailored advice for achieving and maintaining hormonal balance, including thyroid support to regulate energy levels and mood.

In addition, the test provides insights into genetic risks affecting urinary tract health, with guidance to help prevent and manage issues like UTIs. For a well-rounded view of reproductive health, the test includes specific information on sex hormone levels, delivering gene-based recommendations to enhance fertility, hormonal health, and sexual well-being. Insights into sexual health, including STI susceptibility, complete this thorough assessment, empowering you to take proactive steps for balanced, lifelong reproductive health.

Your Precision Hormone, Thyroid, and Reproductive Health Genetic Test comes with evidence-based, actionable, and personalized supplement, diet, and lifestyle recommendations.

  • WHAT YOU GET: 85+ personalized genetic reports and recommendations related to Thyroid, Hormones, Sexual, Reproductive Health and much more
  • WHY PRECISION HEALTH? Precision Health tailors wellness solutions targeting areas like Underactive Thyroid, Cortisol, Testosterone, DHEAS, Weight Gain, Fertility and more based on your unique DNA
  • HOW DOES IT WORK? Once you've opened your kit, register by following the instructions inside. Then, collect your sample and mail it back to us using the prepaid return mailer.
  • ACTIONABLE REPORTS: Practical reports for improving your overall wellness, including insights for TSH, FSH, Prolactin, Insulin, SHBG, Supplements, Diet and Lifestyle Recommendations
  • TARGETED INSIGHTS: Tailor your diet, supplements, and lifestyle to your genetic makeup for optimal health and performance.
  • PERSONALIZED RECOMMENDATIONS: Discover personalized diet, supplement, and lifestyle recommendations tailored to your DNA, all evidence-based and backed by 20,000+ clinical trials.
  • ADVANCED DNA TESTING: Get comprehensive reports with personalized diet, supplement, and lifestyle recommendations to achieve your health goals. Analysis of over 200 million genetic variants.
  • YOUR PRIVACY MATTERS: Your privacy is our priority. We use HIPAA compliant security and advanced encryption, ensuring your personal information is always protected.
  • One test for the rest of your life

    Personalized, actionable advice

    Achieve your health goals faster

    Optimize your diet, vitamins, and lifestyle

    Make Targeted Changes Based on Your DNA

    With personalized dietary, supplement, and lifestyle suggestions, you will understand why specific health recommendations are right for your body and tailored to meet your current health needs. Our recommendations are crafted based on your genetic profile because there is no such thing as one-size-fits-all.

    50 %
    of adults in the U.S. have at least one chronic health condition, many of which are impacted by genetic factors.1
    80 %
    of Americans have nutrient deficiencies, which can impact everything from cognitive function to immunity and metabolic health.2
    25 %
    of U.S. adults are affected by mental health conditions, where genetic predispositions play a key role in conditions such as anxiety, depression, and stress management.3

    How It Works

    Discover lifelong insights from one test.

    Order

    Select your test and purchase directly online. 3-5 days later, your kit will arrive at your door.

    Swab

    Follow the instructions included in your kit to ensure you collect an effective sample.

    Results

    Send your completed DNA specimen back and receive your personalized results.

    From Sofa to Science

    Experience the convenience of Precision Wellness right from your home. Just follow the simple steps included with your kit, and soon your detailed report will arrive at your doorstep.

    Your Kit Contains:

    1x INSTRUCTIONS & REGISTRATION CODE
    1x CHEEK SWAB & TRANSPORT TUBE
    1x BIOHAZARD BAG
    1x PREPAID RETURN MAILER

    Hormone, Thyroid & Reproductive Health Genetic Test

    The following questions are specific to the PlexusDx Hormone, Thyroid & Reproductive Health Genetic Test

    What is the PlexusDx Hormone, Thyroid & Reproductive Health Genetic Test?

    The PlexusDx Hormone, Thyroid, and Reproductive Health Genetic Test is an at-home DNA test that uses a simple cheek swab to deliver comprehensive, personalized insights across more than 85 genetic traits tied to hormone balance, thyroid function, and reproductive health. It includes genetic insights for reproductive health factors related to male and female fertility and pregnancy, hormone pathways involving estrogen, progesterone, and testosterone including tendencies linked to PMS, PMDD, and hot flashes, and thyroid related genetics that influence thyroid function and metabolism, along with personalized diet guidance, meal plans, and supplement recommendations focused only on the specific nutrients most relevant to your genes.

    What is included in the Hormone, Thyroid, & Reproductive Health genetic report?

    Hormones shape how you feel day to day, influencing energy, mood, metabolism, cycle patterns, and reproductive health. The PlexusDx Hormone, Thyroid, and Reproductive Health genetic report translates your DNA into practical guidance across the key hormone systems that affect both men and women. It helps you understand where you may be more sensitive and which lifestyle and nutrition strategies may be most worth prioritizing.

    1) Core sex hormone balance

    These pathways influence mood, body composition, libido, sleep, and overall cycle stability.

    • Estrogen: Genetic patterns that may affect estrogen metabolism and sensitivity, which can influence cycle symptoms, fluid retention, mood changes, and long-term hormone balance.
    • Progesterone: Insights tied to progesterone signaling and balance, often connected to calm, sleep quality, and cycle-related symptoms.
    • Testosterone: Genetics related to androgen balance that can influence strength, motivation, recovery, libido, and body composition.

    2) Thyroid and metabolic regulation

    Thyroid hormones help set your metabolic “pace” and influence temperature regulation, weight trends, energy, and focus.

    • Thyroid: Genetic tendencies that may influence thyroid hormone production, conversion, and sensitivity, helping guide strategies that support metabolism and steady energy.

    3) Cycle symptoms and perimenopause support

    This section focuses on patterns that commonly affect quality of life and can be improved with the right support.

    • PMS: Genetic susceptibility patterns linked to premenstrual symptoms like irritability, cravings, bloating, and sleep changes.
    • PMDD: Genetics tied to sensitivity to hormone shifts that can influence more intense mood-related cycle symptoms.
    • Hot flashes: Genetic signals linked to thermoregulation and hormone transition sensitivity, often relevant during perimenopause and menopause.

    4) Fertility and reproductive health

    These traits provide insight into inherited patterns connected to reproductive outcomes and planning.

    • Infertility: Genetic tendencies that may influence reproductive resilience, helping highlight areas to prioritize for preconception health.
    • Uterine fibroids: Genetic susceptibility patterns related to fibroid risk, supporting awareness and proactive monitoring where appropriate.
    • Pregnancy: Genetics related to pregnancy-related pathways and overall reproductive health support, useful for planning and optimizing preconception habits.

    What you get from this report

    The Hormone, Thyroid, and Reproductive Health report helps you:

    • Understand your hormone balance tendencies across estrogen, progesterone, and testosterone
    • Personalize strategies that support metabolism and energy using thyroid genetics
    • Get clarity on cycle-related sensitivity patterns including PMS, PMDD, and hot flashes
    • Support reproductive planning with insights on infertility, uterine fibroids, and pregnancy

    This report is designed to turn complex hormone genetics into clear priorities you can act on with nutrition, lifestyle, and informed conversations with a clinician when needed.

    Orders

    Find questions related to ordering.

    Does my doctor need to order these tests?

    No. You can order the test directly.

    Can I order these tests for someone else?

    Yes. You can purchase a test for another person. They will need to activate their test kit on our website upon receipt. For minors, parental or guardian consent is required for activation.

    Once someone has successfully responded to PGx registration questions, PlexusDx's Clinician Network will order your test for you.

    How long does it take to receive my results?

    Once we receive your sample at the lab, it takes approximately 10-14 business days to complete the review and analysis for PGx tests and 2-4 weeks for NGx tests.

    Can I use FSA/HSA to cover these tests?

    Yes, the cost of each test is typically reimbursable through both Flexible Spending Accounts (FSA) and Health Savings Accounts (HSA).

    What is Flex and what is their relationship with PlexusDx?

    PlexusDx has partnered with Flex to allow you to use your Health Savings Account (HSA) or Flexible Spending Account (FSA). This means you can now use your HSA or FSA debit card to buy health and wellness tests with pre-tax dollars, resulting in net savings of 30-40%, depending on your tax bracket.

    How do I pay with my HSA or FSA card?

    To use your HSA or FSA debit card, add products to your cart as usual. At checkout, select "Flex | Pay with HSA/FSA" as your payment option, enter your HSA or FSA debit card, and complete your checkout as usual. If you don't see "Flex | Pay with HSA/FSA," you may be in Shop Pay. Select "checkout as guest" to view more payment options.

    What if I don't have my HSA/FSA card available?

    If you don't have your HSA or FSA card handy, still select "Flex | Pay with HSA/FSA" as your payment method. Enter your credit card information and Flex will email you an itemized receipt to submit for reimbursement.

    Why can't I see Flex as a payment method?

    The key here is to make sure you are logged out of Shop Pay. One of the easiest ways to do this is to go through checkout in an incognito window.

    Why is my HSA/FSA card being declined?

    HSA/FSA cards are debit cards, and the most common reason for declines is insufficient funds. Reach out to your HSA/FSA administrator to confirm your balance.

    I submitted my Flex itemized receipt for reimbursement and my FSA requires more information.
    Please forward us the request from your FSA, and we will work with the Flex team to issue you a new receipt.
    Help! I didn't receive an email from Flex with my itemized receipt and/or letter of medical necessity. What should I do?

    Please check your spam folder, as sometimes emails from notifications@withflex.com may be automatically filtered as spam by some email service providers. If you still can't find it, please email support@withflex.com and let them know the email address associated with your order.

    I would like to use multiple HSA/FSA cards to pay for an item. Can I do that?

    No, unfortunately, this isn't a supported feature right now. If there are insufficient funds in a single HSA or FSA account, you can instead enter a credit card on the Flex checkout page. You will receive an itemized receipt and/or Letter of Medical Necessity from Flex, which you can submit for reimbursement.

    Is sales tax covered by HSA/FSA funds, or is it treated separately?

    Sales tax for eligible items is also covered by HSA/FSA funds. If the customer has a split cart, the tax will be divided among the cards based on the items.

    My HSA/FSA Claim was denied. What should I do?

    We strongly recommend checking with your HSA/FSA provider to see if a purchase is eligible prior to completing the purchase. However, if you believe your claim has been wrongly denied, please send over any response from your HSA/FSA provider to us so we can share it with Flex and receive guidance on the next best steps to take. Please note that employer-sponsored FSAs can determine what products are eligible beyond the IRS's guidelines, so it's extremely important to check prior to purchase.

    Can a customer purchase a product now and apply for FSA reimbursement in the next calendar year?

    The ability to apply for FSA reimbursement in a future calendar year depends on the policy of the specific FSA provider. Most FSA administrators require that the purchase be made during the time of coverage. For example, if the FSA coverage is for 2025, all purchases typically need to be made and/or submitted for reimbursement within that coverage period. However, some administrators may have more flexible rules regarding the timing of when the expense occurred. We recommend that customers review their plan policy to confirm the details. Note: Health Savings Accounts (HSAs) are different and generally allow for reimbursement at any time, even in future years.

    Can old (non-Flex) customers use their order confirmation email to apply for HSA/FSA reimbursement?

    Unfortunately, for purchases made without using Flex in the checkout to receive an itemized receipt, it may be difficult to apply for reimbursement. For Health Savings Accounts (HSAs), consumers can use an itemized receipt for reimbursement anytime after they have made the purchase, even if it is many years later. For Flexible Spending Accounts (FSAs), most accounts require that the purchase was made in the calendar year during which the consumer had the FSA, as FSAs typically do not roll over. Some FSAs offer a buffer window, allowing customers additional time to submit receipts for expenses incurred during the previous calendar year.

    Can I speak to a live person?

    Customer Support is available 9am – 5pm EST Monday – Friday.

    877-760-2333

    support@tests.plexusdx.com

    Reporting & Results

    Below are common questions about the test results and reports.

    What is covered by the Precision Wellness Test reports?

    The PlexusDx Precision Wellness Tests cover over 1000 genetic reports related to your overall health. Here is a small sample...

    How you process macronutrients: 

    • Dietary protein
    • Dietary fats
    • Carbohydrates

    Choosing the right types of dietary fat:

    • Saturated fat
    • Omega-3
    • Unsaturated fat

    Getting enough vitamins:

    • Vitamin B6
    • Vitamin E
    • Vitamin D
    • Vitamin B12
    • Folate
    • Vitamin B2
    • Vitamin C
    • Vitamin A
    • Vitamin K

    Getting enough minerals:

    • Zinc
    • Magnesium
    • Iron
    • Potassium
    • Selenium
    • Calcium

    Improving your eating habits:

    • Tendency to overeat
    • Sugar cravings
    • Snacking 
    What steps should I take after getting my test results?

    Receiving your results marks a significant moment in your health journey. They serve as an insightful tool in managing your healthcare effectively. Should you have any inquiries about your results or if you're interested in obtaining clinical advice, please don't hesitate to contact us at results@plexusdx.com.

    Additionally, every client who completes our tests has the opportunity to be connected with either a Clinical Pharmacist or Registered Dietitian through the PlexusDx Network upon request.

    Does this test provide ancestry information?

    This DNA test doesn't offer ancestry details. It focuses solely on how your genes affect your response to specific medications.

    Can this test predict my disease risk?

    This DNA test isn't designed to assess your likelihood of developing diseases, including cancer.

    Privacy

    Below are questions about how we are committed to protecting your privacy and information.

    How does PlexusDx handle my DNA sample?

    Your genetic data is utilized solely for report processing, with no storage or use beyond this requirement. Rest assured, we promptly discard your sample after processing is complete.

    Will you share my data with my insurance or employer?

    No. Your data is for you, and you only.