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PlexusDx DNA test kit with smartphone displaying genetic results on a white background
Longevity & Healthy Aging Genetic Test
Longevity & Healthy Aging Genetic Test
Longevity & Healthy Aging Genetic Test
Longevity & Healthy Aging Genetic Test

Longevity & Healthy Aging Genetic Test

$298.00

150+ Genetic Traits. 4 Comprehensive Reports. 1 Swab.

  • Longevity Report: understand your genetic risks and take proactive steps to enhance your quality of life and potentially increase your lifespan
  • Healthy Aging Report: unlock the secrets to healthy aging with insights related to arthritis, hearing, vision, skin health, inflammation, fatigue, and back pain
  • Cardiometabolic Report: discover your predispositions related to heart health, blood pressure, blood clots, and diabetes
  • Methylation Report: understand and support your energy, mood, focus, and cellular repair
  • Personalized Diets, Meal Plans, and Supplement Recommendations: custom solutions based on your unique genes and biology, with only the specific nutrients you need.

Comprehensive DNA reports including longevity, healthy aging, methylation, and cardiometabolic health. 

Unlock the secrets to aging and longevity with personalized genetic insights and actionable recommendations. Discover how your DNA impacts key areas like eye health, chronic pain, hearing, and skin vitality. Backed by science, receive tailored supplement, diet, and lifestyle guidance to support wellness at every stage. Empower your proactive aging journey to enhance vitality and quality of life.

Pay using HSA/FSA with flex Select Flex at checkout to pay for your HSA/FSA eligible items

Leverage the Power of Genetics to Take Control of Your Longevity and Embrace Healthy Aging

With countless wellness options, finding what truly works for your body can be overwhelming. Precision Wellness Tests provide a personalized roadmap by analyzing how your unique genetics impact key health areas. These insights empower you to make informed decisions aligned with your goals—because health isn’t just about the genetic cards you’re dealt; it’s how you play them.

150+ DNA reports including Biological Age, Telomere Length, Cognition, and Lifespan

Embrace a personalized path to lasting vitality with the Precision Longevity and Healthy Aging Genetic Test. This comprehensive test examines genetic factors that influence aging and longevity, providing you with tailored recommendations to support healthy aging. Gain insights into your genetic predispositions for eye health, with specific strategies to help protect and maintain your vision over time. The test also identifies your susceptibility to chronic pain, offering personalized tips to help manage and alleviate discomfort. By exploring cognitive health, it supports your mental sharpness and brain wellness with actionable insights. Additionally, it evaluates genetic factors related to hearing and balance, providing advice to improve these essential functions. The test also focuses on skin health, examining genetic influences on skin beauty and aging, giving you recommendations for maintaining youthful, vibrant skin. Designed for those committed to a proactive approach to aging, this test empowers you with the knowledge to enhance your quality of life and well-being at every stage.

Your Precision Longevity and Healthy Aging Genetic Test comes with evidence-based, actionable, and personalized supplement, diet, and lifestyle recommendations.

  • WHAT YOU GET: 150+ personalized genetic reports and recommendations related to Biological Age, Telomere Length, Cognition, Lifespan and much more
  • WHY PRECISION HEALTH? Precision Health tailors wellness solutions targeting areas like Frailty, Muscle Loss, Cognitive Decline, Klotho, Artery Hardening and more based on your unique DNA
  • HOW DOES IT WORK? Once you've opened your kit, register by following the instructions inside. Then, collect your sample and mail it back to us using the prepaid return mailer.
  • ACTIONABLE REPORTS: Practical reports for improving your overall wellness, including insights for Aging Eyes, Facial Wrinkles, Hair Graying, Supplements, Diet and Lifestyle Recommendations
  • TARGETED INSIGHTS: Tailor your diet, supplements, and lifestyle to your genetic makeup for optimal health and performance.
  • PERSONALIZED RECOMMENDATIONS: Discover personalized diet, supplement, and lifestyle recommendations tailored to your DNA, all evidence-based and backed by 20,000+ clinical trials.
  • ADVANCED DNA TESTING: Get comprehensive reports with personalized diet, supplement, and lifestyle recommendations to achieve your health goals. Analysis of over 200 million genetic variants.
  • YOUR PRIVACY MATTERS: Your privacy is our priority. We use HIPAA compliant security and advanced encryption, ensuring your personal information is always protected.

    • One test for the rest of your life

    Personalized, actionable advice

    Achieve your health goals faster

    Optimize your diet, vitamins, and lifestyle

    Make Targeted Changes Based on Your DNA

    With personalized dietary, supplement, and lifestyle suggestions, you will understand why specific health recommendations are right for your body and tailored to meet your current health needs. Our recommendations are crafted based on your genetic profile because there is no such thing as one-size-fits-all.

    50 %
    of adults in the U.S. have at least one chronic health condition, many of which are impacted by genetic factors.1
    80 %
    of Americans have nutrient deficiencies, which can impact everything from cognitive function to immunity and metabolic health.2
    25 %
    of U.S. adults are affected by mental health conditions, where genetic predispositions play a key role in conditions such as anxiety, depression, and stress management.3

    How It Works

    Discover lifelong insights from one test.

    Order

    Select your test and purchase directly online. 3-5 days later, your kit will arrive at your door.

    Swab

    Follow the instructions included in your kit to ensure you collect an effective sample.

    Results

    Send your completed DNA specimen back and receive your personalized results.

    From Sofa to Science

    Experience the convenience of Precision Wellness right from your home. Just follow the simple steps included with your kit, and soon your detailed report will arrive at your doorstep.

    Your Kit Contains:

    1x INSTRUCTIONS & REGISTRATION CODE
    1x CHEEK SWAB & TRANSPORT TUBE
    1x BIOHAZARD BAG
    1x PREPAID RETURN MAILER

    Longevity & Healthy Aging Genetic Test

    The following questions are specific to the PlexusDx Longevity & Healthy Aging Genetic Test

    What is the PlexusDx Longevity & Healthy Aging Genetic Test and what reports are included?

    The PlexusDx Longevity and Healthy Aging Genetic Test is an at-home DNA test that uses one cheek swab to deliver insights from more than 150 genetic traits across four comprehensive reports, helping you take a more proactive approach to long-term wellness. It includes a Longevity report focused on genetic risks and steps that may support quality of life and lifespan, a Healthy Aging report covering traits related to areas such as arthritis, hearing, vision, skin health, inflammation, fatigue, and back pain, a Cardiometabolic report addressing predispositions tied to heart health, blood pressure, blood clots, and diabetes, and a Methylation report that supports understanding of energy, mood, focus, and cellular repair, along with personalized diet guidance, meal plans, and supplement recommendations tailored to your genes and focused only on the nutrients most relevant to you.

    What is included in the Longevity & Lifespan genetic report?

    Longevity is not one single pathway. It reflects how well your body repairs cells, protects tissues from damage, and stays resilient over time. The PlexusDx Longevity and Lifespan panel turns your DNA into practical guidance across key biological drivers linked to long-term health, cardiovascular resilience, and cellular aging.

    1) Cellular aging and repair capacity

    A major pillar of longevity is how well your cells protect and renew themselves over time.

    • Telomeres: Telomeres are protective caps on chromosomes that naturally shorten with age. Genetic differences can influence how quickly they may shorten and how resilient your cells may be under stress. This section helps you understand your baseline aging tendency and where lifestyle support may matter most.
    • Heat shock proteins: These proteins help cells respond to stress by stabilizing and repairing damaged proteins. Genetics may influence how strongly your body activates this protective system, which can impact recovery and long-term cellular function.

    2) Metabolic energy and cellular renewal pathways

    Longevity depends on efficient energy production and strong maintenance systems.

    • NAD+: NAD supports energy production, DNA repair, and cellular signaling. This part of the report highlights genetic patterns that may influence NAD-related efficiency and where supportive strategies may be most relevant.

    3) Hormone-like aging regulators and resilience

    Some genes act like master switches for aging-related pathways.

    • Klotho: Klotho is a longevity-associated protein linked to brain health, vascular function, and metabolic resilience. Genetic differences in Klotho-related pathways can influence how strongly you may benefit from habits that support cognitive and cardiovascular aging.

    4) Cardiovascular and lipid factors that shape lifespan

    For many people, long-term health is closely tied to heart and vascular function.

    • Cholesterol: Genetics can influence how your body manages cholesterol and how strongly diet and lifestyle may impact it. This section helps prioritize heart-smart nutrition and habits based on your inherited tendencies.
    • Heart health: This includes genetic drivers tied to vascular function and cardiovascular resilience. It helps you identify whether focusing on blood pressure support, inflammation balance, activity, and cardiometabolic habits may be especially high return for you.

    5) Overall longevity tendency

    This section brings the systems together into a clearer picture of long-term resilience.

    • Longevity: Your longevity genetics reflect combined influences from cellular maintenance, stress resilience, metabolism, and cardiovascular factors. This is not destiny, but it can highlight where you may have more natural resilience and where consistent support may matter most.

    What you get from this panel

    Use this report to:

    • Understand cellular aging and stress resilience, including telomeres and heat shock proteins
    • Support long-term cellular energy and repair capacity through NAD-linked pathways
    • Learn how Klotho-related pathways may influence resilience with age
    • Personalize heart-smart strategies using cholesterol and heart health genetics
    • Focus on the highest impact habits for your biology based on your overall longevity profile
    What is included in the Healthy Aging genetic report?

    Healthy aging is about staying strong, comfortable, and confident as the years add up. The PlexusDx Healthy Aging panel turns your DNA into practical guidance across skin and appearance, mobility, inflammation and energy, and common age-related risks that can affect quality of life.

    1) Skin and appearance aging

    This section looks at how your skin and hair may respond to time, sun exposure, and connective tissue support.

    • Skin aging: Big-picture tendency for changes in firmness, texture, and resilience.
    • Wrinkles: Genetics tied to collagen support and skin elasticity.
    • Sun spots: How strongly sun exposure may influence pigmentation and uneven tone.
    • Stretch marks: Connective tissue and elasticity patterns that affect how skin responds to growth or weight change.
    • Droopy eyelids: Structural factors that can influence support around the eyes.
    • Gray hair: Patterns related to pigment maintenance and timing of graying.
    • Skin cancer: Susceptibility signals that can help you prioritize sun protection and skin screening habits.

      This section supports prevention planning and does not predict a specific outcome.

    2) Mobility, joints, and everyday comfort

    Aging well depends on maintaining strong connective tissue and pain-free movement.

    • Back pain: Tendency toward back discomfort and structural sensitivity, useful for movement, posture, and strength habits.
    • Arthritis: Genetics linked to joint wear and inflammation-related stiffness over time.
    • Tendonitis: Tendon resilience and irritation risk, helpful for training and recovery choices.
    • Osteoporosis: Bone density maintenance and fracture risk tendencies to guide strength training, protein, and bone-supportive nutrients.

    3) Inflammation, fatigue, and recovery

    Many aging-related symptoms are influenced by inflammation control and stress load.

    • Inflammation: Tendencies that can impact joint comfort, skin health, recovery, and resilience.
    • Fatigue: Differences in energy regulation and sensitivity to poor sleep, overtraining, or nutrient gaps.

      This section helps you focus on high-impact levers like sleep quality, recovery, and anti-inflammatory nutrition.

    4) Oral and sensory health

    Quality of life includes oral health and maintaining the senses that keep you connected.

    • Gum disease: Susceptibility to periodontal inflammation and tissue response, supporting smarter prevention habits.
    • Hearing loss: Genetics linked to age-related hearing decline risk, guiding protective habits and screening awareness.

    5) Longer-term aging risks that can affect wellbeing

    This panel also includes traits tied to conditions that become more common with age.

    • Gallstones: Tendencies related to bile and cholesterol handling.
    • Blindness: Broad susceptibility signals related to vision health risks that can support prevention and screening.

    What you get from this panel

    Use this report to:

    • Personalize skin and appearance support for wrinkles, sun spots, stretch marks, droopy eyelids, gray hair, skin aging, and skin cancer
    • Support long-term mobility with insights on back pain, arthritis, tendonitis, and osteoporosis
    • Understand baseline patterns for inflammation and fatigue to improve recovery and daily energy
    • Strengthen prevention strategies for gum disease and hearing loss
    • Stay proactive about gallstones and vision health risks
    What is included in the Cardiometabolic genetic report?

    Cardiometabolic health supports long-term energy, performance, and healthy aging. It reflects how your body manages blood flow, blood pressure, blood sugar, and blood fats, along with factors involved in vascular function and clotting. The PlexusDx Cardiometabolic panel turns your DNA into practical guidance so you can personalize nutrition, exercise, and lifestyle choices that support heart and metabolic resilience over time.

    1) Heart and vascular risk signals

    This section focuses on genetic tendencies that can influence cardiovascular health and circulation.

    • Heart disease: A broad view of inherited risk patterns tied to cardiovascular outcomes. This helps you prioritize the habits that matter most for your biology, including activity, sleep, stress support, and diet quality.
    • Nitric oxide: Nitric oxide supports healthy blood flow by helping blood vessels relax. Genetics here can influence vascular tone and exercise response, and can guide strategies that support circulation and endothelial health.

    2) Blood pressure regulation

    Blood pressure is one of the most important measurable drivers of long-term cardiovascular outcomes.

    • Blood pressure: Evaluates genetic tendencies related to regulation and response, helping guide strategies around sodium balance, weight management, activity, sleep quality, and stress response.

    3) Blood clotting and circulation balance

    Clotting is necessary, but genetic differences can influence how your body balances clot formation and healthy circulation.

    • Blood clots: Susceptibility patterns tied to clotting tendency, supporting awareness and informed conversations with a clinician when relevant.
    • Fibrinogen: A key clotting protein linked to inflammation and cardiovascular risk. Genetics here can influence baseline clotting and inflammatory balance.

      This section supports awareness and prevention habits and does not diagnose any condition.

    4) Blood fats and lipid handling

    Your lipid profile is influenced by genes and lifestyle. This section helps you focus on what is most likely to pay off.

    • Triglycerides: Genetic tendencies related to triglyceride levels and response to diet and exercise. This can guide choices around carbohydrate quality, alcohol intake, omega-3 rich foods, fiber and activity patterns.

    5) Blood sugar and metabolic resilience

    This section covers genetic drivers tied to glucose and insulin handling over time.

    • Diabetes: Tendencies related to type 2 diabetes risk, helping prioritize strategies that support glucose control and insulin sensitivity.
    • Metabolic syndrome: Broader risk patterns tied to waist circumference, blood pressure, triglycerides, blood sugar, and HDL balance. Genetics can influence which habits help most.

    What you get from this panel

    Use this report to:

    • Understand inherited patterns for heart disease risk and vascular function, including nitric oxide support
    • Personalize strategies for blood pressure management
    • Gain clarity on clotting-related factors like blood clots and fibrinogen
    • Optimize diet and exercise choices to improve triglycerides and overall lipid response
    • Support metabolic health with insights on diabetes and metabolic syndrome risk patterns

    Orders

    Find questions related to ordering.

    Does my doctor need to order these tests?

    No. You can order the test directly.

    Can I order these tests for someone else?

    Yes. You can purchase a test for another person. They will need to activate their test kit on our website upon receipt. For minors, parental or guardian consent is required for activation.

    Once someone has successfully responded to PGx registration questions, PlexusDx's Clinician Network will order your test for you.

    How long does it take to receive my results?

    Once we receive your sample at the lab, it takes approximately 10-14 business days to complete the review and analysis for PGx tests and 2-4 weeks for NGx tests.

    Can I use FSA/HSA to cover these tests?

    Yes, the cost of each test is typically reimbursable through both Flexible Spending Accounts (FSA) and Health Savings Accounts (HSA).

    What is Flex and what is their relationship with PlexusDx?

    PlexusDx has partnered with Flex to allow you to use your Health Savings Account (HSA) or Flexible Spending Account (FSA). This means you can now use your HSA or FSA debit card to buy health and wellness tests with pre-tax dollars, resulting in net savings of 30-40%, depending on your tax bracket.

    How do I pay with my HSA or FSA card?

    To use your HSA or FSA debit card, add products to your cart as usual. At checkout, select "Flex | Pay with HSA/FSA" as your payment option, enter your HSA or FSA debit card, and complete your checkout as usual. If you don't see "Flex | Pay with HSA/FSA," you may be in Shop Pay. Select "checkout as guest" to view more payment options.

    What if I don't have my HSA/FSA card available?

    If you don't have your HSA or FSA card handy, still select "Flex | Pay with HSA/FSA" as your payment method. Enter your credit card information and Flex will email you an itemized receipt to submit for reimbursement.

    Why can't I see Flex as a payment method?

    The key here is to make sure you are logged out of Shop Pay. One of the easiest ways to do this is to go through checkout in an incognito window.

    Why is my HSA/FSA card being declined?

    HSA/FSA cards are debit cards, and the most common reason for declines is insufficient funds. Reach out to your HSA/FSA administrator to confirm your balance.

    I submitted my Flex itemized receipt for reimbursement and my FSA requires more information.
    Please forward us the request from your FSA, and we will work with the Flex team to issue you a new receipt.
    Help! I didn't receive an email from Flex with my itemized receipt and/or letter of medical necessity. What should I do?

    Please check your spam folder, as sometimes emails from notifications@withflex.com may be automatically filtered as spam by some email service providers. If you still can't find it, please email support@withflex.com and let them know the email address associated with your order.

    I would like to use multiple HSA/FSA cards to pay for an item. Can I do that?

    No, unfortunately, this isn't a supported feature right now. If there are insufficient funds in a single HSA or FSA account, you can instead enter a credit card on the Flex checkout page. You will receive an itemized receipt and/or Letter of Medical Necessity from Flex, which you can submit for reimbursement.

    Is sales tax covered by HSA/FSA funds, or is it treated separately?

    Sales tax for eligible items is also covered by HSA/FSA funds. If the customer has a split cart, the tax will be divided among the cards based on the items.

    My HSA/FSA Claim was denied. What should I do?

    We strongly recommend checking with your HSA/FSA provider to see if a purchase is eligible prior to completing the purchase. However, if you believe your claim has been wrongly denied, please send over any response from your HSA/FSA provider to us so we can share it with Flex and receive guidance on the next best steps to take. Please note that employer-sponsored FSAs can determine what products are eligible beyond the IRS's guidelines, so it's extremely important to check prior to purchase.

    Can a customer purchase a product now and apply for FSA reimbursement in the next calendar year?

    The ability to apply for FSA reimbursement in a future calendar year depends on the policy of the specific FSA provider. Most FSA administrators require that the purchase be made during the time of coverage. For example, if the FSA coverage is for 2025, all purchases typically need to be made and/or submitted for reimbursement within that coverage period. However, some administrators may have more flexible rules regarding the timing of when the expense occurred. We recommend that customers review their plan policy to confirm the details. Note: Health Savings Accounts (HSAs) are different and generally allow for reimbursement at any time, even in future years.

    Can old (non-Flex) customers use their order confirmation email to apply for HSA/FSA reimbursement?

    Unfortunately, for purchases made without using Flex in the checkout to receive an itemized receipt, it may be difficult to apply for reimbursement. For Health Savings Accounts (HSAs), consumers can use an itemized receipt for reimbursement anytime after they have made the purchase, even if it is many years later. For Flexible Spending Accounts (FSAs), most accounts require that the purchase was made in the calendar year during which the consumer had the FSA, as FSAs typically do not roll over. Some FSAs offer a buffer window, allowing customers additional time to submit receipts for expenses incurred during the previous calendar year.

    Can I speak to a live person?

    Customer Support is available 9am – 5pm EST Monday – Friday.

    877-760-2333

    support@tests.plexusdx.com

    Reporting & Results

    Below are common questions about the test results and reports.

    What is covered by the Precision Wellness Test reports?

    The PlexusDx Precision Wellness Tests cover over 1000 genetic reports related to your overall health. Here is a small sample...

    How you process macronutrients: 

    • Dietary protein
    • Dietary fats
    • Carbohydrates

    Choosing the right types of dietary fat:

    • Saturated fat
    • Omega-3
    • Unsaturated fat

    Getting enough vitamins:

    • Vitamin B6
    • Vitamin E
    • Vitamin D
    • Vitamin B12
    • Folate
    • Vitamin B2
    • Vitamin C
    • Vitamin A
    • Vitamin K

    Getting enough minerals:

    • Zinc
    • Magnesium
    • Iron
    • Potassium
    • Selenium
    • Calcium

    Improving your eating habits:

    • Tendency to overeat
    • Sugar cravings
    • Snacking 
    What steps should I take after getting my test results?

    Receiving your results marks a significant moment in your health journey. They serve as an insightful tool in managing your healthcare effectively. Should you have any inquiries about your results or if you're interested in obtaining clinical advice, please don't hesitate to contact us at results@plexusdx.com.

    Additionally, every client who completes our tests has the opportunity to be connected with either a Clinical Pharmacist or Registered Dietitian through the PlexusDx Network upon request.

    Does this test provide ancestry information?

    This DNA test doesn't offer ancestry details. It focuses solely on how your genes affect your response to specific medications.

    Can this test predict my disease risk?

    This DNA test isn't designed to assess your likelihood of developing diseases, including cancer.

    Privacy

    Below are questions about how we are committed to protecting your privacy and information.

    How does PlexusDx handle my DNA sample?

    Your genetic data is utilized solely for report processing, with no storage or use beyond this requirement. Rest assured, we promptly discard your sample after processing is complete.

    Will you share my data with my insurance or employer?

    No. Your data is for you, and you only.