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Methylation Pathway Genetic Report
Methylation Pathway Genetic Report

Methylation Pathway Genetic Report

Sale price$29.99Regular price $49.00

Summary Reports are only available to existing customers

The PlexusDx Methylation Pathway Genetic Report delivers 75+ genetic insights into methylation and core metabolic pathways (folate/methionine, BH4, formate, choline/betaine, transsulfuration, glutathione, histamine, urea, polyamines), links genotype to methylation risk, nutrient interactions and personalized supplementation, diet and testing recommendations.

Pay using HSA/FSA with flex Select Flex at checkout to pay for your HSA/FSA eligible items

Use the Power of Genetics to Take Control of Your Methylation Pathway

The PlexusDx Methylation Pathway Genetic Report is a premium, evidence-based analysis delivering more than 75 Genetic Insights into core metabolic and methylation processes. The report translates genotype into actionable insight across neurotransmitter methylation, the methionine and folate cycles, BH4 and formate metabolism, choline oxidation and betaine pathways, transsulfuration, glutathione redox and NAC pathways, plus comprehensive nutrient interactions (vitamin B6, B12, folate, riboflavin, choline, zinc, magnesium, iron, selenium, vitamin C). Additional focus includes histamine degradation, urea and polyamine cycles and methylation-related detoxification. Clear interpretations, risk indicators and personalized recommendations empower you to optimize supplementation, diet and follow-up testing. Available exclusively to existing PlexusDx customers who have previously completed a genetic test.

One test for the rest of your life

Personalized, actionable advice

Achieve your health goals faster

Make Targeted Changes Based on Your DNA

With personalized dietary, supplement, and lifestyle suggestions, you will understand why specific health recommendations are right for your body and tailored to meet your current health needs. Our recommendations are crafted based on your genetic profile because there is no such thing as one-size-fits-all.

50 %
of adults in the U.S. have at least one chronic health condition, many of which are impacted by genetic factors.1
80 %
of Americans have nutrient deficiencies, which can impact everything from cognitive function to immunity and metabolic health.2
25 %
of U.S. adults are affected by mental health conditions, where genetic predispositions play a key role in conditions such as anxiety, depression, and stress management.3

How It Works

Discover lifelong insights from one test.

Order

Select your test and purchase directly online. 3-5 days later, your kit will arrive at your door.

Swab

Follow the instructions included in your kit to ensure you collect an effective sample.

Results

Send your completed DNA specimen back and receive your personalized results.

From Sofa to Science

Experience the convenience of Precision Wellness right from your home. Just follow the simple steps included with your kit, and soon your detailed report will arrive at your doorstep.

Your Kit Contains:

1x INSTRUCTIONS & REGISTRATION CODE
1x CHEEK SWAB & TRANSPORT TUBE
1x BIOHAZARD BAG
1x PREPAID RETURN MAILER

Our Tests

The following questions are specific to PGx and NGx testing.

What is Nutrigenomics (NGx)?

Nutrigenomic (NGx) testing investigates the influence of genetic makeup on nutrient needs. The generic advice to “eat right and exercise” means different things depending on your genetics. This test can help you outline what changes you can make to your daily habits that can impact your weight, energy, and overall health.

Is Nutrigenomics (NGx) right for me?

Everyone can benefit from knowing how your genetics influence your body’s response to nutrition, providing you with a lifetime of guidance.

Orders

Find questions related to ordering.

Does my doctor need to order these tests?

No. You can order the test directly.

Can I order these tests for someone else?

Yes. You can purchase a test for another person. They will need to activate their test kit on our website upon receipt. For minors, parental or guardian consent is required for activation.

Once someone has successfully responded to PGx registration questions, PlexusDx's Clinician Network will order your test for you.

How long does it take to receive my results?

Once we receive your sample at the lab, it takes approximately 10-14 business days to complete the review and analysis for PGx tests and 2-4 weeks for NGx tests.

Can I use FSA/HSA to cover these tests?

Yes, the cost of each test is typically reimbursable through both Flexible Spending Accounts (FSA) and Health Savings Accounts (HSA).

What is Flex and what is their relationship with PlexusDx?

PlexusDx has partnered with Flex to allow you to use your Health Savings Account (HSA) or Flexible Spending Account (FSA). This means you can now use your HSA or FSA debit card to buy health and wellness tests with pre-tax dollars, resulting in net savings of 30-40%, depending on your tax bracket.

How do I pay with my HSA or FSA card?

To use your HSA or FSA debit card, add products to your cart as usual. At checkout, select "Flex | Pay with HSA/FSA" as your payment option, enter your HSA or FSA debit card, and complete your checkout as usual. If you don't see "Flex | Pay with HSA/FSA," you may be in Shop Pay. Select "checkout as guest" to view more payment options.

What if I don't have my HSA/FSA card available?

If you don't have your HSA or FSA card handy, still select "Flex | Pay with HSA/FSA" as your payment method. Enter your credit card information and Flex will email you an itemized receipt to submit for reimbursement.

Why can't I see Flex as a payment method?

The key here is to make sure you are logged out of Shop Pay. One of the easiest ways to do this is to go through checkout in an incognito window.

Why is my HSA/FSA card being declined?

HSA/FSA cards are debit cards, and the most common reason for declines is insufficient funds. Reach out to your HSA/FSA administrator to confirm your balance.

I submitted my Flex itemized receipt for reimbursement and my FSA requires more information.
Please forward us the request from your FSA, and we will work with the Flex team to issue you a new receipt.
Help! I didn't receive an email from Flex with my itemized receipt and/or letter of medical necessity. What should I do?

Please check your spam folder, as sometimes emails from notifications@withflex.com may be automatically filtered as spam by some email service providers. If you still can't find it, please email support@withflex.com and let them know the email address associated with your order.

I would like to use multiple HSA/FSA cards to pay for an item. Can I do that?

No, unfortunately, this isn't a supported feature right now. If there are insufficient funds in a single HSA or FSA account, you can instead enter a credit card on the Flex checkout page. You will receive an itemized receipt and/or Letter of Medical Necessity from Flex, which you can submit for reimbursement.

Is sales tax covered by HSA/FSA funds, or is it treated separately?

Sales tax for eligible items is also covered by HSA/FSA funds. If the customer has a split cart, the tax will be divided among the cards based on the items.

My HSA/FSA Claim was denied. What should I do?

We strongly recommend checking with your HSA/FSA provider to see if a purchase is eligible prior to completing the purchase. However, if you believe your claim has been wrongly denied, please send over any response from your HSA/FSA provider to us so we can share it with Flex and receive guidance on the next best steps to take. Please note that employer-sponsored FSAs can determine what products are eligible beyond the IRS's guidelines, so it's extremely important to check prior to purchase.

Can a customer purchase a product now and apply for FSA reimbursement in the next calendar year?

The ability to apply for FSA reimbursement in a future calendar year depends on the policy of the specific FSA provider. Most FSA administrators require that the purchase be made during the time of coverage. For example, if the FSA coverage is for 2025, all purchases typically need to be made and/or submitted for reimbursement within that coverage period. However, some administrators may have more flexible rules regarding the timing of when the expense occurred. We recommend that customers review their plan policy to confirm the details. Note: Health Savings Accounts (HSAs) are different and generally allow for reimbursement at any time, even in future years.

Can old (non-Flex) customers use their order confirmation email to apply for HSA/FSA reimbursement?

Unfortunately, for purchases made without using Flex in the checkout to receive an itemized receipt, it may be difficult to apply for reimbursement. For Health Savings Accounts (HSAs), consumers can use an itemized receipt for reimbursement anytime after they have made the purchase, even if it is many years later. For Flexible Spending Accounts (FSAs), most accounts require that the purchase was made in the calendar year during which the consumer had the FSA, as FSAs typically do not roll over. Some FSAs offer a buffer window, allowing customers additional time to submit receipts for expenses incurred during the previous calendar year.

Can I speak to a live person?

Customer Support is available 9am – 5pm EST Monday – Friday.

877-760-2333

support@tests.plexusdx.com

Reporting & Results

Below are common questions about the test results and reports.

What is covered by the Precision Wellness Test reports?

The PlexusDx Precision Wellness Tests cover over 1000 genetic reports related to your overall health. Here is a small sample...

How you process macronutrients: 

  • Dietary protein
  • Dietary fats
  • Carbohydrates

Choosing the right types of dietary fat:

  • Saturated fat
  • Omega-3
  • Unsaturated fat

Getting enough vitamins:

  • Vitamin B6
  • Vitamin E
  • Vitamin D
  • Vitamin B12
  • Folate
  • Vitamin B2
  • Vitamin C
  • Vitamin A
  • Vitamin K

Getting enough minerals:

  • Zinc
  • Magnesium
  • Iron
  • Potassium
  • Selenium
  • Calcium

Improving your eating habits:

  • Tendency to overeat
  • Sugar cravings
  • Snacking 
What steps should I take after getting my test results?

Receiving your results marks a significant moment in your health journey. They serve as an insightful tool in managing your healthcare effectively. Should you have any inquiries about your results or if you're interested in obtaining clinical advice, please don't hesitate to contact us at results@plexusdx.com.

Additionally, every client who completes our tests has the opportunity to be connected with either a Clinical Pharmacist or Registered Dietitian through the PlexusDx Network upon request.

Does this test provide ancestry information?

This DNA test doesn't offer ancestry details. It focuses solely on how your genes affect your response to specific medications.

Can this test predict my disease risk?

This DNA test isn't designed to assess your likelihood of developing diseases, including cancer.

Privacy

Below are questions about how we are committed to protecting your privacy and information.

How does PlexusDx handle my DNA sample?

Your genetic data is utilized solely for report processing, with no storage or use beyond this requirement. Rest assured, we promptly discard your sample after processing is complete.

Will you share my data with my insurance or employer?

No. Your data is for you, and you only.