Overview
79
genetic insights
24
traits
52
genes
5
focus areas

The Methylation Pathway Genetic Report turns your existing PlexusDx DNA into 79+ insights across 24 methylation-related traits, covering the folate and B-vitamin cycle, methionine and methyl donors, transsulfuration and glutathione, neurotransmitter and histamine processing, and the cofactor nutrients it depends on.

Genes in this report
MTHFRMTRRDHFRBHMTAHCYPEMT
Focus areas
Folate & B-vitamin cycleMethionine & methyl donorsTranssulfuration & glutathioneNeurotransmitter & histamine processingCofactors & support nutrients

For wellness and educational use only. Not intended to diagnose, treat, cure, or prevent disease.

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Data never sold
One test for life

What you'll learn

Folate & B-vitamin cycle

How your genes may use folate and B vitamins (MTHFR).

Methionine & methyl donors

How your body produces the methyl groups methylation needs.

Transsulfuration & glutathione

The link to antioxidant and detox capacity.

Neurotransmitter & histamine processing

Breakdown that can relate to mood and tolerance.

Cofactor needs

The vitamins and minerals methylation depends on.

Personalized supplement planning

Where targeted support may help most.

For an educational overview, see our learning resources

What your report covers

Your report looks at 79 markers across 24 methylation-related traits, from the core biochemical cycles to the cofactor nutrients methylation depends on. We group them into five simple areas so you can see how your genes may shape methylation, the everyday chemistry your body uses to process nutrients, balance neurotransmitters, and support detox. The well-known MTHFR gene sits here.

Folate & B-vitamin cycle

The folate engine of methylation. These genes, including MTHFR, may affect how your body activates and uses folate and related B vitamins.

BH4 CycleFolate Cycle
Featured genesMTHFRMTRRDHFR

Methionine & methyl donors

How your body recycles methionine and produces methyl donors that power methylation across the body.

Choline Oxidation PathwayMethionine CyclePolyamine Cycle
Featured genesBHMTAHCYPEMT

Transsulfuration & glutathione

The branch that links methylation to your antioxidant and detox capacity through glutathione production.

Glutathione Redox CycleTranssulfuration
Featured genesCBSCTHGPX4

Neurotransmitter & histamine processing

How your genes may shape the breakdown of neurotransmitters and histamine, which can relate to mood and tolerance.

Histamine DegradationNeurotransmitter Methylation
Featured genesCOMTHNMTAOC1

Cofactors & support nutrients

The vitamins and minerals methylation depends on, plus supporting pathways. These genes may shape your cofactor needs.

BetaineCholineFolateFormate MetabolismIronMagnesiumMethionineNACRiboflavinSeleniumUrea CycleVitamin B12Vitamin B6Vitamin CZinc
Featured genesALPLTRPM6SELENOP

You do not have to act on all of it. Pick one or two areas, talk them over with your doctor or a dietitian, and build from there. This report is for wellness and education, not diagnosis.

How it works

1
A plain-language summary of what the finding means.
2
The genetic variants and pathway context behind it.
3
Practical lifestyle and discussion points for you and your provider.
4
Clear framing that insights show tendencies, not certainties.
Delivery
Digital delivery via the PlexusDx Results Portal. Typically available within moments (outside of business hours may take slightly longer).
Eligibility
Add-on report for existing PlexusDx genetic test customers only. Requires prior PlexusDx DNA data. No test kit included.
Is this right for you

Who this report is for

This report is for you if

You have completed a PlexusDx genetic test and want more from your DNA.
You want context on MTHFR and methylation efficiency.
You want guidance for precision supplement and nutrient planning.
You want it to work with your other genetic reports and blood test insights.
You manage everything inside your PlexusDx Results Portal.

This report is not

A genetic test kit. No sample collection is included.
A diagnostic or medical test.
Medical advice or individual treatment guidance.
Intended to diagnose, treat, cure, or prevent disease.
What you receive

Everything included with your report

Personalized report

Your own Methylation Pathway Genetic Report.

79 insights analyzed

Methylation-related genetic insights from your DNA.

Plain-English insights

Evidence-based explanations you can actually read.

Practical discussion points

Supplement and nutrient talking points for you and your provider.

Fast access

Typically available within moments (outside business hours may take slightly longer).

Your ecosystem

Part of your bigger picture

Your results live in the PlexusDx Results Portal, alongside your other genetic reports and supplement guidance. One DNA sample keeps unlocking more over time.

Report type
Genetic Report (Add-on)
Intended use
Wellness and education only
Where it lives
PlexusDx Results Portal

For wellness and educational use only. Not intended to diagnose, treat, cure, or prevent disease.

Built on your DNA

Build a smarter supplement plan from your DNA.

Good to know

Frequently asked questions

How many genetic insights are included?

Over 75 genetic insights related to methylation and core metabolic pathways.

Is a genetic test kit included?

No. This is a digital add-on report that uses existing PlexusDx DNA data.

How soon will my report be available?

Typically within moments of purchase. Availability outside business hours may take longer.

Can I purchase this without a PlexusDx genetic test?

No. A completed PlexusDx genetic test is required to unlock this report.

What methylation cycle genes does this report cover and why does it matter?

This report analyzes 79 variants across core methylation genes including MTHFR, MTRR, MTR, COMT, CBS, and BHMT. These pathways are involved in folate and homocysteine processing, neurotransmitter balance, and glutathione-based detox. Methylation may influence energy, mood, and nutrient needs, which makes this report a useful foundation for precision supplement planning.