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Methylation Support
Methylation Support
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Personalized Health for Only $79/month

Methylation Support

Once a day Methylation Support Packs with methylated B-complex, magnesium glycinate & choline to support healthy methylation and normal homocysteine.  Combined benefits* include:
  • Energy & Metabolism: B vitamins fuel energy production, while magnesium supports cellular energy processes.
  • Stress & Mood: Magnesium glycinate calms the nervous system, and active B vitamins support neurotransmitter balance, helping manage stress.
  • Brain Health: Choline and B vitamins support nerve function, cognitive clarity, and neurotransmitter synthesis.
  • Methylation Support: The active B forms, especially 5-MTHF, assist the body's methylation cycle, crucial for detoxification and overall cellular health. 

Get personalized supplements that are tailored to you and backed by science.

PlexusDx Methylation Support Packs make it easy to cover the core nutrients your body relies on for healthy methylation. Each daily morning pack includes an active-form Methylated B-Complex, Magnesium Glycinate, and Choline to support normal methylation processes involved in DNA maintenance, neurotransmitter production, and detox pathways. Ideal for anyone looking to support normal homocysteine metabolism and nutrient activation, especially when diet alone falls short. Subscribe monthly for convenient, pre-sorted daily packs delivered to your door.

Your Daily Supplement Pack Contains:

Capsule #1: Methylated B-Complex

Methylated B-Complex is a high-potency, highly bioavailable blend that delivers the full spectrum of essential B vitamins in their active (coenzymated) forms—making it easy for your body to absorb and use. This comprehensive formula includes B1, B2, B3, B5, P-5-P (B6), biotin, methylfolate, and methylcobalamin to support energy production and metabolism, healthy brain, liver, and nerve function, and balanced neurotransmitter activity for focus, mood, and stress resilience. With methylfolate and methylcobalamin supporting healthy methylation and homocysteine metabolism, it’s a streamlined daily way to cover core B-vitamin needs in one capsule. When used alongside choline (a key methyl donor) and magnesium (an essential enzyme cofactor), this formula helps provide more complete nutritional support for the body’s interconnected methylation pathways. Made without common allergens, it contains no soy, peanuts, tree nuts, eggs, milk, shellfish, sesame, or fish.†

Capsule #2: Magnesium Glycinate

Magnesium Glycinate provides a highly bioavailable, gentle form of magnesium to support daily relaxation and recovery, delivering 133 mg of elemental magnesium per serving. It helps support muscle relaxation and neuromuscular function, which can be especially helpful for muscle tension and occasional cramps, while also supporting calm mood and restful sleep. Magnesium is also essential for heart and bone health and plays a role in energy production to help reduce fatigue. As a key mineral cofactor, magnesium supports many enzyme-driven reactions in the body, including those involved in methylation; when used alongside a Methylated B-Complex (active folate and B12) and choline (methyl-group support), it helps reinforce the body’s interconnected methylation pathways for more complete nutritional support. Formulated to be easy on the stomach, this capsule contains no artificial colors or flavors and is made without dairy, wheat, soy, peanuts, tree nuts, eggs, shellfish, sesame, or fish.†

Capsule #3: Choline

Choline delivers 420 mg of choline chloride per serving to support liver health, brain and cognitive function, and healthy methylation. Choline is essential for phospholipid and cell membrane structure, lipid metabolism and transport, and the production of acetylcholine for healthy neurotransmission, attention, and mental clarity. It also provides important methyl-group support involved in normal homocysteine metabolism and DNA methylation, and choline needs increase during pregnancy to support early brain development. When paired with a Methylated B-Complex (which supplies active folate and B12) and magnesium (a key cofactor in many enzyme reactions), choline helps reinforce the body’s interconnected methylation pathways for more complete nutritional support. This clean formula contains no common allergens and is made without animal products, artificial colors or flavors, dairy, gluten, preservatives, wheat, soy, peanuts, tree nuts, eggs, milk, GMOs, shellfish, sesame, or fish.†

How It Works

Supplement protocols are based on your unique genetics and biomarkers. If you haven't tested yet, start here →

Our algorithm targets specific health needs and provides personalized recommendations.

Your personalized daily‐dose packs are delivered to your door with easy to follow instructions.

Doctor-Formulated for Trusted Quality

Evidence-Backed Daily Essentials that are Third-Party Tested, Sustainably Packaged, and Designed for Bioavailable Absorption

Professional-Grade Premium Quality Supplements

Science-backed, doctor-formulated supplements that are manufactured to the highest standards for purity, potency, and clinical efficacy. All ingredients are sourced from cGMP-certified vendors and manufactured in facilities with a flawless inspection record. Every batch is third-party tested by accredited labs.

Designed for Optimal Bioavailability

Every ingredient is selected for purity and clinical efficacy—active B vitamins, bioavailable minerals, pure amino acids, and standardized botanicals. Our process ensures every supplement delivers superior results.

Highest Quality, Every Step of the Way

From sourcing to final packaging, every step is controlled for quality. Our cGMP-certified facilities, premium ingredients, and comprehensive third-party testing ensure every batch meets the highest standards.

Frequently Asked Questions

What certifications do your supplements have?

All supplements are manufactured in cGMP and FDA-compliant facilities, with third-party ISO-17025 lab testing. Certifications include Organic, Non-GMO, Vegan, and more.

How do you ensure ingredient purity?

Every batch is tested for contaminants, potency, and purity, with Certificates of Analysis available for review.

Are your supplements allergen-free?

Our formulas are designed to be hypoallergenic and free from common allergens whenever possible.

Is PlexusDx compliant with FDA regulations?

Yes. PlexusDx has partnered with the only cGMP certified personalization co-packer adhering to FDA regulations.

All supplements are manufactured in accordance with UL cGMP standards and tested by certified laboratories. Certifications can also include: Organic, Kosher, Halal, herbicide/ pesticide free, Vegan, Vegetarian, Glyphosate free, Non-GMO.

What types of supplements does PlexusDx offer?

PlexusDx's formulary includes over 60 bioavailable supplements, each backed by scientific evidence and rigorously tested to ensure purity, potency, stability and maximum absorption. These include vitamins, herbs, mushrooms, amino acids, among others.

Are supplements tested for quality and safety?

Yes. PlexusDx's manufacturing partners subject all incoming ingredients to rigorous testing. Every formulation and completed product undergoes a thorough evaluation before being dispatched to PlexusDx, guaranteeing purity, potency, and stability.

Impartial verification is obtained from manufacturing partners, confirming that every batch aligns with all requirements, courtesy of independent third-party laboratories that conduct tests for raw material and finished product potency.

All affiliated laboratories are ISO-17025 accredited and subject to regular audits, ensuring accurate results and adherence to appropriate testing methods.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. PlexusDx does not provide medical advice.

†The information provided is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider before using any new product.