Stress and Mental Health Genetic Test
See how your DNA shapes mood, focus, and stress resilience, and turn those insights into personalized guidance you can act on.
Genetic Tests are a one-time purchase
The Stress and Mental Health Genetic Test turns one cheek swab into 120+ DNA insights across 89 genes, covering mood, anxiety, focus, and the serotonin, dopamine, and MTHFR-driven methylation chemistry behind them.
What your DNA reveals in this test
Mood & emotional resilience
How your genes may shape mood, stress sensitivity, and emotional steadiness, from depression and anxiety tendencies to the serotonin and stress-hormone signals behind them. A practical starting point for conversations with your provider.
Neurotransmitter balance
How your body makes and clears brain chemicals like serotonin, dopamine, and norepinephrine, including the well-known COMT gene. Useful context for focus, motivation, and how you handle stress.
Focus, attention & memory
How your genes may shape attention, mental speed, brain fog, and memory, including BDNF for memory and mood. Helpful for understanding your everyday cognitive patterns.
Methylation & folate
How well your body activates folate and B vitamins and produces the methyl groups used to balance neurotransmitters, the chemistry behind methylation. The well-known MTHFR gene sits here.
Transsulfuration & glutathione
Your genetic capacity to manage oxidative stress through glutathione, the branch of methylation that supports antioxidant defense. This reflects genetic capacity, not a measure of anything in your body.
Mood-supporting nutrients
How your genes may shape your need for nutrients that mood and methylation depend on, like magnesium, zinc, and B vitamins, so food and supplement choices can be personal instead of generic.
What this test covers
This test analyzes your DNA across the Cognition & Brain Health and Methylation Pathway reports: 126 markers across 36 traits, grouped into the six areas below.
Mood & emotional resilience
How your genes may shape mood, stress sensitivity, and emotional steadiness. This area looks at depression and anxiety tendencies, including the serotonin transporter SLC6A4 and the stress-hormone receptor CRHR1.
Neurotransmitter balance
How your body makes, signals, and clears brain chemicals like serotonin, dopamine, and norepinephrine. The well-known COMT gene sits here, along with dopamine and serotonin receptors and the enzymes that break histamine down.
Focus, attention & memory
How your genes may shape attention, mental speed, brain fog, and memory. This area covers focus and learning, including BDNF for memory and mood and CHRNA4 for attention.
Methylation & folate
The methylation engine that helps your body activate folate and B vitamins and produce the methyl groups used to build and balance neurotransmitters. The well-known MTHFR gene sits here, alongside MTR and MTRR.
Transsulfuration & glutathione
The branch of methylation that links to your antioxidant and oxidative-stress defenses through glutathione. Genes here, including CBS, may shape how your body manages cellular stress.
Mood-supporting nutrients
The vitamins and minerals that mood and methylation depend on, including magnesium, zinc, and B vitamins. Your genes may shape how well you absorb and use them, including TRPM6 for magnesium and TCN2 for vitamin B12.
You do not have to act on all of it. Pick one or two areas, talk them over with your doctor, and build from there. This test is for wellness and education, not diagnosis.
From kit to results in four steps
Order your kit
We ship your DNA collection kit to your door for free, in discreet packaging.
Register and swab at home
Register your kit online with the included instructions, then take a quick, painless cheek swab. No needles, no clinic visit.
Mail it back
Seal your sample in the prepaid return envelope and drop it in the mail. Our CLIA-certified lab analyzes your DNA on the Illumina Global Screening Array.
Get your reports
In about 2 to 4 weeks, your reports and personalized guidance appear in your PlexusDx Results Portal.
Everything included with your test
Two genetic reports
Your Cognition & Brain Health and Methylation Pathway reports, delivered together in your PlexusDx Results Portal.
An at-home swab kit
The cheek swab, collection vial, and a prepaid return envelope, with free shipping both ways.
Plain-English insights
Your results in clear language, with discussion points for you and your provider, not raw genetic data.
One swab, 126 markers
A single cheek swab covers all 126 markers across the two reports. Your DNA does not change, so you test once.
The reports inside this test
Each one is a full PlexusDx genetic report. Explore what they cover.
Cognition & Brain Health Genetic Report
How your genes may shape focus, memory, mood, and brain chemistry, across attention, processing speed, dopamine, serotonin, and emotional balance.
View reportMethylation Pathway Genetic Report
How well your body runs the methylation cycle, from folate and B-vitamin activation to homocysteine balance, methyl donors, and neurotransmitter processing.
View reportAll your reports live in one place: your PlexusDx Results Portal, alongside any other PlexusDx tests and reports you own. One login, your whole genetic picture.
PlexusDx tests and reports are for wellness and educational purposes only and are not intended to diagnose, treat, cure, or prevent any disease. Results are delivered through the PlexusDx Results Portal.
One cheek swab unlocks 126 DNA insights across mood, focus, and methylation.