Weight Management Protocols
Six prescription weight loss protocols. One transparent monthly price per compound.
Six compounded protocols across four mechanism classes. Provider-prescribed in all 50 states. Every dose has a published price — no membership, no hidden fees.
Six protocols
From $129/mo
Up to $509/mo for premium dual-compound
Licensed care
Real prescribers
No chatbot, no AI rx
Availability
All 50 states
No membership · Cancel anytime
- All-inclusive monthly price — consultation, prescription, medication, shipping, and provider monitoring
- Six compounded protocols — Microdose GLP-1, Semaglutide (injection + oral), Tirzepatide (injection + oral), and GLP-Squared dual-compound
- Provider-prescribed in all 50 states — 5 require a live telehealth call
- Optional Precision Peptide Genetic Test — $99 add-on after first month, 34 weight management insights drawn from a 150+ insight panel across 14 pathways
AI Summary
PlexusDx Weight Management Protocols offer six prescription compounds across four mechanism classes — GLP-1 injectable, GLP-1 oral, microdose, and dual-compound: Microdose GLP-1, Semaglutide Injection, Semaglutide Oral, Tirzepatide Injection, Tirzepatide Oral, and GLP-Squared (Tirzepatide + Semaglutide dual-compound).
Pricing ranges from $129 to $509 per month, all-inclusive — consultation, prescription, medication, shipping, and ongoing provider monitoring with no membership fee. Available in all 50 states, with 5 states requiring a live telehealth consultation — so the protocol works for your body, your goals, and how you want to feel about your progress.
The optional Precision Peptide Genetic Test analyzes 34 Weight Management insights including GIPR rs1800437 — a variant associated with differential GLP-1 response — drawn from a 150+ insight panel across 14 pathways. Available for $99 as an add-on after your first month of treatment.
Weight Management Genetic Pathway
Layer 34 Weight Management genetic insights onto your protocol.
Before you start — or alongside your protocol — the Precision Peptide Genetic Test analyzes 34 Weight Management insights drawn from a 150+ insight panel across 14 pathways.
Includes GIPR rs1800437 — a variant associated with differential glp-1 + gip receptor response. Genetics as a guide, not a guarantee.
Available for $99 as an add-on after your first month of treatment.
Learn About the Genetic Test →Optional · Not required to start your protocol
Compliance
503A pharmacy-grade medication
Compounded under 503A patient-specific pharmacy standards.
Coverage
All 50 states
Available nationwide. 5 states require a scheduled video consultation.
Privacy
HIPAA-secure
Intake, prescriptions, and records via HIPAA-compliant Results Portal.
Pricing
All-inclusive pricing
No membership fee. No hidden fees. No contract.
Choose your compound
Your provider recommends the right compound for your clinical profile. All six are available under one PlexusDx protocol — switch mid-protocol if your provider determines a different compound is a better fit.
Entry-level
Microdose GLP-1
From $129/moBest for: Entry-level GLP-1 with lowest friction and no blood work required.
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Most-studied
Semaglutide Injection
From $179/moBest for: Patients wanting the most-studied GLP-1 with a proven track record.
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Needle-free
Semaglutide Oral
From $209/moBest for: Needle-free daily dosing with Semaglutide's established efficacy.
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Greater weight loss
Tirzepatide Injection
From $229/moBest for: Dual GIP/GLP-1 mechanism — greater average weight loss in head-to-head studies.
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Dual receptor
Tirzepatide Oral
From $229/moBest for: Daily oral dosing of the dual-receptor compound.
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Advanced
GLP-Squared
From $179/moBest for: Advanced Semaglutide + Tirzepatide dual-compound formulation for provider-directed dual-agonist intensity.
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Injection or oral — which fits your life?
Same active compounds, two delivery routes. Here's what patients typically weigh — your licensed provider makes the final call.
Route 01 · Injection
Best for
Highest average weight loss
Longer clinical record · weekly cadence · 4 compounds
Route 02 · Oral
Best for
Needle-free convenience
Daily dosing · easy to travel · 3 compounds
Compare on
Injection
Oral
Clinical evidence
Longer head-to-head track record in weight management studies
Newer category — efficacy varies by formulation and dose
Dosing
One subcutaneous shot per week
Daily oral dose — no refrigeration for most formulations
Compounds
Semaglutide · Tirzepatide · GLP-Squared · Microdose Injection
Semaglutide Oral · Tirzepatide Oral · Microdose Oral
Cost profile
Lower at higher doses — vial pricing scales efficiently
Higher at higher doses — reflects compounded oral pharmacy
The decision
Both routes use the same active compounds. Your licensed provider chooses the final protocol based on your medical history.
Not sure where to start?
Find your protocol in 60 seconds.
Three steps. No charge until your provider approves your prescription. Cancel anytime.
Answer about your goals
Weight loss target, injection comfort, dosing preference
Provider reviews & prescribes
Licensed clinician, all 50 states, async or live
Medication ships to your door
Discreet packaging, all-inclusive pricing, no surprises
Free to use · $0 charge until your provider approves · HIPAA-protected
What happens next
After you order
Your provider, your pharmacy, your ongoing care — what happens once your intake is in.
Licensed review
Provider review & prescription
A licensed US provider reviews your intake, selects the appropriate compound, and writes your prescription. In 5 states, this step is a live video consultation.
503A compounding
Pharmacy ships your medication
Your compounded medication ships from a US 503A pharmacy in discreet packaging. Dosing instructions and supplies (syringes or oral applicators) included.
Care that continues
Ongoing provider care
Unlimited provider messaging, dose adjustments, and automatic refills — all inside your monthly price. Cancel anytime.
Your commitment
Nothing is charged until your provider approves your prescription. Cancel anytime, no fees.
One price, everything in it
What's included in your monthly price
Every PlexusDx Weight Management protocol bundles the full clinical and fulfillment stack into one transparent price.
Clinical care
Licensed provider consultation
Async intake — or live video in the 5 states that require it.
Prescription
Prescription issuance & management
Initial Rx and ongoing dose-level adjustments.
Medication
503A compounded medication
503A patient-specific pharmacy, prepared per prescription.
Shipping
Discreet direct-to-door shipping
Plain packaging, no external labeling.
Ongoing care
Monthly provider monitoring
Dose adjustments as clinically indicated.
Radical transparency
Every dose has a published price.
No membership. No hidden fees. No platform fee stacked on your medication. See the exact monthly price for every dose level on every compound product page — before you enroll, before you're billed.
Eligibility & exclusions
Who these protocols are for
Clinical eligibility signals and exclusion criteria. Final eligibility is confirmed by your licensed provider during intake.
Eligible patients
Who qualifies
BMI THRESHOLD
Adults 18+ with a BMI of 27+ and weight-related conditions, or BMI 30+.
Adults 18+ with a BMI of 27+ and weight-related conditions, or BMI 30+. Standard clinical GLP-1 eligibility criteria.
LIFESTYLE READINESS
Patients who have tried lifestyle changes and want clinical support.
Patients who have tried lifestyle changes and want clinical support. Diet and exercise alone have plateaued.
PRICING MODEL FIT
Anyone who wants one transparent monthly price instead of stacked fees.
Anyone who wants one transparent monthly price instead of stacked fees. All-inclusive: consult, prescription, medication, and shipping.
GENETIC-FIRST INTEREST
Patients interested in the optional genetic insight layer before or during treatment.
Patients interested in the optional genetic insight layer before or during treatment. Available as a $99 add-on during treatment.
STATE COVERAGE
Residents of any US state.
Residents of any US state. Five states require a scheduled video consultation.
Exclusion criteria
Not a fit if
AGE REQUIREMENT
Anyone under 18.
Anyone under 18. Protocols are adult-only.
PREGNANCY STATUS
Pregnant or breastfeeding patients.
Pregnant or breastfeeding patients. GLP-1 medications are contraindicated.
THYROID HISTORY
Personal or family history of medullary thyroid carcinoma or MEN 2.
Personal or family history of medullary thyroid carcinoma or MEN 2. MTC contraindication applies to all GLP-1 compounds.
GI CONDITIONS
Active pancreatitis or severe gastrointestinal disease.
Active pancreatitis or severe gastrointestinal disease. GLP-1 medications may worsen these conditions.
NON-RX SEEKERS
Patients seeking a non-prescription weight loss product.
Patients seeking a non-prescription weight loss product. Compounded GLP-1 requires a provider-issued Rx.
Pricing transparency
What changes. What stays locked.
Every PlexusDx telehealth protocol follows the same four rules. Know exactly what moves your monthly price and what doesn’t before you start.
Published and fixed
What you see is what you pay
DOSE-LEVEL PRICING
Every dose has a published price
See the exact monthly price for every dose level on every compound product page before you enroll.
NO MEMBERSHIP FEE
Zero platform fees, ever
No membership, no platform fee, no per-dose medication markup stacked on top of your price.
NO CONTRACT
Month-to-month, always
No 12-month commitment, no annual lock-in, no early-termination fee.
CANCELLATION TERMS
Cancel before your next billing cycle
Self-service portal cancellation. No retention call, no cancellation fee.
Published and variable
Only two things can move it
DOSE-LEVEL ADJUSTMENT
Your provider moves you to a new dose level
Your price moves to that dose level's published rate. Every rate is visible on the compound product page before you enroll.
COMPOUND SWITCH
Your provider switches you between compounds
Moving from Semaglutide to Tirzepatide or vice versa shifts your price to the new compound's dose-level schedule.
MICRODOSE EXCEPTION
Microdose GLP-1 is our only flat-rate protocol
$129/mo across all four Microdose variants regardless of provider-determined dose. Full-dose compounds use dose-level pricing.
The guarantee
Every dose has a published price. You see it before you enroll. You see it before you’re billed.
How PlexusDx compares
One price. One provider. No asterisks.
Transparent pricing math against the most-searched weight management brands — including Amazon's GLP-1 program launched April 2026.
Why start here
The only all-inclusive model with genetic testing available.
Rx, compounded medication, shipping, and provider monitoring in one monthly price. No membership fee. No per-dose markup. No contract.
Henry Meds
$297/mo flat — Rx + compounded semaglutide
How we compare
PlexusDx Semaglutide Injection starts at $179/mo — same compound, $118/mo less.
Hims Weight Loss
$39 first mo · $149/mo after (meds NOT included)
How we compare
Their $149/mo membership does not include the cost of meds. PlexusDx offers one low price and no membership fees.
Noom GLP-1Rx
$79 first mo · $199/mo after (app-based microdose GLP-1)
How we compare
App-based microdose — no clinical protocol, no genetics. PlexusDx offers the same compound for $129 all-in.
Lemonaid
$49 membership + $199–299 compounded meds
How we compare
$49 membership + $199–299 meds — up to $119/mo more than PlexusDx.
WeightWatchers Clinic
$74/mo program (meds NOT included)
How we compare
$74 program fee + meds on top — 12-month auto-renew.
Found
$99/mo CORE + medication by dose
How we compare
$99 coaching + meds billed by dose — non-refundable.
Calibrate
$138/mo (12-month commitment required)
How we compare
$138/mo × 12 months required. Meds not included.
Amazon One Medical
$149/mo oral · $299/mo injection — FDA-approved only
How we compare
FDA-branded Wegovy only — no compounded 503A option.
Competitor pricing reflects publicly listed rates as of April 2026. PlexusDx pricing is all-inclusive — no membership fee, no per-dose markup, no contract required. Comparison pages for each named competitor are in development.
Frequently Asked
Answers before you enroll
Pricing, eligibility, genetics, compounding, and what happens after you start — directly answered, no hedging.
PRICING
What does the monthly price include?
Your published per-dose price covers the async provider intake, prescription, compounded medication, supplies, shipping, and ongoing provider monitoring. There is no separate membership, no consult fee, and no platform fee stacked on top. If your provider moves you to a different dose level, your price moves to that dose level's published rate — every rate is visible on each compound product page before you enroll. Microdose GLP-1 is the exception: $129/mo flat across all four variants.
COMMITMENT
Is there a contract or minimum commitment?
Month-to-month. No contract, no annual prepayment required. Cancel anytime by messaging your provider or support team — cancellation is processed before your next billing cycle with no penalty or fee.
GENETICS
How does the Precision Peptide Genetic Test fit into my protocol?
The genetic test is optional and available before or during your protocol. It analyzes 14 pathways, 49 peptides, and 150+ genetic insights to help contextualize your response. It does not determine which compound you use — your provider does — and it does not predict response to a named drug.
MEDICATION
What's the difference between injection and oral compounds?
Injection and oral compounds deliver the same active ingredient through different routes. Injections are typically weekly and have longer clinical track records. Oral compounds are daily and needle-free. Your provider recommends the route that fits your preference, lifestyle, and clinical profile.
COMPOUNDING
What is 503A compounding and why does it matter?
503A compounding means your medication is prepared by a licensed pharmacy specifically for your prescription — not mass-manufactured. PlexusDx uses a national network of 503A-compliant pharmacies. This pathway is FDA-regulated and legal for patient-specific prescriptions. It is distinct from FDA-branded retail medications like Wegovy.
ELIGIBILITY
Do I need blood work before starting?
No. Blood work is not clinically required for GLP-1 protocols per current ADA guidance. Some patients opt into our Red Drop Dx at-home blood panel for baseline metabolic data, but it is optional — not gated, not required, not bundled into your monthly price.
STATES
What happens in states requiring a live consultation?
Five states require a live telehealth consultation instead of async intake: you'll schedule a short video call with your provider before your first prescription ships. Everything else — pricing, shipping, monitoring — stays identical. Available in all 50 states either way.
PROVIDER
Can I switch compounds mid-protocol?
Yes. If your provider determines a different compound better fits your response or goals, they can switch you — consultation, new prescription, and shipping are handled inside your protocol pricing. When you move between compounds, your billing shifts to the new compound's dose-level schedule.
Important disclaimer
Compounded medications are not approved by the FDA or reviewed for quality, safety or efficacy. Novo Nordisk, Inc. is the only United States company with FDA-approved products containing semaglutide, identified under the trade names Rybelsus®, Ozempic® and Wegovy®. Lilly USA LLC is the only United States company with FDA-approved products containing tirzepatide identified under the trade names Zepbound® and Mounjaro®. The Precision Peptide Genetic Test analyzes how your genes influence peptide-related biological pathways. It does not recommend, prescribe, or determine which peptides you should use. Consult a qualified healthcare provider before beginning any peptide protocol.