Semaglutide Oral tablets - compounded GLP-1 weight management protocol from PlexusDx
Infographic showing 3 easy steps to order Semaglutide ODT online with a doctor on a phone screen.

Semaglutide Oral

Compounded Semaglutide via licensed providers. Your dose may need to go up. Your price won't.

Care from a licensed provider in your corner — a short online visit, no waiting room

Compounded Semaglutide shipped discreetly to your door — a daily tablet that dissolves in your mouth

1-, 3-, 6- or 12-month plans — HSA and FSA cards accepted at checkout; pay over time on 3-, 6- and 12-month plans

Optional genetic insights about your biology to discuss with your provider — 34 Weight Management insights, $99 after your first month

One price per plan covers provider, prescription, medication, and shipping. Your dose may need to go up. Your price won't.

Starts at
$99/mo — 12-month plan ($1,188 billed up front)
Or $149 month to month. Your monthly price doesn't change as your dose changes.
Start Today

No membership fee · HSA and FSA cards accepted at checkout

WHAT CHANGES FOR YOU

How GLP-1 weight loss works

Real prescription medicine. A licensed provider sets every dose.

THE SCIENCE

When food runs the show. No shot.

Semaglutide acts like GLP-1, the gut hormone that tells your brain you've had enough. A daily tablet that dissolves in your mouth.

THE GOAL

Show up to your day differently

You want clothes that fit, food back in its place, and to feel like yourself again.

HOW LONG IT TAKES

Real change takes a little time

Your provider starts you low and adjusts your dose as you go. You're never doing this alone.

YOUR GENETICS

See what your DNA says

The optional GLP-1 & Peptide Pathways Genetic Test gives you 34 weight management insights to share with your provider.

CLINICAL EVIDENCE

14.9%

Average body weight loss in a 68-week clinical trial of Wegovy® at 2.4mg weekly. Semaglutide is the active ingredient in Wegovy® and Ozempic® (Novo Nordisk).

Wegovy®, Ozempic®, and Rybelsus® are registered trademarks of Novo Nordisk A/S. Novo Nordisk is the only United States company with FDA-approved products containing semaglutide. PlexusDx is not affiliated with or endorsed by Novo Nordisk.

READY?

A plan your provider designs around you.

Start your intake

A short online visit · Cards are charged once your prescription is sent to the pharmacy.

Overview

Compounded Semaglutide is a GLP-1 agonist tablet prescribed by licensed providers. Semaglutide is the active ingredient in Rybelsus®, Wegovy®, and Ozempic® (Novo Nordisk). Your provider sets your starting dose and adjusts it over time. One price per plan covers your provider visit, prescription, medication, and shipping: $99 to $149 a month by plan length, from $99/mo on a 12-month plan ($1,188 billed up front) to $149 month to month. No membership fee.

  • Daily tablet that dissolves in your mouth, provider-titrated
  • GLP-1 receptor agonist mechanism — supports appetite regulation and gastric emptying
  • 1-, 3-, 6- or 12-month plans at $149, $129, $109 or $99 a month — 3-, 6- and 12-month plans are charged once, up front, and renew automatically
  • Real medical authority — U.S.-licensed providers, no AI prescriptions
  • 34 Weight Management genetic insights including FTO rs9939609 — optional GLP-1 & Peptide Pathways Genetic Test, $99 as an add-on after your first month

The optional GLP-1 & Peptide Pathways Genetic Test analyzes 34 Weight Management insights including FTO rs9939609, a variant in a gene involved in hunger and energy balance, drawn from a 150+ insight panel across 14 pathways. Available for $99 as an add-on after your first month of treatment.

Why trust PlexusDx

Compliance

503A pharmacy-grade medication

Your compounded Semaglutide Oral is prepared by a licensed 503A compounding pharmacy for your prescription — not mass-manufactured.

Coverage

Licensed providers across the U.S.

Your provider confirms availability in your state at your visit.

Privacy

HIPAA-compliant platform

Protected under HIPAA. Never sold or shared without your consent. Manage your plan in your patient portal at my.plexusdx.com.

Pricing

Transparent pricing

All-inclusive. Your dose may need to go up. Your price won't.

Pricing

What Semaglutide Oral costs

Your dose may need to go up. Your price won't.

Starts at $99/mo

·

12-month plan, $1,188 billed up front · $149 month to month

All-inclusive. No membership fee.

Plan lengths

  • $149/mo 1-month plan Billed monthly
  • $129/mo 3-month plan $387 billed up front
  • $109/mo 6-month plan $654 billed up front
  • Best value $99/mo 12-month plan $1,188 billed up front Includes a provider check-in at 6 months

3-, 6- and 12-month plans are charged once, up front, and renew automatically. Cancel future renewals anytime.

HSA and FSA cards accepted at checkout · Pay over time on 3-, 6- and 12-month plans

Online visit with a licensed provider Prescription, if appropriate Compounded Semaglutide Oral Shipping included

Provider-determined dosing

Your provider sets your starting dose and adjusts it over time. On the intake's medication step, choose the Semaglutide daily tablet (or the weekly injection if you prefer it).

Start your online visit

Cards are charged once your prescription is sent to the pharmacy.

A short online visit. A licensed provider decides whether a prescription is right for you.

WHAT HAPPENS NEXT

After you order

What happens once your intake is in.

After your visit

LICENSED REVIEW

Provider review & prescription

A licensed U.S. provider reviews your online visit and decides whether a prescription is right for you.

Once prescribed

503A COMPOUNDING

Pharmacy ships your medication

Your compounded Semaglutide oral tablets ship from a US 503A pharmacy in discreet packaging. A 503A pharmacy is a state-licensed compounding facility regulated by FDA and state boards of pharmacy that prepares medications individually for a specific patient based on a valid prescription. Dosing schedule included

Ongoing

CARE THAT CONTINUES

Ongoing provider care

Your provider follows your progress and adjusts your treatment when appropriate.

Anytime

FLEXIBILITY

Manage your plan

Manage your plan in your patient portal at my.plexusdx.com. Cancel future renewals anytime.

OUR COMMITMENT

Cards are charged once your prescription is sent to the pharmacy. Cancel future renewals anytime.

EVERYTHING INCLUDED

What's included

Your provider, your pharmacy, your direct-to-door shipping — everything in your Semaglutide Oral plan.

PROVIDER

Licensed, online

Licensed providers across the U.S.

PHARMACY

503A compounded

Pharmacy-grade Semaglutide prepared for your prescription.

SHIPPING

Direct-to-door

Discreet packaging. Ships from U.S. partner pharmacy.

ALL-INCLUSIVE

One all-inclusive price per plan

Provider, prescription, medication, and shipping — all included. No membership fee.

WHAT YOU WON'T PAY
Membership fee
Consult charge
Hidden fees
REFILLS

Provider-reviewed

Your plan renews automatically. 1-month plans ship a 1-month supply; longer plans ship a 3-month supply in each box.

MONITORING

Provider check-ins

Your provider follows your progress and adjusts your dose when appropriate.

FLEXIBILITY

Manage your plan

Manage your plan in your patient portal. Cancel future renewals anytime.

Optional add-on
Available post-enrollment

The optional GLP-1 & Peptide Pathways Genetic Test analyzes 34 Weight Management insights including FTO rs9939609 — a variant in a gene involved in hunger and energy balance — drawn from a 150+ insight panel across 14 pathways. Available for $99 as an add-on after your first month of treatment.

34
Pathway insights
150+
Total panel
14
Pathways
$99
Add-on
Featured SNP
FTO rs9939609
a variant in a gene involved in hunger and energy balance
Explore the Genetic Test → $99 · one-time · available after your first month of treatment

CLINICAL FIT CHECK

Is this protocol right for you?

We lead with safety considerations first. If any exclusion applies to you, stop here and speak with your primary care provider before starting intake.

SAFETY EXCLUSIONS

Skip this protocol if…

THYROID HISTORY

Personal or family history of medullary thyroid carcinoma (MTC) or MEN2

PANCREATITIS

Any history of pancreatitis

PREGNANCY STATUS

Pregnant, breastfeeding, or planning pregnancy

CONCURRENT GLP-1

Currently taking another GLP-1 or GIP/GLP-1 medication

ELIGIBLE

You're a fit if…

BMI THRESHOLD

BMI ≥27 with a weight-related condition, or BMI ≥30

CLINICAL OVERSIGHT

Want oversight from a U.S.-licensed provider

PRICING TRANSPARENCY

Want every price published up front

DATA-GUIDED CARE

You prefer clinical decisions informed by your personal health data

PROVIDER VERDICT

Your licensed provider confirms final eligibility during intake review. No medication ships without their sign-off.

Built differently

What makes PlexusDx different

Five things every shopper deserves before they sign up.

THE DIFFERENTIATOR

Genetics-informed care from a complete precision health platform

34 Weight Management insights via the GLP-1 & Peptide Pathways Genetic Test — across 14 pathways, 49 peptides. The only telehealth peptide protocol with a genetic testing layer.

TRANSPARENCY

Radically transparent

Every plan and every price published.

PRICING

One plan price

One price for intake, Rx, medication, shipping.

CLINICAL

Online clinical oversight

No in-person visits. A short online visit with a licensed provider.

NO GATE

No membership gate

Your first dollar goes toward care, not a membership fee.

Clinical details

Clinical details

How this compound works and what lab work is involved.

Compound spec

Class

GLP-1 agonist

incretin mimetic

Route

Oral

daily dissolving tablet

Half-life

~7 days

daily dosing schedule

Compounded by

503A pharmacy

licensed US partner

How it works

About this compound

Semaglutide is a GLP-1 receptor agonist — it activates glucagon-like peptide-1 receptors to support appetite regulation, glucose homeostasis, and metabolic function.

Your provider sets your daily dose and adjusts it over time. Semaglutide Oral is a tablet that dissolves in your mouth, taken daily under clinical supervision.

See how PlexusDx customers describe their precision health journey — read Customer Stories.

Why it matters

The optional GLP-1 & Peptide Pathways Genetic Test analyzes 34 Weight Management insights including FTO rs9939609, a variant in a gene involved in hunger and energy balance. Available for $99 as an add-on after your first month of treatment.

Lab requirements
No blood work required at intake. Blood testing is available at patient election and may be recommended by your provider based on your individual health history. At-home blood collection is available through Red Drop Dx — no clinic visit required.
NOT REQUIRED
Compare Compounds

How this compound compares

Compound
Mechanism
Route
Monthly price
Semaglutide Injection
GLP-1 agonist
Subcutaneous injection
$99/mo (12-mo plan) · $149 month to month
Tirzepatide Injection
GIP/GLP-1 dual agonist
Subcutaneous injection
$129/mo (12-mo plan) · $189 month to month
You're viewingSemaglutide Oral
GLP-1 agonist
Daily dissolving tablet
$99/mo (12-mo plan) · $149 month to month
Tirzepatide Oral
GIP/GLP-1 dual agonist
Daily dissolving tablet
$129/mo (12-mo plan) · $189 month to month
Microdose GLP-1
Low-dose GLP-1 agonist
Tablet or injection
$69/mo (12-mo plan) · $99 month to month

If your provider recommends a different medication, unused prepaid value is credited toward it and you pay only the difference.

Semaglutide Oral — FAQ

Answers before you start

Pricing, titration, genetics, and what happens if you need a different dose or compound — directly answered, no hedging.

PRICING

How much does Semaglutide Oral cost?

Semaglutide Oral starts at $99/mo on a 12-month plan ($1,188 billed up front). Or $109/mo for 6 months ($654), $129/mo for 3 months ($387), or $149 month to month. 3-, 6- and 12-month plans are charged once, up front, and renew automatically. Cancel future renewals anytime. No membership fee.

INCLUSIONS

What's included in every plan?

Every Semaglutide Oral plan includes your online visit with a licensed provider, your prescription, compounded semaglutide tablets, and shipping to your door. There is no membership fee and no consult charge. Your price changes only with your plan length, never with your dose. Cancel future renewals anytime.

TITRATION

How does dose titration work — who controls it?

Your licensed provider determines your starting dose and adjusts it over time based on your response. You do not select a dose. Your monthly price stays the same as your dose changes — billing is flat across all dose levels for this compound. Your provider follows your progress throughout your plan.

MECHANISM

What is a GLP-1 agonist and how does Semaglutide work?

Semaglutide is a GLP-1 receptor agonist — it activates the GLP-1 receptor to support appetite regulation, satiety, and metabolic function. The oral form delivers the same compound as a daily tablet rather than a weekly injection. Your provider determines whether the oral form matches your clinical profile and preferences.

GENETICS

Do I need my GLP-1 & Peptide Pathways Genetic Test before starting?

No. You can start Semaglutide Oral first. The optional GLP-1 & Peptide Pathways Genetic Test is a $99 add-on after your first month. It analyzes 150+ insights across 14 pathways, including 34 Weight Management insights such as FTO rs9939609. It reports on your biology. It does not determine which medication you use; your provider does.

FLEXIBILITY

What if I need a different dose or compound?

Your provider manages your dose within Semaglutide Oral, and your price stays the same at every dose. If your provider recommends a different medication, unused prepaid value is credited toward it and you pay only the difference. Cancel future renewals anytime.

PAYMENT

Can I use my HSA or FSA card, or pay over time?

Yes. HSA and FSA cards are accepted at checkout. Eligibility depends on your HSA or FSA plan, so check with your plan administrator. On 3-, 6- and 12-month plans you can also pay over time: pay-later options show at checkout when you're eligible. Pay over time isn't offered on 1-month plans.

DELIVERY

Can I pause or change my deliveries?

Yes. Pause a delivery or update your shipping address in your patient portal at my.plexusdx.com.

─── READY TO START

Start your Semaglutide protocol today

Three reasons to start with PlexusDx.

ENROLL TODAY
Ready to Start Your Semaglutide Protocol?

Order your Semaglutide Oral protocol today. Gain access to 34 Weight Management genetic insights post-enrollment, including FTO rs9939609. Make informed decisions supported by clinical oversight and your unique biology.

Start Today →
Short online visit · Choose the Semaglutide daily tablet on the medication step
TRANSPARENCY
Every plan, every price
Published before you enroll. No intake required.
Radically transparent
PLAN PRICING
One price per plan
Online visit, prescription, medication and shipping: one price per plan.
No surprise billing
GENETICS-INFORMED
Your biology, your care
150+ insights across 14 pathways, available post-enrollment for $99.
The only telehealth layer
Important Information
Compounded medications are not approved by the FDA or reviewed for quality, safety, or efficacy.

Novo Nordisk, Inc. is the only United States company with FDA-approved products containing semaglutide, identified under the trade names Rybelsus®, Ozempic®, and Wegovy®.

Lilly USA LLC is the only United States company with FDA-approved products containing tirzepatide, identified under the trade names Zepbound® and Mounjaro®.

The GLP-1 & Peptide Pathways Genetic Test analyzes how your genes influence peptide-related biological pathways. It does not recommend, prescribe, or determine which peptides you should use. Consult a qualified healthcare provider before beginning any peptide protocol.
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