Overview
238
genetic insights
2
genetic reports
138
genes
6
focus areas

The Food Sensitivity and Allergy Genetic Test turns one cheek swab into 238 DNA insights across 138 genes, covering food and environmental triggers, histamine and intolerance tendencies, and the nutrient chemistry behind them.

Genes in this test
HLA-DQB1TLR6CYP1A2HNMTAOC1HRH1
Focus areas
Food & drink triggersHistamine & intoleranceEnvironmental & seasonal allergiesImmune & inflammation responseVitamins & mineralsNutrition & metabolism
Reports included
Allergies & Food Sensitivities Genetic ReportDiet & Nutrition Genetic Report
HIPAA-compliant platform
Data never sold
One test for life
What you'll learn

What your DNA reveals in this test

Food & drink triggers

How your genes may shape the way you react to gluten, egg, milk, peanut, caffeine, and alcohol, from food sensitivity tendencies to how fast you clear caffeine. A practical starting point for conversations with your provider.

Histamine & intolerance

How well your body breaks histamine down, the chemistry behind food and drink intolerance tendencies. Helpful context for understanding reactions that are not classic allergies.

Environmental & seasonal allergies

How your genes may shape sensitivity to airborne triggers like pollen, grass, mold, and pet dander, including hay-fever-type responses. Useful background for seasonal patterns you may already notice.

Immune & inflammation response

How your genes may shape the immune signaling and inflammation that sit underneath food and skin reactions, including contact responses. Context, not a diagnosis.

Vitamins & minerals

How well your body absorbs and uses key vitamins and minerals like folate, vitamin D, and iron, which shapes how you respond to foods and supplements. The well-known MTHFR gene sits here.

Nutrition & metabolism

How your genes may shape the way you handle fats, carbs, and cholesterol, and which eating patterns may suit you, so food choices can be personal instead of generic.

What this test covers

This test analyzes your DNA across the Allergies & Food Sensitivities and Diet & Nutrition reports: 238 markers across 57 traits, grouped into the six areas below.

Food & drink triggers

How your genes may shape the way you react to common foods and drinks, from gluten, egg, milk, and peanut to caffeine and alcohol. This area includes HLA-DQB1 for peanut response, TLR6 for milk, and CYP1A2 for how fast you clear caffeine.

GlutenPeanutEggMilkCaffeineAlcohol
Featured genesHLA-DQB1TLR6CYP1A2

Histamine & intolerance

How well your body breaks histamine down, the chemistry behind food and drink intolerance tendencies. The histamine enzymes HNMT and AOC1 sit here, along with the HRH1 histamine receptor.

HistamineFODMAP
Featured genesHNMTAOC1HRH1

Environmental & seasonal allergies

How your genes may shape sensitivity to airborne triggers like pollen, grass, mold, and pet dander. This area includes IL33 and TSLP for hay-fever-type responses and LRRC32 for grass and mold.

Hay feverGrassBirch pollenMoldPet danderCockroach
Featured genesIL33TSLPLRRC32

Immune & inflammation response

How your genes may shape immune signaling and inflammation that sit underneath food and skin reactions. This area includes IL6 and IL23R for immune balance and TNF for contact and inflammatory responses.

Immune systemContact dermatitisMercury sensitivity
Featured genesIL6IL23RTNF

Vitamins & minerals

How well your body absorbs and uses key vitamins and minerals, which shapes how you respond to foods and supplements. The well-known MTHFR gene sits here for folate, alongside VDR for vitamin D and HFE for iron.

FolateVitamin B12Vitamin DVitamin B6IronMagnesiumZincSeleniumCalcium
Featured genesMTHFRVDRHFE

Nutrition & metabolism

How your genes may shape the way you handle fats, carbs, and cholesterol, and which eating patterns may suit you. This area includes FTO for diet response, APOA5 for triglycerides, and FADS1 for fatty acids and cholesterol.

CholesterolTriglyceridesCarbohydratesFatty acidsDiet-type responseMicrobiomeCholineAntioxidants
Featured genesFTOAPOA5FADS1

You do not have to act on all of it. Pick one or two areas, talk them over with your doctor, and build from there. This test shows genetic tendencies, not a diagnosis. It does not diagnose allergies and is not for managing severe or life-threatening reactions, so if you have a known allergy keep following your provider's advice and seek emergency care for any severe reaction.

How it works

From kit to results in four steps

1

Order your kit

We ship your DNA collection kit to your door for free, in discreet packaging.

2

Register and swab at home

Register your kit online with the included instructions, then take a quick, painless cheek swab. No needles, no clinic visit.

3

Mail it back

Seal your sample in the prepaid return envelope and drop it in the mail. Our CLIA-certified lab analyzes your DNA on the Illumina Global Screening Array.

4

Get your reports

In about 2 to 4 weeks, your reports and personalized guidance appear in your PlexusDx Results Portal.

Is this test right for you?
Who it's for
You are starting with your DNA and want one cheek swab to cover food sensitivities, allergies, and nutrition in a single kit.
You are curious about how your genes may shape reactions to foods, drinks, and seasonal triggers like pollen.
You want to understand histamine and intolerance tendencies, not just classic allergies.
You want personal nutrient and diet context built on your genetics, not generic advice.
You want a DNA foundation to discuss with your provider and to pair with future blood tests and supplements.
What it is not
A diagnostic or allergy test. It does not diagnose, treat, cure, or prevent any allergy or condition, and it is not for managing severe or life-threatening reactions.
A measure of your current allergy status or nutrient levels. It reflects genetic tendencies only.
A substitute for care from a qualified allergist or medical provider, or for emergency care during a severe reaction.
The right starting point if you already have PlexusDx DNA on file. In that case, add the individual reports from your Results Portal instead.
What you receive

Everything included with your test

Two genetic reports

Your Allergies & Food Sensitivities and Diet & Nutrition reports, delivered together in your PlexusDx Results Portal.

An at-home swab kit

The cheek swab, collection vial, and a prepaid return envelope, with free shipping both ways.

Plain-English insights

Your results in clear language, with discussion points for you and your provider, not raw genetic data.

One swab, 238 markers

A single cheek swab covers all 238 markers across the two reports. Your DNA does not change, so you test once.

Your ecosystem

The reports inside this test

Each one is a full PlexusDx genetic report. Explore what they cover.

Allergies & Food Sensitivities Genetic Report

How your genes may shape reactions to foods, drinks, and environmental triggers, across gluten, egg, milk, peanut, caffeine, histamine, pollen, and pet dander.

View report

Diet & Nutrition Genetic Report

How your genes may shape the way you process vitamins, minerals, fats, and carbs, with diet-type and supplement context to personalize your nutrition.

View report

All your reports live in one place: your PlexusDx Results Portal, alongside any other PlexusDx tests and reports you own. One login, your whole genetic picture.

PlexusDx tests and reports are for wellness and educational purposes only and are not intended to diagnose, treat, cure, or prevent any disease. Results are delivered through the PlexusDx Results Portal.

Built on your DNA

One cheek swab unlocks 238 DNA insights across food triggers, allergies, and nutrition.

$298

Order My Test

Free shipping both ways. One test for life.

Good to know

Frequently asked questions

Is this a diagnostic allergy test?

No. This test provides genetic insights related to food sensitivities and dietary response, not diagnosis of allergies.

Will this tell me which foods I must avoid?

This test highlights genetic tendencies that may influence food response and sensitivity. It does not replace elimination diets or clinical testing.

Do I need to retake this test later?

No. Your DNA does not change, so results remain relevant for life.

How long does it take to get results?

Typically 2 to 4 weeks after the lab receives your sample.

What specific genes and pathways does this test analyze related to food sensitivity?

This test analyzes genetic variants tied to histamine metabolism, gluten and milk response, caffeine processing, and inflammatory pathways linked to dietary triggers. Examples include HNMT and AOC1 for histamine, HLA-DQB1 for peanut response, and MTHFR for folate. Results show genetic tendencies that may influence how your body responds to specific foods and environmental triggers, so you can personalize food choices and discuss them with your provider.