Methylation Panel Blood Test

The Methylation Panel Blood Test measures key biomarkers - Homocysteine, Folate (B9), and Vitamin B12 - to provide critical insight into your body's methylation process. Monitoring these levels helps assess cardiovascular health, nutrient status, and potential methylation imbalances, supporting informed clinical decisions and personalized health strategies. This test is essential for understanding factors that affect DNA synthesis, repair, and overall metabolic function.

Biomarkers:

• Homocysteine: This test measures homocysteine, an amino acid made from methionine. Normally kept low with the help of B vitamins, high levels may indicate deficiencies in B12, folate, or B6. Elevated homocysteine has been linked to heart disease, vitamin deficiencies, and cognitive issues. Since protein-rich meals raise homocysteine, fasting before the test ensures accuracy.
• Folate (Vitamin B9): This test measures vitamin B9 (folate) levels in your blood. Folate is essential for DNA production, amino acid metabolism, blood cell formation, nervous system health, and antioxidant protection. Since the body can’t make it, folate must come from foods like leafy greens and fruits or in supplement form. Stored mainly in the liver, folate deficiency is more common in pregnant women, the elderly, those with gut disorders, people with hemolytic anemia, after weight loss surgery, or those with methylation pathway issues.
• Vitamin B12: This test measures vitamin B12 (cobalamin) levels in your blood. B12 is essential for making blood cells, supporting DNA synthesis, and maintaining brain and nervous system health. Since the body can’t produce it, B12 must come from foods like meat and dairy, or in supplement form. The liver stores years’ worth, so deficiencies usually reflect long-term shortages. Higher-risk groups include vegans, vegetarians, pregnant or breastfeeding women, the elderly, heavy drinkers, obese individuals, and those with digestive disorders or methylation pathway issues.