TrimRx vs PlexusDx: GLP-1 prices and programs compared
Part of our GLP-1 provider research: See how every compounded tirzepatide provider compares →
Month-to-month, PlexusDx charges $189 for semaglutide and TrimRx charges $299. That is $110 less, and PlexusDx costs less over every plan length both programs sell. Both programs are cash-pay, membership-free, and flat at every dose; TrimRx's one edge is a 12-month plan PlexusDx does not offer.
Green marks the better result on that row, for either program.
Prices verified July 18, 2026 · semaglutide first, tirzepatide second · per month unless a row says otherwiseIs TrimRx or PlexusDx better?
It depends on how you want to pay. PlexusDx is $110/month cheaper month-to-month and cheaper at every matching plan length; TrimRx offers a 12-month plan PlexusDx does not.
These two programs are more alike than most: both membership-free, both cash-pay, both flat at every dose, both include shipping. The deciding factors are the month-to-month price, how long a plan you want, and what each program offers beyond a weekly injection.
- You want a 12-month plan. PlexusDx does not offer one; TrimRx's is $2,218 semaglutide and $3,518 tirzepatide, charged as a single total.
- You prefer one long commitment to paying month by month, and a non-refundable balance is acceptable.
- An injection-only program suits you and you don't need oral formats or pharmacist support.
- You want the lower price at any plan length. $189/$289 month-to-month — $110/mo less — and lower at 3 and 6 months too.
- You want the lower cost on a multi-month plan. Six months runs $894/$1,494 at PlexusDx, against TrimRx's $1,268/$1,918.
- You'd rather not inject, or want a genetics layer and a named pharmacist check-in.
| Criterion | PlexusDx | TrimRx |
|---|---|---|
| Month-to-month price ($189/$289 vs $299/$399) | 5.0 | 3.5 |
| Cost at matching plan lengths (3- and 6-month total) | 5.0 | 3.5 |
| Longest plan available (6 months vs 12) | 3.5 | 5.0 |
| Same price at every dose | 5.0 | 5.0 |
| Formats and options available | 5.0 | 3.5 |
| Support included (named PharmD vs doctor consults) | 5.0 | 3.5 |
Scored from each program's published pricing and from TrimRx's own checkout, July 18, 2026. TrimRx scores higher on plan length and ties on dose-flat pricing. We publish this page and we are one of the two programs in it.
How much do TrimRx and PlexusDx cost per month? (Verified July 2026)
PlexusDx costs less at every plan length both programs sell. TrimRx also sells a 12-month plan; PlexusDx does not, so there is no matching length to compare it against.
| Semaglutide — by plan length | PlexusDx | TrimRx | Difference |
|---|---|---|---|
| Month-to-month | $189/mo lower | $299/mo | PlexusDx −$110/mo |
| 3-month plan | $169/mo — $507 for the 3 months | $748 total | PlexusDx −$241 |
| 6-month plan | $149/mo — $894 for the 6 months | $1,268 total | PlexusDx −$374 |
| 12-month plan | Not offered | $2,218 total | No PlexusDx equivalent to compare |
| Tirzepatide — by plan length | PlexusDx | TrimRx | Difference |
|---|---|---|---|
| Month-to-month | $289/mo lower | $399/mo | PlexusDx −$110/mo |
| 3-month plan | $269/mo — $807 for the 3 months | $1,068 total | PlexusDx −$261 |
| 6-month plan | $249/mo — $1,494 for the 6 months | $1,918 total | PlexusDx −$424 |
| 12-month plan | Not offered | $3,518 total | No PlexusDx equivalent to compare |
Every TrimRx figure was recorded at its checkout on July 18, 2026. Its multi-month plans are billed as one total, so each is compared as a total; PlexusDx plan totals are our published monthly rate multiplied by the plan length. Both include shipping and charge no membership fee.
TrimRx advertises one price and its checkout billed another
- Advertised on TrimRx's own site: $199/month semaglutide and $349/month tirzepatide.
- Offered at its checkout on July 18, 2026: $299 and $399 month-to-month, or $748/$1,268/$2,218 and $1,068/$1,918/$3,518 as single totals on its 3-, 6- and 12-month plans.
- Neither $199 nor $349 appeared at any point in the signup flow we completed and captured.
- We publish what the checkout billed, and we publish the advertised figures alongside it so you can check both.
How TrimRx's multi-month plans are billed
- Each multi-month plan is billed as one total, not as a monthly charge — the totals shown in the tables above.
- TrimRx offers 0% financing through Klarna, Afterpay and Affirm to spread a multi-month total. Its terms state financing is an agreement with that provider, and that "TrimRx is not a party to those agreements."
- Refunds: TrimRx's checkout terms state multi-month packages "will not be refunded for unused medication or remaining months," and that cancellation stops future charges only.
See your PlexusDx price. No commitment required.
$189/mo semaglutide, $289/mo tirzepatide, month-to-month with nothing to prepay. A licensed provider reviews your intake before anything is prescribed.
How do PlexusDx and TrimRx compare, feature by feature?
Both are cash-pay, membership-free programs that charge the same price at every dose. PlexusDx adds oral formats, a lower price at every shared plan length, and a genetics add-on; TrimRx adds a 12-month plan.
| Feature | PlexusDx | TrimRx |
|---|---|---|
| Membership fee | None | None |
| Same price at every dose | Yes | Yes |
| Pricing published publicly | Yes | Yes |
| Month-to-month price | $189 / $289 | $299 / $399 |
| Longest prepaid plan | 6 months | 12 months — $2,218 / $3,518 total |
| Oral (no-injection) option | Yes — oral sema & tirz | No — injectable only (as of July 2026) |
| Combination GLP-1 protocol | Yes — GLP-Squared | No |
| Lower-cost microdose entry | Yes — $129/mo | No |
| Optional DNA-based test offered with the program | Yes — $298, or $99 for members | Not part of its published program |
| Support included | Named PharmD check-in — Dr. Jayden Lee | Unlimited doctor consults · 24/7 support |
| Free dose increases | Yes | Yes |
| Shipping included | Yes | Yes |
Compiled from both programs' published information and TrimRx's signup flow as of July 18, 2026. Rows where TrimRx matches or beats PlexusDx are shown as such.
How can you vet TrimRx yourself?
The checks that hold up are the ones you can run first-hand: confirm the licensing, read the checkout terms before you pay, and go to the review platforms directly rather than relying on a figure someone else picked.
- Confirm the provider's licensing. TrimRx prescribes through licensed U.S. providers — you can verify a clinician's standing on your state medical board's public license lookup.
- Confirm the pharmacy's licensing. Compounded GLP-1 is filled by a state-licensed 503A pharmacy; look up the dispensing pharmacy on the relevant state board of pharmacy's public listing.
- Read the checkout terms before you pay. Complete the intake far enough to reach the order summary and read the renewal, refund and financing terms in TrimRx's own words — the same way we did on July 18, 2026. Nothing is charged until a provider approves your prescription.
- Read the review platforms directly. Independent review platforms carry customer feedback for both TrimRx and PlexusDx — read them at the source and weigh the full range of experiences yourself rather than a single headline number.
PlexusDx publishes this page and is one of the two programs compared, so run these checks first-hand rather than taking our word for it.
When is TrimRx the better choice?
TrimRx is the better pick if you want a 12-month plan. PlexusDx's longest is 6 months, so a full year locked at one rate is something only TrimRx sells here.
- It sells a 12-month plan and we don't. $2,218 for semaglutide and $3,518 for tirzepatide, charged as one total. PlexusDx has no 12-month plan to set against it.
- It offers a longer commitment than we do. Our longest plan is 6 months, so if you know you'll stay on treatment for a year, TrimRx is the only one of the two that will lock that in.
- It's a clean operator on the fundamentals — no membership fee, the same price at every dose, free dose increases, shipping included. We won't pretend otherwise.
- It charges $0 at signup and bills only if a provider approves your prescription, and it offers 0% third-party financing on multi-month plans.
When is PlexusDx the better choice?
PlexusDx is the better pick if you want the lower price at any plan length, you'd rather not inject, or you want pharmacist support and an optional genetics layer.
- $110/month less, with nothing to commit to. $189 semaglutide and $289 tirzepatide month-to-month, versus TrimRx's $299 and $399. You can stop between refills.
- Lower at every matching plan length. Three months: $507/$807 at PlexusDx against TrimRx's $748/$1,068. Six months: $894/$1,494 against $1,268/$1,918.
- Lower over a full year, month-to-month. $2,268 semaglutide and $3,468 tirzepatide across twelve months, against TrimRx's $3,588 and $4,788 — with nothing prepaid on either side.
- More ways to take it. Oral semaglutide and oral tirzepatide, a combination protocol, and a $129 microdose. TrimRx's lineup is injection-only as of July 2026.
- A free pharmacist in your corner. A free 15-minute check-in with Dr. Jayden Lee, PharmD, included with your prescription — plus an optional genetics add-on ($298, or $99 for program members).
What does PlexusDx offer that TrimRx doesn't?
PlexusDx sells oral semaglutide and tirzepatide, two combination protocols, a $129 microdose, an optional genetics add-on and a named PharmD check-in. TrimRx's published lineup is injection-only as of July 2026.
PlexusDx formats and options, with published pricing
- Semaglutide injection — $189 / $169 / $149 per month (M-t-M / 3-mo / 6-mo)
- Tirzepatide injection — $289 / $269 / $249 per month
- Oral semaglutide — $289 / $269 / $249 per month (for those who prefer no injection)
- Oral tirzepatide — $349 / $299 / $279 per month
- GLP-Squared combination protocol — $289 / $249 per month
- GLP-Squared Oral combination protocol — $389 / $369 per month
- Microdose GLP-1 — $129/mo flat, a lower-cost entry point
- Precision Peptide Genetic Test — $298 — program members get a $199 discount code about 10 days after their order, bringing it to $99
How does TrimRx pricing work?
TrimRx charges one price per medication at every dose — $299/month semaglutide and $399 tirzepatide month-to-month. Its 3-, 6- and 12-month plans are billed as a single total instead.
- Dose does not change your price. TrimRx states its pricing is the same across all dosage levels and that dose increases are free. PlexusDx works the same way — this is common in the category, not unique to either program.
- Plan length does change your price. Its 3-, 6- and 12-month plans are charged as one total: $748, $1,268 and $2,218 for semaglutide; $1,068, $1,918 and $3,518 for tirzepatide.
- Financing is available. TrimRx offers 0% installments through Klarna, Afterpay and Affirm. Its terms state that financing is between you and that provider, and that "TrimRx is not a party to those agreements."
- Renewal and refunds. Its checkout terms describe enrollment as an auto-renewing subscription, state that cancelling stops future charges only, and state that multi-month packages "will not be refunded for unused medication or remaining months."
- Nothing is charged at signup. TrimRx bills only if a provider approves your prescription. There is no membership fee.
How does PlexusDx pricing work?
PlexusDx charges one flat, all-inclusive price per medication, published before you start and unchanged at every dose — $189/mo semaglutide and $289/mo tirzepatide month-to-month.
- Semaglutide: $189 month-to-month · $169 on 3 months · $149 on 6 months.
- Tirzepatide: $289 month-to-month · $269 on 3 months · $249 on 6 months.
- What the price covers: the provider consult, prescription, compounded medication and shipping. No membership fee, no per-dose markup.
- Your price changes only if you choose a longer plan — never because your dose went up.
- Month-to-month has no contract; you can stop between refills. Our longest plan is 6 months.
- We do not offer a 12-month plan. Our longest is 6 months. If you want a full year locked at one rate, TrimRx sells one and we don't.
How does compounded GLP-1 telehealth work?
You complete an online intake, a licensed provider reviews it, and if treatment is appropriate a state-licensed 503A pharmacy prepares and ships your medication — no in-person visit required.
Both PlexusDx and TrimRx follow this cash-pay telehealth model. You answer a health questionnaire online; a licensed U.S. provider reviews your history and, if appropriate, writes a prescription. A 503A compounding pharmacy — a state-licensed facility that prepares medication for an individual patient based on a valid prescription — fills it and ships it to your door.
Eligibility is typically for adults with a BMI of 27 or higher, or a weight-related health condition, and is confirmed during intake. Your provider selects your starting dose and adjusts it over time; you don't choose your own dose. At both PlexusDx and TrimRx, that titration doesn't change your price — both charge one rate at every dose level. With PlexusDx you can bring any questions to your free check-in with Dr. Jayden Lee, PharmD.
Compounded medications are not FDA-approved and are not reviewed by the FDA for safety, quality, or effectiveness. They are a legal, provider-prescribed option prepared by a licensed pharmacy — not a generic or a substitute the FDA has evaluated.
Does either program look at your genetics?
Neither program includes a DNA-based test as part of its GLP-1 program. PlexusDx offers one as an optional add-on — $298, or $99 for program members.
Bloodwork is not the same thing, and several programs order it. Lab work is common across this category when a clinician asks for it, and PlexusDx makes at-home collection available too. A DNA-based test is a different layer: bloodwork measures what your body is doing now, genetics describes how it is wired.
What it does not do. It does not tell you which medication to take, and it does not predict how you will respond to any drug. Your licensed provider makes every treatment decision. It is context for that conversation, not a prescription.
What support is included with each program?
Both programs include clinical support at no extra charge. TrimRx lists unlimited doctor consults and 24/7 support; PlexusDx includes a check-in with a named Doctor of Pharmacy.
Every PlexusDx prescription includes a free 15-minute check-in with our Medical Director and Doctor of Pharmacy — by video or phone — to talk through medication questions, side effects, and how your protocol is going. It's education and support; your licensed provider still makes every prescribing decision.
How did we verify these prices?
We completed TrimRx's signup and reached its checkout on July 18, 2026, capturing all 46 screens. Every TrimRx figure here came from that flow, not from a marketing headline.
- Method. We went through TrimRx's intake from the first question to the order summary and captured each screen — its treatment selection, all four plan tiers per medication, and the checkout totals. Dated screenshots are on file. We compare published regular rates. Promotional offers are common across this category — ours included — and they change too often to compare fairly, so we exclude them on both sides.
- We publish the whole ladder, including the plans where TrimRx costs less than PlexusDx, rather than quoting only its highest number.
- What we could not reconcile. TrimRx's own marketing pages advertise $199/month for semaglutide and $349/month for tirzepatide. Neither figure appeared anywhere in the signup flow we completed, which showed $299 and $399 month-to-month, with its multi-month plans billed as single totals. We publish what the checkout billed, and name the advertised figures alongside it, rather than pick whichever number suited us.
- Who wrote this. PlexusDx publishes this page and is one of the two programs in it, so we are not a neutral party. That is why we used TrimRx's own checkout as the source, and why we state plainly where TrimRx wins: it offers a 12-month plan we don't.
- Prices change often in this category. Check both sites before you decide.
See your PlexusDx price. No commitment required.
One published, all-inclusive price at every dose, month-to-month with nothing to prepay — reviewed by a licensed provider, no in-person visit. Semaglutide $189/mo, Tirzepatide $289/mo.
Start your intakeFrequently Asked Questions
What is compounded GLP-1?
Compounded GLP-1 is semaglutide or tirzepatide prepared for one patient by a state-licensed 503A pharmacy on a valid prescription. These medications are not FDA-approved and are not reviewed by the FDA for safety, quality, or effectiveness. Both TrimRx and PlexusDx operate in this category.
What is TrimRx?
TrimRx is a cash-pay telehealth program that prescribes compounded semaglutide and tirzepatide through licensed providers, with no membership fee. You complete an online intake, a provider reviews it, and a state-licensed pharmacy prepares your medication.
Is TrimRx legitimate?
TrimRx prescribes through licensed U.S. providers and a state-licensed compounding pharmacy — we verified both at its checkout in July 2026. Its checkout bills only if a provider approves your prescription, with nothing charged at signup. Compounded medications are not FDA-approved, and both TrimRx and PlexusDx operate in that category. We completed TrimRx's full signup to a rendered order summary on July 18, 2026.
Why does TrimRx's website say $199 when this page says $299?
TrimRx advertises $199/month semaglutide and $349 tirzepatide; its checkout billed $299 and $399 when we completed signup on July 18, 2026. Neither advertised figure appeared in the flow we captured. We publish both so you can check.
Is PlexusDx cheaper than TrimRx?
Yes at every plan length both programs sell — PlexusDx is $110/month less month-to-month ($189 vs $299, $289 vs $399). On a 3-month plan PlexusDx runs $507 against TrimRx's $748, and on a 6-month plan $894 against $1,268. TrimRx also sells a 12-month plan; PlexusDx does not, so there is no matching length to compare it against.
How much does TrimRx cost per year?
On its month-to-month plan, TrimRx is about $3,588/year for semaglutide and $4,788 for tirzepatide. PlexusDx is $2,268 and $3,468 across the same twelve months, also month-to-month. TrimRx separately sells a 12-month prepaid plan — $2,218 and $3,518 as a single charge — which has no PlexusDx equivalent to compare against.
Does TrimRx charge more for higher doses?
No — TrimRx charges the same price at every dosage level and includes dose increases at no extra cost. Its plan pages state "Same Price. All Dosage Levels." PlexusDx works the same way, as do most programs in this category.
Can I see TrimRx's price before signing up?
TrimRx publishes rates on its marketing pages, but you must complete its intake to reach the checkout where the plans appear. PlexusDx publishes every price and plan length on its site. Neither charges anything at signup.
Can I cancel anytime, or am I locked into a contract?
On a month-to-month plan both programs let you stop between refills, and neither charges a membership fee. TrimRx's multi-month plans are charged as one total and its terms state they are not refunded for unused months. PlexusDx's longest plan is 6 months.
Is TrimRx worth it?
TrimRx is worth considering if you want a 12-month plan — PlexusDx doesn't sell one, and TrimRx locks a single rate for a full year. The trade-offs are a higher month-to-month rate, a non-refundable balance, and an injection-only lineup as of July 2026.
What are the common side effects, and what support is there?
The most common GLP-1 side effects are gastrointestinal — nausea and digestive changes — usually most noticeable when starting or increasing a dose. Your provider titrates to manage tolerability. Every PlexusDx prescription includes a free check-in with Dr. Jayden Lee, PharmD. This page is not medical advice.
Which states is PlexusDx available in?
PlexusDx is available in most U.S. states where telehealth prescribing of these medications is permitted. You'll confirm whether your state is covered during intake. TrimRx operates on a similar state-by-state basis.
Is shipping included, and how does it work?
Yes — PlexusDx includes direct-to-door shipping in its monthly price, with no separate shipping fee. Your medication ships from a state-licensed 503A pharmacy in discreet packaging after your provider approves it. TrimRx also includes shipping.
Does PlexusDx offer formats TrimRx doesn't?
Yes — PlexusDx sells oral semaglutide and tirzepatide, two combination protocols, a $129 microdose, and an optional genetics add-on. TrimRx's published lineup is injection-only as of July 2026.
Is the compounded medication FDA-approved?
No — compounded medications are not FDA-approved and are not reviewed by the FDA for safety, quality, or effectiveness. Novo Nordisk is the only U.S. company with FDA-approved semaglutide (Wegovy®, Ozempic®, Rybelsus®); Lilly is the only one with FDA-approved tirzepatide (Zepbound®, Mounjaro®).
What does the PlexusDx genetics test do?
It analyzes how your genes influence weight-management-related biological pathways, to inform your conversation with your provider. It does not recommend, prescribe, or determine which medication you should use, and it does not predict your response to any drug.
PlexusDx tells you about your biology. It does not tell you what to put in your body.