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GLP-Squared - compounded Semaglutide and Tirzepatide dual-compound GLP-1 weight management protocol from PlexusDx
Infographic showing 3 easy steps to order GLP-Squared online with a doctor on a phone screen.
GLP-Squared dose levels and pricing table on a white background

GLP-Squared

Advanced Semaglutide + Tirzepatide dual-compound GLP-1 formulation managed by a licensed provider across six dose levels, from 0.4mg/4mg to 3.0mg/24mg daily. Provider intake, prescription, compounded medication, and shipping included. No membership required.

🩺 Licensed provider intake — async, no in-person visit required

💊 Compounded Semaglutide + Tirzepatide dual-peptide prescription shipped to your door

📦 Ongoing monthly supply — no separate pharmacy trip

🧬 34 Weight Management genetic insights — including GIPR rs1800437 — available as a $99 add-on post-enrollment

💳 One price. No membership. No hidden fees. Cancel anytime.

Starting at
$179/mo — All-Inclusive
Your price reflects your current dose level — billing adjusts automatically as your provider titrates.
Coming Soon

This protocol is launching soon. Check back shortly.

AI Summary

The GLP-Squared Protocol from PlexusDx is a compounded Semaglutide + Tirzepatide dual-compound therapy at provider-titrated dose pairs across six dose levels. Price: $179 to $325 per month, all-inclusive — covers async provider consultation, prescription, compounded medication, and shipping available in all 50 states (five states require a scheduled live consultation rather than async intake). No membership required.

The optional Precision Peptide Genetic Test analyzes 34 Weight Management insights including GIPR rs1800437 — a variant associated with differential GLP-1 response — drawn from a 150+ insight panel across 14 pathways. Available for $99 as an add-on after your first month of treatment.

Why trust PlexusDx

Compliance

503A pharmacy-grade medication

Your compounded GLP-Squared is prepared by a licensed 503A compounding pharmacy specifically for your prescription — not mass-manufactured.

Coverage

Licensed providers in all 50 states

PlexusDx protocols are available in all 50 states. Five states require a scheduled live consultation rather than async intake — your provider advises which applies to you.

Privacy

HIPAA-compliant platform

Your health information is protected under HIPAA and is never sold or shared without your consent. Results are delivered securely through the PlexusDx Results Portal.

Pricing

All-inclusive pricing

Your monthly charge covers your provider consultation, prescription, compounded GLP-Squared medication, and direct-to-door shipping in one flat price. No hidden fees. No membership.

Pricing by dose level

GLP-Squared dose levels

Every dose has a published price. What you see is what you pay — provider consultation, compounded medication, and direct-to-door shipping in one monthly charge. No membership. No separate pharmacy fee.

Starts at

$179/mo

Dose levels

6 (provider-titrated)

Membership fee

$0

Availability

All 50 states
Level Daily Doses Monthly Price
Level 1Sema 0.4mgTirz 4mg$179/mo
Level 2Sema 0.8mgTirz 8mg$199/mo
Level 3Sema 1.2mgTirz 12mg$219/mo
Level 4Sema 1.6mgTirz 16mg$249/mo
Level 5Sema 2.0mgTirz 20mg$299/mo
Level 6Sema 3.0mgTirz 24mg$325/mo

What's included at every level

Async provider intake Rx issuance Compounded Semaglutide + Tirzepatide Direct shipping Monthly monitoring
ⓘ Provider-determined dosing Your licensed provider selects your starting dose and advances based on response. Available in all 50 states — five states require a scheduled consultation.

WHAT HAPPENS NEXT

After you order

Your provider, your pharmacy, your ongoing care — what happens once your intake is in.

Same day

LICENSED REVIEW

Provider review & prescription

A licensed US provider reviews your intake, selects the appropriate compound, and writes your prescription. In 5 states, this step is a live video consultation.

3–5 business days

503A COMPOUNDING

Pharmacy ships your medication

Your compounded Semaglutide and Tirzepatide ship from a US 503A pharmacy in discreet packaging. A 503A pharmacy is a state-licensed compounding facility regulated by FDA and state boards of pharmacy that prepares medications individually for a specific patient based on a valid prescription. Dosing instructions, syringes, and alcohol swabs included.

Every month

CARE THAT CONTINUES

Ongoing provider care

Unlimited provider messaging, dose adjustments, and clinical check-ins — all included in your monthly price.

Anytime

FLEXIBILITY

Cancel anytime, no fees

Pause or cancel your protocol anytime from your account — no fees, no long-term contracts. Your provider reviews each refill.

OUR COMMITMENT

Nothing is charged until your provider approves your prescription. Cancel anytime, no fees.

EVERYTHING INCLUDED

What's included

Your provider, your pharmacy, your direct-to-door shipping — everything in your monthly GLP-Squared protocol.

PROVIDER

Licensed, async

Licensed providers in all 50 states. Most patients reviewed within one business day.

PHARMACY

503A compounded

Dual-peptide Tirzepatide + Semaglutide prepared for you.

SHIPPING

Direct-to-door

Cold-chain packed. Ships from U.S. partner pharmacy.

PRICING

$179/mo

Starting price, all-inclusive

WHAT YOU WON'T PAY
Membership fee
Consult charge
Hidden fees
REFILLS

Provider-reviewed

Each refill re-authorized by your provider. Not auto-shipped.

MONITORING

Monthly check-ins

Monthly dose adjustments based on your response and tolerance.

FLEXIBILITY

Cancel anytime

No long-term contract. Pause or stop between refills.

Optional add-on
Available post-enrollment

The optional Precision Peptide Genetic Test analyzes 34 Weight Management insights including GIPR rs1800437 — a variant associated with differential glp-1 response — drawn from a 150+ insight panel across 14 pathways. Available for $99 as an add-on after your first month of treatment.

34
Pathway insights
150+
Total panel
14
Pathways
$99
Add-on
Featured SNP
GIPR rs1800437
A variant associated with differential GLP-1 response
Explore the Genetic Test → $99 · one-time · available after your first month of treatment

CLINICAL FIT CHECK

Is this protocol right for you?

We lead with safety considerations first. If any exclusion applies to you, stop here and speak with your primary care provider before starting intake.

SAFETY EXCLUSIONS

Skip this protocol if…

THYROID HISTORY

Personal or family history of medullary thyroid carcinoma (MTC) or MEN2

PANCREATITIS

Any history of pancreatitis

PREGNANCY STATUS

Pregnant, breastfeeding, or planning pregnancy

CONCURRENT GLP-1

Currently taking another GLP-1 or GIP/GLP-1 medication

ELIGIBLE

You're a fit if…

BMI THRESHOLD

BMI ≥27 with a weight-related condition, or BMI ≥30

CLINICAL OVERSIGHT

Want licensed provider oversight across all 50 states

PRICING TRANSPARENCY

Want one all-inclusive price with no hidden fees

DATA-GUIDED CARE

You prefer clinical decisions informed by your personal health data

PROVIDER VERDICT

Your licensed provider confirms final eligibility during intake review. No medication ships without their sign-off.

Built differently

What makes PlexusDx different

Five things every shopper deserves before they sign up.

THE DIFFERENTIATOR

Genetics-informed care from a complete precision health platform

34 Weight Management insights available post-enrollment via the Precision Peptide Genetic Test — 14 pathways, 49 peptides, 150+ genetic insights total across the platform. The only telehealth peptide protocol with a genetic testing layer.

TRANSPARENCY

Radically transparent

Every dose level and every price published before you start.

Every dose · every price

PRICING

All-inclusive

One price covers intake, Rx, medication, and shipping.

One price · all-in

CLINICAL

Async clinical oversight

No in-person visits required, available in all 50 states.

All 50 states

NO GATE

No membership gate

Your first dollar goes toward your care, not a subscription fee.

No membership

Clinical details

Clinical details

How this compound works and what lab work is involved.

Compound spec

Class

GLP-1 + GIP/GLP-1

dual-compound stack

Route

Subcutaneous

weekly injection

Half-life

~5–7 days

supports once-weekly dosing

Compounded by

503A pharmacy

licensed US partner

How it works

About this compound

GLP-Squared is an advanced Semaglutide + Tirzepatide dual-compound GLP-1 formulation — it combines a GLP-1 receptor agonist (Semaglutide) with a GIP/GLP-1 dual-agonist (Tirzepatide) in a single daily oral dose, engaging three complementary metabolic pathways.

Your provider selects your starting dose and adjusts it based on your response across six dose levels, from 0.4mg/4mg to 3.0mg/24mg daily. Each dose level reflects the combined Semaglutide and Tirzepatide amounts titrated proportionally under clinical supervision.

See how PlexusDx customers describe their precision health journey — read Customer Stories.

Why it matters

GLP-1 response varies widely by genetics. The optional Precision Peptide Genetic Test analyzes 34 Weight Management insights including GIPR rs1800437 — a variant associated with differential GLP-1 response — so your provider can interpret your results in context. Available for $99 as an add-on after your first month of treatment.

Lab requirements
No blood work required at intake. Not clinically required for enrollment. Your provider may recommend blood work based on your individual health profile.
NOT REQUIRED
Compare Compounds

How this compound compares

Compound
Mechanism
Route
Starts at
You're viewingGLP-Squared
GIP + GLP-1 + glucagon
Weekly injection
$179/mo
Tirzepatide
GIP + GLP-1 dual
Weekly injection
$229/mo
Semaglutide
GLP-1 only
Weekly injection
$199/mo

If your provider determines a different compound is the better clinical fit, they'll initiate the switch — no fees, no resubscription, billing adjusts automatically.

GLP-Squared — FAQ

Answers before you start

Pricing, titration, genetics, and what happens if you need a different dose or compound — directly answered, no hedging.

PRICING

How does GLP-Squared pricing work across dose levels?

GLP-Squared pricing starts at $179/mo at Level 1 (0.4mg Semaglutide + 4mg Tirzepatide daily) and scales across six published dose levels from $179 to $325/mo at Level 6. Every dose price is visible on this page before you intake — competitors don't publish this. Your licensed provider selects your starting dose and titrates based on your clinical response; billing adjusts automatically at each change.

INCLUSIONS

What's included in every monthly charge, regardless of dose level?

Every GLP-Squared dose level includes the same all-inclusive bundle — async provider intake, prescription, compounded Semaglutide and Tirzepatide dual-compound medication, supplies, and direct-to-door shipping. There is no separate membership fee, no consult charge, and no hidden surcharges at any dose level. Cancel anytime with no fees. One monthly charge covers everything, regardless of whether you're at Level 1 or Level 6.

TITRATION

How does dose titration work — who controls it?

Your licensed provider determines your starting dose and adjusts it over time based on your response. You do not select a dose. Billing updates automatically if your dose level changes, and your provider reviews each refill before it ships.

MECHANISM

What is GLP-Squared and how is it different from single-compound protocols?

GLP-Squared is a dual-compound protocol pairing Semaglutide and Tirzepatide in a single daily regimen. Semaglutide activates the GLP-1 receptor; Tirzepatide activates both GIP and GLP-1 receptors. Together they engage the GIP and GLP-1 pathways via two active compounds instead of one. Your provider determines whether dual-compound coverage matches your clinical profile.

GENETICS

Do I need my Precision Peptide Genetic Test before starting?

No — you can enroll in the protocol first. The Precision Peptide Genetic Test is a $99 post-enrollment add-on that analyzes 14 pathways, 49 peptides, and 150+ genetic insights — including 34 Weight Management insights that contextualize your response. It does not determine which compound you use; your provider does.

FLEXIBILITY

What if I need a different dose or compound?

Your provider manages titration within GLP-Squared. If your clinical needs require a different protocol — for example, moving to a single-compound Tirzepatide or Semaglutide protocol — your provider initiates that change. Your billing updates to reflect the new compound at that point. No fees to switch.

─── READY TO START

Start your GLP-Squared protocol today

Three reasons to start with PlexusDx.

ENROLL TODAY
Ready to Start Your GLP-Squared Protocol?

Order your GLP-Squared protocol today. Gain access to 34 Weight Management genetic insights post-enrollment, including GIPR rs1800437. Make informed decisions supported by clinical oversight and your unique biology.

Coming Soon
~60 second intake · $0 until Rx approved
TRANSPARENCY
Every dose, every price
Published before you enroll. No intake required.
Radically transparent
ALL-INCLUSIVE
One price, all-in
Intake, Rx, medication, and shipping — one monthly price.
No surprise billing
GENETICS-INFORMED
Your biology, your care
150+ insights across 14 pathways, available post-enrollment for $99.
The only telehealth layer
Important Information
Compounded medications are not approved by the FDA or reviewed for quality, safety, or efficacy.

Novo Nordisk, Inc. is the only United States company with FDA-approved products containing semaglutide, identified under the trade names Rybelsus®, Ozempic®, and Wegovy®.

Lilly USA LLC is the only United States company with FDA-approved products containing tirzepatide, identified under the trade names Zepbound® and Mounjaro®.

The Precision Peptide Genetic Test analyzes how your genes influence peptide-related biological pathways. It does not recommend, prescribe, or determine which peptides you should use. Consult a qualified healthcare provider before beginning any peptide protocol.