GLP-Squared - compounded Semaglutide and Tirzepatide dual-compound GLP-1 weight management protocol from PlexusDx
Infographic showing 3 easy steps to order GLP-Squared online with a doctor on a phone screen.

GLP-Squared Injection

Compounded GLP-Squared via licensed providers. Your dose may need to go up. Your price won't.

Care from a licensed provider in your corner — no in-person visit, no waiting room

Your dual-compound protocol shipped discreetly to your door — ready when you are

Ongoing monthly care without a single trip to the pharmacy

Optional genetics layer to refine your protocol — 34 insights, $99 post-enrollment

Your dose may need to go up. Your price won't.

Starts at
$249/mo — All-Inclusive
Your monthly price doesn't change as your dose changes. Same price every dose level.
Start Today

No membership required. Cancel anytime.

WHAT CHANGES FOR YOU

What changes when this works

Most patients describe the first changes within two weeks. Visible weight changes follow over 8 to 12 weeks.

WHAT CHANGES

Two hunger fighters, working together

GLP-Squared puts two proven hunger fighters in one treatment: Semaglutide and Tirzepatide. Cravings fade, smaller meals fill you up, and food stops running your day.

WHAT YOU'LL FEEL

Show up to your day differently

Clothes start to fit the way you want. You have more energy in the afternoon. The steady pull toward food gets quiet, so you feel more like yourself.

HOW LONG IT TAKES

Real change takes a little time

Most people feel less hunger in the first two weeks. The weight comes off over the next two to three months. Your provider checks in every month, so you are never doing this alone.

WHY IT WORKS FOR YOU

Built for your body, not the average

Your genes shape how well this medicine works for you. Add the optional genetic test and it reads 34 weight insights from your DNA. Your plan gets built around you, not someone else.

CLINICAL EVIDENCE

14.9–20.9%

Average body weight loss range across the 68-week Wegovy® 2.4mg trial (14.9%) and the 72-week Zepbound® 15mg trial (20.9%). Semaglutide is the active ingredient in Wegovy® (Novo Nordisk); Tirzepatide is the active ingredient in Zepbound® (Eli Lilly). GLP-Squared is a compounded combination formulation; trial data above reflect the individual active ingredients, not the combination.

Wegovy® and Ozempic® are registered trademarks of Novo Nordisk A/S; Zepbound® and Mounjaro® are registered trademarks of Eli Lilly and Company. Novo Nordisk and Eli Lilly are the only United States companies with FDA-approved products containing semaglutide and tirzepatide respectively. PlexusDx is not affiliated with or endorsed by Novo Nordisk or Eli Lilly.

READY?

Feel the difference your provider designs around you.

Start your intake

~60-second intake · $0 until your provider approves your prescription

Overview

Compounded GLP-Squared is a dual-compound GLP-1 formulation combining Semaglutide and Tirzepatide, prescribed by licensed providers as a clinical step-up. The active ingredients are the same as those in Wegovy®, Ozempic® (Novo Nordisk); Zepbound®, Mounjaro® (Eli Lilly and Company). Your provider titrates your dose based on clinical response, and your monthly price is flat across every dose level. One monthly price covers your provider visit, prescription, medication, and shipping — $249 to $289 per month, all-inclusive, depending on commitment tier. No membership fee. Eligible adults across all 50 states.

  • Daily subcutaneous injection, provider-titrated across dose levels
  • Dual-compound formulation — combines Semaglutide and Tirzepatide across multiple incretin pathways
  • Two commitment tiers: $289 month-to-month and $249 on the 3-month plan — all-inclusive, Your dose may need to go up. Your price won't.
  • Real medical authority — licensed providers in your state, no AI prescriptions
  • 34 Weight Management genetic insights including GIPR rs1800437 — optional Precision Peptide Genetic Test, $99 as an add-on after your first month

The optional Precision Peptide Genetic Test analyzes 34 Weight Management insights including GIPR rs1800437 — a variant associated with differential GLP-1 response — drawn from a 150+ insight panel across 14 pathways. Available for $99 as an add-on after your first month of treatment.

Why trust PlexusDx

Compliance

503A pharmacy-grade medication

Your compounded GLP-Squared is prepared by a licensed 503A compounding pharmacy for your prescription — not mass-manufactured.

Coverage

Licensed providers in all 50 states

Available in all 50 states. Five states require a scheduled video consultation — your provider advises.

Privacy

HIPAA-compliant platform

Protected under HIPAA. Never sold or shared without your consent. Results delivered securely through the PlexusDx Results Portal.

Pricing

One transparent price

All-inclusive. Your dose may need to go up. Your price won't.

Telehealth across the US — see state availability below

Pricing

What you pay

Your dose may need to go up. Your price won't.

Starts at $249 /mo

All-inclusive. No membership. Cancel anytime.

Choose your commitment tier

Month-to-month

$289/mo
Best value

3-month

$249/mo
Async provider intake Rx issuance Compounded GLP-Squared Direct shipping

Provider-determined dosing

Your provider selects your starting dose and titrates based on your clinical response. GLP-Squared Injection is a dual-compound formulation — Semaglutide + Tirzepatide — provided as a single patient-choice bundle delivered by daily subcutaneous injection. Dose titration advances both compounds proportionally.

GLP-Squared injection — monthly cost by dose

Same dual-compound price, every dose — from $249/mo all-inclusive

Daily dose (dual)LevelMonthly price
Sema 0.4 mg · Tirz 4 mgLevel 1 · startingfrom $249/mo
Sema 0.8 mg · Tirz 8 mgLevel 2from $249/mo
Sema 1.2 mg · Tirz 12 mgLevel 3from $249/mo
Sema 1.6 mg · Tirz 16 mgLevel 4from $249/mo
Sema 2.0 mg · Tirz 20 mgLevel 5from $249/mo
Sema 3.0 mg · Tirz 24 mgLevel 6 · maintenancefrom $249/mo

WHAT HAPPENS NEXT

After you order

What happens once your intake is in.

Same day

LICENSED REVIEW

Provider review & prescription

A licensed US provider reviews your intake, selects the compound, and writes your prescription.

3–5 business days

503A COMPOUNDING

Pharmacy ships your medication

Your compounded Semaglutide and Tirzepatide ship from a US 503A pharmacy in discreet packaging. A 503A pharmacy is a state-licensed compounding facility regulated by FDA and state boards of pharmacy that prepares medications individually for a specific patient based on a valid prescription. Dosing schedule included

Every month

CARE THAT CONTINUES

Ongoing provider care

Unlimited provider messaging, dose adjustments, and clinical check-ins.

Anytime

FLEXIBILITY

Cancel anytime, no fees

Cancel anytime — no fees, no contracts. Your provider reviews each refill.

OUR COMMITMENT

Nothing is charged until your provider approves your prescription. Cancel anytime, no fees.

EVERYTHING INCLUDED

What's included

Your provider, your pharmacy, your direct-to-door shipping — everything in your monthly GLP-Squared Injection program.

PROVIDER

Licensed, async

Licensed providers in all 50 states. Most patients reviewed within one business day.

PHARMACY

503A compounded

Pharmacy-grade dual-compound medication prepared for your prescription.

SHIPPING

Direct-to-door

Cold-chain packed. Ships from U.S. partner pharmacy.

ALL-INCLUSIVE

One all-inclusive price

Provider, prescription, medication, and shipping — in one monthly charge. No membership.

WHAT YOU WON'T PAY
Membership fee
Consult charge
Hidden fees
REFILLS

Provider-reviewed

Each refill re-authorized by your provider. Not auto-shipped.

MONITORING

Monthly check-ins

Monthly dose adjustments based on your response and tolerance.

FLEXIBILITY

Cancel anytime

No long-term contract. Pause or stop between refills.

Optional add-on
Available post-enrollment

The optional Precision Peptide Genetic Test analyzes 34 Weight Management insights including GIPR rs1800437 — a variant associated with differential glp-1 response — drawn from a 150+ insight panel across 14 pathways. Available for $99 as an add-on after your first month of treatment.

34
Pathway insights
150+
Total panel
14
Pathways
$99
Add-on
Featured SNP
GIPR rs1800437
A variant associated with differential GLP-1 response
Explore the Genetic Test → $99 · one-time · available after your first month of treatment

CLINICAL FIT CHECK

Is this protocol right for you?

We lead with safety considerations first. If any exclusion applies to you, stop here and speak with your primary care provider before starting intake.

SAFETY EXCLUSIONS

Skip this protocol if…

THYROID HISTORY

Personal or family history of medullary thyroid carcinoma (MTC) or MEN2

PANCREATITIS

Any history of pancreatitis

PREGNANCY STATUS

Pregnant, breastfeeding, or planning pregnancy

CONCURRENT GLP-1

Currently taking another GLP-1 or GIP/GLP-1 medication

ELIGIBLE

You're a fit if…

BMI THRESHOLD

BMI ≥27 with a weight-related condition, or BMI ≥30

CLINICAL OVERSIGHT

Want licensed provider oversight across all 50 states

PRICING TRANSPARENCY

Want one all-inclusive price with no hidden fees

DATA-GUIDED CARE

You prefer clinical decisions informed by your personal health data

PROVIDER VERDICT

Your licensed provider confirms final eligibility during intake review. No medication ships without their sign-off.

Built differently

What makes PlexusDx different

Five things every shopper deserves before they sign up.

THE DIFFERENTIATOR

Genetics-informed care from a complete precision health platform

34 Weight Management insights via the Precision Peptide Genetic Test — across 14 pathways, 49 peptides. The only telehealth peptide protocol with a genetic testing layer.

TRANSPARENCY

Radically transparent

Every dose level and every price published.

PRICING

All-inclusive

One price for intake, Rx, medication, shipping.

CLINICAL

Async clinical oversight

No in-person visits. Available in all 50 states.

NO GATE

No membership gate

Your first dollar goes toward care, not a subscription.

Clinical details

Clinical details

How this compound works and what lab work is involved.

Compound spec

Class

GLP-1 + GIP/GLP-1

dual-compound stack

Route

Subcutaneous

weekly injection

Half-life

~5–7 days

supports once-weekly dosing

Compounded by

503A pharmacy

licensed US partner

How it works

About this compound

GLP-Squared Injection is an advanced Semaglutide + Tirzepatide dual-compound GLP-1 formulation — it combines a GLP-1 receptor agonist (Semaglutide) with a GIP/GLP-1 dual-agonist (Tirzepatide) in a single daily subcutaneous injection, engaging the GIP and GLP-1 incretin pathways.

Your provider titrates across dose levels of dual Semaglutide + Tirzepatide content. GLP-Squared Injection is provider-determined and clinically supervised throughout titration, delivered as a daily subcutaneous injection.

See how PlexusDx customers describe their precision health journey — read Customer Stories.

Why it matters

GLP-1 response varies by genetics. The optional Precision Peptide Genetic Test analyzes 34 Weight Management insights including GIPR rs1800437 — a variant associated with differential GLP-1 response. Available for $99 as an add-on after your first month of treatment.

Lab requirements
No blood work required at intake. Blood testing is available at patient election and may be recommended by your provider based on your individual health history. At-home blood collection is available through Red Drop Dx — no clinic visit required.
NOT REQUIRED
Compare Compounds

How this compound compares

Compound
Mechanism
Route
Starts at
Semaglutide Injection
GLP-1 agonist
Subcutaneous injection
Starts at $149/mo
Tirzepatide Injection
GIP/GLP-1 dual agonist
Subcutaneous injection
Starts at $249/mo
Semaglutide Oral
GLP-1 agonist
Oral tablet
Starts at $249/mo
Tirzepatide Oral
GIP/GLP-1 dual agonist
Oral tablet
Starts at $279/mo
You're viewingGLP-Squared Injection
Dual-compound (Sema + Tirz)
Subcutaneous injection
Starts at $249/mo
GLP-Squared Oral
Dual-compound (Sema + Tirz)
Oral tablet
Starts at $369/mo
Microdose GLP-1
Low-dose GLP-1 agonist
ODT or injection
$129/mo

If your provider determines a different compound is the better clinical fit, they'll initiate the switch — no fees, no resubscription, billing adjusts automatically.

GLP-Squared Injection — FAQ

Answers before you start

Pricing, titration, genetics, and what happens if you need a different dose or compound — directly answered, no hedging.

PRICING

How much does GLP-Squared cost?

GLP-Squared is flat per-compound pricing across two commitment tiers: $289/mo month-to-month and $249/mo on the 3-month plan. One price covers your licensed provider, prescription, compounded medication, and shipping — no membership, no hidden fees. Your dose may need to go up. Your price won't.

INCLUSIONS

What's included in every monthly charge?

Every GLP-Squared charge includes the same all-inclusive bundle — async provider intake, prescription, compounded dual-compound medication, syringes, alcohol swabs, and direct-to-door shipping. There is no separate membership fee, no consult charge, and no hidden surcharges. Cancel anytime with no fees. Your monthly price is flat across every dose level for this compound — it changes only with your commitment tier, never with your dose.

TITRATION

How does dose titration work — who controls it?

Your licensed provider determines your starting dose and adjusts it over time based on your response. You do not select a dose. Your monthly price stays the same as your dose changes — billing is flat across all dose levels for this compound. Your provider reviews each refill before it ships.

MECHANISM

What is GLP-Squared and how is it different from single-compound protocols?

GLP-Squared is a dual-compound formulation combining Semaglutide (a GLP-1 receptor agonist) and Tirzepatide (a GIP/GLP-1 dual agonist) in one protocol. It engages multiple incretin pathways. Your provider routes here when a dual-compound approach matches your clinical profile — it is a clinical step-up, not a default first-line protocol.

GENETICS

Do I need my Precision Peptide Genetic Test before starting?

No — you can enroll in the protocol first. The Precision Peptide Genetic Test is a $99 post-enrollment add-on that analyzes 14 pathways, 49 peptides, and 150+ genetic insights — including 34 Weight Management insights that contextualize your response. It does not determine which compound you use; your provider does.

FLEXIBILITY

What if I need a different dose or compound?

Your provider manages dosing within GLP-Squared, and your monthly price stays flat across every dose level. If your clinical needs change — for example, stepping back to Semaglutide Injection or Tirzepatide Injection — your provider initiates that change. Your billing updates to reflect the new compound at that point. No fees to switch.

─── READY TO START

Start your GLP-Squared Injection protocol today

Three reasons to start with PlexusDx.

ENROLL TODAY
Ready to Start Your GLP-Squared Protocol?

Order your GLP-Squared protocol today. Gain access to 34 Weight Management genetic insights post-enrollment, including GIPR rs1800437. Make informed decisions supported by clinical oversight and your unique biology.

Start Today →
~60 second intake · $0 until Rx approved
TRANSPARENCY
Every dose, every price
Published before you enroll. No intake required.
Radically transparent
ALL-INCLUSIVE
One price, all-in
Intake, Rx, medication, and shipping — one monthly price.
No surprise billing
GENETICS-INFORMED
Your biology, your care
150+ insights across 14 pathways, available post-enrollment for $99.
The only telehealth layer
Important Information
Compounded medications are not approved by the FDA or reviewed for quality, safety, or efficacy.

Novo Nordisk, Inc. is the only United States company with FDA-approved products containing semaglutide, identified under the trade names Rybelsus®, Ozempic®, and Wegovy®.

Lilly USA LLC is the only United States company with FDA-approved products containing tirzepatide, identified under the trade names Zepbound® and Mounjaro®.

The Precision Peptide Genetic Test analyzes how your genes influence peptide-related biological pathways. It does not recommend, prescribe, or determine which peptides you should use. Consult a qualified healthcare provider before beginning any peptide protocol.