Last reviewed: September 5, 2026 Last updated: September 22, 2026

Written by: Jay Hastings, CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Director, with a PharmD and MBA specializing in pharmacogenomics and clinical product development. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

This article is part of the PlexusDx Education Hub — evidence-based guidance on GLP-1 therapies and weight-management care. Browse all Peptides & GLP-1 education

Editorial note: PlexusDx publishes this editorial review and offers one of the programs discussed. PlexusDx is not affiliated with MEDVi and has no commercial relationship with the companies named in this article; there are no affiliate links. Information is based on the sources and dates shown.

As of September 22, 2026, MEDVi's compounded semaglutide injection is $179 for the first month (new patients) and $299 per billing cycle on refills, as displayed on its program page. OrderlyMeds lists compounded semaglutide injection at $249/mo month-to-month or $166/mo on a three-month starter ($498), and tirzepatide injection at $399/mo or $266/mo on a three-month starter ($798). MEDVi's ongoing month-to-month rate for compounded tirzepatide injection is $399 per billing cycle, verified September 22, 2026; its tirzepatide first-month offer is shown after the questionnaire, so confirm it in the official offer. Neither charges a membership fee. Which is cheaper depends on how many cycles you stay and whether you prepay.

Medication and route match

Both programs center on compounded injections prescribed by licensed providers in their networks and filled by compounding pharmacies. MEDVi lists compounded semaglutide injection, compounded tirzepatide injection and a compounded semaglutide tablet, plus a separate branded pathway for Wegovy® and Zepbound® that bills a membership and the medication separately. OrderlyMeds lists compounded semaglutide injection, compounded tirzepatide injection and compounded semaglutide tablets.

So the like-for-like rows are semaglutide injection, tirzepatide injection and semaglutide tablets. Compounded products are not FDA-approved and are not generic versions of Wegovy®, Ozempic®, Zepbound® or Mounjaro®; the FDA's statement on unapproved GLP-1 drugs explains the distinction. A compounded tablet is also not the FDA-approved oral product.

Current introductory and refill charges

The table shows month-to-month rates for the same medication and route. MEDVi's first-month price is a labeled part of its standard offer for new patients; the refill rate is the comparison basis. The PlexusDx month-to-month row is included because PlexusDx publishes this comparison; its 3- and 6-month commitment tiers are shown separately below.

PlexusDx publishes this comparison and offers one of the programs discussed. Information is based on the sources and dates shown.

Item MEDVi OrderlyMeds PlexusDx (month-to-month) Checked
Semaglutide injection, first month $179 first month (new patients) No separate first-month rate published $189/mo from month one Sept 22, 2026
Semaglutide injection, recurring $299 per billing cycle, refill / recurring, as displayed September 22, 2026 $249/mo month-to-month $189/mo Sept 22, 2026
Tirzepatide injection, recurring $399 per billing cycle, ongoing month-to-month rate, verified September 22, 2026 (first-month offer shown after the questionnaire) $399/mo month-to-month $289/mo Sept 22, 2026
Semaglutide tablets, recurring About $70 per cycle over MEDVi's injection rate for the same compound (plan-selection screen); MEDVi publishes no tablet total — confirm in MEDVi's official offer $324 (comparison table on OrderlyMeds' site) $289/mo (Semaglutide Oral) Sept 22, 2026
Membership fee None on compounded programs ("No membership or hidden fees") None ("no membership") None Sept 22, 2026

Sources: MEDVi's program page and OrderlyMeds' site, both read September 22, 2026. MEDVi's recurring figures are its ongoing month-to-month rates, verified September 22, 2026; confirm them in its official offer before enrolling. For the full MEDVi price breakdown, see MEDVi Cost: Semaglutide, Tirzepatide, Membership, and Plan Prices.

Compare PlexusDx plans

PlexusDx Weight Management Protocols: compounded semaglutide injection from $189/mo and tirzepatide injection from $289/mo month-to-month, all-inclusive (provider visit, prescription, medication, shipping). No membership fee. Flat price at every dose.

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On the recurring semaglutide rate, OrderlyMeds ($249/mo) is below MEDVi ($299 refill). On month one only, MEDVi ($179) is below OrderlyMeds ($249). The older claim that OrderlyMeds undercuts everyone therefore holds for MEDVi refills, but not for MEDVi's first month and not against PlexusDx's $189/mo month-to-month semaglutide rate. For tirzepatide, OrderlyMeds ($399/mo month-to-month) matches MEDVi's ongoing $399 per billing cycle (verified September 22, 2026); PlexusDx Tirzepatide Injection is $289/mo month-to-month, $110 a month less than MEDVi's ongoing rate ($3,468 versus $4,788 over 12 billing cycles at the ongoing rates).

Dose and supply-length conditions

MEDVi states "Same fair price at every dose" on its start page. OrderlyMeds states the same price regardless of dose for semaglutide; its tirzepatide page does not make that statement in the material we read, so confirm before assuming. PlexusDx states its monthly price is flat across every dose level for a compound.

Supply length is the quieter variable. MEDVi bills per billing cycle and does not publish the cycle length, so twelve MEDVi cycles should not be assumed to equal a calendar year. OrderlyMeds describes its rates as monthly and its starter as three months. Ask both what a "month" of supply contains and how a dose change affects the next shipment.

Upfront payment and renewal

OrderlyMeds' lower per-month rates require the three-month starter paid as a block: $498 for semaglutide or $798 for tirzepatide. MEDVi offers 3-, 6- and 12-month bundles; their rates appear in its signup flow and are not published here, so the only MEDVi path we can price is monthly. As a new patient, three MEDVi semaglutide cycles cost $179 + 2 × $299 = $777 (assumption: one first-month price, then refills at the displayed rate). OrderlyMeds' comparable three-month starter is $498. For tirzepatide, three refill-only MEDVi cycles at the ongoing rate cost 3 × $399 = $1,197 (no new-patient series is computed because MEDVi's tirzepatide first-month offer is not published); OrderlyMeds' comparable three-month starter is $798.

Renewal terms differ in what is published. MEDVi requires a cancellation request at least 72 hours before the next billing date, does not refund the month in which you cancel, and refunds multi-month plans only for months with no medication shipped. OrderlyMeds' refund and cancellation terms could not be read from its site, so treat them as unknown and request them in writing before paying for a starter.

Support inclusions

MEDVi's published bundle is broader: physician review, a personalized plan, 1:1 guidance, a metabolic report, free dietitian visits and care coaching, unlimited 24/7 support, free shipping and HSA/FSA eligibility. OrderlyMeds includes the provider visit, unlimited check-ins and shipping in its price. Neither published bundle tells you about response times or continuity of clinician; publicly posted MEDVi customer reviews describe a range of experiences on those points, with the usual limits of self-selected reviews.

Choosing based on your priorities

If your priority is the lowest recurring semaglutide rate between these two, OrderlyMeds' $249/mo month-to-month is below MEDVi's $299 refill, and its $166/mo starter is lower still if you accept a $498 upfront block. If you want to test one cycle cheaply, MEDVi's $179 first month is the lower entry. If dietitian visits and 24/7 support matter, MEDVi publishes them and OrderlyMeds does not. If you need tirzepatide, MEDVi's ongoing $399 per billing cycle matches OrderlyMeds' $399/mo month-to-month; OrderlyMeds' $266/mo starter is lower if you accept the $798 upfront block, and MEDVi's tirzepatide first-month offer is shown after the questionnaire, so confirm it in the official offer.

Where PlexusDx fits

PlexusDx Weight Management Protocols are all-inclusive with no membership fee and a flat price at every dose: Semaglutide Injection $189/mo month-to-month ($169/mo on a 3-month plan, $507 commitment total; $149/mo on a 6-month plan, $894 commitment total) and Tirzepatide Injection $289/mo month-to-month ($269/mo on a 3-month plan, $807 commitment total; $249/mo on a 6-month plan, $1,494 commitment total). Payment schedule for multi-month plans is shown at checkout. Month-to-month plans can be cancelled anytime, and you pay $0 until your provider approves. See the full MEDVi vs PlexusDx comparison.

A note on genetics (optional)

PlexusDx offers compounded semaglutide and tirzepatide through its Weight Management Protocols. Separately, and only if it interests you, the GLP-1 & Peptide Pathways Genetic Test ($298) analyzes 14 pathways, 49 peptides, 150+ genetic insights, including variants in FTO, MC4R and TCF7L2 that relate to appetite and glucose-handling pathways. It does not predict how you will respond to any medication and does not tell you which drug, dose or provider is right for you; it is context for a conversation with your clinician. Test before you invest, and treat genetics as a guide, not a guarantee.

This article is educational. PlexusDx is not affiliated with MEDVi and has no commercial relationship with the companies discussed. PlexusDx offers compounded semaglutide and tirzepatide through its own Weight Management Protocols; this article compares approaches in the GLP-1 telehealth space. The GLP-1 & Peptide Pathways Genetic Test analyzes how your genes influence peptide-related biological pathways. It does not predict response to any specific medication and does not recommend, prescribe, or determine which peptides you should use. Consult a qualified healthcare provider before beginning any peptide protocol. Compounded semaglutide and tirzepatide are not FDA-approved drug products; they are prepared by state-licensed compounding pharmacies under federal compounding rules and are not the same as Wegovy®, Ozempic®, Zepbound® or Mounjaro®. Zepbound® and Mounjaro® are registered trademarks of Eli Lilly and Company; Wegovy® and Ozempic® are registered trademarks of Novo Nordisk A/S. PlexusDx is not affiliated with or endorsed by either company.

Frequently Asked Questions

Is OrderlyMeds cheaper than MEDVi for semaglutide?

On the recurring rate, yes as of September 22, 2026: OrderlyMeds lists $249 per month month-to-month, while MEDVi's refills display at $299 per billing cycle. For the first month only, MEDVi's $179 new-patient price is lower. OrderlyMeds' $166 per month rate requires a three-month starter paid as a $498 block, so compare on your expected length of stay.

What does MEDVi charge for tirzepatide compared with OrderlyMeds?

OrderlyMeds lists compounded tirzepatide injection at $399 per month month-to-month or $266 per month on a three-month starter of $798. MEDVi's ongoing month-to-month rate for compounded tirzepatide injection is $399 per billing cycle, verified September 22, 2026, which matches OrderlyMeds' month-to-month rate; MEDVi shows its tirzepatide first-month offer after the questionnaire, so confirm it in the official offer before comparing month one.

Does either program charge a membership fee?

No. MEDVi states there is no membership or hidden fee on its compounded programs and that medication is included in the program cost. OrderlyMeds states it has no membership and includes the visit, check-ins and shipping. MEDVi's separate branded Wegovy and Zepbound pathway does bill a membership plus medication cost, so that is a different comparison.

What are the cancellation terms at MEDVi and OrderlyMeds?

MEDVi asks for a cancellation request at least 72 hours before the next billing date, continues service to the end of the cycle, and does not refund the month in which you cancel. OrderlyMeds' refund and cancellation terms could not be read from its site as of September 22, 2026, so request them in writing before paying for a three-month starter.

Is compounded semaglutide from either provider the same as Wegovy?

No. Compounded semaglutide and tirzepatide are prepared by state-licensed compounding pharmacies and are not FDA-approved drug products; they are not generic or equivalent versions of Wegovy, Ozempic, Zepbound or Mounjaro. A licensed pharmacy or prescriber does not confer FDA approval. Brand-trial results do not establish identical outcomes for compounded injections or tablets.

Sources and dates checked

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This article is part of the PlexusDx Education Hub. Browse all Peptides & GLP-1 education

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. Sources and the dates they were checked are listed at the end of the article.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services, and offers compounded GLP-1 programs through its Weight Management Protocols. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.

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