MEDVi vs OrderlyMeds: 2026 GLP-1 Pricing Compared Head-to-Head

Last reviewed: September 5, 2026 Last updated: September 5, 2026

Written by: Jay Hastings, CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

PlexusDx publishes this comparison and is one of the providers discussed. We use the same evidence rules for our own program and competing programs.

The short answer

OrderlyMeds posts the lowest ongoing rate for compounded semaglutide injection—$149/month—and compounded tirzepatide injection—$299/month—versus MEDVi's $299 and $399 refill prices and PlexusDx's $189 and $289 month-to-month rates. OrderlyMeds requires a two-month prepaid starter ($149 for semaglutide, $299 for tirzepatide) that lowers the effective first-month cost but locks in two months upfront. MEDVi charges a first-month introductory rate ($179 semaglutide injection, $279 tirzepatide) then steps up to refill pricing, so the 12-month cost averages $289/month for semaglutide and $389/month for tirzepatide. PlexusDx month-to-month and multi-month commitments land between those extremes. OrderlyMeds wins on headline price; PlexusDx offers month-to-month flexibility and lower 12-month averages than MEDVi; MEDVi bundles unlimited clinician calls, dietitian visits, and coaching. Both competitors have substantial Trustpilot records—OrderlyMeds at 3.6 stars (~634 reviews, captured September 4, 2026) with reported refund and shipping complaints, MEDVi at 4.3 stars (~15,000 reviews, captured September 4, 2026). PlexusDx holds a 4.2-star rating on Trustpilot, with 76% of reviews at five stars and 81% at four stars or higher (captured September 4, 2026).

At-a-glance comparison

All prices verified September 4–5, 2026. OrderlyMeds pricing from https://orderlymeds.com/pricing/; MEDVi from checkout flow at https://glp1.medvi.org/; PlexusDx from live product pages.

Normalized 12-month costs: like-for-like month-to-month comparison

Starter periods and refill jumps make monthly headline figures misleading. Below we calculate total spend and average monthly cost over 12 months for each program's month-to-month path, assuming no cancellation and continuous treatment.

Compounded semaglutide injection

OrderlyMeds: The two-month starter requires $149 upfront (covering months 1–2), then $149/month for months 3–12. Total: $149 + (10 × $149) = $1,639 over 12 months, or $136.58 per month average (our calculation). The prepaid structure front-loads two months but delivers the lowest ongoing and average rate in this comparison.

MEDVi: $179 first month (introductory rate) + $299/month refill for months 2–12. Total: $179 + (11 × $299) = $3,468 over 12 months, or $289 per month average (our calculation). MEDVi also offers 3-, 6-, and 12-month bundles that reduce the per-month cost; specific bundle rates are not published in our captured evidence, but the bundles are non-refundable for unused months.

PlexusDx month-to-month: $189/month × 12 = $2,268 over 12 months. PlexusDx 3-month commitment: $169/month × 12 = $2,028. PlexusDx 6-month commitment: $149/month × 12 = $1,788. All figures are our calculation; the 3-month and 6-month rates are prepaid per term and non-refundable.

OrderlyMeds' 12-month average of $136.58 beats PlexusDx's 6-month rate ($149/month committed) by roughly $12/month and beats MEDVi's refill rate by $162/month. PlexusDx month-to-month ($189) sits $110/month below MEDVi's refill rate and offers cancel-anytime flexibility without prepay.

Compounded tirzepatide injection

OrderlyMeds: $299 two-month starter prepaid, then $299/month ongoing. Total: $299 + (10 × $299) = $3,289 over 12 months, or $274.08 per month average (our calculation).

MEDVi: $279 first month + $399/month refill for months 2–12. Total: $279 + (11 × $399) = $4,668 over 12 months, or $389 per month average (our calculation).

PlexusDx month-to-month: $289/month × 12 = $3,468. PlexusDx 3-month: $269/month × 12 = $3,228. PlexusDx 6-month: $249/month × 12 = $2,988 (all our calculation).

OrderlyMeds delivers the lowest 12-month average ($274.08), $25/month below PlexusDx 6-month and $115/month below MEDVi's refill-driven average. PlexusDx month-to-month ($289) undercuts MEDVi's refill rate by $110/month with no prepay requirement.

Oral semaglutide: MEDVi vs PlexusDx

OrderlyMeds offers injection only. MEDVi charges a $70 surcharge for semaglutide tablets over injection: $249 first month (introductory rate) and $369/month refill. Over 12 months that yields $249 + (11 × $369) = $4,308 total, or $359 per month average (our calculation).

PlexusDx semaglutide oral capsules run $289 month-to-month, $269/month on a 3-month commitment, and $249/month on a 6-month commitment—all significantly below MEDVi's refill rate. The PlexusDx 6-month oral rate ($249) matches MEDVi's first-month tablet price and saves $120/month versus the MEDVi refill rate.

Decision factors beyond the monthly figure

Prepay structure and cash-flow impact

OrderlyMeds' starter requires the full two-month payment upfront ($149 for semaglutide, $299 for tirzepatide). That delivers the lowest per-month average over 12 months but removes the option to cancel after one month without loss. MEDVi's first-month discount lets you test for one month at a lower entry cost ($179 semaglutide injection, $279 tirzepatide) before the refill jump, but the refill rate drives the 12-month average well above both OrderlyMeds and PlexusDx. PlexusDx month-to-month plans charge one month at a time with no prepay requirement and land between OrderlyMeds' average and MEDVi's refill in headline cost; PlexusDx multi-month commitments close the gap with OrderlyMeds' starter-driven average while preserving a known per-month rate across the term.

Clinician access and support inclusions

MEDVi explicitly includes unlimited doctor calls, a free dietitian visit, and free care coaching in its advertised price. OrderlyMeds and PlexusDx both include clinician oversight and messaging support; neither publishes a separate support-tier menu. MEDVi's published support bundle may justify its higher refill rate for patients who anticipate frequent clinician contact or need structured coaching; OrderlyMeds' and PlexusDx's lower rates assume standard oversight is sufficient.

Service consistency and reported customer experience

OrderlyMeds holds a 3.6-star Trustpilot rating from approximately 634 reviews (captured September 4, 2026). Negative themes reported on the platform include refund delays, slow customer-service response times, and shipping issues. These are individual customer reports and do not establish a pattern across all users, but they appear with enough frequency to warrant attention when prepaying two months upfront.

MEDVi holds a 4.3-star rating from roughly 15,000 Trustpilot reviews (captured September 4, 2026). The large review volume and higher average suggest more consistent reported satisfaction; no dominant negative theme emerged in the captured evidence.

PlexusDx holds a 4.2-star rating on Trustpilot, with 76% of reviews at five stars and 81% at four stars or higher (captured September 4, 2026).

Dose titration and price stability

MEDVi states that dose increases do not raise the monthly price. OrderlyMeds and PlexusDx pricing pages do not specify dose-ceiling policies; both advertise fixed per-month rates without dose-tier qualifications in the captured evidence. If your treatment plan involves rapid titration or high maintenance doses, confirm whether the advertised rate holds across the full dose range before committing to a prepaid term.

Choose OrderlyMeds if…

• You want the lowest 12-month average cost for semaglutide ($136.58/month) or tirzepatide ($274.08/month) and are comfortable prepaying two months upfront.
• You plan to remain on treatment for at least three months and the two-month lock-in presents no liquidity or flexibility concern.
• You prefer injection-only delivery and do not require an oral option.
• You are willing to accept the 3.6-star Trustpilot record and reported service delays in exchange for the headline savings.

Choose MEDVi if…

• You value unlimited clinician calls, dietitian access, and structured coaching as part of the advertised price and expect to use those services frequently.
• You want to test GLP-1 therapy for one month at a modest entry price ($179 semaglutide injection, $279 tirzepatide) before committing to the higher refill rate.
• You are considering a multi-month bundle (3-, 6-, or 12-month options available) and want 0% financing via Klarna; note that bundles are non-refundable for unused months and specific per-month bundle rates are not published in our captured evidence.
• The 4.3-star rating from ~15,000 reviews gives you confidence in service consistency, and you accept the $299 semaglutide or $399 tirzepatide refill rate as the trade-off for that support layer.

Where PlexusDx fits

PlexusDx month-to-month plans offer cancel-anytime flexibility with no prepay requirement and no refill-rate jump. At $189/month for semaglutide injection and $289/month for tirzepatide injection, PlexusDx sits below MEDVi's refill rates by $110/month and above OrderlyMeds' ongoing $149/$299 by $40 per compound. The 3-month and 6-month PlexusDx commitments narrow the gap with OrderlyMeds—PlexusDx semaglutide at $149/month (6-month) matches OrderlyMeds' ongoing rate exactly, and PlexusDx tirzepatide at $249/month (6-month) runs $50/month below OrderlyMeds' $299. PlexusDx oral options (semaglutide oral $289 MTM, $249 6-month; tirzepatide oral $349 MTM, $279 6-month) provide needle-free alternatives unavailable from OrderlyMeds and priced well below MEDVi's oral refill rates. The 4.2-star Trustpilot rating with 76% five-star reviews offers a middle ground between OrderlyMeds' 3.6-star record and MEDVi's 4.3-star volume. PlexusDx works with licensed 503A compounding pharmacies and includes clinician oversight, dose adjustments, and shipping in the advertised price with no separate membership fee.

Methodology and freshness

OrderlyMeds pricing verified from the company's public pricing page at https://orderlymeds.com/pricing/ (captured September 4, 2026, 13:49:55 UTC). MEDVi pricing verified through checkout flow at https://glp1.medvi.org/ (captured September 4, 2026, 13:49:55 UTC; cross-checked September 5, 2026, 10:43:47 UTC). PlexusDx pricing from live product pages. Trustpilot ratings and review volumes captured September 4, 2026. All 12-month cost calculations, per-month averages, and prepaid equivalents are our calculation and labeled as such. We do not publish MEDVi's multi-month bundle per-month rates because those figures are not published on MEDVi's public pages or checkout flow; we note only that bundles exist, are non-refundable, and offer a per-month discount versus the refill rate. Promotional and introductory rates (OrderlyMeds' two-month starter, MEDVi's first-month pricing) appear only in the article body with explicit labels and capture dates; standard ongoing rates are used in titles, meta fields, and summary comparisons. We apply the same evidence standard to PlexusDx, OrderlyMeds, and MEDVi: if a price or policy is not verified by checkout flow or official published page with a capture date, we do not present it as fact.

Frequently Asked Questions

Does OrderlyMeds' $149 semaglutide rate require prepayment?

Yes. OrderlyMeds' starter plan requires $149 upfront to cover the first two months of semaglutide injection, then $149/month ongoing. The two-month prepaid structure delivers the lowest 12-month average cost but removes the option to cancel after one month without financial loss.

Why does MEDVi's first-month price jump so much at refill?

MEDVi uses an introductory rate ($179 semaglutide injection, $279 tirzepatide) for the first month, then charges the standard refill rate ($299 semaglutide, $399 tirzepatide) from month two onward. Over 12 months the refill rate dominates the average, raising MEDVi's effective cost well above OrderlyMeds and PlexusDx month-to-month plans.

Can I get an oral GLP-1 from OrderlyMeds?

No. OrderlyMeds offers compounded semaglutide and tirzepatide by injection only. MEDVi and PlexusDx both offer oral semaglutide and tirzepatide options; PlexusDx oral rates run $120–$150 per month below MEDVi's oral refill prices depending on compound and commitment term.

Do these prices include clinician visits and shipping?

Yes. All three providers bundle clinician consultation, prescription, medication, and shipping into the advertised monthly price with no separate membership fee for compounded plans. MEDVi explicitly includes unlimited doctor calls, a dietitian visit, and coaching; OrderlyMeds and PlexusDx include standard clinician oversight and messaging support without publishing separate support tiers.

What happens if I cancel OrderlyMeds or MEDVi after the first month?

OrderlyMeds' starter is prepaid for two months; canceling after one month means you have already paid for month two. MEDVi month-to-month plans allow cancellation anytime, but MEDVi's multi-month bundles are non-refundable for unused months. PlexusDx month-to-month plans allow cancellation anytime; prepaid 3-month and 6-month commitments are non-refundable.

Sources

• OrderlyMeds pricing page, https://orderlymeds.com/pricing/, accessed September 4, 2026.
• MEDVi GLP-1 program page and checkout flow, https://glp1.medvi.org/, accessed September 4, 2026; cross-checked September 5, 2026.
• PlexusDx product pages, https://plexusdx.com/products/semaglutide-injection and https://plexusdx.com/products/tirzepatide-injection, accessed September 5, 2026.
• Trustpilot reviews for OrderlyMeds, MEDVi, and PlexusDx, captured September 4, 2026.

Compounded medication disclosure: Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. PlexusDx works with licensed 503A compounding pharmacies.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.