MEDVi Membership Fees vs PlexusDx (2026)

Last reviewed: May 12, 2026 Last updated: May 12, 2026

Written by: Jay Hastings , CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

This article is part of the PlexusDx Education Hub — your resource for evidence-based guidance on GLP-1 therapies, weight management protocols, and the genetic variables that shape every metabolic decision. Browse all Peptides & GLP-1 education

If you’re trying to figure out whether MEDVi charges a separate membership fee on top of medication, the short answer is: it depends which path you choose. MEDVi’s compounded semaglutide and tirzepatide plans are sold as a single bundled monthly price — medication, provider visit, shipping, and ongoing support included — while MEDVi’s branded Wegovy and Zepbound paths add a separate $99/month membership fee on top of the medication cost. That distinction matters because the same provider page uses the word “membership” in two different ways, which is why review sites contradict each other. This guide reconciles MEDVi’s actual fee structure, explains how billing works on a 28-day cycle, and shows where PlexusDx Weight Management Protocols sit relative to MEDVi — specifically Microdose GLP-1 Protocol at $129/mo flat, Semaglutide Injection at $149/mo, and Tirzepatide Injection at $249/mo. PlexusDx is cash-pay with no membership fee on any protocol.

Does MEDVi have a membership fee? The clean answer

MEDVi runs as a recurring subscription, but whether you see a separate “membership” line on your invoice depends on the medication path. On the compounded semaglutide and tirzepatide plans, the monthly price shown on MEDVi’s GLP pricing page is bundled — physician review, care plan, prescription, the compounded vial, and shipping all sit inside one charge. There is no second line item labeled “membership.” On the branded Wegovy and Zepbound paths, MEDVi adds a $99/month membership charge separate from the medication cost. The medication itself is then dispensed at branded pricing through a partner pharmacy. Both paths are subscriptions that auto-renew every 28 days, which is why MEDVi’s cancellation policy describes the program as a “Subscription Service” even when no separate membership line appears on the bill. Compare that to PlexusDx Semaglutide Injection or Tirzepatide Injection, where the listed monthly price is the full cash-pay total: no membership fee, no platform fee, and a calendar-month billing cycle rather than a 28-day cycle.

What MEDVi’s compounded plans actually cost

MEDVi’s current GLP page advertises compounded semaglutide injections at $179 for the first month and $299/month ongoing, with the price including physician review, personalized care plan, guidance, metabolic report, and prescription medication shipped to your door. MEDVi’s terms note the final charge may fluctuate based on the prescribed medication and the chosen pharmacy. That bundled structure makes the headline number easy to compare against PlexusDx: Semaglutide Injection on PlexusDx runs $149/mo across five dose levels (0.25mg to 2.0mg weekly), so the entry tier matches MEDVi’s introductory $179 and the highest tier is well below MEDVi’s $299 ongoing rate. Tirzepatide Injection on PlexusDx runs $249/mo across six dose levels (2.5mg to 15mg weekly). For patients prioritizing the lowest-cost compounded option, the Microdose GLP-1 Protocol at $129/mo flat sits below every MEDVi tier and offers four delivery formats (capsule, troche, lozenge, sublingual) for needle-averse patients. None of the PlexusDx prices include a membership fee or platform charge.

What MEDVi’s branded path costs — where the $99 membership lives

The $99/month membership fee that confuses readers applies specifically to MEDVi’s branded routes — Wegovy pill, Wegovy injection, and Zepbound injection. On those paths, the $99 covers the platform, provider access, and ongoing care; the medication is billed separately at the branded price (typically $1,000–$1,350/month at Wegovy or Zepbound list, or roughly $499/month for Lilly Direct’s Zepbound self-pay vials when available). For patients with insurance that reliably covers branded GLP-1 therapy at a low copay, the $99 plus copay path can be the cheapest overall. For patients without that coverage, the branded route at MEDVi runs $13,000–$16,000/year before any insurance discount. PlexusDx does not dispense Wegovy or Zepbound — PlexusDx Weight Management Protocols use compounded semaglutide and tirzepatide. If your goal is the FDA-approved finished product, MEDVi’s branded path or a direct manufacturer program is the route. If your goal is cash-pay compounded therapy at a flat monthly price with no membership add-on, compare PlexusDx Semaglutide Injection, Tirzepatide Injection, and GLP-Squared against MEDVi’s compounded tier directly.

The 28-day billing cycle — why MEDVi customers pay 13 times a year

MEDVi’s cancellation policy states that subscriptions automatically renew every 28 days. Over 365 days that produces 13 billing cycles instead of 12, which adds roughly one extra month of cost compared to a calendar-month subscription advertised at the same headline price. On the $299 compounded refill rate, 13 cycles equals $3,887/year rather than the $3,588 a 12-cycle reading of $299/mo would imply. Cancellation requires at least 72 hours’ notice before the next billing date, and ordinary cancellations after medication has been ordered generally do not trigger a refund. PlexusDx Weight Management Protocols bill on a calendar-month cycle — 12 charges per year — with no membership tier and no separate platform fee. On the lowest-cost Microdose GLP-1 Protocol, 12 months at $129/mo is $1,548/year. On Semaglutide Injection, 12 months at $149 is $2,148–$2,748/year. On Tirzepatide Injection, 12 months at $249 is $2,748–$3,708/year. The billing-cycle difference alone makes the cost comparison less obvious than the headline numbers suggest.

Compounded vs branded — what each path actually dispenses

Both MEDVi’s compounded plans and PlexusDx Weight Management Protocols dispense compounded semaglutide and tirzepatide prepared by licensed U.S. compounding pharmacies. Compounded semaglutide and tirzepatide are not FDA-approved finished drug products — they are pharmacy-prepared versions of the same active ingredients found in Wegovy, Ozempic, Mounjaro, and Zepbound. MEDVi’s branded path dispenses the FDA-approved finished products themselves, the same medications that ran the SUSTAIN, STEP, and SURMOUNT clinical trials. The boxed warning for thyroid C-cell tumors applies to both semaglutide and tirzepatide based on rodent studies, regardless of whether the product is compounded or FDA-approved branded. PlexusDx differentiates on two axes neither MEDVi tier addresses: a four-format delivery menu (weekly injection, daily oral tablet, microdose troche/capsule/lozenge/sublingual, and dual-compound stacks via GLP-Squared) and an optional Precision Peptide Genetic Test that anchors dose selection to the patient’s GLP1R, FTO, MC4R, TCF7L2, and GIPR rs1800437 variants before titration begins.

Auto-renewal, cancellation, and refunds — what to verify before signing up

Three operational details cause most MEDVi billing surprises and apply to every cash-pay subscription model worth comparing. First, the renewal cadence: MEDVi auto-renews every 28 days; many comparable telehealth GLP-1 platforms run on calendar months. Confirm the cycle length before enrolling so the “per month” price translates correctly into annual cost. Second, the cancellation window: MEDVi requires at least 72 hours’ notice before the next billing date, with cancellation through the patient portal chat or by emailing hello@medvi.org. Cancel earlier than that or you’ll be charged for the next cycle. Third, refund policy: MEDVi generally does not refund once medication has been ordered, with medical disqualification as the main documented exception. PlexusDx is also cash-pay with no membership tier; review the protocol page for billing cadence and cancellation specifics before enrolling. The Precision Peptide Genetic Test is a one-time $298 standalone purchase or a $99 add-on after your first month on any protocol — it is not a subscription.

Annualized cost head-to-head — MEDVi compounded vs PlexusDx

For a cash-pay patient with no GLP-1 insurance coverage, the compounded paths line up like this. MEDVi compounded semaglutide injection: $179 first month + $299 × 12 ongoing cycles (28-day billing produces 13 cycles in a 365-day year, so this is approximate) ≈ $3,767–$3,887/year. PlexusDx Microdose GLP-1 Protocol: $129 × 12 = $1,548/year. PlexusDx Semaglutide Injection: $149 × 12 = $2,148–$2,748/year. PlexusDx Tirzepatide Injection: $249 × 12 = $2,748–$3,708/year. PlexusDx GLP-Squared dual-compound: $249 × 12 = $2,148–$3,900/year. Add the optional Precision Peptide Genetic Test as a $99 add-on after month one and the genetic-baseline-included totals stay below MEDVi on every PlexusDx protocol except the highest GLP-Squared and Tirzepatide tiers. The lowest-cost direct comparison — Microdose GLP-1 Protocol at $1,548/year vs MEDVi compounded at roughly $3,800/year — is a difference of more than $2,200/year for cash-pay patients prioritizing total spend.

Why PlexusDx adds a genetic baseline neither tier of MEDVi includes

GLP-1 response varies meaningfully across patients. Variants in GLP1R (the GLP-1 receptor itself), FTO (appetite regulation), MC4R (satiety signaling), and TCF7L2 (insulin response) are associated with measurably different response patterns to semaglutide and tirzepatide; GIPR rs1800437 is the headline variant for differential GLP-1 response. The Precision Peptide Genetic Test maps 48 genes and 57 variants across 14 health pathways — including 34 weight-management insights — so the prescribing clinician can see whether a faster titration, a slower titration, or a tirzepatide-first approach is more likely to fit your biology before the first dose. Neither MEDVi’s compounded plans nor MEDVi’s branded path performs this step; both rely on a population-average titration schedule adjusted by subjective tolerability over the first 8–12 weeks. PlexusDx anchors that same conversation to a measurable genetic baseline, available standalone for $298 or as the $99 add-on after your first month on any of the six Weight Management Protocols.

Frequently asked questions

Does MEDVi charge a separate monthly membership fee?

Not on the compounded GLP-1 plans — MEDVi’s GLP page shows compounded semaglutide and tirzepatide as bundled pricing with medication, provider review, and shipping included in one monthly charge. On the branded Wegovy and Zepbound paths, MEDVi adds a separate $99/month membership fee on top of the medication cost. PlexusDx Weight Management Protocols have no membership fee on any of the six protocols.

Is MEDVi’s $179 first-month price the total amount charged?

For the compounded semaglutide injection program, MEDVi’s page states the $179 first month includes physician review, personalized care plan, guidance, metabolic report, and prescription medication shipped to your door. MEDVi’s terms note the final charge may fluctuate based on medication and pharmacy, so confirm the exact total at checkout.

How much does MEDVi cost after the first month?

MEDVi’s semaglutide FAQ states refills are $299/month for compounded semaglutide injections after the first introductory month. By comparison, PlexusDx Semaglutide Injection is $149/mo across five dose levels with no introductory discount and no price step-up after month one.

Does MEDVi auto-renew every month or every 28 days?

Every 28 days, per MEDVi’s cancellation policy. Over a year, that produces roughly 13 billing cycles instead of 12, which adds approximately one extra month of cost compared to a calendar-month subscription at the same headline price.

Can you cancel MEDVi anytime?

Yes — MEDVi runs month-to-month with no contract and no cancellation fee, but you must cancel through the patient portal chat or by emailing hello@medvi.org at least 72 hours before your next billing date to avoid being charged for the next cycle.

Does MEDVi take insurance for compounded GLP-1?

MEDVi’s compounded medications are cash-pay; insurance reimbursement may be possible for some branded options, and HSA and FSA payments are accepted at checkout. PlexusDx is also cash-pay across all six Weight Management Protocols and accepts HSA and FSA payments where eligible.

What does PlexusDx charge for compounded GLP-1 compared to MEDVi?

PlexusDx Weight Management Protocols are flat-priced with no membership fee: Microdose GLP-1 Protocol $129/mo, Semaglutide Injection $149/mo, Tirzepatide Injection $249/mo, and GLP-Squared $249/mo. The Microdose tier is below every MEDVi tier on annualized cost.

Does MEDVi Have Membership Fees? MEDVi vs PlexusDx (2026) | PlexusDx