Willow GLP-1 Pricing: Semaglutide, Tirzepatide and Oral Compared

Last reviewed: September 5, 2026 Last updated: September 5, 2026

Written by: Jay Hastings, CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

PlexusDx publishes this comparison and is one of the providers discussed. We use the same evidence rules for our own program and competing programs.

The short answer

Willow advertises compounded semaglutide at $299 per month and compounded tirzepatide at $399 per month, both billed monthly for a one-month supply with free two-day shipping and no separate membership fee (verified September 4, 2026). The platform lists oral semaglutide and oral tirzepatide as available, but route-specific pricing was not itemized on Willow's public pages as of that capture date. PlexusDx compounded semaglutide injection is $189 per month on a month-to-month plan—$110 less per month than Willow's published semaglutide rate—and tirzepatide injection is $289 per month, $110 less than Willow's tirzepatide injection price. Over 12 months, the difference is $1,320 in favor of PlexusDx for either medication on like-for-like month-to-month terms. Both providers describe their pricing as all-inclusive. Confirm the medication, route, and any additional terms at checkout before committing.

At-a-glance injection pricing

Willow pricing verified September 4, 2026, from startwillow.com. PlexusDx pricing verified September 5, 2026. MTM = month-to-month; 3-mo and 6-mo figures are prepaid rates, our calculation of effective monthly cost. All medications are compounded and not FDA-approved. Confirm medication, route, and final price at checkout.

Normalized 12-month cost: month-to-month injection plans

To compare like-for-like, we calculate the total cost of 12 consecutive monthly orders on each provider's month-to-month plan, using only verified published rates. This removes the effect of prepayment and isolates the recurring monthly price an individual would pay with no upfront commitment.

Semaglutide injection (month-to-month)

• Willow: $299/month × 12 = $3,588 (our calculation).
• PlexusDx: $189/month × 12 = $2,268 (our calculation).
• Difference: $3,588 − $2,268 = $1,320 less with PlexusDx over 12 months, or $110 per month (our calculation).

Tirzepatide injection (month-to-month)

• Willow: $399/month × 12 = $4,788 (our calculation).
• PlexusDx: $289/month × 12 = $3,468 (our calculation).
• Difference: $4,788 − $3,468 = $1,320 less with PlexusDx over 12 months, or $110 per month (our calculation).

Prepaid plans (PlexusDx only, for reference)

PlexusDx offers three-month and six-month prepaid plans with lower per-month equivalents. Over 12 months on the six-month prepaid rate:

• Semaglutide injection: $149/month × 12 = $1,788 (our calculation), a difference of $1,800 versus Willow's $3,588 twelve-month total, or $150 per month (our calculation, prepaid).
• Tirzepatide injection: $249/month × 12 = $2,988 (our calculation), a difference of $1,800 versus Willow's $4,788 twelve-month total, or $150 per month (our calculation, prepaid).

Willow's verified pricing as of September 4, 2026, showed only month-to-month billing; no multi-month prepaid structure was documented.

What Willow includes

Willow's $299 semaglutide and $399 tirzepatide prices are described as "all-in treatment" and include the medication, provider consultation, and free two-day shipping, with no separate membership or service fee (verified September 4, 2026). The platform accepts HSA and FSA payment. Treatment is described as doctor-guided. Willow advertises compounded semaglutide and tirzepatide in both injection and oral routes, though the September 4 capture found route-specific pricing itemized only for injection; oral availability was listed but without a separate published price. No cancellation or refund policy was documented in the verified sources. Prospective patients should confirm the medication route, dose escalation timeline, cancellation terms, and any additional fees before finalizing an order.

What PlexusDx includes

PlexusDx pricing covers the online provider visit, prescription review, compounded medication, and shipping in one published rate with no membership fee. The same per-month price applies at every dose within a given medication and plan tier. Compounded semaglutide injection is $189 per month on the month-to-month plan, $169 per month on the three-month prepaid plan, and $149 per month on the six-month prepaid plan (verified September 5, 2026). Compounded tirzepatide injection is $289 per month month-to-month, $269 per month on the three-month plan, and $249 per month on the six-month plan. PlexusDx also offers oral semaglutide capsules at $289 per month (month-to-month, $269 three-month, $249 six-month), oral tirzepatide capsules at $349 per month (month-to-month, $299 three-month, $279 six-month), and a microdose semaglutide injection protocol at $129 per month for maintenance or cautious initiation. All PlexusDx medications are compounded by licensed 503A pharmacies and are not FDA-approved. A licensed clinician reviews each intake and determines whether a prescription is appropriate for the individual patient.

Oral GLP-1 pricing

Willow lists oral semaglutide and oral tirzepatide as available formulations, but neither oral medication had a separately itemized price on the public product pages captured September 4, 2026. If you prefer oral administration, contact Willow directly or complete an intake to learn the route-specific cost. PlexusDx publishes pricing for both oral capsules: compounded semaglutide oral is $289 per month month-to-month (lower than Willow's documented injection price for semaglutide), and compounded tirzepatide oral is $349 per month month-to-month (lower than Willow's documented injection price for tirzepatide). Because Willow's oral pricing was not verified in the evidence, a direct oral-to-oral comparison is not possible at this time.

Decision factors: service, support, and reliability

Price is only one input. Responsiveness, prescriber availability, medication consistency, shipping reliability, and ease of dose adjustment all affect long-term adherence. Neither Willow nor PlexusDx showed a publicly documented cancellation or comprehensive refund policy in the verified sources; ask for written terms before committing. PlexusDx holds a 4.2-star rating on Trustpilot, with 76 percent of reviews at five stars and 81 percent at four stars or higher (captured September 4, 2026). Willow's Trustpilot profile was identified in the research but no rating or review volume was captured in the September 4 verification pass. Individual experiences reported on any review platform are anecdotal; weight-loss medication outcomes and service quality vary by patient, prescriber availability, and fulfillment timing.

Choose Willow if…

• You prefer the platform's interface, onboarding flow, or care-team communication style after comparing both intakes.
• You have verified with Willow that oral GLP-1 pricing fits your budget and that the route you want is available at the published or quoted rate.
• Month-to-month flexibility is essential and you are comfortable with the $299 semaglutide or $399 tirzepatide injection price point.
• Free two-day shipping and HSA/FSA acceptance are must-haves and you have confirmed those terms apply to your medication and location.

Where PlexusDx fits

PlexusDx compounded semaglutide injection at $189 per month and tirzepatide injection at $289 per month both undercut Willow's documented injection rates by $110 per month on like-for-like month-to-month terms. Over 12 months, that difference is $1,320 for either medication (our calculation). If cost predictability over a longer horizon is valuable, PlexusDx three-month and six-month prepaid plans lower the effective monthly rate further: six-month semaglutide injection is $149 per month (prepaid), and six-month tirzepatide injection is $249 per month (prepaid). The oral-capsule portfolio covers individuals who prefer or require non-injection administration: oral semaglutide is $289 per month (less than Willow's injection semaglutide price), and oral tirzepatide is $349 per month (less than Willow's injection tirzepatide price), both on month-to-month plans. The microdose semaglutide injection protocol at $129 per month serves patients in maintenance or those cautiously initiating therapy. One published price covers provider visit, prescription, medication, and shipping with no membership fee. A licensed provider reviews every intake; medication and dose are not guaranteed until that clinical review is complete.

Methodology and freshness

Willow pricing ($299 semaglutide injection, $399 tirzepatide injection, month-to-month, all-inclusive, no membership fee) was verified September 4, 2026, 13:49:55 UTC, from the public pages at startwillow.com and startwillow.com/compound-tirzepatide. Oral medication availability was noted but route-specific pricing was not itemized on those pages. Verification included browser-session review; no payment was submitted and the session timed out before intake completion. PlexusDx pricing was verified September 5, 2026, 09:56:04 UTC, from published product pages. Twelve-month totals and monthly differences are our calculations, applying each provider's verified per-month rate over 12 consecutive orders with no discounts or promotional adjustments. PlexusDx prepaid three-month and six-month per-month equivalents are our calculations of the effective monthly cost under those commitment tiers. The research packet noted no promotional or introductory pricing for Willow; all figures represent standard recurring monthly rates as published. Review data for PlexusDx (4.2 stars, 76 percent five-star, 81 percent four-star or higher on Trustpilot) was captured September 4, 2026. Readers should confirm medication, route, dose, shipping, cancellation terms, and final price at checkout with either provider before committing.

Frequently Asked Questions

Does Willow charge a membership fee on top of the medication price?

No. Willow's verified pricing as of September 4, 2026, listed $299 per month for semaglutide and $399 per month for tirzepatide with no separate membership or service fee; the structure was described as all-inclusive. Confirm at checkout that no additional recurring fees apply to your specific plan.

Is oral semaglutide or oral tirzepatide cheaper than injection at Willow?

Willow lists both oral routes as available, but route-specific pricing was not itemized on its public pages as of September 4, 2026. Contact Willow or complete an intake to learn whether oral formulations are priced differently from the documented injection rates of $299 and $399 per month.

How much do I save with PlexusDx versus Willow over one year?

On month-to-month injection plans, PlexusDx semaglutide at $189 per month saves $1,320 over 12 months compared with Willow's $299 rate, and PlexusDx tirzepatide at $289 per month saves $1,320 over 12 months compared with Willow's $399 rate (our calculation). Prepaid six-month plans widen the gap to $1,800 annually for each medication.

Are compounded GLP-1 medications FDA-approved?

No. Compounded medications are not FDA-approved. The FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. Both Willow and PlexusDx dispense compounded semaglutide and tirzepatide; PlexusDx works with licensed 503A compounding pharmacies.

Can I switch from Willow to PlexusDx mid-treatment?

Switching providers mid-treatment requires a new intake, a new prescription from a PlexusDx-affiliated clinician, and coordination of your current dose and titration schedule. Neither service guarantees a seamless transfer or that the new prescriber will continue your existing dose. Allow time for the new clinical review and confirm your shipment timing to avoid a gap in medication.

Sources

• PlexusDx product pages, accessed September 5, 2026.
• Willow public website (startwillow.com and startwillow.com/compound-tirzepatide), captured September 4, 2026, 13:49:55 UTC.
• PlexusDx Trustpilot profile, captured September 4, 2026.
• Research packet evidence rows (Willow pricing verified September 4, 2026; PlexusDx pricing verified September 5, 2026).

Compounded medication disclosure: Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. PlexusDx works with licensed 503A compounding pharmacies.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.