TrimRx vs Henry Meds vs PlexusDx (2026): Real Cost, Reviews & Genetic-Guided GLP-1

Last reviewed: July 20, 2026 Last updated: July 20, 2026

Written by: Jay Hastings, CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison specializing in pharmacogenomics and clinical product development, with more than 10 years of professional experience in clinical pharmacy, academia, and research.

This article is part of the PlexusDx Education Hub. Browse all Peptides & GLP-1 education

If you are comparing TrimRx and Henry Meds for compounded GLP-1 weight loss, the key detail about TrimRx is that its advertised price and its checkout price differ. This article uses both, plus Henry Meds’ published rates, so the comparison is honest. (TrimRx pricing verified by completing its signup to checkout, July 2026; Henry Meds pricing per its published pages.)

Full head-to-head: PlexusDx vs Henry Meds →

Full head-to-head: PlexusDx vs TrimRx →

TrimRx vs Henry Meds vs PlexusDx: how the pricing works

TrimRx advertises compounded semaglutide from $199/month and compounded tirzepatide from $349/month on its pricing pages. When we completed TrimRx’s signup in July 2026, the checkout billed $299/month ongoing for semaglutide and $399/month for tirzepatide, with a promotional first month of $179 (semaglutide) or $279 (tirzepatide). Its multi-month plans are billed as one total: semaglutide 3-month at $289/mo month-to-month, or from $249/mo on the 6-month plan ($628 charged), 6-month at $191/mo ($1,148 charged), 12-month at $174/mo ($2,098 charged); tirzepatide 3-month at $316/mo ($948 charged), 6-month at $299/mo ($1,798 charged), 12-month at $283/mo ($3,398 charged). Because TrimRx’s advertised and checkout numbers differ, verify your exact plan in the checkout flow before paying. TrimRx charges no membership fee and holds price flat across doses. Henry Meds lists $297/month month-to-month for injectable compounded semaglutide on its programs page, per Henry Meds’ published rates as of July 2026; its tirzepatide is an oral dissolving tablet only (3-month supply, $1,047, or $891 paid in full) — Henry does not offer injectable tirzepatide. PlexusDx Weight Management Protocols use compounded semaglutide and tirzepatide from licensed 503A compounding pharmacies with no membership and flat pricing: Microdose GLP-1 Protocol at $129/mo, Semaglutide Injection at $189/mo, and Tirzepatide Injection at $289/mo, plus the optional Precision Peptide Genetic Test ($298, or $99 for program members).

The annual math, labeled honestly

On the rate we saw billed at checkout, TrimRx compounded semaglutide runs about $3,468 in the first year ($179 promotional first month + $299 × 11); its 6-month plan annualizes to $2,296 (two $1,148 charges) and its 12-month prepaid plan lowers the year to $2,098, paid up front. Henry Meds at $297/month runs about $3,564/year, per its published rates as of July 2026. PlexusDx bills flat monthly with no membership: Microdose GLP-1 Protocol $1,548/year ($129/mo), Semaglutide Injection $2,268/year ($189/mo), and Tirzepatide Injection $3,468/year ($289/mo). PlexusDx is lower than TrimRx at every plan length both programs sell and meaningfully below Henry Meds on compounded semaglutide; TrimRx’s 12-month plan ($174/mo) sits below the PlexusDx month-to-month rate but above the PlexusDx 6-month equivalent, so it is not simply the lowest price in the comparison.

Concede what is true about TrimRx

TrimRx charges no membership fee, keeps price flat as the dose increases, includes dose increases and shipping, charges $0 at signup, and offers a 12-month prepaid plan PlexusDx does not. The only caution for shoppers is that TrimRx’s advertised, promotional, and checkout numbers differ, so confirm your plan price at checkout.

What genetics add

GLP-1 response varies across patients. Variants in GLP1R, GIPR (notably rs1800437), FTO, MC4R, and TCF7L2 relate to different response patterns to semaglutide and tirzepatide. The Precision Peptide Genetic Test maps 49 genes and 58 variants across 14 health pathways, including weight-management insights and the GIPR rs1800437 variant. These are pathway-level associations for context before titration; they do not predict your response to a specific medication or determine which one you should take. Neither of the other programs compared here includes a DNA-based test. Genetics is a guide, not a guarantee.

Frequently Asked Questions

Is TrimRx or Henry Meds cheaper for semaglutide?

On published standard pricing, TrimRx advertises $199/month versus Henry Meds’ $297/month — but TrimRx’s checkout billed $299/month ongoing when we completed signup in July 2026, so confirm your plan at checkout. PlexusDx Semaglutide Injection at $189/mo (or $149/mo on the 12-month plan) flat is below both.

How much does TrimRx actually cost?

TrimRx advertises $199/month for compounded semaglutide, but when we completed signup in July 2026 the checkout billed $299/month ongoing after a $179 promotional first month. Multi-month prepaid plans lower the monthly rate ($289/mo month-to-month, or from $249/mo on the 6-month plan/$191/$174 for 3/6/12 months) but are charged as one total up front.

Does TrimRx or Henry Meds charge a membership fee?

Neither advertises a separate membership fee, and neither does PlexusDx. Confirm the current terms at checkout for each provider.

Does genetic testing tell me which GLP-1 to take?

No. The Precision Peptide Genetic Test analyzes pathway-level genetics only. It gives you and your provider context; it does not predict your response to a specific medication or determine which one you should take.

This article is part of the PlexusDx Education Hub. Browse all Peptides & GLP-1 education

Disclaimer: This article is educational and is not medical advice. PlexusDx offers compounded semaglutide and tirzepatide through its Weight Management Protocols. TrimRx pricing reflects its advertised rates and the rate billed at checkout as verified in July 2026; Henry Meds pricing is per its published pages; actual costs may vary by state, plan, and eligibility. Compounded semaglutide and tirzepatide are not FDA-approved finished drug products. Consult a licensed clinician before starting any medication.

Medical and Editorial Standards

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.