PlexusDx vs 10Rx: Monthly vs Quarterly GLP-1 Pricing Compared

Last reviewed: September 4, 2026 Last updated: September 4, 2026

Written by: Jay Hastings, CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

PlexusDx publishes this comparison and is one of the providers discussed. We use the same evidence rules for our own program and competing programs.

The short answer

10Rx's prepaid quarterly packages—$299 every three months for compounded semaglutide with B12, $450 for tirzepatide with B12—deliver the lowest effective monthly cost we documented: $99.67 and $150 per month respectively over 12 months (our calculation, captured September 4, 2026). PlexusDx month-to-month plans cost $189 for semaglutide injection and $289 for tirzepatide injection, with no prepayment required. PlexusDx 3-month and 6-month commitment tiers ($169 and $149 for semaglutide; $269 and $249 for tirzepatide) narrow the gap but remain higher than 10Rx's prepaid equivalent. The trade-off is cash flow versus flexibility: 10Rx requires $299 or $450 upfront every quarter; PlexusDx charges month by month or offers prepaid discounts without a single large quarterly outlay on the month-to-month tier. Both programs include medication, shipping, and clinician access in the base price; neither charges a membership fee.

At-a-glance comparison

Evidence note: 10Rx's primary pricing page (checked September 4, 2026) confirms the quarterly prepaid structure, flat pricing across dose strengths, and inclusions, but suppresses the numeric package totals. The $299 semaglutide and $450 tirzepatide figures are documented as secondary corroboration across multiple sources captured the same day. We state the conflict plainly and advise confirming totals at checkout.

Normalized 12-month costs

Both programs charge a flat rate regardless of dose strength—a shared advantage for patients titrating upward. To compare fairly, we calculate the total cost of 12 months on each plan and the effective monthly rate. All prepaid per-month figures are labeled as our calculation.

10Rx quarterly prepaid

Semaglutide with B12: $299 every three months × 4 quarters = $1,196 per year, or $99.67 per month (our calculation, prepaid quarterly).

Tirzepatide with B12: $450 every three months × 4 quarters = $1,800 per year, or $150 per month (our calculation, prepaid quarterly).

Each quarter requires the full $299 or $450 payment upfront. The rate does not change after the first quarter; this is the ongoing cost as long as the program continues quarterly billing.

PlexusDx month-to-month and multi-month tiers

Semaglutide injection:

• Month-to-month: $189/month × 12 = $2,268 per year
• 3-month commitment: $169/month × 12 = $2,028 per year ($169/month prepaid equivalent, our calculation)
• 6-month commitment: $149/month × 12 = $1,788 per year ($149/month prepaid equivalent, our calculation)

Tirzepatide injection:

• Month-to-month: $289/month × 12 = $3,468 per year
• 3-month commitment: $269/month × 12 = $3,228 per year ($269/month prepaid equivalent, our calculation)
• 6-month commitment: $249/month × 12 = $2,988 per year ($249/month prepaid equivalent, our calculation)

The month-to-month tier charges each month separately with no upfront lump sum. The 3-month and 6-month tiers offer progressively lower per-month rates in exchange for a longer commitment.

Head-to-head over 12 months

10Rx's quarterly prepaid model delivers the lowest 12-month total for both compounds—$1,072 less than PlexusDx month-to-month for semaglutide, $1,668 less for tirzepatide (our calculation). Even PlexusDx's most aggressive 6-month tier runs $592 higher for semaglutide and $1,188 higher for tirzepatide over a full year.

What the price difference buys

10Rx's advantage is purely economic: the quarterly prepaid structure locks in the lowest effective monthly rate we documented. The program includes next-day shipping and clinician evaluation; medication is co-formulated with B12. Same price at every dose strength means no surprise increases during titration. The trade-off is liquidity: you pay $299 or $450 every three months, and cancellation or refund terms are not documented in the sources we reviewed (captured September 4, 2026).

PlexusDx's month-to-month tier costs more per month but spreads payment across 12 smaller transactions. The 3-month and 6-month commitment tiers offer discounts—$20 and $40 off per month for semaglutide, $20 and $40 off for tirzepatide—without requiring a single large quarterly outlay on the month-to-month plan. All tiers include medication, shipping, and provider access with no membership fee. PlexusDx works with licensed outsourcing-facility compounding pharmacies; 10Rx states that pharmacy options vary but does not specify compounding-facility type in the sources reviewed.

Neither program documents dose-adjustment fees, consultation charges, or hidden add-ons in the evidence we captured.

Compounded medication is not FDA-approved

Both programs dispense compounded semaglutide and tirzepatide. Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient.

Choose 10Rx if…

• You can commit $299 (semaglutide) or $450 (tirzepatide) every three months and want the lowest documented per-month equivalent.
• You prefer a single quarterly transaction over monthly billing.
• Next-day shipping and B12 co-formulation are priorities.
• You are comfortable with secondary-corroborated pricing figures and will confirm the exact quarterly total at checkout (the primary pricing page suppresses numeric package totals as of September 4, 2026).

Choose PlexusDx if…

• You want true month-to-month flexibility with no large upfront payment—$189 or $289 charged each month, cancel or adjust anytime.
• You prefer a middle path: PlexusDx 3-month ($169 semaglutide, $269 tirzepatide) or 6-month ($149 semaglutide, $249 tirzepatide) tiers offer prepaid-equivalent discounts, narrowing the gap to 10Rx without a quarterly lump sum.
• You value transparent, directly verified pricing published on product pages (captured July 17–23, 2026) with no evidence conflicts.
• You want a provider that documents its outsourcing-facility compounding-pharmacy relationships in public-facing materials.

PlexusDx does not beat 10Rx on raw 12-month cost for either compound, but the month-to-month structure eliminates quarterly cash-flow pressure, and the multi-month tiers deliver partial discounts without the $299/$450 quarterly commitment. If budget is the sole deciding factor and you can prepay every quarter, 10Rx's documented rates are lower. If flexibility, incremental payment, or transparent primary-source pricing matter, PlexusDx's tiers offer a different trade-off.

Methodology and freshness

We captured 10Rx pricing and program details on September 4, 2026, from the primary pricing page (https://www.take10rx.com/pricing) and secondary corroborating sources. The primary page confirms the quarterly prepaid structure, flat pricing across dose strengths, and inclusions, but suppresses the numeric package totals of $299 for semaglutide and $450 for tirzepatide; those figures come from secondary sources reviewed the same day. We state this conflict plainly and advise readers to confirm totals at checkout. PlexusDx pricing was captured July 17–23, 2026, from public product pages. All 12-month totals and effective monthly rates for prepaid plans are our calculation, derived by multiplying the documented per-period price by the number of periods in a year. No promotional, first-month, or introductory rates are included; all figures reflect standard ongoing costs. Cancellation and refund terms for 10Rx were not documented in the sources reviewed. No negative review themes for 10Rx were captured in Trustpilot or Reddit searches conducted September 4, 2026.

Frequently Asked Questions

Does 10Rx charge the same $299 or $450 rate every quarter, or does it increase after the first cycle?

The evidence documents $299 per quarter for semaglutide and $450 per quarter for tirzepatide with no indication of a first-quarter discount or subsequent increase. We interpret these as ongoing quarterly rates, but the primary pricing page suppresses totals; confirm the recurring rate at checkout.

Can I pay month-to-month with 10Rx?

No. The sources confirm that 10Rx operates on a prepaid quarterly billing cycle—$299 or $450 every three months. Month-to-month payment is not documented as an option as of September 4, 2026.

How does PlexusDx bill the 3-month and 6-month commitment tiers?

PlexusDx 3-month and 6-month tiers bill at the discounted per-month rate ($169, $149, $269, or $249 depending on compound and tier). You commit to the duration and receive the lower monthly price for that period.

Are compounded semaglutide and tirzepatide FDA-approved?

No. Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient.

Which program saves more money over 12 months?

10Rx's quarterly prepaid model delivers the lowest documented 12-month total: $1,196 for semaglutide ($1,072 less than PlexusDx month-to-month) and $1,800 for tirzepatide ($1,668 less). PlexusDx's 6-month tier narrows the gap but still runs $592 and $1,188 higher respectively over a year (our calculation).

Sources

• PlexusDx product pages (semaglutide injection, tirzepatide injection), accessed July 17–23, 2026
• 10Rx primary pricing page (https://www.take10rx.com/pricing), accessed September 4, 2026
• 10Rx secondary pricing corroboration (multiple sources), accessed September 4, 2026
• Trustpilot and Reddit searches for 10Rx service reports, conducted September 4, 2026

Compounded medication disclosure: Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. PlexusDx works with licensed outsourcing-facility compounding pharmacies.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.