AltRx vs MEDVi: GLP-1 First-Month Rates and Ongoing Costs Compared

Last reviewed: September 5, 2026 Last updated: September 5, 2026

Written by: Jay Hastings, CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

PlexusDx publishes this comparison and is one of the providers discussed. We use the same evidence rules for our own program and competing programs.

The short answer

MEDVi advertises first-month introductory rates—$179 for compounded semaglutide injection, $279 for tirzepatide—then bills $299 or $399 per refill each month thereafter (captured September 4, 2026). AltRx published promotional rates as low as $89/month for semaglutide and $149/month for tirzepatide through September 5, 2026; post-promotion pricing was not captured, and readers signing up after that date should confirm current rates at checkout. Over 12 months at captured rates, MEDVi's semaglutide costs $3,468 (first month $179 plus eleven $299 refills), MEDVi's tirzepatide costs $4,668 (first month $279 plus eleven $399 refills), AltRx's promotional semaglutide ranges from $900 to $1,068 depending on commitment tier, and AltRx's promotional tirzepatide ranges from $1,500 to $1,788. PlexusDx charges $189/month semaglutide ($2,268/year month-to-month, $1,788 with six-month commitment) and $289/month tirzepatide ($3,468/year month-to-month, $2,988 with six-month commitment), with no separate introductory rate.

At a glance: MEDVi vs AltRx vs PlexusDx

All figures captured September 4, 2026, except where noted. AltRx promotional pricing expires September 5, 2026; confirm current rates at checkout after that date.

MEDVi: introductory rates and refill pricing

MEDVi advertises a first-month introductory rate of $179 for compounded semaglutide injection, then charges $299 per refill for each subsequent month (captured September 4, 2026). Compounded tirzepatide starts at $279 for the first month, then $399 per refill (captured September 4, 2026). Compounded semaglutide oral tablets add a $70 surcharge, bringing the first-month price to $249 and refills to $369 (captured September 4, 2026).

The introductory rate applies only to the first month; every refill thereafter is billed at the higher ongoing rate. MEDVi bills monthly with no contract, so members may cancel before any refill. Medication, clinician consult, unlimited support, and shipping are included in the advertised price; dose increases do not raise the monthly cost (captured September 4, 2026).

MEDVi also offers 3-, 6-, and 12-month bundles with 0% financing via Klarna (captured July 20, 2026), though specific bundle rates were not published in the evidence reviewed. The company states it is "not a party" to the financing agreement (captured July 20, 2026).

MEDVi 12-month cost at captured refill rates

• Compounded semaglutide injection: $179 (first month) + $299 × 11 refills = $3,468 total year one (our calculation)
• Compounded tirzepatide: $279 (first month) + $399 × 11 refills = $4,668 total year one (our calculation)

If MEDVi charged the ongoing refill rate uniformly across all 12 months with no introductory discount, semaglutide would total $3,588 and tirzepatide $4,788 (our calculation).

AltRx: promotional tiers ending September 5, 2026

AltRx published promotional rates for compounded semaglutide and tirzepatide, each available in 1-month, 3-month, 6-month, and 12-month tiers (captured September 4, 2026). The promotion expires September 5, 2026, and post-promotion pricing was not captured; readers should confirm current rates at checkout if signing up after that date.

AltRx promotional semaglutide pricing (expires Sep 5 2026)

• 1-month tier: $89/month
• 3-month tier: $85/month ($255 upfront)
• 6-month tier: $80/month ($480 upfront)
• 12-month tier: $75/month ($900 upfront)

AltRx promotional tirzepatide pricing (expires Sep 5 2026)

• 1-month tier: $149/month
• 3-month tier: $144/month ($432 upfront)
• 6-month tier: $130/month ($780 upfront)
• 12-month tier: $125/month ($1,500 upfront)

Medical oversight, medication, support, and shipping are included; there is no separate membership fee, and the price remains the same at all doses (captured September 4, 2026). AltRx states "cancel anytime," though multi-month tiers require upfront payment for the selected period (captured September 4, 2026). Individual reports on Trustpilot and Reddit allege unexpected annual prebilling despite month-to-month selection (captured September 4, 2026); these are anecdotal complaints, not confirmed policy.

AltRx 12-month cost at promotional rates (expires Sep 5 2026)

• Semaglutide 1-month tier: $89 × 12 = $1,068 (our calculation)
• Semaglutide 12-month prepaid: $900
• Tirzepatide 1-month tier: $149 × 12 = $1,788 (our calculation)
• Tirzepatide 12-month prepaid: $1,500

These figures reflect promotional pricing ending September 5, 2026. Standard rates after that date are unknown and should be confirmed at checkout.

PlexusDx: month-to-month and commitment pricing

PlexusDx charges the same rate every month with no introductory discount and no refill-rate increase. Compounded semaglutide injection is $189/month month-to-month, $169/month with a three-month commitment, or $149/month with a six-month commitment. Compounded tirzepatide injection is $289/month month-to-month, $269/month with a three-month commitment, or $249/month with a six-month commitment. Commitment plans bill monthly at the discounted rate for the commitment period; no upfront lump sum is required.

Each plan includes the online provider visit, prescription, medication, and shipping in one price. There is no membership fee, no separate visit charge, and no price increase when dose is adjusted within the protocol.

PlexusDx 12-month cost

• Semaglutide month-to-month: $189 × 12 = $2,268 (our calculation)
• Semaglutide 6-month commitment: $149 × 12 = $1,788 (our calculation)
• Tirzepatide month-to-month: $289 × 12 = $3,468 (our calculation)
• Tirzepatide 6-month commitment: $249 × 12 = $2,988 (our calculation)

Like-for-like month-to-month comparison

Comparing month-to-month options at captured rates:

At captured promotional rates, AltRx's 1-month tier offers the lowest advertised month-to-month price. MEDVi's introductory rate is lower than PlexusDx for the first month only; from month two onward, MEDVi's refill rate ($299 semaglutide, $399 tirzepatide) exceeds PlexusDx's month-to-month rate ($189 semaglutide, $289 tirzepatide).

AltRx's promotional pricing expires September 5, 2026, and post-promotion rates are unknown. Readers signing up after that date should confirm current pricing at checkout.

Prepaid and commitment tiers

AltRx's promotional 12-month prepaid tier—$900 semaglutide ($75/month equivalent) and $1,500 tirzepatide ($125/month equivalent)—requires full upfront payment and delivers the lowest advertised 12-month total at captured rates. PlexusDx's six-month commitment ($149/month semaglutide, $249/month tirzepatide, billed monthly) totals $1,788 semaglutide and $2,988 tirzepatide over 12 months (our calculation), higher than AltRx's promotional prepaid tiers but lower than MEDVi's refill-based total.

MEDVi mentions 3-, 6-, and 12-month bundles with 0% Klarna financing (captured July 20, 2026), but specific bundle rates were not published in the evidence reviewed.

Decision factors

Timing and promotional uncertainty

AltRx's promotional rates expire September 5, 2026, and no standard post-promotion pricing was captured. Readers considering AltRx after that date face uncertainty about the actual ongoing cost and should confirm rates at checkout before committing. MEDVi's introductory and refill rates were checkout-verified as recently as September 4, 2026, and PlexusDx's published rates are current as of the same date.

Introductory-rate structures

MEDVi's introductory rate lowers the first-month cost but increases sharply at the first refill. Readers who cancel before the first refill pay only $179 semaglutide or $279 tirzepatide; those who continue pay $299 or $399 every month thereafter. This structure favors short trials but raises year-one cost for sustained use. PlexusDx charges the same rate every month, so total cost scales predictably with duration.

Prepayment requirements

AltRx's multi-month tiers require upfront payment for the selected period (e.g., $900 for 12 months of semaglutide at the promotional rate). Individual Trustpilot and Reddit reports allege unexpected annual prebilling despite month-to-month selection (captured September 4, 2026); these are anecdotal complaints, not confirmed policy, but readers should review billing terms carefully at checkout. MEDVi and PlexusDx bill monthly with no upfront lump sum for their standard plans.

Service quality and reliability

PlexusDx holds a 4.2-star rating on Trustpilot, with 76% of reviews at five stars and 81% at four stars or higher (captured September 4, 2026). MEDVi and AltRx Trustpilot profiles were identified in the evidence (captured September 4, 2026), but detailed review summaries were not provided. The individual AltRx billing complaints noted above suggest careful review of subscription terms before committing to multi-month prepaid tiers.

Choose MEDVi if…

• You want to trial compounded semaglutide or tirzepatide for one month at a lower introductory rate ($179 semaglutide, $279 tirzepatide) and are prepared for the refill-rate increase ($299 semaglutide, $399 tirzepatide) if you continue.
• You value included care coaching, a free dietitian visit, and unlimited doctor calls (captured July 20, 2026).
• You prefer monthly billing with no contract and the option to cancel before any refill.
• You are comfortable with a two-tier pricing structure (introductory, then refill) and have confirmed the refill rate fits your budget for sustained use.

Choose AltRx if…

• You are signing up before September 5, 2026 and can lock in the advertised promotional rates ($89–$75/month semaglutide, $149–$125/month tirzepatide depending on commitment tier).
• You are comfortable prepaying for a multi-month tier to capture the lowest promotional per-month equivalent ($75 semaglutide, $125 tirzepatide for 12-month prepaid).
• You have reviewed AltRx's subscription and billing terms carefully at checkout, particularly if selecting a prepaid tier, given individual reports of unexpected annual prebilling.
• You accept that post-promotion pricing is unknown and are prepared to confirm current rates if signing up after the promotional deadline.

Where PlexusDx fits

PlexusDx offers predictable month-to-month pricing with no introductory-then-refill switch, no membership fee, and no upfront lump sum. At captured rates, PlexusDx's month-to-month semaglutide ($189) sits between AltRx's promotional 1-month tier ($89, expires September 5, 2026) and MEDVi's ongoing refill rate ($299). PlexusDx's six-month commitment ($149/month semaglutide, $249/month tirzepatide, billed monthly) delivers a 12-month total ($1,788 semaglutide, $2,988 tirzepatide, our calculation) lower than MEDVi's refill-based year-one cost but higher than AltRx's promotional prepaid tiers.

PlexusDx does not require upfront payment for commitment plans; the discounted rate is billed monthly for the commitment period. The same rate applies every month, so cost scales predictably. PlexusDx holds a 4.2-star Trustpilot rating with 76% five-star reviews and 81% four-star or higher (captured September 4, 2026).

Choose PlexusDx if you want a single flat rate with no introductory discount followed by a higher refill price, prefer monthly billing over prepayment, and value transparent all-inclusive pricing (visit, prescription, medication, and shipping in one charge). PlexusDx works with licensed 503A compounding pharmacies.

Methodology and freshness

All MEDVi prices and inclusions were checkout-verified or captured from publicly accessible pricing pages between July 20 and September 4, 2026. AltRx promotional rates were captured from publicly accessible promotional grids on September 4, 2026; the promotion expires September 5, 2026, and post-promotion pricing was not captured. PlexusDx prices reflect published rates as of September 4, 2026.

Twelve-month cost calculations for MEDVi, AltRx, and PlexusDx are our calculations, derived by multiplying monthly or per-period rates by the number of billing cycles in one year and labeled as such throughout this article. MEDVi's year-one total incorporates the first-month introductory rate plus eleven refills at the ongoing rate; AltRx's prepaid-tier totals reflect the upfront lump sum for the selected period; PlexusDx's totals reflect month-to-month or commitment rates billed monthly over 12 months.

Review data for PlexusDx (Trustpilot 4.2 stars, 76% five-star, 81% four-star or higher) was captured September 4, 2026. Individual AltRx billing complaints on Trustpilot and Reddit (unexpected annual prebilling allegations) were captured September 4, 2026; these are anecdotal reports, not confirmed policy.

Readers should confirm all pricing, billing terms, subscription structures, and promotional availability at checkout, particularly for AltRx after September 5, 2026, and for MEDVi's bundle options, which were mentioned but not detailed in the evidence reviewed.

Frequently Asked Questions

Does MEDVi's introductory rate apply every month?

No. MEDVi's introductory rate ($179 semaglutide, $279 tirzepatide, captured September 4, 2026) applies only to the first month. Every refill thereafter is billed at the ongoing refill rate ($299 semaglutide, $399 tirzepatide). Readers who continue past the first month pay the higher refill rate each subsequent month.

What happens to AltRx pricing after the promotional deadline?

AltRx's promotional rates expire September 5, 2026, and standard post-promotion pricing was not captured in the evidence reviewed. Readers signing up after that date should confirm current rates, billing terms, and subscription options at checkout before committing to any tier.

Does PlexusDx require upfront payment for commitment plans?

No. PlexusDx's three-month and six-month commitment plans bill the discounted rate monthly for the commitment period. There is no upfront lump sum; you pay the lower rate each month for the duration of the commitment.

Are compounded semaglutide and tirzepatide FDA-approved?

No. Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. PlexusDx works with licensed 503A compounding pharmacies.

How do I compare MEDVi's introductory pricing with PlexusDx's flat rate over one year?

At captured rates, MEDVi's semaglutide costs $179 in month one, then $299 each month for eleven refills, totaling $3,468 over 12 months (our calculation). PlexusDx charges $189 every month with no introductory discount, totaling $2,268 over 12 months month-to-month, or $1,788 with a six-month commitment (our calculation). MEDVi's first month is lower, but PlexusDx's year-one total is lower for sustained use.

Sources

• MEDVi pricing and inclusions (compounded semaglutide, tirzepatide, injection, oral, introductory and refill rates, support offerings, bundle mention) – checkout-verified and publicly accessible pages, captured July 20, 2026 and September 4, 2026
• AltRx promotional pricing grids (semaglutide, tirzepatide, 1-month through 12-month tiers, promotional expiration September 5, 2026) – publicly accessible promotional pages, captured September 4, 2026
• PlexusDx pricing (semaglutide, tirzepatide, month-to-month and commitment tiers) – published rates, current September 4, 2026
• PlexusDx Trustpilot rating (4.2 stars, 76% five-star, 81% four-star or higher) – Trustpilot.com, captured September 4, 2026
• AltRx Trustpilot and Reddit review mentions (individual billing complaints) – Trustpilot.com and Reddit.com, captured September 4, 2026

Compounded medication disclosure: Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. PlexusDx works with licensed 503A compounding pharmacies.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.