Willow Pricing Explained: Monthly GLP-1 Rates Compared to PlexusDx

Last reviewed: September 22, 2026 Last updated: September 22, 2026

Written by: Jay Hastings, CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

PlexusDx publishes this comparison and is one of the providers discussed. We use the same evidence rules for our own program and competing programs.

The short answer

Willow charges $299 per month for compounded semaglutide and $399 per month for compounded tirzepatide, billed monthly with no separate membership fee. Our sources captured September 4, 2026 document only monthly billing—no three-month, six-month, or twelve-month prepaid discount options are mentioned on Willow's site. That means a year of Willow semaglutide costs $3,588 ($299 × 12) and tirzepatide costs $4,788 ($399 × 12), both our calculation. PlexusDx offers the same compounds at lower month-to-month rates ($189 semaglutide injection, $289 tirzepatide injection) and further discounts for prepaid commitments: six-month semaglutide runs $149/month ($1,788 annualized, our calculation), saving $1,800 per year versus Willow's monthly-only rate. If you value month-to-month flexibility and want minimal account management, Willow's single-rate structure is straightforward; if you want the lowest per-month cost and can commit upfront, PlexusDx prepaid plans deliver measurably lower spend over twelve months.

At a glance: Willow monthly-only vs PlexusDx monthly and prepaid

*Our calculation. Willow prices verified September 4, 2026. PlexusDx 6-month per-month figures are prepaid equivalents ($149/mo = $894 every six months; $249/mo = $1,494 every six months). Both providers include medication, provider visit, and shipping in the listed price.

Willow's monthly-only pricing: what the $299 and $399 rates cover

Willow's pricing is all-inclusive and straightforward. For compounded semaglutide—offered in both injection and oral routes, though route-specific pricing is not itemized—you pay $299 per month. Compounded tirzepatide injection costs $399 per month. Both rates include the medication, doctor-guided treatment, and free two-day shipping, with no separate membership or service fee added to your bill. HSA and FSA cards are accepted. (Willow pricing verified September 4, 2026 from startwillow.com.)

Our sources captured September 4, 2026 document only monthly billing cycles; no three-month, six-month, or twelve-month prepaid discount plans are described on Willow's site. That means every billing cycle renews at the same $299 or $399 rate, and your twelve-month cost is simply the per-month rate multiplied by twelve.

Twelve-month cost comparison: monthly-only vs prepaid options

Because Willow bills monthly with no documented prepaid discount, a full year of treatment costs:

• Willow semaglutide: $299/month × 12 = $3,588 per year (our calculation).
• Willow tirzepatide: $399/month × 12 = $4,788 per year (our calculation).

PlexusDx offers the same compounded medications at lower month-to-month rates and adds further savings for customers who prepay three or six months:

• PlexusDx semaglutide injection, month-to-month: $189/month × 12 = $2,268/year (our calculation)—a $1,320 annual saving versus Willow's monthly rate.
• PlexusDx semaglutide injection, six-month prepaid: $149/month × 12 = $1,788/year (our calculation; $894 charged every six months)—a $1,800 annual saving versus Willow.
• PlexusDx tirzepatide injection, month-to-month: $289/month × 12 = $3,468/year (our calculation)—a $1,320 annual saving versus Willow's monthly rate.
• PlexusDx tirzepatide injection, six-month prepaid: $249/month × 12 = $2,988/year (our calculation; $1,494 charged every six months)—a $1,800 annual saving versus Willow.

The six-month prepaid option requires paying $894 (semaglutide) or $1,494 (tirzepatide) upfront every six months, which may not fit every budget in a single billing cycle. The month-to-month plan spreads costs evenly but still delivers a $110/month reduction compared to Willow's single monthly rate.

Decision factors beyond the per-month rate

Monthly flexibility. Willow's single monthly rate means you can pause or cancel anytime without forfeiting a prepaid balance. If your insurance situation changes, you need to switch medications, or you reach your goal weight mid-year, you walk away cleanly. PlexusDx month-to-month plans offer the same flexibility at a lower rate; prepaid plans lock in savings but require upfront commitment.

Cash-flow preference. A $299 or $399 monthly charge is predictable and fits a regular budget cadence. Prepaying $894 or $1,494 every six months demands larger lump sums but reduces total annual spend. If cash flow is tight, monthly billing—whether Willow's or PlexusDx's—avoids sticker shock; if you can budget the upfront cost, prepaid plans deliver measurable per-dose savings.

Service reputation. PlexusDx holds a 4.3-star rating on Trustpilot, with 79 percent of reviews at five stars and 83 percent at four stars or higher (captured September 9, 2026; trustpilot.com/review/plexusdx.com). We did not locate verified aggregate review data for Willow in our sources captured through September 4, 2026. Both providers offer doctor-guided treatment and include shipping in the listed price.

Route and compound variety. Willow documents semaglutide in injection and oral forms and tirzepatide as injection; route-specific pricing for semaglutide oral is not itemized in our sources. PlexusDx offers injection and oral routes for both semaglutide and tirzepatide, with transparent per-route pricing: semaglutide oral $289/month month-to-month, $269/month three-month prepaid, $249/month six-month prepaid; tirzepatide oral $349/month month-to-month, $299/month three-month prepaid, $279/month six-month prepaid. If you prefer oral dosing, confirm route availability and exact pricing at checkout with either provider.

Choose Willow if…

You want a single, predictable monthly rate with no prepaid commitment, you value a streamlined account experience with one billing cadence, and the $299 semaglutide or $399 tirzepatide rate fits your budget without needing to compare multi-month discount tiers. Willow's all-inclusive monthly pricing is transparent and requires no upfront lump sum.

Choose PlexusDx if…

You want the lowest per-month cost and can commit to three or six months upfront, or you prefer month-to-month flexibility at a rate $110–$150 lower than Willow's monthly-only option. PlexusDx semaglutide injection at $189/month month-to-month or $149/month six-month prepaid, and tirzepatide injection at $289/month month-to-month or $249/month six-month prepaid, deliver verified savings over twelve months. The platform holds a 4.3-star Trustpilot rating with 83 percent of reviews at four stars or higher, and transparent route-specific pricing covers injection and oral options for both compounds.

Methodology and freshness

Willow pricing ($299 semaglutide, $399 tirzepatide, monthly billing, no prepaid options documented) verified September 4, 2026 from startwillow.com. PlexusDx pricing verified September 22, 2026 from plexusdx.com product pages. PlexusDx Trustpilot rating (4.3 stars, 79% five-star, 83% four-star or higher) captured September 9, 2026 from trustpilot.com/review/plexusdx.com. Twelve-month totals, prepaid per-month equivalents, and annual savings figures are our calculation, derived by multiplying verified per-month rates by twelve or by the applicable prepaid cycle length. We confirmed no three-month, six-month, or twelve-month prepaid discount plans are mentioned in Willow's indexed site content as of September 4, 2026; if Willow has since introduced prepaid options, verify current pricing at startwillow.com before committing. No eligibility, medication, dose, transfer continuity, result, or side-effect outcome is guaranteed by any provider.

Compounded medication disclosure: Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. PlexusDx works with licensed 503A compounding pharmacies.

Frequently Asked Questions

Does Willow offer any prepaid discount if I pay for multiple months upfront?

Our sources captured September 4, 2026 document only monthly billing at $299 for semaglutide and $399 for tirzepatide, with no three-month, six-month, or twelve-month prepaid discount plans mentioned on Willow's site. Confirm current plan options at startwillow.com if you prefer to prepay.

How much do I save over a year by choosing PlexusDx instead of Willow?

PlexusDx semaglutide injection month-to-month ($189/month) saves $1,320 per year versus Willow's $299/month rate; the six-month prepaid plan ($149/month, our calculation) saves $1,800 per year. Tirzepatide month-to-month ($289/month) saves $1,320 annually versus Willow's $399/month; six-month prepaid ($249/month) saves $1,800 annually. All figures are our calculation.

Are Willow's medications chemically identical to Ozempic or Mounjaro?

Willow dispenses compounded semaglutide and tirzepatide, which are not FDA-approved and are not reviewed by FDA for safety, effectiveness, or quality before marketing. Ozempic and Mounjaro are branded, FDA-approved drugs. A licensed clinician determines whether a compounded prescription is appropriate for an individual patient.

What is included in Willow's $299 and $399 monthly rates?

Both rates are all-inclusive: medication, doctor-guided treatment, and free two-day shipping, with no separate membership or service fee. HSA and FSA cards are accepted. Route-specific pricing for semaglutide oral is not itemized in our sources; confirm at checkout if you prefer oral dosing.

Can I switch from Willow to PlexusDx mid-treatment without losing progress?

Switching providers requires a new intake, provider review, and prescription. Dose continuity depends on your current regimen, the new provider's titration protocol, and clinical judgment at the time of transfer. Neither Willow nor PlexusDx guarantees uninterrupted medication or dose matching when you switch; discuss your current dose and timeline with the new provider during intake.

Sources

• Willow pricing and plan structure, startwillow.com, accessed September 4, 2026.
• PlexusDx product pages (semaglutide injection, tirzepatide injection, oral routes), plexusdx.com, accessed September 22, 2026.
• PlexusDx Trustpilot reviews, trustpilot.com/review/plexusdx.com, accessed September 9, 2026.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.