Ro and LifeMD charge identical first-month rates for branded GLP-1s but separate membership from medication; PlexusDx bundles compounded semaglutide at $189/month and tirzepatide at $289/month with no membership fee.

Switching from Wegovy or Zepbound to a compounded semaglutide or tirzepatide program raises cost, continuity, and safety questions. Here are the evidence-backed decision points for 2026.

Willow charges $299/month for compounded semaglutide and $399/month for tirzepatide, billed monthly with no prepaid options documented. We compare these rates to PlexusDx month-to-month and prepaid plans, showing 12-month costs and per-dose economics.

IVIM Health requires a $75/month membership on top of prepaid medication bundles. Over 12 months, does a 6-month bundle beat month-to-month pricing, and how does the all-in cost compare to flat-rate alternatives?

SlimDownRx's prepaid tirzepatide plans start at $258 per month equivalent for six-month commitments. Seven alternatives offer month-to-month flexibility, semaglutide access, and lower annual costs—PlexusDx tirzepatide runs $249 monthly on comparable six-month terms, $112 cheaper per year.

Amble charges $289/month for tirzepatide starter doses and $329/month for higher doses. We break down how the two-tier pricing affects your first-year cost and show the like-for-like alternatives.

Calibrate charges $199 per month for its 12-month metabolic reset program, billed as $2,388 upfront, but medication, labs, and copays are separate and not disclosed on the pricing page.

Eden charges $99/month for semaglutide medication plus a required $99/month membership—$198 total every month. We break down the two-part billing, first-month discount, renewal costs, and head-to-head comparison with PlexusDx's $189 all-inclusive rate.

PlushCare charges $19.99/month membership plus $129 initial visit but does not sell tirzepatide medication. Patients fill prescriptions at retail pharmacies where branded Zepbound or Mounjaro typically costs $900–$1,400/month without insurance.

We screened twenty telehealth providers offering compounded semaglutide and tirzepatide, then ranked the ten lowest all-inclusive monthly costs for like-for-like plans.

PlexusDx publishes this comparison and is one of the providers discussed. We use the same evidence rules for our own program and competing programs.

Eden offers injection-only GLP-1s at flat monthly rates with required membership. For higher-dose patients needing flexibility, format options, or predictable committed-term costs, structural differences matter. Evidence-based comparison of Eden versus PlexusDx for maintenance-phase therapy.