What Supplements Should You Take with GLP-1 Medications?

Last reviewed: May 12, 2026 Last updated: May 12, 2026

Written by: Jay Hastings, CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

This article is part of the PlexusDx Education Hub — science-backed guidance on GLP-1 medications, metabolic health, and precision weight management.

As GLP-1 medications reduce appetite, some people eat less overall and wonder whether supplements can help fill nutritional gaps. Protein, hydration, and certain micronutrients often come up in this context. This article covers the supplements commonly discussed alongside GLP-1 therapy and why individual needs vary.

Key Supplements to Consider

A high-quality multivitamin can serve as a foundational supplement for anyone on GLP-1 medications. Since these medications can diminish appetite and food intake, a multivitamin helps fill in the gaps in nutrients that may be lacking in your diet. It’s essential to choose a multivitamin that provides a broad spectrum of vitamins and minerals.

Vitamin B12 is vital for energy production, nervous system health, and red blood cell formation. Individuals on GLP-1 medications may be at risk for B12 deficiency due to reduced food intake, particularly if they do not consume enough animal products. We recommend supplementing with 500-1000 mcg of B12 daily, especially if you are on long-term therapy.

Vitamin D is essential for bone health, immune function, and mood regulation. As many people are already deficient in vitamin D, and weight loss can sometimes affect its levels, it’s prudent to monitor and supplement as needed. A daily dose of 1000-2000 IU of vitamin D3 is typically recommended, but checking your levels with a healthcare provider is advisable.

Calcium works in tandem with vitamin D to support bone health. Individuals on GLP-1 medications should ensure they receive adequate calcium, especially if their appetite decreases. The general recommendation is about 1000-1200 mg of calcium daily, which can be obtained through dietary sources or supplements.

Omega-3 fatty acids are crucial for heart health and can help reduce inflammation. While GLP-1 medications do not directly affect omega-3 levels, ensuring adequate intake is important, especially if your diet becomes more restricted. We suggest considering a daily supplement of 1000 mg of EPA and DHA if you do not consume fatty fish regularly.

How to Choose the Right Supplements

Navigating the world of supplements can be daunting, especially when considering individual health needs and potential interactions with medications. Here are some tips to help you choose the right supplements:

1. Consult Your Healthcare Provider: Before starting any new supplements, discuss your plans with your healthcare provider to ensure they are appropriate for your health status and medication regimen.
2. Prioritize Quality: Look for reputable brands that provide transparency regarding their sourcing, manufacturing, and third-party testing.
3. Focus on Your Dietary Gaps: Assess your current diet and identify any areas where you may be lacking. This will help guide your supplement choices.
4. Start with the Essentials: If you’re unsure where to begin, starting with a multivitamin and vitamin D is a good foundation.
5. Monitor Your Response: Pay attention to how you feel after introducing new supplements. Adjust your regimen as needed, based on your body’s response.

How Your Genetics Relate to GLP-1 Pathways

Not everyone responds to GLP-1 medications the same way. Genetic variants — including GIPR rs1800437, FTO rs9939609, and MC4R rs17782313 — relate to the biological pathways these medications act on. These are pathway-level associations only and do not predict how much weight you will lose or how you will respond to any specific medication. PlexusDx maps 14 pathways, 49 peptides, and 150+ genetic insights so you and your provider can see how your genes relate to these pathways. It does not recommend, prescribe, or determine which medication, dose, or peptide is right for you. The PlexusDx Precision Peptide Genetic Test ($298) gives you and your provider pathway-level genetic context to support a more personalized conversation. Genetics is a guide, not a guarantee.

Access Personalized GLP-1 Care Through PlexusDx

PlexusDx offers seven prescription GLP-1 protocols to all 50 states — no membership, no insurance required, async intake or live consult. The Semaglutide Oral is $289/mo month-to-month, or from $249/mo on the 6-month plan. Medications are dispensed from licensed 503A compounding pharmacies following strict quality and safety standards. Add a Precision Peptide Genetic Test for $298 to personalize your protocol from day one.

Frequently Asked Questions

What are GLP-1 medications, and how do they work?

GLP-1 medications mimic the action of the GLP-1 hormone, which helps regulate appetite and insulin secretion. They slow gastric emptying and promote feelings of fullness, making it easier for individuals to reduce calorie intake.

Why is it important to take supplements while on GLP-1 medications?

Due to reduced appetite and food intake, individuals may not get enough essential nutrients. Supplements can help fill these gaps, preventing deficiencies that could impact overall health and weight loss efforts.

Which supplements should I prioritize while on GLP-1 medications?

Key supplements to consider include multivitamins, vitamin B12, vitamin D, calcium, omega-3 fatty acids, magnesium, fiber supplements, protein supplements, probiotics, and electrolytes.

How do I know if I need to take supplements?

Consult with your healthcare provider to evaluate your dietary intake and determine if supplementation is necessary. They can help you identify any potential deficiencies based on your lifestyle and medication use.

Can I take supplements alongside my GLP-1 medication?

In most cases, yes, but it’s crucial to discuss any new supplements with your healthcare provider to ensure there are no contraindications or interactions with your medication regimen.

Related Reading

• Supplements That Increase Glp 1
• Glp 1 Supplements
• Glp 1 Medications
• Do Genetic Tests Help Identify People Who Will Benefit From Glp 1 Medications

Pricing and availability current as of May 2026. Compounded GLP-1 medications are not FDA-approved drug products; they are prepared by licensed compounding pharmacies under federal compounding regulations. Compounded semaglutide and tirzepatide are not the same as Wegovy, Ozempic, Zepbound, or Mounjaro. This article is for informational purposes only and does not constitute medical advice. Consult a licensed healthcare provider before starting, stopping, or changing any medication.

Return to the PlexusDx Education Hub for more evidence-based resources on GLP-1 therapy, metabolic health, and personalized weight management.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.