Last reviewed: September 23, 2026
Last updated: September 23, 2026
Written by: Jay Hastings, CEO of PlexusDx
Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.
Medically reviewed by: Jayden Lee, PharmD, EMBA
Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.
PlexusDx publishes this comparison and is one of the providers discussed. We use the same evidence rules for our own program and competing programs.
The short answer
10Rx structures its program as quarterly prepaid packages: $299 every three months for compounded semaglutide and $450 every three months for compounded tirzepatide (secondary-corroborated figures; 10Rx's primary pricing page verifies the quarterly structure and all-inclusive model but does not display numeric totals; confirm the exact charge at checkout; captured September 4, 2026). The quarterly package includes the clinician evaluation, next-day shipping, and ongoing support with no separate consultation fee, membership fee, or shipping charge. Over twelve months, the effective monthly cost is $99.67 for semaglutide and $150 for tirzepatide (our calculation from the quarterly prepaid total). That rate is lower than most month-to-month competitors, but you pay the full quarter upfront every three months. PlexusDx offers month-to-month billing at $189 for semaglutide injection and $289 for tirzepatide injection, with three-month and six-month commitment tiers that reduce the monthly rate without requiring quarterly prepayment.
Comparing quarterly prepaid vs. month-to-month billing?
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At-a-glance: 10Rx pricing structure and inclusions
| Item |
10Rx |
| Billing cadence |
Quarterly prepaid (3-month supply per package) |
| Semaglutide quarterly package |
$299 every 3 months (secondary-corroborated; verify at checkout) |
| Tirzepatide quarterly package |
$450 every 3 months (secondary-corroborated; verify at checkout) |
| Clinician evaluation |
Included, no separate consultation fee |
| Membership fee |
$0 |
| Shipping |
Next-day shipping included, no separate charge |
| Support |
Included, no add-on fees |
| Dose flexibility |
Same package price across all available strengths |
| Lab fees |
Not documented in available evidence |
Source: 10Rx pricing page (https://www.take10rx.com/pricing) and secondary corroboration, captured September 4, 2026. The primary pricing page verifies the quarterly structure, all-inclusive model, and flat pricing across strengths but does not display the $299 and $450 numeric totals; those figures are secondary-corroborated and should be confirmed at checkout.
Quarterly prepaid vs. effective monthly cost
10Rx advertises its program as an effective monthly rate—$99.67 for semaglutide and $150 for tirzepatide—but those figures are our calculation from the quarterly prepaid total. You pay $299 or $450 upfront every three months, not a recurring monthly charge. Over twelve months, the math is straightforward:
-
Semaglutide: 4 quarters × $299 = $1,196 per year ÷ 12 months = $99.67/month effective (our calculation).
-
Tirzepatide: 4 quarters × $450 = $1,800 per year ÷ 12 months = $150/month effective (our calculation).
The quarterly package is all-inclusive: compounded medication with B12, clinician evaluation, next-day shipping, and support. No separate consultation fee, no membership fee, no shipping charge, and the same package price at every available strength. The dataset does not document lab fees; if labs are required, confirm whether they are included or billed separately.
12-month cost comparison: 10Rx vs. PlexusDx
Because 10Rx offers only a quarterly prepaid plan, a like-for-like month-to-month comparison is not possible. The table below shows 10Rx's twelve-month total alongside PlexusDx's month-to-month rate (no prepayment) and PlexusDx's three-month commitment rate (billed monthly, closest structure to 10Rx's quarterly model).
| Provider & Plan |
Semaglutide 12-Month Total |
Tirzepatide 12-Month Total |
Notes |
| 10Rx (quarterly prepaid) |
$1,196 ($99.67/month effective) |
$1,800 ($150/month effective) |
Prepaid every 3 months; $299 or $450 upfront each quarter |
| PlexusDx (month-to-month) |
$2,268 ($189/month) |
$3,468 ($289/month) |
No prepayment; cancel anytime |
| PlexusDx (3-month commitment) |
$2,028 ($169/month) |
$3,228 ($269/month) |
Billed monthly on 3-month commitment |
All twelve-month totals are our calculation. 10Rx figures are secondary-corroborated and should be verified at checkout. PlexusDx pricing from internal rate table, September 23, 2026.
10Rx's twelve-month cost is substantially lower because it requires quarterly prepayment. If you can commit to three months at a time and prefer to pay upfront, the effective monthly rate is competitive. If you want month-to-month flexibility or prefer to avoid large upfront charges, PlexusDx's month-to-month plan or monthly-billed three-month commitment may be a better fit.
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What "no hidden fees" means in practice
10Rx's pricing page states that the quarterly package is all-inclusive: clinician evaluation, medication, next-day shipping, and support. The dataset confirms:
-
Consultation fee: $0—the clinician evaluation is included in the quarterly package.
-
Membership fee: $0—no recurring subscription separate from the medication charge.
-
Shipping: Next-day shipping included with no separate fee.
-
Support: Included with no add-on charges.
-
Dose adjustments: Same package price across all available strengths, so titration does not trigger a new tier.
The dataset does not document lab fees. Some GLP-1 programs require baseline or monitoring labs; if 10Rx orders labs, confirm whether they are covered by the quarterly package or billed separately. PlexusDx does not charge separately for clinician visits, shipping, or membership; labs ordered by the provider are the patient's responsibility and typically covered by insurance or available through third-party lab networks.
Strengths and limitations of the quarterly prepaid model
Strengths:
- Lower effective monthly cost if you can commit to and afford the quarterly prepayment.
- Predictable all-in price every three months with no monthly billing surprises.
- Next-day shipping and support included without separate line-item fees.
- Same package price at every dose, so titration is straightforward.
Limitations:
- $299 or $450 upfront every quarter; no month-to-month option documented in the available evidence.
- The numeric quarterly totals are secondary-corroborated and should be verified at checkout; 10Rx's primary pricing page confirms the structure but does not display the dollar figures.
- No Trustpilot profile located as of September 4, 2026, so third-party service feedback is limited.
- Cancellation and refund terms are not documented in the dataset; confirm the policy before prepaying if flexibility is a priority.
- Lab fee policy is not documented; ask whether baseline or monitoring labs are included or billed separately.
Choose 10Rx if…
- You can commit to three months at a time and prefer to pay the full quarter upfront in exchange for a lower effective monthly rate.
- You want an all-inclusive package with next-day shipping and support bundled in, and you're comfortable with the secondary-corroborated pricing (verify at checkout).
- You prioritize simplicity: one flat price across all dose strengths, no membership fee, no per-visit charges.
- You're willing to work with a newer provider that does not yet have a public Trustpilot review profile.
Choose PlexusDx if…
- You want true month-to-month flexibility with no quarterly prepayment—cancel anytime with no upfront commitment beyond the current month.
- You prefer a provider with an established third-party review record: PlexusDx holds a 4.3-star rating on Trustpilot, with 79% of reviews at five stars and 83% at four stars or higher (captured September 9, 2026; trustpilot.com/review/plexusdx.com).
- You want the option to commit for three or six months and receive a lower monthly rate while still being billed monthly (no large upfront charge).
- You value transparent, published pricing with no secondary-corroboration caveats—one flat rate per medication and route, displayed directly on the product page.
Methodology and freshness
This comparison is based on evidence captured September 4, 2026, from 10Rx's pricing page (https://www.take10rx.com/pricing) and secondary sources, plus PlexusDx internal pricing data current as of September 23, 2026, and PlexusDx's Trustpilot profile captured September 9, 2026. The $299 semaglutide and $450 tirzepatide quarterly totals for 10Rx are secondary-corroborated; 10Rx's primary pricing page verifies the quarterly prepaid structure, all-inclusive model, and flat pricing across strengths but does not display the numeric package totals. We advise confirming the exact quarterly charge at checkout. All twelve-month totals and effective monthly rates are our calculation from the documented quarterly or monthly prices. Telehealth program details—eligibility criteria, clinician protocols, cancellation terms, and lab policies—change; confirm current terms directly with each provider before committing. We apply the same evidence standard to PlexusDx and competing programs.
Frequently Asked Questions
Does 10Rx charge separately for clinician visits or follow-up consultations?
No. The clinician evaluation and ongoing support are included in the quarterly prepaid package with no separate consultation fee or membership charge, according to evidence captured September 4, 2026. Confirm current policy at enrollment.
Is next-day shipping really included, or is there a shipping fee at checkout?
Next-day shipping is documented as included in the quarterly package with no separate shipping charge. The all-inclusive model bundles medication, clinician evaluation, shipping, and support into the single quarterly price.
What happens if I need to adjust my dose mid-quarter?
10Rx's pricing page states that the same package price applies across all available strengths, so titration should not trigger a new cost tier. Confirm the dose-adjustment process and any restocking or change fees directly with 10Rx before prepaying the quarter.
Are the $299 and $450 quarterly prices guaranteed, or should I verify at checkout?
Those figures are secondary-corroborated. 10Rx's primary pricing page verifies the quarterly structure and all-inclusive model but does not display the numeric totals. We recommend confirming the exact quarterly charge at checkout before committing.
Does 10Rx include baseline labs or monitoring labs in the quarterly package?
The dataset does not document lab fees or lab inclusion. Some GLP-1 programs require baseline metabolic panels or periodic monitoring; ask 10Rx whether labs are covered by the quarterly package or billed separately, and whether you can use insurance or a third-party lab network.
Sources
- 10Rx pricing page, https://www.take10rx.com/pricing, accessed September 4, 2026
- 10Rx secondary pricing corroboration, captured September 4, 2026
- PlexusDx internal pricing data, September 23, 2026
- PlexusDx Trustpilot profile, https://www.trustpilot.com/review/plexusdx.com, accessed September 9, 2026
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Compounded medication disclosure: Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. PlexusDx works with licensed 503A compounding pharmacies.
Medical and Editorial Standards
Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.
Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.
Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.
Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.
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