HSA | FSA CARDS ARE NOW ACCEPTED

Last reviewed: May 12, 2026 Last updated: May 12, 2026

Written by: Jay Hastings , CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

The IGF1 rs35767 Variant, the Sermorelin Pathway, and Muscle Growth: What Your Genotype May Mean

Sermorelin is a peptide that supports the body’s natural release of growth hormone, which can help drive protein synthesis, muscle recovery, and repair of connective tissues like tendons and ligaments. A key partner in this pathway is IGF1, a hormone made in response to growth hormone that helps cells grow, regenerate, and remodel tissue, especially in muscle. Healthy IGF1 signaling may support the repair of damaged fibers, collagen production, and adaptation after exercise. Differences in IGF1 activity can influence how strongly these growth and repair signals work, showing how genetics can shape individual responses to muscle and tissue recovery pathways.

Genetic variation in the IGF1 gene may influence how efficiently the biological processes connected to Sermorelin and Muscle Growth function. The rs35767 variant is analyzed in the PlexusDx Precision Peptide Genetic Test as part of the Muscle Growth pathway. Depending on your genotype, this variant may have a modest to meaningful influence on muscle protein synthesis, growth factor signaling, and recovery capacity. Understanding your result gives you a personalized starting point for targeted lifestyle, dietary, and supplement strategies grounded in your unique biology.

Practical Foundations for Everyone

Regardless of your IGF1 rs35767 genotype, the following lifestyle inputs consistently support lean mass development, training adaptation, and physical performance. Carriers of the effect allele often notice a stronger return on these habits when applied consistently — which makes regularity more valuable than intensity.

  • Consistent nutrition: A whole-food dietary pattern rich in vegetables, quality protein, healthy fats, and fiber provides the micronutrient foundation that supports muscle growth-related pathways at a cellular level.
  • Regular movement: Physical activity — particularly a combination of aerobic exercise and resistance training — supports the metabolic signaling and growth factor pathways that interact with muscle growth and biological resilience.
  • Quality sleep: Restorative sleep is essential for cellular repair, hormone regulation, and the metabolic processes that underpin muscle growth and recovery. Consistent sleep timing amplifies the benefits of other lifestyle habits.
  • Stress management: Chronic stress elevates cortisol and inflammatory markers that can blunt the efficiency of pathways related to muscle growth. A daily stress-reduction practice — even five to ten minutes of slow breathing or mindfulness — helps maintain biological balance.

Diet Recommendations for IGF1 rs35767 and the Sermorelin Pathway

A targeted nutritional approach for the IGF1 rs35767 variant focuses on supplying the micronutrients and macronutrient balance that support muscle protein synthesis, growth factor signaling, and recovery capacity and reduce the metabolic burden on pathways connected to Sermorelin. Priority nutrients vary by pathway but consistently center on anti-inflammatory whole foods, adequate protein for cellular and tissue support, and micronutrient density from colorful produce and quality fats.

The High Protein Diet is designed to support this pathway. A vegan meal plan delivering 100+ grams of daily protein from diverse plant sources to support muscle strength and energy....

Build meals around quality protein sources (fish, poultry, legumes, eggs), fiber-rich carbohydrates (vegetables, whole grains, legumes), and healthy fats (olive oil, avocado, nuts, seeds). Minimize ultra-processed foods, excessive added sugars, and alcohol — all of which increase oxidative and inflammatory burden on pathways that interact with muscle growth and Sermorelin-related signaling.

Supplement Considerations for IGF1 rs35767 Support

Supplements cannot modify your IGF1 rs35767 genotype, but targeted supplementation can address nutritional gaps and support the biological pathways connected to Sermorelin and muscle growth and recovery. A foundations-first approach — prioritizing the basics before adding specialty products — produces the most consistent outcomes. Always discuss supplementation with your healthcare provider before starting, especially if you take medications or manage ongoing health conditions.

The PlexusDx Muscle Support is a personalized daily pack designed to support this pathway. PlexusDx Muscle Support is a personalized daily pack featuring creatine, BCAAs, and magnesium to help support muscle strength, recovery, and preservation. It promotes improved workout performance, reduced muscle fatigue, and healthy muscle function day to day....

Key nutrients commonly relevant to the Muscle Growth pathway include those that support muscle protein synthesis, growth factor signaling, and recovery capacity. Assess dietary gaps first; targeted supplementation is most valuable when it addresses a specific nutritional shortfall confirmed by food tracking or lab results rather than used as a substitute for consistent lifestyle habits.

Lifestyle Recommendations for Muscle Growth and Sermorelin Pathway Support

Consistent lifestyle habits are the most durable and evidence-supported way to reinforce the biological pathways associated with Sermorelin and muscle growth and recovery. For carriers of the IGF1 rs35767 effect allele, these habits tend to produce a more noticeable return because they directly influence the signaling environments where the variant has its greatest impact.

A practical weekly target is 150 minutes or more of moderate aerobic activity combined with two to three resistance training sessions. Sleep consistency — a fixed wake time, morning outdoor light, and a 60 to 90 minute wind-down before bed — supports cellular recovery and the hormonal balance that underpins muscle growth and recovery. Stress management practices such as slow breathing, mindfulness, or low-stimulation outdoor time help maintain the biological stability that Sermorelin-related pathways depend on for efficient function. Avoiding chronic sleep debt, late-day caffeine, and excessive alcohol further removes common suppressors of muscle growth-related signaling.

Genetic Interpretations for rs35767 (IGF1)

2 Effect Alleles: GG (+/+)

You have the GG genotype for rs35767, which means you carry two copies of the effect allele in the IGF1 gene. This variation is associated with differences in IGF-1 expression and may influence the magnitude of anabolic signaling downstream of growth hormone release. In the context of the Sermorelin pathway, which stimulates endogenous growth hormone production, this genotype may contribute to a more robust IGF-1 response following growth hormone stimulation, potentially enhancing muscle protein synthesis, satellite cell activation, and tissue regeneration. This can support efficient muscle recovery, hypertrophy, and connective tissue repair following physical stress or resistance training. Individuals with this genotype may benefit from maintaining a high-protein diet rich in essential amino acids (particularly leucine), along with nutrients that support anabolic and hormonal pathways such as creatine, magnesium, zinc, and vitamin D. Lifestyle strategies including progressive resistance training, proper recovery cycles, and high-quality sleep are important for maximizing growth hormone–IGF-1 signaling and long-term musculoskeletal adaptation.

1 Effect Allele: GA (+/-)

You have the GA genotype for rs35767, which means you carry one copy of the effect allele and one copy of the non-effect allele in the IGF1 gene. This intermediate genotype may be associated with balanced IGF-1 production and steady downstream signaling in response to growth hormone stimulation. In relation to the Sermorelin pathway, this suggests a reliable and consistent activation of anabolic processes involved in muscle repair, tissue regeneration, and connective tissue remodeling. Individuals with this genotype may experience stable improvements in recovery and performance when supported by appropriate training and nutrition. A balanced diet that includes adequate protein, healthy fats, and key micronutrients, along with supplementation such as magnesium, vitamin D, and omega-3 fatty acids, may help support optimal IGF-1 signaling. Regular resistance training, proper hydration, recovery optimization, and sufficient sleep further enhance growth hormone–mediated pathways and long-term tissue resilience.

0 Effect Alleles: AA (-/-)

You have the AA genotype for rs35767, which means you carry two copies of the non-effect allele in the IGF1 gene. This genotype is generally associated with typical IGF-1 expression and baseline anabolic signaling activity. In the context of the Sermorelin pathway, this suggests that growth hormone–stimulated IGF-1 production occurs within expected physiological ranges, supporting effective but more regulated muscle repair, protein synthesis, and tissue regeneration. While recovery capacity remains solid, individuals with this genotype may benefit from optimizing external inputs to enhance anabolic signaling efficiency. Emphasizing a nutrient-dense diet with sufficient protein and essential amino acids, along with supplements such as creatine, magnesium, and omega-3 fatty acids, may help support muscle recovery and reduce inflammation. Lifestyle practices including consistent resistance training, progressive overload, adequate rest, and high-quality sleep are key to maximizing muscle regeneration and maintaining long-term musculoskeletal health.

Inconclusive — No Result

Your genetic data for rs35767, a IGF1 gene variant, was not successfully called by the laboratory. This means the test did not detect a reliable result for this position, which can occur for technical reasons such as low signal intensity, DNA quality issues, or limitations of the genotyping array. Without a result, we cannot determine whether you carry the typical or effect variant for this gene. If this information is important for your health decisions, you may wish to consider retesting or confirming this variant through a targeted genetic test or sequencing method.

When to Talk to Your Healthcare Provider

If you have concerns related to muscle growth, the Sermorelin pathway, or how your IGF1 rs35767 results fit into your broader health picture, consult your healthcare provider. They can interpret your genetic results alongside your symptoms, health history, and lab values to guide appropriate testing, dietary adjustments, and supplementation where relevant.

PlexusDx provides genetic insights to help you understand how your genes may influence nutrient needs and biological pathways. This information is provided for educational and wellness purposes only and does not diagnose, treat, or recommend any specific medication, peptide, or therapy, some of which may be prescription-only, investigational, or intended for research use only. Always consult with a qualified healthcare provider before making changes to your supplement regimen, diet, or health plan based on genetic information.

Frequently Asked Questions About IGF1 rs35767 and Sermorelin

What does the IGF1 rs35767 variant mean for my muscle growth and recovery?

The rs35767 variant in the IGF1 gene may influence how efficiently biological processes connected to Sermorelin and Muscle Growth function in your body. Depending on your genotype, this can have a modest to meaningful effect on muscle protein synthesis, growth factor signaling, and recovery capacity. Understanding your result gives you a personalized starting point for a targeted lifestyle and nutrition strategy grounded in your unique genetic biology.

How does the Sermorelin pathway relate to IGF1 and muscle growth and recovery?

Sermorelin is a peptide being studied for its potential role in supporting lean mass development, training adaptation, and physical performance. Researchers are interested in how Sermorelin-associated pathways may interact with genes like IGF1, which contribute to the signaling environments that influence muscle growth function. The PlexusDx Precision Peptide Genetic Test analyzes 14 pathways, 49 peptides, and 150 genetic insights — including IGF1 rs35767 — to provide a comprehensive view of how your genetics may influence these interconnected systems.

Can lifestyle changes support IGF1 function regardless of my genotype?

Yes. Consistent lifestyle habits — regular exercise, quality sleep, anti-inflammatory nutrition, and stress management — support muscle growth-related biological pathways across all genotypes. For carriers of the effect allele at rs35767, these habits tend to produce a stronger measurable return because they directly reinforce the signaling environments where this variant has its greatest influence. Consistency and habit stacking — combining exercise, sleep, and nutrition improvements together — tends to produce better outcomes than any single change in isolation.

What tests can help me learn more about my muscle growth and recovery and the Sermorelin pathway?

The PlexusDx Precision Peptide Genetic Test analyzes 14 pathways, 49 peptides, and 150 genetic insights — including IGF1 rs35767 — to deliver a comprehensive picture of how your genetics may influence peptide-related health pathways. The Peptide Pathways Report translates your results into personalized, actionable guidance. Your healthcare provider can also recommend targeted blood tests based on your specific pathway results and health history to complement your genetic insights with current biomarker data.

If this genetic variant is present in your PlexusDx results, the following tests and reports are commonly used to explore it further:

🧬 Genetic Tests:

📄 Genetic Report:

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.