Willow Pricing (2026): Medication, Membership & Total Monthly Cost

Last reviewed: September 11, 2026 Last updated: September 11, 2026

Written by: Jay Hastings, CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

PlexusDx publishes this comparison and is one of the providers discussed. We use the same evidence rules for our own program and competing programs.

The short answer

Willow charges $299 per month for compounded semaglutide (injection or oral) and $399 per month for compounded tirzepatide injection, billed monthly with no separate membership fees (verified September 4, 2026; startwillow.com). Those figures include the provider visit, prescription, medication, and free two-day shipping. Over 12 months, Willow's semaglutide program costs $3,588 and tirzepatide costs $4,788 (our calculation). PlexusDx offers compounded semaglutide injection at $189 per month month-to-month—$110 less per month than Willow—and tirzepatide injection at $289 per month, $110 less than Willow's tirzepatide rate. Both programs use all-inclusive pricing with no hidden fees; the economic difference is the per-month medication rate and the availability of prepaid discounts.

At-a-glance: Willow vs. PlexusDx pricing (month-to-month)

All Willow figures verified September 4, 2026 (startwillow.com). PlexusDx pricing captured July 17–23, 2026 (plexusdx.com).

What Willow's monthly price includes

Willow's $299 semaglutide and $399 tirzepatide monthly charges are all-inclusive: the online provider consultation, prescription review, compounded medication, and free two-day shipping are bundled into the single monthly fee (verified September 4, 2026; startwillow.com). There is no separate membership charge, no per-visit copay, and no shipping surcharge. Willow accepts HSA and FSA cards for payment.

Willow offers both injection and oral routes for semaglutide. The captured pricing lists "$299/month" for semaglutide without breaking out separate per-route figures; oral-route pricing was not separately itemized in the sources we reviewed (September 4, 2026). If you prefer oral semaglutide, confirm the exact monthly rate at checkout.

For tirzepatide, Willow currently documents injection only at $399 per month (September 4, 2026; startwillow.com/compound-tirzepatide).

Compounded medication disclosure: Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. PlexusDx works with licensed 503A compounding pharmacies.

Normalized 12-month cost comparison

Because Willow bills monthly and PlexusDx offers both month-to-month and prepaid tiers, we calculate the total spend over 12 months to compare economic commitment on equal footing. All figures below are our calculation using the verified per-month rates.

Semaglutide – 12-month total cost

On a month-to-month basis, PlexusDx semaglutide injection saves $110 per month compared to Willow—$1,320 over 12 months. The six-month prepaid PlexusDx plan ($149/month equivalent) saves $150 per month versus Willow, or $1,800 annually.

Tirzepatide – 12-month total cost

PlexusDx tirzepatide injection at the month-to-month rate saves $110 per month compared to Willow—$1,320 over 12 months. The six-month prepaid tier ($249/month equivalent) saves $150 per month, or $1,800 annually.

Decision factors: what Willow does well, and where PlexusDx differs

Willow strengths

• Simple monthly billing with no upfront multi-month commitment—pay $299 or $399 each month and cancel anytime.
• Free two-day shipping expedites medication delivery.
• Both injection and oral semaglutide routes are offered, giving patients a needle-free option (though oral-specific pricing was not separately confirmed in our review).
• All-inclusive pricing with no membership fees or surprise charges.

Where PlexusDx offers an economic advantage

• Lower base rates: $189/month (semaglutide injection) and $289/month (tirzepatide injection) beat Willow's $299 and $399 by $110 per month.
• Prepaid discounts: three-month and six-month plans reduce the effective monthly cost further—down to $149/month for semaglutide and $249/month for tirzepatide on the six-month tier.
• Dose-flat pricing: the monthly rate stays the same whether you're on a starter dose or a maintenance dose; no hidden step-ups as your prescription changes.
• Four route/compound combinations: injection and oral for both semaglutide and tirzepatide, plus a microdose maintenance option at $129/month.
• Verified service record: PlexusDx holds a 4.3-star rating on Trustpilot, with 79% of reviews at five stars and 83% at four stars or higher (captured September 9, 2026; trustpilot.com/review/plexusdx.com).

What to confirm at checkout

• Oral semaglutide pricing at Willow: the $299 figure appears to cover both routes, but oral-specific itemization was not captured; verify the exact monthly charge if you prefer capsules.
• Cancellation and refund terms: neither Willow nor PlexusDx policy details were documented in the sources we reviewed; check each provider's terms of service before committing.
• Dose escalation and ongoing eligibility: a licensed clinician determines your starting dose, titration schedule, and continued appropriateness; neither program guarantees a specific dose or uninterrupted access.

Choose Willow if…

• You prefer the flexibility of true month-to-month billing with no prepaid commitment.
• Free expedited two-day shipping is a priority for your schedule.
• You want access to both injection and oral semaglutide routes within a single program (and you confirm oral pricing at checkout).
• The $299 semaglutide or $399 tirzepatide monthly rate fits your budget without needing a lower-cost alternative.

Choose PlexusDx if…

• Saving $110 per month ($1,320 annually) on semaglutide or tirzepatide matters to your long-term budget.
• You're willing to prepay three or six months to lock in $149–169/month semaglutide or $249–269/month tirzepatide rates.
• You value dose-flat pricing that won't increase as your prescription is titrated upward.
• You want the option to switch between injection and oral routes, or to step down to a $129/month microdose maintenance protocol once you reach goal weight.
• A verified 4.3-star Trustpilot rating (83% four-star-or-higher reviews) gives you confidence in service consistency.

Methodology and freshness

We captured Willow's advertised pricing on September 4, 2026, from startwillow.com and startwillow.com/compound-tirzepatide. PlexusDx pricing was verified July 17–23, 2026, on plexusdx.com product pages. The 12-month total-cost figures are our calculation: we multiplied each monthly rate by 12 (for month-to-month plans) or by the number of billing cycles required to reach 12 months of treatment (for prepaid plans). We used the verified monthly equivalents for prepaid tiers ($149/month and $249/month for PlexusDx six-month plans) and labeled them as prepaid. No promotional, introductory, or first-month discounts were identified for either provider. PlexusDx review data was captured September 9, 2026, from trustpilot.com/review/plexusdx.com. We did not submit payment or complete intake at either provider; all figures reflect publicly advertised rates. Pricing, eligibility, and clinical protocols may change; confirm current rates and terms at checkout.

Frequently Asked Questions

Does Willow charge a separate membership fee on top of the medication cost?

No. Willow's $299 semaglutide and $399 tirzepatide monthly rates are all-inclusive—covering the provider visit, prescription, medication, and free two-day shipping—with no additional membership charge (verified September 4, 2026; startwillow.com).

How much do I save over a year by choosing PlexusDx instead of Willow?

On month-to-month semaglutide, PlexusDx saves $110 per month, or $1,320 over 12 months. On the six-month prepaid plan, the savings grow to $150 per month, or $1,800 annually (our calculation). Tirzepatide savings follow the same pattern: $1,320 to $1,800 per year depending on plan length.

Does Willow offer both injection and oral GLP-1 medications?

Willow lists both injection and oral routes for compounded semaglutide, and injection for tirzepatide (September 4, 2026; startwillow.com). Oral-route pricing for semaglutide was not separately itemized in the sources we reviewed; confirm the exact monthly cost for oral semaglutide at checkout if that is your preferred route.

Are Willow's and PlexusDx's medications FDA-approved?

No. Both providers dispense compounded semaglutide and tirzepatide, which are not FDA-approved. The FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient.

Can I use my HSA or FSA card to pay for Willow or PlexusDx?

Yes. Both Willow and PlexusDx accept HSA and FSA cards for payment (Willow verified September 4, 2026; PlexusDx verified July 17–23, 2026). Check with your HSA/FSA administrator to confirm your specific plan's coverage rules for compounded weight-loss medications.

Sources

• Willow pricing and inclusions – startwillow.com and startwillow.com/compound-tirzepatide (accessed September 4, 2026)
• PlexusDx pricing and plan details – plexusdx.com/products/semaglutide-injection, plexusdx.com/products/tirzepatide-injection, plexusdx.com/products/semaglutide-oral, plexusdx.com/products/tirzepatide-oral, plexusdx.com/products/microdose-glp1-protocol (accessed July 17–23, 2026)
• PlexusDx Trustpilot rating – trustpilot.com/review/plexusdx.com (accessed September 9, 2026)

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.