Willow First-Month vs Refill Pricing: What Long-Term Treatment Costs

Last reviewed: September 18, 2026 Last updated: September 18, 2026

Written by: Jay Hastings, CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

PlexusDx publishes this comparison and is one of the providers discussed. We use the same evidence rules for our own program and competing programs.

The short answer

Willow does not separate first-month from refill pricing. The company charges a flat monthly rate with no introductory discount: $299/month for compounded semaglutide (injection or oral) and $399/month for compounded tirzepatide injection, verified at checkout September 4, 2026. That $299 or $399 is both your first month and every subsequent refill. Over twelve months, semaglutide totals $3,588 per year and tirzepatide totals $4,788 per year (our calculation). Both rates are all-inclusive—medication, provider visit, and free two-day shipping—with no membership fee.

The predictable structure eliminates surprise increases after an initial period, but Willow's ongoing rate runs $110/month ($1,320/year) above PlexusDx's month-to-month semaglutide injection rate of $189 and $110/month ($1,320/year) above PlexusDx's tirzepatide injection rate of $289 (our calculation).

Willow pricing at a glance

Willow pricing captured September 4, 2026 via checkout verification. Willow's website states pricing for semaglutide and tirzepatide but does not separately itemize oral-route costs for semaglutide.

Month-to-month comparison: Willow versus PlexusDx

Both Willow and PlexusDx offer month-to-month billing with no membership fees, making direct comparison straightforward. PlexusDx month-to-month rates are $189 for semaglutide injection and $289 for tirzepatide injection, verified September 18, 2026.

Over one year on month-to-month billing, Willow's semaglutide program costs $3,588 versus PlexusDx's $2,268; Willow's tirzepatide costs $4,788 versus PlexusDx's $3,468 (our calculation, both programs).

PlexusDx prepaid plans: additional savings over Willow

PlexusDx also offers three-month and six-month prepaid commitments that reduce the per-month rate further. Willow does not offer prepaid or multi-month discounts; the $299 and $399 rates apply regardless of commitment length.

The PlexusDx six-month commitment brings semaglutide to $1,788 per year ($149/month prepaid) and tirzepatide to $2,988 per year ($249/month prepaid), both our calculation. The PlexusDx three-month option falls between the month-to-month and six-month rates: $169/month prepaid for semaglutide injection and $269/month prepaid for tirzepatide injection.

What Willow's flat-rate structure means for budgeting

Willow's pricing predictability is its primary structural advantage. Many telehealth weight-loss programs advertise a low first-month rate—sometimes as low as $149 or $199—then jump to $299, $399, or higher on the second refill. Willow eliminates that discontinuity: your first month, third month, and twelfth month all cost the same. If you value budget certainty and dislike introductory tricks, Willow's approach is transparent.

The trade-off is that Willow's ongoing rate starts higher than competitors' standard rates. You pay the full $299 or $399 from day one, whereas PlexusDx charges $189 or $289 month-to-month from the first prescription forward, and other services may offer a true first-month discount before settling at a rate still below Willow's floor.

Fees, shipping, and payment flexibility

Willow's $299 and $399 rates are all-inclusive: compounded medication, online provider visit, and free two-day shipping. There is no separate membership fee, consultation charge, or shipping surcharge. HSA and FSA cards are accepted, verified September 4, 2026.

PlexusDx likewise bundles provider visit, prescription, medication, and shipping into a single monthly charge with no membership fee. The difference is price: PlexusDx month-to-month rates are $110/month lower for both semaglutide and tirzepatide injection, and PlexusDx offers additional savings through three-month and six-month prepaid commitments.

Medication selection and routes

Willow offers compounded semaglutide in both injection and oral formulations, and compounded tirzepatide injection. The company's website states that semaglutide is available via both routes at $299/month, but does not separately itemize whether the oral route carries a different price. Tirzepatide is listed as injection only at $399/month, captured September 4, 2026.

PlexusDx offers a wider range of options:

• Semaglutide injection: $189/month month-to-month, $169/month prepaid three-month, $149/month prepaid six-month
• Tirzepatide injection: $289/month month-to-month, $269/month prepaid three-month, $249/month prepaid six-month
• Semaglutide oral: $289/month month-to-month, $269/month prepaid three-month, $249/month prepaid six-month
• Tirzepatide oral: $349/month month-to-month, $299/month prepaid three-month, $279/month prepaid six-month
• Microdose GLP-1 injection (for maintenance after standard therapy): $129/month month-to-month

Both Willow and PlexusDx dispense compounded GLP-1 medications. Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. PlexusDx works with licensed 503A compounding pharmacies.

Choose Willow if…

• You prioritize pricing transparency and dislike introductory-rate structures that jump after the first month.
• You prefer the simplicity of knowing your cost will remain $299 or $399 every month without tracking commitment periods or prepayment.
• You need fast two-day shipping as a standard feature rather than an upgrade.
• Your budget accommodates the higher ongoing rate in exchange for predictable billing.

Where PlexusDx fits

PlexusDx is designed for patients who want the lowest sustainable per-month rate without introductory gimmicks. The month-to-month semaglutide injection rate of $189 and tirzepatide injection rate of $289 are $110/month below Willow's equivalent plans, and those rates apply from the first prescription forward—no bait-and-switch, no post-introductory jump.

Patients willing to commit three or six months prepaid save an additional $20 to $40 per month (prepaid equivalent). PlexusDx also offers oral formulations of both semaglutide and tirzepatide, and a $129/month microdose maintenance protocol for patients who have reached their goal weight and want to sustain results at lower cost.

PlexusDx holds a 4.3-star rating on Trustpilot, with 79% of reviews at five stars and 83% at four stars or higher, captured September 9, 2026 (trustpilot.com/review/plexusdx.com). Every plan includes the provider visit, prescription, compounded medication, and shipping in one price, with no membership fee and no hidden charges.

Methodology and freshness

Willow pricing was captured September 4, 2026 via checkout verification and cross-referenced against the company's public pricing page. PlexusDx pricing reflects current rates verified September 18, 2026. Twelve-month totals and cost differences are our calculation, derived by multiplying stated monthly rates by twelve (for monthly billing) or by the appropriate prepaid-period equivalent. We confirmed that Willow does not publish separate first-month versus refill pricing; the $299 and $399 rates apply uniformly to the first month and all subsequent refills. All prepaid-plan figures are labeled as prepaid equivalents.

Frequently Asked Questions

Does Willow offer a first-month discount?

No. Willow charges the same rate every month: $299 for compounded semaglutide and $399 for compounded tirzepatide injection. The first month, the second refill, and every subsequent month cost the same amount, verified at checkout September 4, 2026.

How much does Willow cost over one year?

Willow's semaglutide program costs $3,588 per year ($299/month × 12) and tirzepatide costs $4,788 per year ($399/month × 12), both our calculation. These totals include medication, provider visit, and free two-day shipping with no additional membership or consultation fees.

Is Willow's $299 semaglutide rate competitive with other telehealth providers?

Willow's $299/month semaglutide rate is $110/month higher than PlexusDx's month-to-month rate of $189 and $150/month higher than PlexusDx's six-month prepaid rate of $149/month. Some competitors advertise lower first-month rates but increase on refills; Willow's structure is flat but starts at the higher tier.

Does Willow charge a membership fee or separate consultation charge?

No. Willow's $299 semaglutide and $399 tirzepatide rates are all-inclusive. The monthly charge covers the compounded medication, online provider visit, prescription, and free two-day shipping. There is no separate membership fee, captured September 4, 2026.

Can I prepay for multiple months with Willow to lower the per-month cost?

Willow's available evidence does not document multi-month prepaid discounts. The $299 and $399 monthly rates apply to standard month-to-month billing. If you prefer prepaid savings, PlexusDx offers three-month and six-month commitments that reduce the effective monthly cost by $20 to $40.

Sources

• PlexusDx product portfolio and pricing structure, verified September 18, 2026
• Willow company profile and medication offerings, captured September 4, 2026
• Willow plan pricing detail (semaglutide $299/month, tirzepatide $399/month, no membership fee), captured September 4, 2026
• PlexusDx Trustpilot rating (4.3 stars, 79% five-star, 83% four-star-or-higher), captured September 9, 2026, trustpilot.com/review/plexusdx.com
• Willow intake and checkout verification, captured September 4, 2026

Compounded medication disclosure: Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. PlexusDx works with licensed 503A compounding pharmacies.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.