Yes — MTHFR C677T and A1298C connect to longevity through at least five distinct biological mechanisms, from vascular aging and epigenetic clock acceleration to glutathione substrate depletion and DNA repair impairment. The Precision Peptide Genetic Test maps MTHFR within 14 pathways, 49 peptides, and 150+ genetic insights, revealing how your methylation genetics shapes your aging biology.

Glutathione synthesis, recycling, and detoxification capacity are all genetically variable — GCLC, GCLM, GSR, GPX1, GSTM1, and NFE2L2 each shape a different step. The Precision Peptide Genetic Test maps these variants across 14 pathways, 49 peptides, and 150+ genetic insights, revealing where your antioxidant production is genetically strongest and where it leaks.

Yes — but how much NAD+ you can raise, through which pathway, and where your biggest genetic leak is all depend on your DNA. The Precision Peptide Genetic Test analyzes NAD+ pathway genetics across 14 pathways, 49 peptides, and 150+ genetic insights, revealing whether your rate-limiting step is synthesis, salvage, or overconsumption.

Yes — FOXO3 is one of the most replicated longevity genes in human genetics, and rs2802292 is the variant that explains why. The Precision Peptide Genetic Test analyzes FOXO3 alongside 14 pathways, 49 peptides, and 150+ genetic insights, revealing how your transcription factor genetics shapes oxidative stress resistance, DNA repair, and cellular lifespan.

Mitochondria generate the energy that powers every biological process — and mitochondrial decline is one of the most upstream drivers of aging. NRF2, KLOTHO, SOD2, SIRT1, FOXO3, and MTHFR all converge on mitochondrial biology. The Precision Peptide Genetic Test analyzes 17 Longevity & Aging insights spanning 14 pathways, 49 peptides, and 150+ genetic insights.

Growth hormone axis output declines with age — a process called somatopause. GHSR variants determine GH pulse sensitivity. IGF1 variants set downstream anabolic signal baseline. GHR variants shape how efficiently GH converts to IGF-1. The Precision Peptide Genetic Test analyzes all three as part of 17 Longevity & Aging insights spanning 14 pathways, 49 peptides, and 150+ genetic insights.

MTHFR converts dietary folate into the active form the methylation cycle requires. The C677T (rs1801133) and A1298C (rs1801131) variants reduce enzyme activity by 30–65%, limiting DNA repair, homocysteine clearance, and epigenetic age regulation. The Precision Peptide Genetic Test analyzes MTHFR as part of 17 Longevity & Aging insights spanning 14 pathways, 49 peptides, and 150+ genetic insights.

Telomeres are the protective chromosome caps that shorten with each cell division. TERT encodes telomerase, the enzyme that rebuilds them. The variant rs2736100 influences baseline telomerase activity and lifetime telomere attrition rate. The Precision Peptide Genetic Test analyzes TERT as part of 17 Longevity & Aging insights spanning 14 pathways, 49 peptides, and 150+ genetic insights.

SIRT1 is a NAD+-dependent enzyme that regulates DNA repair, inflammation, metabolic efficiency, and cellular stress response. Variants at rs12778366 and related loci influence how actively SIRT1 operates at baseline. The Precision Peptide Genetic Test analyzes SIRT1 as part of 17 Longevity & Aging insights spanning 14 pathways, 49 peptides, and 150+ genetic insights.

APOE comes in three allele variants — e2, e3, and e4 — that produce meaningfully different cardiovascular and cognitive aging trajectories. It is the most studied aging-related gene in human genetics. The Precision Peptide Genetic Test analyzes APOE as part of 17 Longevity & Aging insights within a panel spanning 14 pathways, 49 peptides, and 150+ genetic insights.

SOD2 encodes the primary antioxidant enzyme inside your mitochondria — responsible for neutralizing reactive oxygen species at their source. The A16V variant (rs4880) determines how efficiently SOD2 is imported into the mitochondrial matrix. The Precision Peptide Genetic Test analyzes SOD2 as part of 17 Longevity & Aging insights spanning 14 pathways, 49 peptides, and 150+ genetic insights.

FOXO3 is the most replicated longevity gene in science — variants are consistently associated with exceptional lifespan across independent centenarian cohorts in Japan, Italy, and the United States. The Precision Peptide Genetic Test analyzes FOXO3 as part of 17 Longevity & Aging insights within a panel spanning 14 pathways, 49 peptides, and 150+ genetic insights.

The Precision Peptide Genetic Test analyzes 17 longevity and aging genetic insights — FOXO3, SOD2, APOE, SIRT1, and TERT among them — within a panel of 14 pathways, 49 peptides, and 150+ genetic insights. This pillar guide breaks down each longevity gene, what it signals about healthspan, and why your DNA is the highest-leverage variable in any aging strategy.