Last reviewed: May 12, 2026 Last updated: May 12, 2026

Written by: Jay Hastings , CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

Unlocking the Genetic Code of Hemorrhoids: Can Your DNA Influence Your Risk?

Throughout history people have suffered from hemorrhoids which involve swollen veins in the rectum and anus area. The condition of hemorrhoids which causes discomfort and bleeding has affected different celebrities including Marilyn Monroe, George Clooney and Lil Wayne. Genetic factors may affect how likely you are to develop hemorrhoids. Hemorrhoids arise from multiple risk factors including genetics while other contributors consist of excessive straining, constipation, aging and pregnancy. People with a certain version of the MORC2 gene are more likely to develop constipation which subsequently increases their risk of straining during bowel movements. If you comprehend how genetics and other factors connect you can adjust your lifestyle to lessen your risk. Examining your DNA allows you to discover important genetic data about your risk of developing hemorrhoids. Personalized recommendations for your health become available when you use a genetic risk score that analyzes over 680,000 genetic variants to match your specific genetic profile. The insights give you the ability to actively make changes that could decrease your hemorrhoid risk.

Managing Hemorrhoids:

Up to 75% of adults will experience hemorrhoids, which occur internally or externally during their lifetime. The development of hemorrhoids due to aging and pregnancy presents varying symptoms based on the hemorrhoid type. Hemorrhoids can lead to discomfort and distress through symptoms of itching and swelling as well as bleeding and pain. Home management of mild hemorrhoid cases typically involves dietary fiber increase along with hydration maintenance and topical treatments such as creams or suppositories while taking warm baths and pain relievers can provide additional relief. It becomes necessary to obtain medical advice when hemorrhoid symptoms last longer than seven days. Muscular function in the anus, gut, and blood vessels can be affected by genetic differences which potentially determine how likely someone is to develop hemorrhoids. People with a high genetic risk for hemorrhoids should focus on avoiding bowel movement straining and manage constipation to prevent and manage this widespread condition. Use the Precision Health & Wellness tests from PlexusDx to understand your genetic susceptibility to hemorrhoids so you can manage your health better. Genetic testing gives you valuable information that helps you make educated choices about your overall health. Start your individualized health journey right now by visiting PlexusDx.com and browse through selections on Amazon or Walmart. Through understanding the genetic roots of hemorrhoids you can identify your risk factors and learn how to take early steps to prevent this widespread condition. Understanding your genetics and making lifestyle changes allows you to manage your health and well-being which leads to a more vibrant future.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.

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