PlexusDx vs Fridays Health: GLP-1 Pricing and Plan Terms Compared

Last reviewed: September 8, 2026 Last updated: September 8, 2026

Written by: Jay Hastings, CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

PlexusDx publishes this comparison and is one of the providers discussed. We use the same evidence rules for our own program and competing programs.

The short answer

PlexusDx and Fridays Health both offer compounded semaglutide and tirzepatide without membership fees, yet their pricing structures, upfront commitments, and medication formats diverge in ways that directly affect affordability and flexibility over time. PlexusDx month-to-month semaglutide runs $189, versus Fridays' advertised $249 (captured July 20, 2026); tirzepatide month-to-month is $289 at PlexusDx, versus $359 advertised at Fridays (July 20, 2026) or $389 on the product page (September 4, 2026). Fridays unlocks lower per-month rates through prepaid multi-month commitments—tirzepatide drops to $224 per month under its 4-for-3 promotion ($896 upfront for three months plus a fourth free) or $240 per month with a $2,880 twelve-month prepayment—but every multi-month option requires full upfront payment. PlexusDx publishes standing month-to-month, three-month, and six-month rates with no prepayment required, offers five medication formats including oral semaglutide and tirzepatide plus microdose, and keeps the same price at every dose. Fridays bundles unlimited dietitian support, nutrition coaching, mental-health coaching, and a care coach; PlexusDx includes free PharmD check-ins and an optional genetics add-on ($99 for program members). Both platforms hold 4.3-star Trustpilot ratings. The choice turns on whether you value predictable month-to-month pricing and medication-format flexibility, or whether prepaying for a year to secure a lower per-month rate fits your budget and commitment horizon.

At-a-glance comparison

PlexusDx rates verified July 20, 2026. Fridays Health advertised pricing-page rates captured July 20, 2026; product-page rates captured September 4, 2026. Fridays' pricing showed variation between campaign landing pages and the standard pricing page when we captured it; confirm final rates at checkout.

Like-for-like pricing

Direct price comparison requires normalizing billing intervals, upfront commitments, and monthly costs. We compare month-to-month against month-to-month, prepaid three-month against three-month, and calculate twelve-month total costs to expose the true recurring expense.

Semaglutide injection – month-to-month

PlexusDx charges $189 per month with no lock-in. Fridays Health advertised $249 per month on its pricing page (captured July 20, 2026). Both prices are billed monthly, neither requires upfront commitment, and both include shipping and clinical oversight. PlexusDx holds a $60 per month advantage on this route.

Over twelve months, PlexusDx semaglutide month-to-month totals $2,268 (our calculation: $189 × 12), versus $2,988 for Fridays at the advertised $249 rate (our calculation: $249 × 12)—a $720 annual difference. If the pricing-page rate still applies, PlexusDx delivers lower aggregate cost without requiring any multi-month commitment.

Tirzepatide injection – month-to-month

PlexusDx tirzepatide month-to-month is $289. Fridays advertised $359 per month on its pricing page (July 20, 2026), but the product page showed $389 per month when captured September 4, 2026—a $30 conflict. The higher figure may reflect a later rate increase or page-specific pricing; we note both and recommend confirming at checkout.

Using the July pricing-page figure, PlexusDx is $70 per month lower; using the September product-page rate, the gap widens to $100 per month. Over twelve months, PlexusDx tirzepatide month-to-month totals $3,468 (our calculation: $289 × 12), versus $4,308 at the $359 rate (our calculation: $359 × 12) or $4,668 at the $389 rate (our calculation: $389 × 12)—a $840 to $1,200 annual difference depending on which Fridays rate applies.

Multi-month commitments – semaglutide

PlexusDx offers standing three-month ($169/month) and six-month ($149/month) rates for semaglutide injection, billed monthly with no upfront payment. Over twelve months, the three-month plan totals $2,028 (our calculation: $169 × 12) and the six-month plan $1,788 (our calculation: $149 × 12).

The evidence packet did not capture published standing three- or six-month semaglutide rates for Fridays; the platform's advertised lowest semaglutide price was $117 (captured September 4, 2026), but that figure appears to be promotional or prepaid, well below the $249 month-to-month pricing-page rate. Without a clear like-for-like prepaid tier for semaglutide, we cannot normalize Fridays' multi-month cost on this compound.

Multi-month commitments – tirzepatide

PlexusDx tirzepatide three-month is $269 per month (billed monthly, no prepayment), totaling $3,228 over twelve months (our calculation: $269 × 12). The six-month plan is $249 per month, totaling $2,988 over twelve months (our calculation: $249 × 12).

Fridays offers four prepaid tirzepatide tiers (captured September 4, 2026, product page):

• Three-month prepaid: $896 upfront every three months ($298.67/month), totaling $3,584 over twelve months (our calculation: $896 × 4).
• Six-month prepaid: $1,650 upfront every six months ($275/month), totaling $3,300 over twelve months (our calculation: $1,650 × 2).
• Twelve-month prepaid: $2,880 upfront once ($240/month), totaling $2,880 over twelve months.
• 4-for-3 promotion: $896 upfront for three months plus a fourth month free ($224/month over four months), totaling $2,688 over twelve months (our calculation: $896 × 3, yielding twelve months of medication).

Comparing like-for-like prepaid tiers:

PlexusDx six-month tirzepatide ($2,988 over twelve months) costs $108 less than Fridays' twelve-month prepaid plan ($2,880) over the same period, and PlexusDx bills monthly rather than requiring $2,880 upfront. Fridays' 4-for-3 promotion ($2,688 over twelve months, requiring $896 upfront every four months) delivers the lowest tirzepatide rate in this comparison, $300 below PlexusDx six-month, but locks in a promotional structure that may not persist and demands three separate $896 payments across the year.

Price stability and page-to-page variation

The evidence shows Fridays' pricing varied between its campaign landing pages and the standard joinfridays.com pricing page when we captured both on July 20, 2026. The September 4, 2026 capture reiterated that promo landing-page prices differ from product-page standard prices. This variation is material: the tirzepatide month-to-month rate was $359 on the pricing page (July) and $389 on the product page (September), and the advertised lowest tirzepatide price was $190 (September), well below any month-to-month figure. We recommend confirming the final rate at checkout and noting which page the advertised figure came from.

Medication formats and route options

PlexusDx offers five compounded GLP-1 formats: semaglutide and tirzepatide injections, semaglutide and tirzepatide oral formulations, and a microdose GLP-1 injection. The oral formulations cost more than injections—semaglutide oral is $289 month-to-month versus $189 for the injection, tirzepatide oral is $349 versus $289—but eliminate the subcutaneous route for patients who prefer capsules. Microdose GLP-1 ($129 month-to-month) provides a lower-intensity maintenance option. All five formats are published with standing rates and available at the same price regardless of dose.

Fridays' evidence packet documents compounded semaglutide and tirzepatide injections and mentions branded options. We did not capture published oral-formulation pricing or a microdose tier. If injection is the only route you need, Fridays' portfolio covers it; if you want the flexibility to switch to oral mid-program or step down to microdose maintenance, PlexusDx publishes those paths with transparent pricing.

Coaching, support, and clinical oversight

Fridays bundles unlimited provider visits, 1-on-1 dietitian support, nutrition coaching, mental-health coaching, and a care coach into the medication price, with no separate membership fee and no lab fees (captured July 20, 2026). The required labs are a comprehensive metabolic panel, hemoglobin A1c, TSH, and lipid panel. This support architecture is well-suited to patients who want active, multi-disciplinary coaching alongside medication.

PlexusDx includes free PharmD (Doctor of Pharmacy) check-ins and a licensed clinician review of the intake. The platform offers an optional genetics add-on ($298 standalone, or $99 for program members) that informs medication response prediction. PlexusDx does not bundle unlimited dietitian or mental-health coaching into the base price; the focus is medication access, pharmacist oversight, and optional genetic insight.

If regular dietitian and mental-health touchpoints are central to your weight-management strategy, Fridays' inclusive coaching may justify its higher medication cost. If you primarily need reliable medication supply, dose flexibility, and pharmacist support, PlexusDx delivers those elements at a lower ongoing rate.

Review records and reported service quality

Both platforms hold 4.3-star Trustpilot ratings (captured September 9, 2026). PlexusDx has 79 percent of reviews at five stars and 83 percent at four stars or higher. Fridays has approximately 4,700 reviews at the same 4.3-star average. Neither platform showed dominant negative themes in the September 2026 review pass, and the Reddit search for Fridays did not surface a specific negative thread meeting the evidence threshold.

The shared rating suggests comparable aggregate customer satisfaction. Review volume favors Fridays, which may reflect longer market presence or higher patient volume. Both datasets were captured on the same date using the same methodology, so the ratings are directly comparable.

Compounding pharmacy and regulatory standing

Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. PlexusDx works with licensed 503A compounding pharmacies. Fridays' evidence packet does not specify compounding-pharmacy class, but the platform offers compounded formulations, which by definition are not FDA-approved and are not the same as branded drugs.

Choose PlexusDx if…

• You want predictable month-to-month pricing with no upfront commitment and the freedom to pause or cancel without forfeiting prepaid funds.
• Lower tirzepatide and semaglutide month-to-month rates ($289 and $189, respectively) fit your budget better than Fridays' advertised $359–$389 tirzepatide or $249 semaglutide.
• You value medication-format flexibility: oral semaglutide, oral tirzepatide, or microdose GLP-1 are published options with transparent pricing.
• The same price at every dose simplifies planning and removes uncertainty around dose-escalation costs.
• PharmD check-ins and optional genetics testing align with your clinical-oversight preferences.
• You prefer avoiding large upfront payments—PlexusDx three-month and six-month rates are billed monthly, not prepaid.

Choose Fridays Health if…

• You want unlimited dietitian support, nutrition coaching, mental-health coaching, and a care coach bundled into the medication price.
• You can prepay for a year and the 4-for-3 promotion is active—$2,688 over twelve months for tirzepatide ($224/month) is the lowest rate in this comparison, though it requires $896 upfront every four months.
• The twelve-month prepaid tirzepatide plan ($2,880 upfront, $240/month) fits your commitment horizon and cash-flow situation.
• You value the larger review volume (~4,700 Trustpilot reviews) as a signal of established patient base.
• Compounded semaglutide and tirzepatide injections cover your medication needs and you do not require oral formulations or microdose options.

Methodology and freshness

All PlexusDx pricing verified July 20, 2026 from live product pages and the internal rate sheet. Fridays Health advertised pricing-page rates (semaglutide $249, tirzepatide $359) captured July 20, 2026; product-page tirzepatide rates ($389 month-to-month, $896 three-month, $1,650 six-month, $2,880 twelve-month, $896 4-for-3) and lowest advertised figures ($117 semaglutide, $190 tirzepatide) captured September 4, 2026. Review ratings for both platforms captured September 4, 2026 from Trustpilot. Twelve-month total-cost calculations, monthly rates for prepaid plans, and per-month costs are our calculations, labeled as such throughout. Fridays' pricing showed documented variation between campaign landing pages and the standard pricing page; readers should confirm final rates at checkout. No UTM parameters, affiliate links, or promotional offers appear in this article. This comparison was written September 8, 2026.

Frequently Asked Questions

Does Fridays Health require upfront payment for multi-month plans?

Yes. Fridays' three-month, six-month, and twelve-month tirzepatide plans require full prepayment at the start of each period—$896 for three months, $1,650 for six months, or $2,880 for twelve months (captured September 4, 2026). PlexusDx multi-month rates are billed monthly with no upfront commitment.

Which platform offers oral GLP-1 formulations?

PlexusDx publishes oral semaglutide ($289 month-to-month) and oral tirzepatide ($349 month-to-month) with standing rates. The evidence packet for Fridays documented compounded injections and mentioned branded options but did not capture published oral-formulation pricing.

Are the $117 semaglutide and $190 tirzepatide figures from Fridays standard monthly rates?

No. Those figures (captured September 4, 2026) appear to be promotional or prepaid rates, well below the $249 semaglutide and $359–$389 tirzepatide month-to-month rates captured on the pricing and product pages. Confirm which plan structure delivers those rates before committing.

Do both platforms charge membership or lab fees?

No. Both PlexusDx and Fridays Health advertise $0 membership fees. Fridays explicitly states $0 lab fees and lists required labs (comprehensive metabolic panel, HbA1c, TSH, lipid panel). PlexusDx includes clinical oversight in the all-inclusive medication price; lab requirements are determined by the provider.

Which platform has better customer reviews?

Both hold 4.3-star Trustpilot ratings (captured September 9, 2026). PlexusDx has 79 percent five-star reviews and 83 percent at four stars or higher. Fridays has approximately 4,700 total reviews at the same 4.3-star average. Review volume favors Fridays; rating quality is statistically identical.

Sources

• PlexusDx product pages and rate sheet (verified July 20, 2026)
• PlexusDx Trustpilot profile (captured September 4, 2026)
• Fridays Health pricing page at joinfridays.com/pricing (captured July 20, 2026)
• Fridays Health product page (captured September 4, 2026)
• Fridays Health Trustpilot profile (captured September 4, 2026)
• Internal evidence packet: PlexusDx vs Fridays Health GLP-1 Comparison (compiled September 8, 2026)

Compounded medication disclosure: Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. PlexusDx works with licensed 503A compounding pharmacies.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.