PlexusDx vs Fridays Health: Monthly and Multi-Month GLP-1 Costs

Last reviewed: September 4, 2026 Last updated: September 4, 2026

Written by: Jay Hastings, CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

PlexusDx publishes this comparison and is one of the providers discussed. We use the same evidence rules for our own program and competing programs.

The short answer

PlexusDx and Fridays Health both offer compounded semaglutide and tirzepatide injections with no separate membership fee. Fridays Health's month-to-month tirzepatide is billed at $389 per month (product page captured September 4, 2026) or advertised at $359 per month (pricing page verified July 20, 2026)—a $30 conflict readers should confirm at checkout. PlexusDx month-to-month tirzepatide injection is $289. On a six-month rate, PlexusDx tirzepatide costs $249 per month ($2,988 annually, our calculation) versus Fridays' six-month prepaid rate of $275 per month ($1,650 upfront, or $3,300 annually, our calculation). Fridays' 12-month prepaid tirzepatide plan drops to $240 per month ($2,880 upfront, our calculation), undercutting PlexusDx's six-month rate by $108 annually, but requires full-year commitment and upfront payment. For semaglutide, PlexusDx month-to-month is $189 versus Fridays' advertised $249; PlexusDx's six-month rate of $149 per month ($1,788 annually, our calculation) saves $1,200 annually compared with Fridays' month-to-month rate ($2,988 annually, our calculation). Fridays bundles unlimited provider visits, dietitian support, nutrition and mental-health coaching, and $0 lab fees; PlexusDx includes a free PharmD check-in and optional genetic testing ($99 for program members, $298 standalone, verified July 20, 2026). Choose Fridays if you value unlimited coaching and are confident in a long prepay commitment; choose PlexusDx if you want lower month-to-month rates and standing multi-month pricing without upfront lock-in.

At-a-glance comparison

Month-to-month pricing: PlexusDx lower on both compounds

PlexusDx semaglutide injection is $189 per month, verified July 20, 2026. Fridays Health advertises $249 per month semaglutide on its pricing page (verified July 20, 2026), a $60 per month gap. PlexusDx tirzepatide injection is $289 per month. Fridays Health's product page shows $389 per month for its one-month tirzepatide plan (captured September 4, 2026), while its pricing page advertises $359 per month (verified July 20, 2026)—a $30 conflict. We recommend confirming the rate at checkout; using the higher product-page figure, PlexusDx undercuts Fridays by $100 per month on tirzepatide.

Over twelve months at month-to-month rates, PlexusDx semaglutide totals $2,268 ($189 × 12, our calculation) versus Fridays' $2,988 ($249 × 12, our calculation), a $720 annual difference. For tirzepatide, PlexusDx month-to-month totals $3,468 ($289 × 12, our calculation) versus Fridays' product-page rate of $4,668 ($389 × 12, our calculation) or pricing-page rate of $4,308 ($359 × 12, our calculation), a difference of $1,200 to $840 annually depending on which Fridays rate applies.

Neither provider charges a separate membership fee. PlexusDx includes a licensed provider review and a free PharmD check-in in its single all-inclusive price. Fridays includes unlimited provider visits, one-on-one dietitian support, nutrition coaching, mental-health coaching, a care coach, and $0 lab fees in its medication price, as verified July 20, 2026. Free shipping was captured at Fridays' checkout on the same date.

Multi-month pricing: structure and commitment differ

PlexusDx publishes standing three-month and six-month rates billed monthly with no upfront prepay. Semaglutide injection is $169 per month on a three-month rate and $149 per month on a six-month rate. Tirzepatide injection is $269 per month on a three-month rate and $249 per month on a six-month rate. These rates were verified July 20, 2026, and remain published on PlexusDx product pages.

Fridays Health offers prepaid multi-month plans for tirzepatide (captured September 4, 2026). The three-month plan costs $896 upfront, or $298.67 per month (our calculation). The six-month plan costs $1,650 upfront, or $275 per month (our calculation). The 12-month plan costs $2,880 upfront, or $240 per month (our calculation). Fridays also offers a "4-for-3" plan: pay $896 upfront, commit to three months, receive the fourth month free—$224 per month over four months (our calculation). No standing multi-month semaglutide rates appear in the September 4, 2026 capture.

On a like-for-like three-month comparison for tirzepatide, PlexusDx costs $269 per month billed monthly ($807 over three months, our calculation) versus Fridays' prepaid three-month plan at $298.67 per month ($896 upfront). PlexusDx is $89 cheaper over three months (our calculation).

On a six-month comparison, PlexusDx tirzepatide is $249 per month billed monthly ($1,494 over six months, our calculation) versus Fridays' prepaid six-month plan at $275 per month ($1,650 upfront). PlexusDx is $156 cheaper over six months (our calculation).

Fridays' 12-month prepaid tirzepatide plan costs $2,880 upfront, or $240 per month. PlexusDx does not offer a 12-month tirzepatide rate; its longest published rate is six months at $249 per month. Over 12 months, PlexusDx at the six-month rate totals $2,988 ($249 × 12, our calculation) versus Fridays' 12-month prepaid total of $2,880. Fridays wins by $108 annually on a 12-month commitment, but requires full upfront payment and one-year lock-in.

Twelve-month cost calculations

The table below shows total cost over 12 months for tirzepatide injection at each available rate or plan length, normalized so the same commitment period is compared across both providers. All figures are our calculation except where a 12-month plan exists.

For semaglutide injection, PlexusDx offers month-to-month at $189, three-month rate at $169, and six-month rate at $149. Fridays advertises month-to-month semaglutide at $249 (pricing page, July 20, 2026); no multi-month semaglutide rates appear in our September 4, 2026 capture. Over 12 months, PlexusDx semaglutide at the six-month rate totals $1,788 ($149 × 12, our calculation) versus Fridays month-to-month at $2,988 ($249 × 12, our calculation), a $1,200 annual difference favoring PlexusDx.

Included services: unlimited visits vs PharmD check-in and optional genetics

Fridays Health bundles unlimited provider visits, one-on-one dietitian support, nutrition coaching, mental-health coaching, a care coach, $0 lab fees, and free shipping in its medication price (verified July 20, 2026). Required labs typically include a comprehensive metabolic panel, hemoglobin A1C, TSH, and lipid panel (verified July 20, 2026). This is a substantial inclusion package for patients who anticipate frequent clinical or coaching touchpoints during dose titration or maintenance.

PlexusDx includes a licensed provider review before prescription and a free PharmD (Doctor of Pharmacy) check-in. PlexusDx charges one flat all-inclusive price covering the consult, prescription, medication, and shipping (verified July 20, 2026). There is no separate membership fee (verified July 20, 2026). PlexusDx offers an optional genetic testing add-on: $298 standalone or $99 for program members (verified July 20, 2026). The genetics test is not required and is not part of the standard medication price.

If you expect to use frequent provider visits, dietitian sessions, or mental-health coaching, Fridays' bundled support may justify its higher month-to-month rate. If you prefer a lower base price and plan to add services only when needed, PlexusDx's unbundled model offers more control over total spend.

Pricing transparency and stability

PlexusDx publishes standing rates that do not vary by landing page or campaign. The rates verified July 20, 2026 remain current and displayed on product pages. Month-to-month plans carry no lock-in (verified July 20, 2026). Multi-month rates (three-month and six-month) are billed monthly at the discounted rate; no upfront prepayment is required.

Fridays Health's pricing shows material variation between pages. On July 20, 2026, the Fridays pricing page advertised $249 semaglutide and $359 tirzepatide month-to-month. On September 4, 2026, the product-page checkout showed tirzepatide one-month plan at $389—$30 higher than the pricing-page advertised rate. A separate capture on September 4, 2026 noted Fridays' lowest advertised semaglutide figure as $117, with no detail on plan length or commitment; the pricing-page month-to-month rate remains $249. Our research documentation states "Promo landing-page prices differ from product-page standard prices" and "Campaign landing page priced differently from joinfridays.com site." Readers should verify the exact rate and plan terms at checkout before committing, especially on prepaid multi-month plans.

Medications and formats

PlexusDx offers five GLP-1 formats: semaglutide injection ($189 month-to-month, $169 three-month, $149 six-month), tirzepatide injection ($289 month-to-month, $269 three-month, $249 six-month), semaglutide oral capsules ($289 month-to-month, $269 three-month, $249 six-month), tirzepatide oral capsules ($349 month-to-month, $299 three-month, $279 six-month), and microdose GLP-1 injection ($129 month-to-month). All are compounded. Oral formats offer a needle-free route for patients with injection aversion or travel constraints. The microdose option is designed for maintenance and costs less than full-dose injection protocols.

Fridays Health offers compounded semaglutide and tirzepatide injections, as well as branded GLP-1 options (captured September 4, 2026). Verified pricing in our dataset covers compounded tirzepatide multi-month plans and month-to-month rates for both compounds; branded-medication pricing was not captured. Fridays does not appear to offer oral compounded GLP-1 formats or a microdose maintenance tier in the materials reviewed.

Regulatory and compounding disclosures

Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. PlexusDx works with licensed 503A compounding pharmacies. Fridays Health also dispenses compounded medications (captured September 4, 2026); regulatory disclosures should be confirmed on the Fridays site.

Neither PlexusDx nor Fridays Health guarantees eligibility, specific medication, dose, results, or side-effect outcomes. A licensed provider must review intake information and approve a prescription before any medication ships.

Choose Fridays Health if…

• You place high value on unlimited provider visits, one-on-one dietitian support, and mental-health coaching bundled into the medication price.
• You are confident in committing to a 12-month prepaid plan to capture the $240 per month rate ($2,880 upfront) for tirzepatide, which is $108 per year cheaper than PlexusDx's six-month rate over a 12-month period (our calculation).
• You prefer a model where lab fees are $0 and all support services are included with no add-on decisions.
• You can verify the exact month-to-month or multi-month rate at checkout and are comfortable with the $30 pricing-page vs product-page discrepancy documented in our captures.

Choose PlexusDx if…

• You want the lowest month-to-month rates for both semaglutide ($189 vs $249 advertised) and tirzepatide ($289 vs $389 or $359 depending on Fridays page) with no lock-in.
• You prefer standing multi-month rates billed monthly rather than prepaid lump sums—PlexusDx three-month and six-month rates require no upfront payment and no commitment beyond the rate period.
• You value price transparency and consistency; PlexusDx rates do not vary by landing page or campaign and are published openly.
• You want access to five GLP-1 formats including oral capsules and a microdose maintenance option, giving you flexibility to switch routes or step down dose without changing providers.
• You prefer an unbundled model where the base price is lower and optional services (such as genetic testing at $99 for members) are added only when you choose them.

Methodology and freshness

This comparison uses pricing, fee, inclusion, and service data captured from PlexusDx and Fridays Health websites and checkout flows between July 20, 2026 and September 4, 2026. PlexusDx rates were verified July 20, 2026 and remain published on product pages. Fridays Health pricing-page rates were verified July 20, 2026; product-page checkout rates and multi-month plan details were captured September 4, 2026. Fridays' Trustpilot rating and review volume were captured September 4, 2026.

Where Fridays' pricing-page advertised rate ($359 tirzepatide month-to-month) conflicts with its product-page checkout rate ($389), we present both figures with capture dates and advise readers to confirm at checkout. All 12-month cost calculations are our calculation unless a 12-month prepaid plan exists. Prepaid per-month figures (for example, $1,650 upfront for six months = $275 per month) are labeled as our calculation. No discount arithmetic was applied to derive prices; only rates actually observed in captures are published.

No customer testimonials, first-hand trial accounts, or anecdotal efficacy claims appear in this article. Review rating and volume for Fridays were captured; no thematic negative review analysis was coded in the research packet. All price-per-month figures are for medication; no separate membership, signup, or hidden fees were documented at either provider. Free shipping at Fridays was captured at checkout July 20, 2026. PlexusDx shipping is included in the single all-inclusive price.

Frequently Asked Questions

Does Fridays Health charge a separate membership fee?

No. Fridays Health charges $0 membership fee and $0 signup fee, as verified July 20, 2026. Unlimited provider visits, dietitian support, coaching, and $0 lab fees are bundled into the medication price. No separate monthly or annual membership subscription was documented.

Why does Fridays' tirzepatide price differ between the pricing page and product page?

On July 20, 2026, Fridays' pricing page advertised tirzepatide month-to-month at $359. On September 4, 2026, the product-page checkout showed the one-month plan at $389—a $30 difference. Our research documentation notes that promo landing-page prices differ from product-page standard prices at Fridays. Confirm the exact rate at checkout before purchasing.

Can I switch from PlexusDx injection to oral GLP-1 without changing providers?

Yes. PlexusDx offers five GLP-1 formats on the same platform: semaglutide injection, tirzepatide injection, semaglutide oral capsules, tirzepatide oral capsules, and microdose GLP-1 injection. Switching routes or stepping down to microdose for maintenance does not require transferring to a new provider or restarting intake.

Are Fridays' multi-month plans billed monthly or prepaid?

Fridays' one-month plan is billed monthly. The three-month, six-month, and 12-month plans are prepaid: you pay the full amount upfront ($896 for three months, $1,650 for six months, $2,880 for 12 months) as captured September 4, 2026. PlexusDx multi-month rates are billed monthly at the discounted rate with no upfront lump sum required.

What is included in PlexusDx's $289 month-to-month tirzepatide price?

The $289 per month covers the licensed provider review, prescription, compounded tirzepatide injection medication, and shipping—one flat all-inclusive charge with no separate membership fee, as verified July 20, 2026. A free PharmD check-in is included. Optional genetic testing is $99 for program members or $298 standalone.

Sources

• PlexusDx product pages and pricing (verified July 20, 2026)
• PlexusDx policy documentation (verified July 17–23, 2026)
• Fridays Health pricing page (verified July 20, 2026)
• Fridays Health product-page checkout capture (September 4, 2026)
• Fridays Health company profile and advertised rates (captured September 4, 2026)
• Fridays Health Trustpilot profile (captured September 4, 2026)

Compounded medication disclosure: Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. PlexusDx works with licensed 503A compounding pharmacies.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.