GLP-1 Pricing Calculator: Compare Monthly, Quarterly and Annual Plans

Last reviewed: September 12, 2026 Last updated: September 12, 2026

Written by: Jay Hastings, CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

PlexusDx publishes this comparison and is one of the providers discussed. We use the same evidence rules for our own program and competing programs.

The Short Answer

Monthly, quarterly, and annual GLP-1 plans all exist in the telehealth market—and the arithmetic can look compelling. Prepaid quarterly and annual commitments advertise per-month rates as low as $149 (compounded semaglutide, 12-month prepay) to $299 (compounded tirzepatide, various multi-month tiers), compared to month-to-month floors around $189–$299 for semaglutide and $289–$399 for tirzepatide. But the effective-rate math hides three material realities: upfront cash, dose-escalation uncertainty, and zero recourse if side effects or efficacy force a switch. Month-to-month plans cost more per cycle but preserve the option to stop, change dose, or move to a different compound without forfeiting hundreds or thousands of dollars already paid.

The comparison that follows maps advertised monthly rates, multi-month prepaid terms, 12-month total cost, and cancellation rules for 12 telehealth GLP-1 providers captured July–September 2026. We show the full upfront outlay alongside the effective monthly equivalent, note which programs separate medication from membership fees, and state plainly when a price requires three, six, or twelve months paid in advance. If you already know you tolerate a specific dose and compound, a prepaid tier may deliver $500–$1,200 in annual savings. If you are starting GLP-1 therapy or unsure whether semaglutide, tirzepatide, or a microdose protocol fits best, month-to-month enrollment costs more per shipment but far less in aggregate risk.

At-a-Glance Pricing: Monthly, Quarterly, and Annual Plans

The table below shows advertised month-to-month rates, the lowest available multi-month effective rate, the contract term that unlocks that rate, and the upfront payment required. Figures labeled "our calculation" derive from published prepay totals divided by plan months; figures labeled "advertised" appear on the provider's checkout or plan page. All prices captured July 20–September 9, 2026.

Key observations: Eden and MEDVi offer month-to-month semaglutide below $200 all-in, though Eden separates a $99 membership fee from the $99 medication charge and MEDVi's introductory first-month rate of $179 steps to $299 on refill. PlexusDx month-to-month semaglutide sits at $189 with no membership and the same price at every dose; the 6-month plan drops to $149/month (our calculation: $894 upfront). Found and Henry Meds unlock their lowest effective rates—$169 and $197 respectively for injectable semaglutide—only after paying the full 12-month total in advance ($2,028 and $2,364). Fridays Health advertises a $117/month prepaid semaglutide tier, but the upfront total and contract length remain unpublished as of this capture; confirm at checkout.

Month-to-Month vs. Multi-Month: Normalized 12-Month Cost

Prepaid discount math looks attractive on a per-month basis but obscures the cash outlay and cancellation penalty. The table below calculates total 12-month cost for each plan structure—true monthly (12 × monthly rate), 3-month rolling (4 × quarterly charge), 6-month rolling (2 × half-year charge), and 12-month prepaid (one upfront payment)—so you can see both the effective monthly rate and the aggregate dollar commitment. All figures are our calculation from published rates captured July–September 2026.

12-month savings analysis (our calculation):

• PlexusDx semaglutide injection: Moving from month-to-month ($2,268) to the 6-month plan ($1,788) saves $480 over 12 months, or $40/month on average—but requires two $894 upfront payments across the year.
• PlexusDx tirzepatide injection: Moving from month-to-month ($3,468) to the 6-month plan ($2,988) saves $480 over 12 months—two $1,494 prepayments required.
• Found semaglutide: The 12-month prepaid plan ($2,028) saves $1,440 versus rolling monthly ($3,468), but the entire $2,028 is due at enrollment; no monthly exit before month 13.
• Henry Meds semaglutide injection: The 12-month paid-in-full plan ($2,364) saves $1,200 versus rolling monthly ($3,564), again with full payment upfront and no option to stop early without forfeiting the remainder.
• Henry Meds sublingual semaglutide: The 12-month paid-in-full plan ($1,788) saves $1,200 versus rolling monthly ($2,988), the largest absolute dollar savings in this snapshot—and also the largest single cash outlay for a compounded oral product.

When a provider advertises "$149/month" or "$169/month," confirm whether that figure is the true monthly charge or an effective rate requiring six or twelve months paid upfront. Effective rates are real savings—if you remain on that exact medication and dose for the entire prepaid period. If your prescriber adjusts compound, route, or dose, or if side effects require a switch, the unused portion of a prepaid plan is typically forfeited or subject to partial-refund policies that vary by provider and are rarely detailed before purchase.

Decision Factors: When Prepaid Plans Make Sense—and When They Don't

Prepaid Plans Favor Established, Stable Patients

Multi-month and annual prepaid discounts deliver measurable savings when three conditions align: you already know you tolerate a specific GLP-1 compound and route (injection vs. oral), your target dose is stable or follows a predictable escalation schedule the provider supports without extra charge, and you have high confidence you will remain with that provider and protocol for the full prepaid term. In that scenario, paying $1,788 upfront for 12 months of Henry Meds sublingual semaglutide ($149/month effective) instead of $2,988 in rolling monthly charges is a straightforward $1,200 gain—provided nothing changes.

Month-to-Month Plans Preserve Optionality During Dose-Finding and Compound Trials

First-time GLP-1 users, patients switching from branded to compounded medications, and anyone trialing semaglutide vs. tirzepatide face material uncertainty: side-effect tolerance varies widely, weight-loss velocity differs by compound, and dose escalation timelines are individualized by the prescriber based on response and tolerability. A six-month prepaid commitment made during week one locks in cost but eliminates the ability to pivot to a different compound, add adjunct medications, or switch providers if the care experience falls short—all without forfeiting the unused balance. Month-to-month plans cost $20–$50 more per cycle but allow a clean exit or direction change every 30 days with zero sunk cost.

Membership Fees and Visit Charges Add Hidden Layers

Eden's $198/month all-in semaglutide rate separates into $99 medication and $99 membership, both billed monthly; if you pause medication, the membership fee continues unless you cancel the entire service. Found's $289 month-to-month cash rate drops to an effective $169/month on the 12-month prepaid plan—but that $2,028 covers program access and compounded medication together, and switching to a branded medication during the term adds separate, per-prescription costs. MEDVi's introductory first-month rate of $179 rises to $299 on every refill, producing a 12-month total of $3,767 (our calculation) if you stay the full year—higher than PlexusDx month-to-month semaglutide at $2,268, despite the lower advertised launch price. When comparing plans, separate medication, membership, visits, and shipping into distinct line items, then sum them over 12 months to see the true recurring cost.

Cancellation Terms and Refund Policies Rarely Appear Before Purchase

Most telehealth GLP-1 providers state that month-to-month plans "cancel anytime," but fewer publish refund or proration policies for prepaid quarterly, semi-annual, or annual commitments. The research packet notes that Found, Henry Meds, TrimRx, Peak Wellness, and Fridays Health all offer multi-month prepaid tiers, yet none of the captured checkout flows or plan pages detailed what happens if you stop at month four of a six-month prepaid term. Before committing to any prepaid plan, ask the provider in writing: (a) whether unused months are refunded, prorated, or forfeited; (b) whether a compound or dose change mid-term voids the prepaid discount; and (c) whether pausing shipments (e.g., during a medication shortage or insurance transition) extends the term or counts as a cancellation. Absent clear answers, assume zero recourse and zero refund.

Choose PlexusDx If…

• You want transparent, like-for-like comparison: $189/month true monthly semaglutide injection, $169/month on a 3-month plan (our calculation: $507 upfront), $149/month on a 6-month plan (our calculation: $894 upfront), with no membership fee and the same flat rate at every dose.
• You value the option to switch compounds or routes mid-treatment without forfeiting prepaid balances: tirzepatide injection, semaglutide oral, tirzepatide oral, and microdose GLP-1 ($129/month, month-to-month only) are all available under the same clinical team and fulfill from the same licensed compounding pharmacies.
• You prefer a single all-in price that includes medication, provider access, and shipping—no separate membership, no per-visit charges, no hidden fees.
• You want the ability to cancel month-to-month plans anytime without penalty, and transparent 3-month or 6-month prepaid tiers that lower the effective monthly rate while keeping the commitment window under one year.

PlexusDx publishes this comparison and is one of the providers discussed; the same evidence rules govern our own program and competing programs. Where a competitor's price, policy, or review record is superior, we state it plainly.

Choose Eden If…

• You want the lowest documented month-to-month semaglutide all-in rate in this comparison: $198/month ($99 medication + $99 membership), verified September 4, 2026.
• You prefer month-to-month flexibility with no prepaid commitment and are comfortable with medication and membership billed as separate line items.
• You value a strong overall review profile: Eden holds a 4.5-star rating on Trustpilot with approximately 5,000 reviews (captured September 4, 2026), higher than PlexusDx's 4.3-star rating.

Reported service concern: One September 4, 2026 Trustpilot review (1 star) described an 11-day order delay and repeated requests for records the patient reported Eden had previously issued. We cite this as an individual report; it does not establish a pattern, but prospective patients may wish to confirm current order fulfillment timelines and records-transfer processes during onboarding.

Choose Found If…

• You are certain you will remain on compounded semaglutide for 12 consecutive months and can pay $2,028 upfront to lock in an effective $169/month rate—$20/month below PlexusDx's 6-month plan and $20/month above PlexusDx's month-to-month rate, but requiring full annual prepayment.
• You want integrated insurance support for branded GLP-1 prescriptions alongside cash-pay compounded options, and are comfortable with the insurance-support tier adding a typical ~$30 copay on top of the $99–$199/month program fee.
• You accept that switching from compounded to branded medication mid-term will add separate per-prescription charges outside the prepaid program total.

Choose Henry Meds If…

• You want the widest menu of compounded GLP-1 routes and the lowest 12-month effective rate for sublingual semaglutide in this comparison: $149/month effective ($1,788 paid in full upfront), matching PlexusDx's 6-month semaglutide injection rate but in oral form.
• You value a very strong review profile: Henry Meds holds a 4.4-star rating with approximately 13,000 Trustpilot reviews (captured September 4, 2026), the highest review volume in this snapshot.
• You are comfortable with tirzepatide offered only as an oral dissolving tablet (not injection) and are willing to prepay six or twelve months to access the lowest advertised per-month rates.
• You accept the internal copy inconsistencies flagged in the research packet (September 4, 2026 capture) and plan to confirm exact quarterly/semi-annual upfront totals and contract terms at checkout before committing.

Choose MEDVi If…

• You prefer a low first-month entry point—introductory rate of $179 for semaglutide injection (checkout verified September 4, 2026)—and understand that the refill rate rises to $299/month, producing a higher 12-month total ($3,767, our calculation) than many month-to-month competitors.
• You want month-to-month flexibility with no contract and are comfortable with a two-tier pricing structure (introductory vs. refill).
• You value a strong review profile: MEDVi holds a 4.3-star rating with approximately 15,000 Trustpilot reviews (captured September 4, 2026), matching PlexusDx's star rating and offering the second-highest review volume in this comparison.

Methodology and Freshness

All pricing, contract terms, and review ratings were captured July 20–September 9, 2026 from provider checkout flows, public plan pages, and Trustpilot profiles. Where a figure is labeled "our calculation," we derived it from published prepay totals divided by plan months or from explicitly separated line items (medication + membership). Where a source contained conflicting copy or internal inconsistencies—Henry Meds oral tirzepatide 3-month delivery schedule, Fridays Health promo-page vs. product-page pricing—we noted the conflict in the text and advised confirming at checkout. No provider gave us preferential access; PlexusDx pricing comes from the same public sources (plexusdx.com product pages, captured September 12, 2026). Review ratings come from Trustpilot profiles captured September 4–9, 2026; individual review themes are paraphrased from single captured reports and labeled as such. We re-verify all figures quarterly; if you see a price or policy that differs from what appears here, confirm the current rate at checkout and note the date—telehealth GLP-1 pricing remains fluid as of September 2026.

Frequently Asked Questions

Is a 12-month prepaid GLP-1 plan always cheaper than paying month-to-month?

On a per-month basis, yes—prepaid annual plans in this comparison ranged from $149 to $197/month effective, versus $189–$299 month-to-month. But the arithmetic ignores upfront cash ($1,788–$2,364 due at enrollment), zero recourse if you need to switch compounds or providers mid-year, and the opportunity cost of capital. If you're uncertain about dose tolerance or compound fit, the prepaid discount rarely compensates for forfeited flexibility.

Can I switch from semaglutide to tirzepatide mid-term on a prepaid plan?

Policy varies by provider and is rarely detailed on public pricing pages. Some programs allow compound changes within a prepaid term and adjust the remaining balance; others treat a switch as a plan cancellation with partial or zero refund. Before committing to any multi-month plan, ask the provider in writing whether compound, dose, or route changes void the prepaid rate or allow prorated continuation.

Do membership fees continue if I pause my GLP-1 medication?

For providers that separate membership from medication—Eden charges $99/month for each—the membership fee typically continues unless you cancel the entire account, even if you pause shipments. Confirm the pause policy at enrollment: some programs let you freeze membership during medication breaks, others bill the membership in full regardless of shipment status.

How do I compare effective monthly rates when one provider charges upfront and another bills monthly?

Divide the total prepaid amount by the number of months to get the effective monthly rate (our calculation labels these). Then compare that figure to the true monthly rate of a rolling month-to-month plan. For example, $1,788 prepaid ÷ 12 months = $149/month effective, versus $189/month true monthly. The $40/month difference is real savings if you stay the full term; if you stop early, calculate the cost-per-month-actually-used to see whether the prepaid tier delivered value or a net loss.

Are compounded GLP-1 medications on prepaid plans the same as branded Wegovy or Zepbound?

No. Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. Compounded semaglutide and tirzepatide use the same active pharmaceutical ingredients as the branded products but are prepared by licensed compounding pharmacies under different regulatory pathways. Prepaid telehealth plans in this comparison cover compounded medications unless explicitly labeled otherwise (Found and MEDVi offer separate branded-medication paths with insurance support).

Sources

• PlexusDx product pages (semaglutide injection, tirzepatide injection, semaglutide oral, tirzepatide oral, microdose GLP-1), accessed September 12, 2026
• Eden pricing and membership page, accessed July 20, 2026 and September 4, 2026
• Embody plan page, accessed July 20, 2026
• Found cash-pay and insurance-support pricing pages, accessed July 20, 2026 and September 4, 2026
• Henry Meds product catalog and plan pricing (compounded semaglutide injection, sublingual semaglutide, oral tirzepatide, compounded liraglutide), accessed July 20, 2026 and September 4, 2026
• Peak Wellness pricing page, accessed July 20, 2026
• TrimRx advertised and checkout-verified pricing, accessed July 20, 2026
• BetterMe Rx questionnaire gate, accessed July 20, 2026
• Fridays Health advertised and product-page pricing, accessed July 20, 2026 and September 4, 2026
• MEDVi checkout-verified pricing, accessed July 20, 2026 and September 4, 2026
• Remedy Meds advertised daily-rate pricing, accessed September 4, 2026
• Zealthy advertised quarterly pricing, accessed September 4, 2026
• Trustpilot profiles: PlexusDx (4.3 stars, accessed September 9, 2026), Eden (4.5 stars, accessed September 4, 2026), Found (4.1 stars, accessed September 4, 2026), Henry Meds (4.4 stars, accessed September 4, 2026), Fridays Health (4.2 stars, accessed September 4, 2026), MEDVi (4.3 stars, accessed September 4, 2026), Remedy Meds (4.7 stars displayed during intake, accessed September 4, 2026)

Compounded medication disclosure: Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. PlexusDx works with licensed compounding pharmacies.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.