Fifty410 Semaglutide Cost — 2026 Pricing, Plans, and Verdict

Last reviewed: September 13, 2026 Last updated: September 13, 2026

Written by: Jay Hastings, CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

PlexusDx publishes this comparison and is one of the providers discussed. We use the same evidence rules for our own program and competing programs.

The short answer

Fifty410 charges $199 per month for compounded semaglutide injections, billed monthly, with no subscription or membership fee (fifty410.com/pricing, captured September 4, 2026). The charge covers consultation, medication, and shipping in a single monthly bill. PlexusDx charges $189 per month on a month-to-month plan for the same compound and delivery route, $169 per month on a three-month plan, and $149 per month on a six-month plan (plexusdx.com, captured July 17–23, 2026). Both platforms ship compounded medication and require a prescriber's approval before any charge.

At-a-glance comparison: Fifty410 vs. PlexusDx semaglutide

Sources: fifty410.com/pricing, plexusdx.com; capture dates as noted. Both platforms dispense compounded semaglutide and require prescriber approval.

Normalized like-for-like pricing: 12-month cost calculations

Comparing one month against another hides the effect of prepayment discounts. The table below standardizes both platforms to a 12-month horizon, assuming steady-state dosing and no pauses or dose changes. All prepaid figures are labeled; all derived totals are our calculation.

Semaglutide injection, month-to-month billing

Month-to-month savings: PlexusDx runs $10 lower per month and $120 lower over 12 months when both are billed monthly (our calculation).

Semaglutide injection, three-month prepaid comparison

Fifty410 does not offer a discount for semaglutide when paid in longer intervals; the $199 monthly rate holds regardless of commitment length (fifty410.com/pricing, captured September 4, 2026). PlexusDx drops to $169 per month on a three-month plan, billed as $507 every three months.

Three-month savings: PlexusDx runs $30 lower per month and $360 lower over 12 months when prepaid quarterly, compared with Fifty410's unchanged monthly rate (our calculation).

Semaglutide injection, six-month prepaid comparison

PlexusDx offers a six-month plan at $149 per month, billed as $894 every six months. Fifty410 continues to bill $199 monthly with no long-term discount.

Six-month savings: PlexusDx runs $50 lower per month and $600 lower over 12 months when prepaid semi-annually, compared with Fifty410's flat monthly rate (our calculation).

What's included in each platform's pricing

Fifty410

Fifty410's $199 per month semaglutide charge includes the initial provider consultation, compounded semaglutide injection, and shipping (fifty410.com/pricing, captured September 4, 2026). There is no separate membership or subscription fee. The platform bills monthly and ships a four-week supply each cycle. You pay only if a prescriber approves your prescription.

PlexusDx

PlexusDx bundles the provider visit, compounded semaglutide injection, and shipping into one monthly, quarterly, or semi-annual charge—no membership fee, no hidden visit charges, no separate shipping line. The month-to-month rate is $189; the three-month prepaid rate is $169 per month ($507 per quarter); the six-month prepaid rate is $149 per month ($894 per cycle). Every plan renews automatically unless you cancel, and you may pause or cancel at any time without penalty (plexusdx.com, captured July 17–23, 2026).

Tirzepatide pricing: structure and upfront commitment

Fifty410 offers compounded tirzepatide injections in three dose tiers, all shipped as three-month supplies and billed upfront (fifty410.com/pricing, captured September 4, 2026):

• Starter dose: $399 for three months ($133 per month prepaid equivalent, our calculation)
• Mid dose: $499 for three months ($166 per month prepaid equivalent, our calculation)
• High dose: $549 for three months ($183 per month prepaid equivalent, our calculation)

These per-month figures are our calculation and require the full quarterly charge upfront. Over 12 months, the starter tier totals $1,596, the mid tier $1,996, and the high tier $2,196, assuming you renew at the same dose each quarter (our calculation).

PlexusDx charges $289 per month month-to-month for compounded tirzepatide injection, $269 per month on a three-month plan ($807 per quarter), and $249 per month on a six-month plan ($1,494 per cycle). The month-to-month 12-month total is $3,468; the three-month prepaid total is $3,228; the six-month prepaid total is $2,988 (our calculation). A direct dose-to-dose comparison is not possible because Fifty410 defines tiers by dose level rather than offering a single monthly rate across all doses.

Decision factors: monthly flexibility vs. prepaid savings

Fifty410's strengths

• Monthly semaglutide billing with no contract: you can stop or change plans month by month without forfeiting prepaid months.
• No separate membership fee: one charge covers consultation, medication, and shipping.
• High Trustpilot rating: 4.8 stars across 5,891 reviews signals strong aggregate satisfaction (fifty410.com, captured September 4, 2026; trustpilot.com).
• Low upfront commitment for tirzepatide starters: $399 for three months of starter-dose tirzepatide is lower than many competitor quarterly minimums.

PlexusDx's strengths

• Lower month-to-month semaglutide rate: $189 vs. $199 saves $10 per month with identical billing flexibility.
• Multi-month discounts: prepaying three or six months drops the effective rate to $169 or $149, saving $30 to $50 per month vs. Fifty410's flat $199.
• Single tirzepatide rate across doses: no need to predict which tier you will land in; one price covers titration through maintenance.
• Flexible cancellation: prepaid plans may be paused or canceled at any time without penalty, though you forfeit unused prepaid months.

Gaps and caveats

• Neither platform guarantees eligibility, dose, or results; a prescriber decides whether a prescription is appropriate.
• Compounded medications are not FDA-approved; FDA does not review compounded drugs before marketing for safety, effectiveness, or quality.
• Both platforms rely on compounded semaglutide and tirzepatide; availability depends on ongoing FDA shortage declarations and state pharmacy regulations.
• PlexusDx's multi-month savings require upfront payment; if you pause or cancel mid-cycle, you forfeit the balance.
• Fifty410's tirzepatide pricing is structured by dose tier; if you titrate across tiers, quarterly costs will vary.
• Pricing should be confirmed at checkout; the research packet notes that Fifty410's help-center content once showed different tier structures, though the current pricing page (captured September 4, 2026) reflects the figures in this article.

Choose Fifty410 if…

• You want semaglutide on a true month-to-month basis with no prepayment and are comfortable paying $199 per month.
• You value a provider with a large Trustpilot footprint and a 4.8-star average.
• You prefer tirzepatide priced by explicit dose tier and are willing to commit to three-month cycles upfront.
• You want a simple, single-fee structure with no separate membership charges.

Choose PlexusDx if…

• You want the lowest available month-to-month semaglutide rate ($189) or are willing to prepay for deeper discounts ($169 or $149).
• You prefer a single tirzepatide price across all doses, making budgeting simpler as you titrate.
• You value the flexibility to pause or cancel without penalty, even on prepaid plans (though you forfeit unused months).
• You want transparent multi-month pricing with no hidden visit or shipping fees.

Methodology and freshness

Fifty410 pricing was captured from fifty410.com/pricing on September 4, 2026. PlexusDx pricing was captured from plexusdx.com between July 17 and July 23, 2026. Trustpilot ratings were captured September 4, 2026 (Fifty410) and September 9, 2026 (PlexusDx). All 12-month totals, effective monthly rates, and prepaid per-month equivalents are our calculation. We retained both the current Fifty410 pricing page and references to older help-center content; the figures in this article reflect the current pricing page. Confirm all rates, tier definitions, and included services at checkout before committing to any plan.

Frequently Asked Questions

Does Fifty410 charge a membership or subscription fee for semaglutide?

No. Fifty410's $199 monthly semaglutide charge covers the provider consultation, compounded medication, and shipping in a single bill with no separate membership or subscription fee (fifty410.com/pricing, captured September 4, 2026).

Can I get a discount on Fifty410 semaglutide if I pay for multiple months upfront?

No. Fifty410 bills semaglutide monthly at $199 per month regardless of commitment length. The platform does not advertise a multi-month prepaid discount for semaglutide (fifty410.com/pricing, captured September 4, 2026).

How does PlexusDx's three-month semaglutide plan compare to Fifty410's monthly rate?

PlexusDx charges $169 per month when you prepay for three months ($507 per quarter), saving $30 per month and $360 over 12 months compared to Fifty410's $199 monthly rate. Both figures include consultation, medication, and shipping (our calculation based on pricing captured July 17–23, 2026 and September 4, 2026).

What happens if I cancel a PlexusDx prepaid plan mid-cycle?

You may pause or cancel at any time without penalty, but you forfeit any unused prepaid months. For example, if you prepay six months and cancel after two, the remaining four months are not refunded. Month-to-month plans avoid this risk (plexusdx.com policies, captured July 2026).

Are Fifty410 and PlexusDx semaglutide injections FDA-approved medications?

No. Both platforms dispense compounded semaglutide, which is not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient.

Sources

• Fifty410 pricing page (fifty410.com/pricing), captured September 4, 2026
• PlexusDx product pages and pricing (plexusdx.com), captured July 17–23, 2026
• Trustpilot: Fifty410 provider page, captured September 4, 2026
• Trustpilot: PlexusDx review profile (trustpilot.com/review/plexusdx.com), captured September 9, 2026

Compounded medication disclosure: Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. PlexusDx works with licensed 503A compounding pharmacies.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.