What Ozempic, Wegovy and Compounded Semaglutide Cost Without Insurance

Without insurance, the Ozempic pen costs $349 for a 28-day supply at the 0.25, 0.5 or 1 mg dose and $499 at 2 mg, though a new patient pays $199 for each of the first two fills at 0.25 or 0.5 mg. Ozempic also comes as a daily pill, which costs $149 for the first month's 1.5 mg starting dose, then $199 a month at 4 mg or $299 at 9 mg.^{1, 2, 3, 4} Novo Nordisk, which makes Ozempic and Wegovy, charges these cash prices only when the prescription is for one of Ozempic's FDA-approved uses. All of those uses are for adults with type 2 diabetes.^{3, 5, 6, 4}

For weight management within Wegovy's label, Novo's semaglutide is Wegovy, at $349 a box of pens or $399 for the 7.2 mg Wegovy HD dose. The Wegovy pill costs $149 to $299 a month, and the $149 buys only the first month's starting dose.^{2, 3, 7} Novo prices Wegovy pens by the 28-day box, so 12 months take 13 boxes: $4,537, or $4,237 for a new patient whose first two boxes cost $199 each (see a year of fills). For either brand at NovoCare Pharmacy, the $199 offer needs the prescription written and received by December 31, 2026.^{2, 3}

With Medicare Part D, you may qualify for Wegovy through Medicare's GLP-1 Bridge for a $50 copay per monthly supply instead (see Medicare and insurance).⁸

Compounded semaglutide, made by a pharmacy for one patient's prescription, is not FDA-approved, and FDA does not review it for safety, effectiveness or quality.^{9, 31} Where the companies in our table other than PlexusDx list one monthly price that includes the prescriber's care, it ran from $99 (Eden) to $199 (Fifty 410's starting price) month to month on October 3, 2026. Alloy lists the medicine from $70 a month and Mochi Health from $60, each plus a separate fee.^{10, 11, 12, 13, 14, 15}

We checked Novo Nordisk's and the other companies' prices on October 3, 2026. Further down: which price you can use, every dose and a year's total, label warnings, compounded offers, doses in units, Medicare, insurance and free-medicine help, list prices and what it costs to make and PlexusDx's program.

Can you buy Ozempic for weight loss at these prices?

Not on Novo Nordisk's terms. Its cash program at NovoCare Pharmacy, a home-delivery service filled by partner pharmacies, and its Ozempic savings offers both require a prescription for a use on Ozempic's FDA label.^{3, 5} Which of Novo's prices you can use depends on why semaglutide is prescribed:

• To treat type 2 diabetes: the Ozempic pen or pill at the prices in the table below. If Medicare Part D or a plan from work covers your drugs, compare what that coverage pays first. Uninsured with a low household income? Novo's assistance program may give you Ozempic pens free if you meet its rules.
• For weight management within Wegovy's label: the Wegovy pill or pens, at prices in the same table. With Medicare Part D, check the $50 Bridge first. If a work or Marketplace plan covers Wegovy, compare your copay before paying cash.
• For either, paying cash: ask your prescriber to send the prescription to NovoCare Pharmacy, which delivers free and can connect you with a prescriber if you need one, or to a local pharmacy that takes Novo's savings offer.^{2, 1, 16}
• If neither label fits you: Novo's cash prices aren't open to you, and any GLP-1 used to lose weight would be off-label. See your own doctor first, before paying any online seller for a prescription, and that includes PlexusDx; our page on GLP-1s for people without obesity or overweight explains why.
• Compounded semaglutide: FDA has not approved it for any use; its prices and FDA's rules on it are further down.⁹

Every Ozempic use requires type 2 diabetes: along with diet and exercise, the pen and the pill improve blood sugar in adults with type 2 diabetes. Both also lower the risk of heart attack, stroke and cardiovascular death in some of these adults, and the pen lowers the risk of kidney decline, kidney failure and cardiovascular death in those with chronic kidney disease. Neither form of Ozempic has been shown safe and effective in children.^{6, 4}

Ozempic and Wegovy both contain semaglutide, but taking Ozempic only to lose weight is off-label, meaning outside its approved uses.^{6, 4} Prescribed that way, it qualifies for neither of Novo's offers, so the $349 and $499 prices don't apply; Novo's list price, the price before any discount, is about $1,000 a pen (see list prices).^{3, 5, 43}

Each of Wegovy's approved uses is in combination with a reduced-calorie diet and more physical activity. It helps adults with obesity, or with overweight and at least one weight-related condition such as high blood pressure or high cholesterol, lose excess weight and keep it off. The injection, though not at the 7.2 mg dose, is also approved for this in children 12 and older with obesity.⁷

Both forms are also approved to cut the risk of heart attack, stroke or cardiovascular death in adults who have established cardiovascular disease along with obesity or overweight. The injection, again not at 7.2 mg, also has accelerated approval for adults with MASH (metabolic dysfunction-associated steatohepatitis, a form of fatty liver disease with inflammation and liver damage that can lead to scarring) whose scarring is moderate to advanced (stage F2 or F3) but not cirrhosis. Continued approval for this use may depend on a confirming trial.⁷

In Wegovy's adult weight-loss trials, obesity meant a body mass index (BMI) of 30 or more, and overweight a BMI of 27 to 29.9 with a weight-related condition; its trial in children 12 and older enrolled those with a BMI at or above the 95th percentile for their age and sex.⁷ All of these drugs carry a boxed warning about thyroid tumors, so read what the labels warn about before you choose.

Novo Nordisk's cash price for every dose, and what a year costs

Novo sells all of these through NovoCare Pharmacy and through local pharmacies that accept a Novo savings offer, with a prescription but no insurance needed.^{2, 1, 16} The prices are for the medicine only, so a prescriber's care costs extra: for example, Optum Perks Online Care charges $39 for each prescription request, new or refill, and $39 for each follow-up visit, with no monthly fee, as of October 3, 2026.¹⁷ Our guide to GLP-1 costs compares ways to pay a prescriber without a membership fee.

A fill is a bottle of 30 tablets, or a 28-day supply of pens: one Ozempic pen, or a box of four single-dose Wegovy pens. Wegovy's 2.4 mg dose also comes as a FlexTouch pen that holds four doses. NovoCare's terms price boxes of single-dose pens, so ask NovoCare whether these prices apply to FlexTouch.^{3, 7}

For the $199 pen price at NovoCare Pharmacy, "new" means you have never filled that brand's pen there. The prescription must be written and received by December 31, 2026, and shipped by January 31, 2027.³ With a Wegovy or Ozempic savings offer at a local pharmacy instead, "new" means you have not used that brand's offer in the past 365 days, and the fill must happen by December 31, 2026.^{18, 5} NovoCare calls the $199 price a limited-time offer and says that pricing will be updated after December 31, 2026.¹⁹

Both pills start at 1.5 mg for 30 days before the dose steps up, and the Ozempic pill's label says that starting dose does not control blood sugar.^{7, 4} Buying ahead doesn't lower the price: two or three boxes of Wegovy pens cost $698 or $1,047.¹⁸ NovoCare Pharmacy offers a 90-day supply option and dispenses tablets only in multiples of 30.^{20, 3}

Paying cash means paying outside your insurance. NovoCare does not accept insurance, and if you have coverage, money spent at these prices won't count toward your deductible or out-of-pocket limit.^{3, 16} NovoCare takes HSA and FSA cards; our page on paying with an HSA, FSA or CareCredit covers the account rules.²⁰

What 12 months of fills add up to

Pen totals use 13 fills of 28 days (364 days); pill totals use 12 bottles of 30 tablets (360 days).³ Each row follows the starting schedule in the drug's label only to price each fill, and your prescriber sets your dose.^{7, 6, 4} Novo says it can change or cancel these programs at any time and that its planned 2027 list-price cut will not change them, so fills in 2027 are priced here as they are today.^{2, 21}

The Wegovy HD row assumes what the label requires before 7.2 mg: at least 4 weeks of tolerating 2.4 mg, and a prescriber's judgment that more weight loss is needed. In its trials, 22% of people on 7.2 mg reported changes in skin sensation (dysesthesia), compared with 6% on 2.4 mg.⁷

Here is the first row on a calendar. Say your first box of Wegovy pens ships October 15, 2026. Fills 1 and 2, on October 15 and November 12, cost $199 each. Fill 3, on December 10, is the 1 mg step at $349, and the other 10 fills follow every 28 days from January 7 to September 16, 2027, also at $349; the last one lasts through October 13, 2027.^{7, 3}

That is $398 + 11 × $349 = $4,237 for 364 days, with $747 of it paid in 2026 and $3,490 in 2027, when Novo's prices could change. If you start near the deadline, check with NovoCare that your second box will still get the $199 price, since it must ship by January 31, 2027.³ The later-year column is the one to plan around, because Wegovy is approved for keeping weight off long term.⁷

An exploratory follow-up tracked 327 people from the STEP 1 trial, all adults without diabetes, for a year after the trial's treatment and lifestyle program stopped. Those who had taken brand-name semaglutide 2.4 mg had lost an average of 17.3% of their weight over 68 weeks and regained 11.6 percentage points of it, about two-thirds, during that year. The authors wrote that the findings suggest ongoing treatment is needed to keep the benefits.²² The trial tested no compounded product.

Stopping early is common. In a study of 125,474 U.S. adults with overweight or obesity who started liraglutide, semaglutide or tirzepatide between 2018 and 2023, 64.8% of those without type 2 diabetes had stopped within a year. Moderate or severe stomach and bowel side effects were linked to stopping.²³ Novo charges fill by fill, while a plan paid 12 months ahead, like some compounded plans below, can include months you never use.³

If you take Rybelsus

Novo says Rybelsus, its other semaglutide tablet for type 2 diabetes, is being replaced by the Ozempic pill. Switching takes a new prescription, and Novo says the Ozempic pill will have the same insurance coverage as Rybelsus.²⁴ Novo also says Ozempic tablets of 1.5, 4 and 9 mg work like Rybelsus 3, 7 and 14 mg.²⁴ Their shared label says the two can't be swapped milligram for milligram and that patients should not switch from one to the other during the first 30 days of treatment, so your prescriber writes the new dose.⁴

The prices differ, too: Rybelsus has a $25 copay offer only for people whose commercial plan covers it, and the offer excludes people paying fully in cash, while the Ozempic pill sells for cash at the prices above.^{5, 1}

For other GLP-1 drugs, see what GLP-1 medicines cost without insurance; for Zepbound and Mounjaro, see tirzepatide prices without insurance.

What the Wegovy and Ozempic labels warn about, at any price

Paying less does not change the risks. The FDA labels for Wegovy, the Ozempic pen and the Ozempic pill (one label covers both the Ozempic pill and Rybelsus) set out the warnings below.^{7, 6, 4} They are not the full list, so read the Medication Guide that comes with each prescription and check with your prescriber how each point fits you before you start or change treatment. For the signs below that call for help right away, get the help first and ask afterward.

The most common side effects. On all three labels they include nausea, diarrhea, vomiting, constipation and stomach pain. The pill label adds decreased appetite, and Wegovy's label adds headache, tiredness, dizziness and hair loss, among others.^{7, 6, 4}

Who must avoid semaglutide. All three labels rule it out for anyone with a personal or family history of medullary thyroid carcinoma (MTC), a type of thyroid cancer, or with multiple endocrine neoplasia syndrome type 2 (MEN 2), an endocrine gland condition. They also rule it out after a serious allergic reaction to semaglutide or any other ingredient in the product. None of the three is recommended for people with severe gastroparesis, in which the stomach empties very slowly.^{7, 6, 4}

Thyroid tumors. Each label's boxed warning says semaglutide caused thyroid C-cell tumors in rodents, and whether it does so in people is unknown. The Medication Guides say a lump or swelling in your neck, hoarseness, trouble swallowing or shortness of breath may be signs of thyroid cancer, so tell your prescriber about any of them.^{7, 6, 4}

Before you start. The Medication Guides ask you to tell your prescriber about current or past problems with your pancreas (the Wegovy and pill guides also ask about your kidneys), about diabetic eye disease (diabetic retinopathy) and about all the medicines you take, especially other diabetes medicines.^{7, 6, 4}

Pancreatitis and gallbladder problems. Inflammation of the pancreas (pancreatitis) can occur, and some cases have been severe or fatal. Stop the medicine and call your prescriber right away if you have severe stomach pain that won't go away, with or without vomiting, sometimes felt through to the back. Gallbladder problems such as gallstones also happen, more often with Wegovy than with a placebo. Their signs include upper stomach pain, fever, yellow skin or eyes and clay-colored stools; tell your prescriber right away if you notice them.^{7, 6, 4}

Fluid loss and the kidneys. Vomiting or diarrhea can dehydrate you enough to injure your kidneys, in some cases badly enough to need dialysis. Drink fluids, and tell your prescriber right away about nausea, vomiting or diarrhea that won't stop. Severe stomach problems can happen too; tell your prescriber about any that are severe or won't go away.^{7, 6, 4}

Serious allergic reactions. Stop the medicine and get medical help right away if your face, lips, tongue or throat swell, or if you have trouble breathing or swallowing, a severe rash or itching, fainting or dizziness, or a very rapid heartbeat.^{7, 6, 4}

Low blood sugar. Semaglutide can cause low blood sugar, most often when taken with insulin or a sulfonylurea. Sulfonylureas, such as glipizide and glyburide, are diabetes pills that prompt the pancreas to make insulin. Your prescriber may lower those doses when you start.^{7, 6, 4, 25, 26} Wegovy's label also reports low blood sugar with GLP-1 drugs in adults without type 2 diabetes, including 3 serious episodes on Wegovy injection versus 1 on placebo in its heart trial; people who had had weight-loss (bariatric) surgery, which the label calls a risk factor, had more serious episodes on Wegovy than on placebo.⁷

If you notice signs of low blood sugar, such as shakiness, sweating, dizziness or a fast heartbeat, treat it right away the way your prescriber showed you, then tell them. Low blood sugar so severe that you can't treat it yourself, with confusion, fainting or a seizure, is an emergency: whoever is with you should call 911.^{7, 27}

Eyes, heart rate and anesthesia. In people with type 2 diabetes, the labels warn that diabetic retinopathy (eye damage from diabetes) can get worse, so tell your prescriber about vision changes.^{7, 6, 4} Wegovy can raise your resting heart rate; its label calls for regular checks, and its Medication Guide says to tell your prescriber if your heart races or pounds for several minutes.⁷ Rarely, people taking these drugs have breathed food or liquid into their lungs during surgery or a procedure under general anesthesia or deep sedation, so tell anyone planning one that you take semaglutide.^{7, 6, 4}

Pregnancy differs by label. Wegovy may harm an unborn baby: its label says to stop it when a pregnancy is recognized if you take it for weight or heart risk, and to use it in pregnancy for MASH only if the benefit justifies the risk.⁷ The Ozempic pen and pill labels allow use in pregnancy only if the possible benefit justifies the possible risk. So if you take Ozempic for diabetes and become pregnant, call your prescriber right away; they will decide whether to stop it and how to keep your blood sugar in range.^{6, 4} All three labels say to stop at least 2 months before a planned pregnancy, and breastfeeding is not recommended with the Wegovy pill or the Ozempic pill.^{7, 6, 4}

Pens and pills. Never share an Ozempic pen or a Wegovy FlexTouch pen, even with a new needle; both labels say sharing can spread infections carried in the blood.^{6, 7} The pill labels say to take them in the morning on an empty stomach, with up to 4 ounces of plain water. Then wait at least 30 minutes before eating, drinking or taking other pills.^{7, 4} Wegovy's label says its pill has not been studied for weight loss in people with type 2 diabetes, in whom the 25 mg pill gave lower average blood levels of semaglutide than the 2.4 mg injection, so if you have type 2 diabetes, ask your prescriber which form suits you.⁷

Other medicines. Semaglutide slows how quickly the stomach empties, which can change how other pills are absorbed: semaglutide tablets raised levels of levothyroxine, a thyroid medicine, by 33% in one study, so tell your prescriber if you take it or another medicine that needs close monitoring.^{7, 4} Don't take Wegovy with any other semaglutide medicine, such as Ozempic or compounded semaglutide, or with another GLP-1 drug such as tirzepatide; its label advises against it.⁷

Taking too much. An overdose can cause severe nausea, vomiting and low blood sugar. Get help right away from your prescriber, Poison Help (1-800-222-1222) or an emergency room; semaglutide leaves the body slowly (its half-life is about a week), so symptoms can last for days.^{7, 6, 28, 29}

Side-effect reports for compounded semaglutide. It comes with no FDA-approved label of its own. FDA had received 990 reports of adverse events associated with compounded semaglutide as of May 31, 2026, and says the true number is likely higher, because federal law does not require state-licensed compounding pharmacies that have not registered with FDA as outsourcing facilities to report them.^{9, 30} FDA also says many side effects reported for compounded products look like those reported for the approved drugs, so your prescriber should go through these warnings with you, too.⁹ FDA collects side-effect reports through MedWatch, online or at 1-800-FDA-1088.^{28, 7}

Compounded semaglutide: advertised prices and the fine print

Compounded semaglutide is made by a pharmacy for one patient's prescription. It is not FDA-approved, so it is not a generic either. FDA does not review compounded drugs for safety, effectiveness or quality before they reach patients.^{31, 30, 9} "Compounded Ozempic" and "compounded Wegovy" do not exist: those names belong only to Novo's approved products.^{6, 7}

PlexusDx, which publishes this page, is in the last row; the other six companies' prices come from their own pages. Between them, the six show three ways these prices are set: one monthly price, the medicine plus a separate fee, and a plan paid ahead. They were picked for that, not for price, so the list is neither complete nor a ranking.

Eden, Fifty 410, NexLife and Trimi say their price includes the prescriber's care, Alloy's $99 fee covers its doctors' messaging, check-ins and dose changes, and Mochi's membership fee does not include the medicine.^{10, 13, 11, 12, 14, 15} PlexusDx's Terms of Service say its plan price covers the medicine, the prescriber's care, shipping and any injection supplies needed, but not outside lab tests, emergency, specialist or in-person care, patient-caused replacement medication, extraordinary early-fill costs, or applicable taxes or government charges. A prescription through PlexusDx generally runs up to six months, so the 12-month plan, like a year on any of its plans, includes another clinical review partway through; if that review isn't done, shipments pause and your unused prepaid time is kept.

A plan with no membership fee can still renew on its own, and paying for months ahead puts more money at risk if you stop. Before you prepay any seller, read its own refund terms; our comparison of telehealth programs explains how renewal, cancellation and refunds work.

FDA recommends that patients get an FDA-approved drug when one is available and appropriate, and approved semaglutide now comes as pens and pills.^{32, 7, 4} FDA declared the semaglutide shortage resolved on February 21, 2025, and the grace periods that followed have ended. Now a pharmacy may not regularly make copies of an approved drug unless the prescriber records a change that makes a significant difference for that patient; FDA's guidance says a lower price is not enough.^{31, 33}

Its examples of a real reason are an allergy to a dye in the approved drug or the need for a liquid form that isn't otherwise available, noted on the prescription.³³ FDA's red flags for people buying through telehealth companies include "deep discounts or prices that seem too good to be true"; our GLP-1 cost guide explains what FDA says about price.⁹ Our tirzepatide provider guide explains these compounding rules, which cover semaglutide too, and how to check a seller's prescriber and pharmacy.

Some compounders add vitamin B12 or other ingredients to semaglutide, and FDA says the safety and effectiveness of those combinations has not been established. FDA also warns that semaglutide sodium and semaglutide acetate, salt forms it says some compounders may use, are different active ingredients from the one in the approved drugs, and says it knows of no lawful basis for using them in compounding.^{28, 9} The same guide explains why FDA may still treat semaglutide with added B12 as a copy of an approved drug.

If you want a pill, the Wegovy pill (for weight management or heart risk in adults) and the Ozempic pill (for adults with type 2 diabetes) are FDA-approved for those uses, at the prices above. A compounded semaglutide tablet is not a version of either.^{7, 4}

Microdosing means taking less than a label's starting dose (0.25 mg a week for the Wegovy and Ozempic pens, 1.5 mg a day for the pills), spacing doses further apart than the label says, or staying long term on a dose below the label's maintenance doses, the ones meant for ongoing use. It is off-label: no label approves semaglutide used that way.^{7, 6, 4} Our guide to GLP-1 costs explains what is known about microdosing. These cautions apply to compounded semaglutide prescribed through PlexusDx too; PlexusDx's section says what form each product takes, whether anything is added and what doses Microdose GLP-1 uses.

Why "how much is 50 units?" has no safe answer

A price or dose quoted in "units" of semaglutide tells you little. Compounded instructions sometimes give doses in units rather than milligrams, and how much semaglutide a unit holds depends on the product's concentration, which varies between compounders; one compounder may sell several concentrations.²⁸ FDA has received reports of side effects, some needing hospital care, that may be related to these mistakes, including patients told to inject 5 units who drew up 50 and doses 5 to 20 times what was intended.^{28, 9} A 2023 poison control center report of three cases described two people who gave themselves 10 times their dose, and noted that vials lack the safety features of prefilled pens.²⁹

For the same reason, a price per unit can't be compared from one seller to the next. Use only the dose your prescriber wrote and the directions on your pharmacy label, and before your first injection ask your prescriber or pharmacist to show you how to measure it, as FDA advises.²⁸ With a multiple-dose vial, FDA's advice is a fresh sterile needle and syringe every time, discarding the vial 28 days after its first use even if medicine remains, and never using an injectable GLP-1 that arrives warm.⁹ Our provider guide lists what to check when a shipment arrives, and our page on pens and vials compares the two.

Lower prices with Medicare, Medicaid or a plan that covers it

Medicare and weight loss. Medicare's temporary GLP-1 Bridge covers Wegovy, as the pen or the pill, but not Ozempic, for a $50 copay per monthly supply through December 31, 2027. It is for adults with Part D coverage who meet its BMI-based criteria and get prior authorization (advance approval), and the $50 doesn't count toward the Part D deductible or out-of-pocket limit.^{8, 34} People already getting a GLP-1 through Part D can't use it, and neither can people with type 2 diabetes, moderate to severe obstructive sleep apnea, or MASH with moderate to advanced scarring (stage F2 or F3) but not cirrhosis; for those conditions, a Part D plan may cover a GLP-1 instead.^{34, 8}

Cardiovascular disease does not shut you out. A past heart attack or stroke, or peripheral artery disease with symptoms, is one of the conditions that can qualify you at a BMI of 27 or more when Wegovy is prescribed for weight; a prescription written to lower heart risk goes to your Part D plan instead.^{34, 8} The Bridge section of our UnitedHealthcare page explains how to qualify and how approval works.

Medicare and type 2 diabetes. Novo says most Medicare drug plans cover Ozempic.³⁵ Part D caps what you pay for covered drugs: the deductible is at most $615 in 2026 ($700 in 2027), and after your out-of-pocket costs reach $2,100 in 2026 ($2,400 in 2027), you pay nothing more for covered drugs that year.³⁶ Novo also says Wegovy prescribed to lower the risk of heart attack and stroke is covered through regular Part D benefits for eligible patients.³⁷

Paying cash while on Medicare. Novo's terms let people with Medicare or other government coverage buy Wegovy or Ozempic at the cash prices above if they pay outside their plan. They agree not to ask the plan to pay them back, and the spending doesn't count toward a deductible or the Part D out-of-pocket limit.^{3, 20, 5}

Novo's assistance program. People with Medicare drug coverage can no longer get Ozempic through Novo's Patient Assistance Program, which gives free medicine to people who qualify. Uninsured people can still get Ozempic pens through it if they meet its rules, which include being a US citizen or legal resident and having a household income at or below 200% of the federal poverty level. In 2026 that is $31,920 a year for one person in the 48 contiguous states and Washington, D.C., and more for larger households. Wegovy, Rybelsus and the Ozempic pill are not on its 2026 product list.^{35, 38, 39}

Medicare's 2027 price. The Centers for Medicare & Medicaid Services (CMS), the federal agency that runs Medicare, negotiated a single price for Ozempic, Rybelsus and Wegovy that takes effect January 1, 2027: $274 for a 30-day supply, 71% below the 2024 list price. The price per package varies, for example $276.78 for one Ozempic pen that gives 1 mg doses (4 mg in the pen) and $385.63 for a box of four Wegovy 2.4 mg pens.^{40, 6} That is the price of the drug in Part D, not what you pay.⁴⁰

Medicaid. CMS says Medicaid generally doesn't cover GLP-1s for weight loss. Under its voluntary BALANCE Model, CMS negotiates prices and coverage terms with drugmakers for state Medicaid programs that join between May 2026 and January 1, 2027, and every form of Ozempic, Rybelsus and Wegovy is included, but CMS says the model guarantees coverage for no one.⁴¹ Our page on Medicaid coverage of GLP-1s has the state picture.

Employer, Marketplace and other private plans. If your plan covers Wegovy or Ozempic, Novo's copay offers can bring your share down to as little as $25. Savings are capped at $100 for a 1-month fill, so you pay $25 only when your share under the plan is $125 or less. Anyone in Medicare, Medicaid, TRICARE, the VA or another government program is excluded.^{18, 5} Novo's and Lilly's discounts are sorted by type of coverage in our GLP-1 cost guide.

Coverage itself varies by plan, so check your plan's drug list or call the member number on your card. If a plan turns down a drug it covers, ask your prescriber about an appeal and act quickly: a Medicare drug plan's deadline is 65 days from the date on the denial notice, and other plans set their own.⁴² Our guide to prior authorization and appeals has the steps, and we look at specific coverage on our UnitedHealthcare, Anthem, Ambetter and TRICARE and VA pages.

Why list prices run about $1,000 to $1,350, and what semaglutide costs to make

List price is not what most insured people pay. It is the price Novo sets before discounts or rebates: $1,349.02 per package for any form of Wegovy, and $1,027.51 per Ozempic pen or pill strength on NovoCare's list-price page as of October 3, 2026 (its phone version shows $997.58). Novo says most people whose insurance covers the drug don't pay it.^{16, 43} At list price, 13 fills a year would cost $17,537.26 for Wegovy pens and $13,357.63 for Ozempic pens at $1,027.51.

The 2027 list-price cut. On January 1, 2027, Novo plans to lower the list price of Wegovy, Ozempic and Rybelsus to $675 a month at every dose, about 50% less for Wegovy and 35% less for Ozempic. Novo says the change is aimed at people whose costs are tied to list price, such as those with high-deductible plans or coinsurance, and that it does not affect its cash prices.²¹

What it costs to make. Researchers have estimated this from ingredient and production costs. A 2023 study of weight-loss medicines estimated that semaglutide could be made and sold for about $40 for a 30-day course, counting ingredients, formulation, tax and a 10% profit, against a U.S. price of $804 at the time.⁴⁴ A 2024 study estimated that injectable semaglutide at a diabetes dose of 0.77 mg a week could be sold for $0.89 to $4.73 a month while covering the cost of making it, other operating costs, a profit margin and tax.⁴⁵ These are models, not prices anyone sells at, and they say nothing about the quality of any compounded product.

No generic yet. FDA tentatively approved one generic version of semaglutide injection, from Apotex, on April 7, 2026, and lists its marketing status as "None (Tentative Approval)." A tentative approval does not let a company sell the drug until patent or exclusivity issues are resolved.^{46, 47}

Considering PlexusDx for compounded semaglutide

PlexusDx publishes this page, and the compounded semaglutide prescribed through its program competes with the companies in the table above, so our financial interest here is direct. Like all compounded semaglutide, it is not FDA-approved, FDA has not reviewed it for safety, effectiveness or quality, and it has no FDA-approved label of its own. Go over the Wegovy and Ozempic warnings above with the prescriber, along with the dosing and handling cautions in the compounded section. Everything in this section reflects PlexusDx as of October 19, 2026.

Approved semaglutide comes as Wegovy and Ozempic pens and pills, so the first questions about any compounded offer are what form it takes and what is in it. PlexusDx's compounded semaglutide is offered as a shot once a week or as an orally disintegrating tablet (ODT) once a day, at one plan price for both. Each semaglutide injection in the catalog is combined with vitamin B12 or with glycine; an injection of semaglutide alone is not offered. California residents pick between the two in the intake before checkout; for everyone else the pharmacy that fills it decides, checkout does not show which, and the label or the pharmacy can tell you. Lone Star says any reason for using the add-in must come from the patient's own clinical needs. PlexusDx has not published what else its tablets contain. FDA-approved semaglutide tablets are Rybelsus (also labeled as Ozempic tablets) and Wegovy tablets; FDA has not approved any compounded semaglutide tablet. The Microdose semaglutide injection, also made with B12, steps from 0.12 mg to 0.5 mg a week. PlexusDx has not confirmed from pharmacy records whether each product is made from semaglutide itself or from a salt form such as semaglutide sodium or semaglutide acetate, and even a product made without a salt would not match Wegovy or Ozempic in safety, effectiveness or quality; FDA does not review compounded semaglutide for any of these. If you tell the intake about an allergy, the physician reviews it before deciding; B12 and glycine do not appear on its allergy checklist, so name them if they affect you.

PlexusDx also offers Microdose GLP-1, in semaglutide and tirzepatide versions. It uses doses below those that FDA labels approve for long-term weight management, and dosing below a label is off-label, so the microdosing caution in the compounded section applies to both versions. The tirzepatide version is a different drug with label warnings of its own, and PlexusDx's section of our tirzepatide cost guide covers it.

The semaglutide version costs $99 a month on a 1-month plan, charged monthly, or $267, $474 or $828 charged up front for a 3-, 6- or 12-month plan ($89, $79 or $69 a month), as of October 19, 2026, and its price covers the same care, medicine, shipping and supplies as the regular plans. Over 12 months, that comes to $1,188, $1,068, $948 or $828 on the 1-, 3-, 6- or 12-month plan, and here too the 12-month plan includes another clinical review partway through, since a prescription generally runs up to six months.

FDA's copy rule in the compounded section applies to semaglutide prescribed through PlexusDx as it does to anyone's. Asked how its prescribers apply that rule, Lone Star Virtual Health said each physician has to individualize the reason, record it, and explain it to the patient, along with the fact that compounded semaglutide lacks FDA approval. There is no stock answer, it said, and a reason built on added B12, B6 or glycine needs that patient's clinical needs to support it. It is a fair question for any prescriber, including one you reach through PlexusDx: what makes compounded semaglutide a better medical fit for you than Wegovy or Ozempic?

PlexusDx does not practice medicine, and it does not make the drug. It uses only state-licensed 503A compounding pharmacies, which between them can fill prescriptions for patients in all 50 states, and you may ask for a pharmacy you prefer, if it is available and legally able to fill the prescription; otherwise one is assigned. An assigned pharmacy's name appears in the patient portal after approval, the same step that triggers the charge. PlexusDx has not published each pharmacy's sterile-compounding licensing or when it last reviewed the pharmacies' licenses, disciplinary history and FDA records; Bask Health, the platform PlexusDx runs on, vets the pharmacies in its own network. If a pharmacy is assigned to you, the pharmacy checks in our provider guide can be run only once you know which pharmacy fills your prescription.

PlexusDx's prescribing clinicians are provided by Lone Star Virtual Health, a separate company, and, like the pharmacies, they cover all 50 states. A Lone Star clinician, not PlexusDx, reviews your medical history and decides whether you qualify, whether to prescribe and whether to change your dose, and no medication ships without that clinician's prescription. When a live consultation is clinically required, the plan price includes it. Your treating provider is identified once you complete the intake, a step that comes after you enter card details and before any charge. PlexusDx and Bask Health both vet Lone Star and its physicians, though no dated record of prescriber license checks has been made public, so look yours up on DocInfo once you know the name. Lone Star's prescribers are all licensed physicians; it does not use nurse practitioners.

You must be at least 18 to use PlexusDx, and no one is promised that they will qualify for treatment. The rules are the same for compounded semaglutide, compounded tirzepatide and Microdose GLP-1, with Lone Star's physicians making the final call: someone who hasn't used a GLP-1 in two months needs a BMI of 25 or higher, and someone continuing one needs 22 or higher. Wegovy's weight-management label begins at a BMI of 30, or 27 with a related condition such as high blood pressure, so starting anyone below that line would be off-label. The intake's questions reach most of Wegovy's warnings, including thyroid cancer, MEN 2 in the family, pancreatitis, slow stomach emptying (gastroparesis), eating disorders, pregnancy and insulin or sulfonylurea use, but not diabetic retinopathy, which Wegovy's label flags for people with type 2 diabetes, nor plans for anesthesia or sedation, nor a B12 or glycine allergy. Under Lone Star's policy, a live visit comes first in 12 jurisdictions; our provider guide has those and the full list of questions.

PlexusDx does not bill health insurance. You are charged only after a prescriber approves treatment, so you owe nothing if you are not approved, though your card may be verified when you enroll. Until your prescription goes to the pharmacy, canceling after approval gets you a full refund; after that, generally not.

You can cancel or pause the next renewal in the self-service portal until that charge goes through, or by email or support request 3 or more business days ahead. Canceling a prepaid plan stops the next renewal but does not create a prorated refund (a refund of the unused share) of the current prepaid term.

Refunds still apply in some cases: for example, if the prescriber ends treatment for medical reasons, PlexusDx refunds prepaid months the pharmacy has not yet dispensed. PlexusDx starts approved refunds within 3 to 5 business days. PlexusDx's Refund & Cancellation Policy has the other cases, and our comparison of telehealth programs sets these terms beside other programs'. At checkout the purchase is labeled your plan, and PlexusDx is the name on your card statement. You can see prices on PlexusDx's product pages before you start; within the intake, the plan's cost, its renewal terms and the refund and cancellation rules appear at checkout, which follows questions about your goals, weight and current GLP-1 use and precedes the detailed health history.

PlexusDx does not sell or ship brand-name medications such as Ozempic or Wegovy. If you prefer a brand-name, FDA-approved medication, your provider may write a prescription you can fill at the pharmacy of your choice.

You can reach PlexusDx, Inc. at support@plexusdx.com or 6110 McFarland Station Drive, #604, Alpharetta, GA 30004.

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How we made this page

Every Novo Nordisk price, offer deadline and label fact here was read on October 3, 2026, in NovoCare's pages, price guide and offer terms and in the Wegovy and Ozempic labels on DailyMed, along with Medicare.gov, CMS, FDA's compounding pages, the cited studies, six compounded-semaglutide sellers' price pages and Optum Perks' fee page. Novo's prices and conditions are spread over 13 NovoCare pages, terms and PDFs and three FDA-approved labels, and they do not always agree (NovoCare's list-price page shows $1,027.51 on a computer and $997.58 on a phone), so AI tools collected and compared them on one day and drafted the text. A script then recomputed every total, including the ones in PlexusDx's own row, along with the list-price totals and the dated example, because details such as the 28-day pen fill and the December 31 and January 31 deadlines are easy to misread. Automated quote checks and the AI reviews that followed the draft compared each statement with the source it cites; that is a check against the sources, not a medical or legal review.

The page replaces three older PlexusDx posts on Ozempic and compounded semaglutide prices and reuses none of their text, figures or ratings. Each other company's prices link to that company's own page; PlexusDx's row and section speak for the company itself, as of October 19, 2026. For this page we did not use or buy from any of the other six companies in the compounded table, and no link here earns a commission. Ozempic, Rybelsus and Wegovy are registered trademarks of Novo Nordisk A/S.^{7, 4}

Jay Hastings, CEO of PlexusDx, reviewed and approved this version on October 19, 2026. Dr. Asad K. Niazi, MD, MPH, reviewed the medical content on October 17, 2026. He is co-founder and CEO of Lone Star Virtual Health, the company that provides PlexusDx's prescribing clinicians, so he has a business relationship with PlexusDx. PlexusDx sells compounded GLP-1 treatment, so we have a financial interest in this topic. Read our editorial policy.