As of October 3, 2026, the lowest self-pay price we found for an FDA-approved GLP-1 weight-loss medicine is $149 a month. NovoCare Pharmacy (Novo Nordisk) charges that for the starting dose of the Wegovy pill, and LillyDirect (Eli Lilly) charges it for the two lowest doses of Foundayo, also a daily pill.1, 2
Prices rise with the dose. The Wegovy pill costs $299 at the label's long-term dose and Foundayo $299 from 9 mg up, while weekly Wegovy and Zepbound injections cost $349 to $449 at long-term doses.1, 2, 3, 4 Foundayo's two highest doses and Zepbound from 7.5 mg keep those prices only if you refill within 45 days of your last delivery.2, 4 A year at a long-term dose comes to roughly $3,600 to $5,800.
Neither drugmaker's program lists a membership fee, but you need a prescription from a licensed clinician. It can be your own, one the drugmaker's program connects you with (ask what that clinician charges) or one at a pay-per-visit telehealth service that charges $39 to $49 a visit with no monthly fee (see how to skip membership fees).1, 4, 5, 6
If you have Medicare Part D, check the $50-a-month Medicare GLP-1 Bridge first.7 If a private plan won't pay, the cash prices are still open to you; if it covers the drug but turned down your request, a prior authorization or appeal may change its answer (see insurance, Medicare and the discounts you can use).8, 9 Some sellers advertise compounded semaglutide at $99 a month, but compounded drugs are not FDA-approved, and FDA recommends an approved drug when one is available and appropriate for you (see what FDA says about price).10, 11, 12, 13
Self-pay prices, checked October 3, 2026
Doses appear only because prices depend on them; your prescriber decides what fits you. Every Zepbound and Wegovy dose is priced on our pages on tirzepatide and semaglutide costs.
Prices without insurance as of October 3, 2026. The brand-name and generic options are FDA-approved for weight management; compounded drugs are not.3, 14, 15, 16 Brand-name prices cover the medicine only.
| Option |
Price without insurance |
| Wegovy pill (semaglutide), daily |
$149 a month at the 1.5 mg starting dose; $299 at the 25 mg long-term dose (30 tablets)1, 3
|
| Foundayo (orforglipron), daily pill |
$149 a month at 0.8 mg or 2.5 mg, $199 at 5.5 mg, $299 at 9 mg, 14.5 mg or 17.2 mg (30 days; on-time refills needed at the two highest doses; 2.5 and 5.5 mg prices reduced through December 31, 2026)2
|
| Wegovy pen (semaglutide), weekly |
$349 per 28-day box up to 2.4 mg; $199 each for a new patient's first two boxes, a limited-time offer; $399 for Wegovy HD 7.2 mg1, 8
|
| Zepbound (tirzepatide) vials or KwikPen (a four-dose pen), weekly |
$299 at the 2.5 mg starting dose; $399 at 5 mg; $449 at 7.5 mg and up if each refill is bought within 45 days of the last delivery (otherwise $499 at 7.5 mg and $699 from 10 mg); 28-day supply4, 9
|
| Generic liraglutide (generic Saxenda), daily injection |
$716.50 for a box of five 18 mg pens, about 30 days at 3 mg a day (longer while the dose is being raised), at Mark Cuban Cost Plus Drug Company; shipping and pen needles cost extra17, 18
|
| Compounded semaglutide or tirzepatide (not FDA-approved) |
Examples: Eden, $99 a month for semaglutide on a monthly subscription; Trimi, $99 a month for semaglutide or $125 for tirzepatide on a 12-month plan billed $1,188 or $1,500 upfront10, 11
|
Who these drugs are approved for. For adults, Wegovy, Foundayo, Zepbound and liraglutide are approved for obesity, or for overweight plus at least one weight-related health problem, alongside a reduced-calorie diet and more exercise. In the trials behind those approvals, obesity meant a body mass index (BMI) of 30 or more, and overweight a BMI of 27 to just under 30 with a condition such as high blood pressure, unhealthy cholesterol, sleep apnea or heart disease.3, 14, 15, 18 Wegovy injections and liraglutide are also approved for some children 12 and older with obesity, a decision for the child's own doctor.3, 18
Novo's cash prices for Wegovy, and Lilly's for the Zepbound KwikPen and Foundayo, are only for prescriptions written for an FDA-approved use.8, 9, 19, 20 If you are an adult and don't fit these uses, taking a GLP-1 for weight loss would be off-label for you, so weigh that with a clinician who knows your health history, such as your own doctor (see GLP-1s for people who are not obese or overweight). All of these drugs carry serious warnings, including a boxed warning about thyroid tumors (see the warnings).
How to skip the membership fee
NovoCare Pharmacy and LillyDirect fill a valid prescription for an approved use at the prices above, list no membership fee, and offer to connect you with a prescriber if you don't have one.1, 4 What you pay on top of the medicine depends on who writes the prescription. Four common setups, with examples from each company's own website:
Four ways GLP-1 care is billed, with examples as of October 3, 2026
| Setup |
What you pay |
| Your own clinician, or one the drugmaker connects you with |
That clinician's fee (ask first), plus the self-pay price for each fill |
| Pay-per-visit telehealth, medicine bought separately |
Optum Perks Online Care: $39 for each prescription request, including refills, and $39 per follow-up visit, with no monthly fee.5 Walgreens Weight Management: $49 per visit with no subscription; it does not currently serve Medicare patients.6
|
| A membership, medicine billed separately |
Ro: $39 for the first month, then $149 a month, or from $74 a month if you prepay a year. Ro says the membership includes provider check-ins, messaging and insurance help; GLP-1 medication costs extra.21
|
| One price for compounded medicine (not FDA-approved) |
Eden: $99 a month for semaglutide, which Eden says includes provider review and delivery, with no separate membership fee and a subscription you can cancel at any time.10 Trimi: $99 a month for semaglutide, only on a 12-month plan billed $1,188 upfront, or $175 a month without that commitment. Trimi says plans include the medicine, provider consultations and shipping, and annual plans don't renew automatically.11
|
Visit fees add up over a year. At $39 for each prescription request or follow-up visit, four a year add $156 to the cost of the medicine and twelve add $468. Your prescriber decides how often you need one.
Before paying any program, add up a year of charges at the dose you expect to take, and ask how often you will be billed, whether you must prepay several months and how cancelling and refunds work, since a plan with no membership fee can still renew every month. For renewal, prepaid-plan and refund terms compared across programs, see how GLP-1 telehealth programs bill.
Why a year costs more than the first month suggests
The first price you see is rarely what a year costs, for five reasons.
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Starting doses cost least. The $149 prices are for the Wegovy pill's 1.5 mg starting dose and Foundayo's 0.8 mg and 2.5 mg tablets, which its label uses as steps on the way to 5.5 mg or more. Its main trial tested 5.5, 9 and 17.2 mg.1, 2, 3, 14 Zepbound's $299 dose, 2.5 mg, is only for starting treatment, and the label's long-term doses are 5, 10 or 15 mg.4, 15
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A month of injections is 28 days. A box of four Wegovy pens and a month of Zepbound each last 28 days, so 13 purchases cover 364 days. The pills come in 30-day supplies, so 12 fills cover 360 days.1, 2, 4, 8
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Late refills cost more. Zepbound's $449 price at 7.5 mg and up, and Foundayo's $299 price at 14.5 mg and 17.2 mg, hold only if each refill is bought within 45 days of the last delivery; otherwise Lilly's regular prices apply, up to $699 for Zepbound and $349 for Foundayo.9, 20
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Several offers have 2026 deadlines. Novo's $199 price on a new patient's first two Wegovy pen boxes, which saves $300, needs a prescription by December 31, 2026. NovoCare Pharmacy must receive it by then and ship the boxes by January 31, 2027; a local pharmacy must fill it by December 31.8, 19 Lilly's reduced Foundayo prices at 2.5 mg and 5.5 mg end December 31 and return to $199 and $299. Its savings cards for cash buyers of the Zepbound KwikPen (up to 11 fills a calendar year) and Foundayo (up to 10) end the same day.9, 20 Both drugmakers say they can change or end their offers at any time.1, 9, 20
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Supplies and taxes are extra. Zepbound vials and KwikPens need needles or syringes, bought separately, and Lilly lists its prices as starting prices and says taxes and fees may apply.4, 9
These drugs are meant for long-term use, and in trials people who stopped the brand-name drugs regained much of the weight they had lost, so plan for the cost to continue.22, 23 If today's prices hold, a year at a long-term dose comes to:
- Wegovy pill at 25 mg: $3,588 (12 fills of 30 days at $299).1, 3
- Wegovy pen: $4,537 (13 boxes at $349).1, 8
- Zepbound vials at 5 mg: $5,187 (13 fills at $399).4
- Zepbound vials at 7.5 mg and up: $5,837 (13 fills at $449, with every refill on time).4
A full year of KwikPens or Foundayo at these prices is not assured, because Lilly's cash-buyer cards cover up to 11 and 10 fills a calendar year, so ask LillyDirect what further fills would cost.9, 20 Starting doses make the first year a little cheaper; for the first year added up fill by fill, see what tirzepatide and semaglutide cost without insurance.
List prices, set before discounts or rebates, are much higher: $1,349.02 per package for Wegovy and up to $1,086.37 per fill for Zepbound.24, 25 Novo Nordisk plans to cut Wegovy's list price to $675 a month on January 1, 2027, and says the change will not affect its self-pay prices.26
Insurance, Medicare and the drugmaker discounts you can use
Drugmakers run two kinds of offers. Copay cards lower your share when commercial insurance covers the drug, and Lilly's Zepbound card also sets a price when it doesn't. Cash self-pay prices are for buying outside insurance, and people who have insurance can use them too.8, 9
Which offers each buyer can use, from the drugmakers' terms and Medicare.gov, as of October 3, 20267, 8, 9, 20
| Your coverage |
Cash price |
Copay card |
Bridge ($50) |
| None |
Yes |
No |
No |
| Private plan that covers the drug |
Yes, outside your plan |
Yes |
No |
| Private plan that excludes it |
Yes |
Lilly only* |
No |
| Medicare Part D |
Yes, if you don't bill your plan |
No |
If you qualify |
| Medicaid, TRICARE or VA (no Medicare) |
Yes, if you don't bill your program |
No |
No |
*Lilly's Zepbound savings card also sets a price for commercial plans that don't cover Zepbound: as little as $499 a month for single-dose pens (one dose per pen), through December 31, 2026. That is more than the on-time cash price for vials or KwikPens.9
Copay card limits. Novo's Wegovy card caps savings at $100 a month, so you pay $25 only if your plan's share is $125 or less.8 Lilly's $25 Zepbound price is for single-dose pens your plan covers, with savings capped at $100 a month and $1,300 a year until the card ends on December 31, 2026.9 Lilly says people whose commercial plan covers Foundayo could pay as little as $25 a month, with savings capped at $100 a month and $1,000 a year and up to 10 fills a year, also through December 31, 2026 (see what Foundayo costs with insurance).2, 20
Paying cash when you have coverage. The drugmakers' cash-price terms ask you not to bill your plan or count the cost toward its deductible or out-of-pocket limit, so these purchases won't help you reach those limits.8, 9
Medicare. Since July 1, 2026, the temporary Medicare GLP-1 Bridge has covered Foundayo, Wegovy (pill or pen) and the Zepbound KwikPen for a $50 monthly copay, for people who meet BMI and health criteria narrower than the drugs' approved uses.7 It excludes people who already get a GLP-1 through Part D, and people with type 2 diabetes, moderate to severe obstructive sleep apnea, or MASH (a form of fatty liver disease with inflammation and liver damage that can lead to scarring) with moderate to advanced scarring (stage F2 or F3) but not cirrhosis, because Part D plans can cover GLP-1s for those conditions.7, 27 Its BMI tiers and approval steps are on our UnitedHealthcare page, and Medicare.gov suggests comparing cash prices on TrumpRx.gov, which lists prices but doesn't sell drugs.7
If your plan said no. If your plan covers Zepbound or Wegovy but turned down your request, ask your prescriber whether a prior authorization (the plan's approval before it pays) or an appeal could change that; see how Zepbound prior authorization works. For specific insurers, see our pages on UnitedHealthcare and Anthem coverage.
Free-medicine programs. Neither drugmaker's free-medicine list included its weight-loss GLP-1s on October 3, 2026. Novo Nordisk's list has Ozempic, for uninsured people within its income limit, but not Wegovy, and Ozempic is approved only for type 2 diabetes, so this is not a route to free weight-loss treatment. The Lilly Cares Foundation lists Trulicity but not Zepbound, Mounjaro or Foundayo.28, 29, 30, 31
Other coverage questions. See our pages on Medicaid coverage of GLP-1s, TRICARE and VA coverage and paying with an HSA, FSA or CareCredit.
Compounded GLP-1s, and what FDA says about price
Compounded semaglutide and tirzepatide are often advertised for less than the brand-name self-pay prices, though not always, so compare a full year at the dose you would take.
Not approved, not reviewed. Compounded drugs are not FDA-approved, and FDA does not review them for safety, effectiveness or quality before they are sold. FDA says they should be used only by patients whose medical needs an approved drug cannot meet, and it recommends an FDA-approved drug when one is available and appropriate.12, 13 Since FDA declared the shortages of both drugs over, a state-licensed pharmacy may still compound them for an individual patient's prescription, but it may not regularly make what FDA calls essentially copies of the approved drugs unless the prescriber records a change that makes a significant difference for that patient.32 Our provider guide sets out the rules since the shortages ended; see also whether your own doctor can prescribe compounded tirzepatide.
A lower price is not a medical reason. FDA's guidance says a lower price is not enough to show that a compounded drug is not essentially a copy of an approved one. Its examples of a real patient-specific reason are a patient who is allergic to a dye in the approved product, or who cannot swallow a tablet and needs a liquid form that isn't otherwise available, with the reason documented on the prescription.33 If you are offered a compounded GLP-1, ask the prescriber what makes it medically right for you instead of an approved drug.
Price as a warning sign. One of FDA's warning signs for buying these drugs online is a company that "offers medicine at deep discounts or prices that seem too good to be true." FDA lists several others, such as a company that claims a compounded drug is the same as an FDA-approved one, or that does not require a screening and a prescription by a licensed doctor.12 Our guide to checking a compounded provider before you pay goes through them.
Bundles and tablets. Adding vitamin B12 or another ingredient, or selling the drug as a tablet or under-the-tongue form, does not make a compounded GLP-1 approved or shown to work better, and that holds for any such product, including any dispensed to people who enroll through PlexusDx. A 2026 review of such products found little justification for the added nutrients and no shown advantage for those forms over approved tablets.34 Our provider guide covers added ingredients and pills in more depth.
Microdosing. "Microdosing" usually means taking less than a drug's labeled starting dose, or spacing doses further apart than the label says. People use it to try to ease side effects, cut costs or stretch supplies, and it is off-label. A September 2026 commentary in Expert Opinion on Pharmacotherapy said high-quality evidence for it is essentially absent, and that safety concerns persist about compounded products, nonstandard dose measurement and dosing accuracy.35 FDA has received reports of adverse events, some needing hospital care, that may be related to dosing errors with compounded semaglutide injections.12 That caution applies to any microdose offer, wherever you see it. Your dose should come from your prescriber and your pharmacy label.
Pills, generic liraglutide and older medicines
If you want a pill. The Wegovy pill and Foundayo, both in the price table, are FDA-approved GLP-1 pills for weight loss.3, 14 NovoCare also sells Ozempic for self-pay as a pen and as a pill, and Rybelsus is another semaglutide tablet. Ozempic (pen and pill) and Rybelsus are approved only for adults with type 2 diabetes, so taking them just for weight loss is off-label, and NovoCare's cash prices for Ozempic require a prescription for a use on its label.1, 19, 30, 36
Generic liraglutide. In August 2025, Teva launched a generic version of Saxenda (liraglutide), the first generic GLP-1 approved for weight loss.16 It is injected once a day. Its label sets one long-term adult dose, 3 mg a day, with lower doses used only to work up to it, and says your prescriber should stop it if you have not lost at least 4% of your weight after 16 weeks.18 Generic does not automatically mean cheaper, and prices vary between pharmacies: Mark Cuban Cost Plus Drug Company, for example, lists a box of five pens at $716.50 plus shipping, so ask what a month at your prescribed dose would cost.17
Older medicines that are not GLP-1s. The National Institute of Diabetes and Digestive and Kidney Diseases, part of NIH, lists other FDA-approved medicines for long-term weight management, including orlistat, phentermine-topiramate and naltrexone-bupropion. It advises learning a medicine's side effects and warnings before taking it, and never taking weight-loss medicines during pregnancy or when planning one.37 Ask your clinician and pharmacist what one would cost you.
Results and risks behind the prices
Results differ by drug, too. In separate main trials, not head-to-head comparisons, average weight loss was lower with Foundayo or liraglutide than with Wegovy or Zepbound, and none of the trials tested compounded products.3, 14, 15, 18 For how weight loss builds over time, see expected weight loss per month on tirzepatide.
A $149 starting dose carries the same boxed warning as a $449 injection. These points come from the labels for Wegovy, Zepbound, Foundayo and Saxenda. Compounded semaglutide and tirzepatide come with no FDA label. But FDA says many side effects reported with them resemble those reported with the FDA-approved drugs, and that compounded drugs pose a higher risk because FDA does not review them, so go through these warnings with a prescriber before taking a compounded product too.12, 13
Boxed warning on thyroid tumors. In rodent studies, semaglutide, tirzepatide and liraglutide caused thyroid C-cell tumors; orforglipron, the drug in Foundayo, does not act on the GLP-1 receptor in rats or mice, so those studies could not show whether it causes them. Its label says it would be expected to have the same effect if it did act on that receptor in rats, so Foundayo carries the same boxed warning. It is not known whether any of these drugs causes thyroid C-cell tumors, including a type of thyroid cancer called medullary thyroid carcinoma (MTC), in people. None of them is for anyone with a personal or family history of MTC, anyone with multiple endocrine neoplasia syndrome type 2 (MEN 2), or anyone who has had a serious allergic reaction to the drug or its ingredients.3, 14, 15, 18
Other warnings. All four labels list these, except where noted.3, 14, 15, 18
- Pancreatitis, including severe forms that have been fatal. The labels call for stopping the drug if it is suspected.
- Gallbladder problems, such as gallstones.
- Low blood sugar, most often in people who also take insulin or a sulfonylurea; the Wegovy, Zepbound, Foundayo and Saxenda labels say it has also occurred in people without type 2 diabetes.3, 14, 15, 18
- Dehydration from nausea, vomiting or diarrhea, which can lead to sudden kidney injury, in some cases needing dialysis.
- Severe stomach and bowel problems. The drugs are not recommended for people with severe gastroparesis (very slow stomach emptying).
- Serious allergic reactions, such as anaphylaxis and angioedema (swelling under the skin).
- Food or liquid getting into the lungs during general anesthesia or deep sedation, so tell every clinician that you take one before a procedure.
- Possible harm to a developing baby. The labels say to stop when a pregnancy is recognized, and Wegovy's says to stop at least 2 months before a planned pregnancy.
- No doubling up: each label advises against taking the drug with any other GLP-1 medicine, including compounded semaglutide or tirzepatide, so never take two GLP-1 products at the same time.
- Worsening diabetic eye disease in people with type 2 diabetes (on the Wegovy, Zepbound and Foundayo labels).3, 14, 15
- Pens are for one person: never share a KwikPen, Wegovy FlexTouch pen or Saxenda pen, even with a new needle, because sharing can spread blood-borne infections (Zepbound, Wegovy and Saxenda labels).3, 15, 18
Differences that can change which one fits you:
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Birth control pills. Foundayo and Zepbound may make birth control pills less effective. Their labels advise switching to a non-pill method, or adding a barrier method, for 30 days after starting Foundayo or 4 weeks after starting Zepbound, and for the same period after each dose increase. Foundayo's label also advises effective birth control throughout treatment.14, 15
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Taking the Wegovy pill. It is taken on an empty stomach with no more than 4 ounces of water, with nothing else by mouth, including other pills, for at least 30 minutes afterward; Foundayo can be taken with or without food. In a study, semaglutide tablets raised levels of levothyroxine (a thyroid hormone medicine) by about a third, so tell your prescriber if you take it.3, 14
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Other medicines and Foundayo. List everything you take for your prescriber and pharmacist, because some medicines raise or lower the amount of Foundayo in the blood. Its label says to avoid or limit some that strongly block or speed up a liver enzyme called CYP3A4 (ritonavir is its example), and limits how much simvastatin, a cholesterol medicine, can be taken with it.14
-
Severe liver disease. Foundayo's label says it is not recommended for people with severe liver impairment, so tell your prescriber about any serious liver problem.14
-
Breastfeeding. It is not recommended while taking the Wegovy pill or Foundayo; ask your provider about the injections.3, 14
-
Heart rate. Wegovy and Saxenda can raise resting heart rate, and their labels call for regular checks. Foundayo raised it by 4 to 5 beats a minute on average in trials.3, 14, 18
The most common side effects on these labels are stomach and bowel symptoms such as nausea, diarrhea, vomiting and constipation.3, 14
When to get help. Stop taking the medicine and get help at once for either of these:
- Severe stomach pain that won't go away. Call your provider right away.
- Signs of a serious allergic reaction, such as swelling of the face, lips, tongue or throat, or trouble breathing or swallowing. Get medical help right away.3
If you think you took too much, which can cause severe nausea, vomiting and low blood sugar, call your provider or Poison Help at 1-800-222-1222, or go to an emergency room.3
Call your provider right away about either of these:
- Pain in the upper stomach, fever, yellowing of the skin or eyes, or clay-colored stools, which can signal gallbladder problems.3, 14, 15
- Nausea, vomiting or diarrhea that won't stop.3, 14, 15, 18
Call your provider promptly about any of these:
- A lump or swelling in the neck, hoarseness, trouble swallowing or shortness of breath.
- Vision changes, if you have type 2 diabetes.
- A racing heartbeat at rest that lasts several minutes.3
If you take insulin or a sulfonylurea, ask how to recognize and treat low blood sugar.3
PlexusDx's compounded plans and their terms
PlexusDx publishes this page and earns money from the offer described here. Treatment through PlexusDx uses compounded medicine, which is not FDA-approved; FDA does not review it for safety, effectiveness or quality before it is sold.12 Go through the warnings above with your clinician before starting it.
Prices, as of October 19, 2026. Each product comes in 1-, 3-, 6- and 12-month plans. The 1-month plan is charged monthly; longer plans are charged in full once a clinician approves treatment, so their monthly figures are for comparison. There is no separate membership fee. Plans renew automatically for the same length at your existing price, which will not rise without your agreement, until you cancel or pause.
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Compounded tirzepatide (weekly injection with vitamin B12 or glycine added, or daily orally disintegrating tablet, at the same price): $189 a month on a 1-month plan; $169 a month on a 3-month plan, charged $507 up front; $149 a month on a 6-month plan, charged $894 up front; or $129 a month on a 12-month plan, charged $1,548 up front.
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Compounded semaglutide (weekly injection with added vitamin B12 or glycine, or daily orally disintegrating tablet, priced the same): $149 a month on a 1-month plan; $129 a month on a 3-month plan, charged $387 up front; $109 a month on a 6-month plan, charged $654 up front; or $99 a month on a 12-month plan, charged $1,188 up front.
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Microdose GLP-1 (tirzepatide or semaglutide, as a weekly injection with vitamin B12 added or as a daily tablet): $99 a month on a 1-month plan; $89 a month on a 3-month plan, charged $267 up front; $79 a month on a 6-month plan, charged $474 up front; or $69 a month on a 12-month plan, charged $828 up front. Doses below those on the FDA-approved tirzepatide and semaglutide labels are off-label, and the microdosing caution above applies to this plan.
A prescription generally covers up to six months, so a 12-month plan includes a renewed clinical review; if it is not completed, shipments pause and unused prepaid time is kept.
What the price covers. Clinician care (including any clinically required live visit), the compounded medicine, injection supplies where needed and shipping are included, with no separate shipping charge; extras such as outside lab tests, emergency, specialist or in-person care, and taxes are not. For the same medication and plan, a dose change by your clinician does not by itself raise the price; switching medicines moves you to the new medicine's price.
Medicine and pharmacy. PlexusDx's Terms of Service say added ingredients may vary by pharmacy and fill. As the price list shows, each drug comes as an injection taken weekly or an orally disintegrating tablet (ODT) taken daily, and the form does not change the price. No tirzepatide tablet is FDA-approved. FDA-approved semaglutide tablets are Rybelsus (also labeled as Ozempic tablets) and Wegovy tablets; FDA has not approved any compounded semaglutide tablet. Each injection in the catalog contains vitamin B12 or glycine, so none comes without an add-in; only California residents are asked which they prefer, and elsewhere the pharmacy determines it without checkout saying which. Lone Star requires any clinical case for the add-in to rest on the patient's own needs, and the full makeup of the tablets is not published. Microdose GLP-1 injections, made with B12, go from 0.12 mg to 0.5 mg of semaglutide a week, or tirzepatide doses from 0.5 mg up to 1.5 mg; ask the prescriber what dose a Microdose tablet would use. Allergies you report in the intake go to the physician to weigh, and because vitamin B12 and glycine are missing from its allergy checklist, name them yourself if they apply.
Under federal law, a 503A compounding pharmacy compounds each drug for an individual patient based on a prescription.32 PlexusDx uses only state-licensed 503A compounding pharmacies, covering all 50 states. Patients may request a specific pharmacy, if it is available and the law allows; otherwise one is assigned. The portal shows you which pharmacy was assigned after a clinician approves treatment, which is when the charge is taken, so to check a pharmacy before you pay, request one you have already looked up.
Billing and cancelling. PlexusDx may verify your payment method when you enroll but charges nothing unless a clinician approves treatment. Cancel or pause a renewal in the self-service portal before it is charged; send email or support requests at least three business days before renewal.
Cancelling stops the next renewal but does not create a prorated refund (money back for the unused months) of the current prepaid term; the treatment you paid for stays available through the term while clinically appropriate. You can still ask for a full refund if you cancel after approval but before the prescription is sent to the pharmacy. If a clinician stops treatment for medical reasons, PlexusDx refunds the prepaid months not yet dispensed, at the monthly rate you actually paid. The full rules are in PlexusDx's Refund & Cancellation Policy and Terms of Service; for other programs' terms, see how GLP-1 telehealth programs bill.
Checkout labels the purchase a plan, and your card statement will show the charge under the name PlexusDx.
Who decides. PlexusDx is not a medical practice or a pharmacy. The decision to prescribe belongs to a U.S.-licensed clinician who is independent of PlexusDx: that clinician reviews your medical history, confirms whether you are eligible, and must approve before any medication ships. PlexusDx's prescribers come from the provider group Lone Star Virtual Health and cover all 50 states.
You must be at least 18 to use PlexusDx. Lone Star's physicians apply one set of rules to PlexusDx's three GLP-1 plans, Microdose GLP-1 included: new patients need a BMI of at least 25, and people who have used a GLP-1 medicine within the last two months need at least 22 to keep going. The 25 cutoff sits under the approved labels' lines for Zepbound and Wegovy, a BMI of 30, or 27 plus a weight-related condition, so starting someone between those numbers would be off-label.
Compounded medication through PlexusDx is cash pay and is not billed to insurance. PlexusDx does not sell or ship brand-name medicines. If you would prefer a brand-name, FDA-approved medicine, your provider may write a prescription that you can fill at the pharmacy of your choice.
Sources
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NovoCare Pharmacy: Get Your GLP-1 Medications Delivered, Novo Nordisk, accessed October 3, 2026.
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Foundayo (orforglipron) | LillyDirect, Eli Lilly and Company, accessed October 3, 2026.
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WEGOVY (semaglutide) injection and tablets: prescribing information and Medication Guide (revised 6/2026), Novo Nordisk, via DailyMed, National Library of Medicine, accessed October 3, 2026.
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Zepbound (tirzepatide) | LillyDirect, Eli Lilly and Company, accessed October 3, 2026.
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Get Your GLP-1 Prescription For Weight Loss Online, Optum Perks Online Care, accessed October 3, 2026.
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GLP-1s for Weight Loss: Online Treatment, Walgreens Weight Management, accessed October 3, 2026.
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Weight loss drugs (Medicare GLP-1 Bridge), Centers for Medicare & Medicaid Services, Medicare.gov, accessed October 3, 2026.
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Wegovy Savings Offer and Self-Pay Offer: Terms and Conditions, Novo Nordisk, accessed October 3, 2026.
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How we made this page
This page replaces five older PlexusDx posts about GLP-1 costs. Those posts led with PlexusDx's own "Microdose" price as the cheapest option without saying that doses below the labeled ones are off-label, called compounded drugs generic or identical to brand-name drugs, made claims about PlexusDx's service that we could not verify, and repeated competitor prices we could not check. None of their text or prices was kept.
What a GLP-1 costs depends on the dose, the refill date, how many fills you get and who pays, and each of those rules sits in a different dated document: two drugmakers' card and offer terms, Medicare's and CMS's Bridge pages, FDA's statements and guidance, the drug labels and six other companies' price pages. AI tools gathered those documents and the other sources listed above as they read on October 3, 2026, and drafted the text only from the listed sources and PlexusDx's own terms. A script recomputed the yearly totals, and automated quote checks and later AI review passes compared each price, condition and medical statement with its cited source; these automated checks are not a medical or legal review.
Competitor prices come only from each company's own website; for this page we did not use or test those services, and the page has no affiliate links. PlexusDx's prices are its own as of October 19, 2026, confirmed by Jay Hastings; its other terms come from its published policies, linked above. Jay Hastings reviewed and approved this version on October 19, 2026 and is responsible for it. Dr. Asad K. Niazi, MD, MPH, reviewed the medical content on October 17, 2026. He is co-founder and CEO of Lone Star Virtual Health, the company that provides PlexusDx's prescribing clinicians, so he has a business relationship with PlexusDx. PlexusDx sells compounded GLP-1 treatment, so we have a financial interest in this topic. Read our editorial policy.
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