Best Month-to-Month Semaglutide Providers: 2026 Pricing Compared

Last reviewed: September 8, 2026 Last updated: September 8, 2026

Written by: Jay Hastings, CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

PlexusDx publishes this comparison and is one of the providers discussed. We use the same evidence rules for our own program and competing programs.

The short answer

If you want a month-to-month semaglutide plan with no upfront commitment and no separate membership fee, PlexusDx ($189/month for compounded semaglutide injection) and OrderlyMeds ($149/month ongoing, after a two-month $149 starter) deliver the lowest effective 12-month costs in the no-membership category. Eden ($198/month ongoing: $99 medication + $99 membership) and Henry Meds ($297/month) offer month-to-month billing but carry higher ongoing totals. MEDVi advertises a $179 introductory first month but refills at $299, raising the 12-month cost above providers with flat rates. Mochi Health has an advertised first-month rate of $99 ($60 medication + $39 membership) for the starting dose but uses per-dose pricing, so total cost depends on your prescribed dose over time. We normalize first-month promotions, refill rates, membership structures, and 12-month totals below so you can compare like billing models and identify hidden fees before checkout.

At-a-glance month-to-month semaglutide comparison

All pricing captured September 4–8, 2026. Month-to-month rates and 12-month costs are our calculations based on provider-published rates. Effective 12-month costs assume uninterrupted monthly billing at the stated ongoing rate after any introductory period.

Normalized 12-month cost breakdown

Advertised monthly rates often separate first-month promotions from ongoing refills, and some providers charge membership fees on top of medication costs. We calculate the effective 12-month total—medication, membership, and any introductory discounts combined—so you see the true recurring expense.

PlexusDx: $189/month, $2,268 over 12 months

PlexusDx charges $189/month for compounded semaglutide injection with month-to-month billing. The same price applies at every dose, and there is no separate membership fee. Medication, clinician review, unlimited support, and shipping are included. Over 12 months the total is $2,268 (our calculation: $189 × 12). You may cancel anytime. PlexusDx works with licensed 503A compounding pharmacies (pricing captured September 8, 2026; September 4, 2026).

OrderlyMeds: $149/month ongoing, $1,639 over 12 months

OrderlyMeds offers a two-month starter pack for $149 total—an effective rate of $74.50 per month (our calculation) for the first two months—then bills $149/month ongoing. Over 12 months the total is $1,639 (our calculation: $149 starter + $149 × 10). This is the lowest 12-month cost in the group. The platform also lists Wegovy pens at $1,839 per 28 days and Zepbound pens at $1,498 per 28 days for branded options. Compounded semaglutide and tirzepatide injections are available, and no separate membership fee is advertised (pricing captured September 4, 2026).

OrderlyMeds holds a 3.6-star rating across approximately 634 reviews on Trustpilot. Captured one- and two-star reviews cite fast initial charging but slow refunds, non-response to support inquiries, delayed shipping, pharmacy changes mid-treatment, and continued calls and texts after opting out (Trustpilot, captured September 4, 2026). If delivery reliability and support responsiveness are priorities, weigh these reports against the lower cost.

Eden: $198/month ongoing, $2,316 over 12 months

Eden separates medication and membership. The advertised first-month rate is $39 membership plus $99 medication, for a total of $138. From month two onward, membership rises to $99/month, so the ongoing all-in rate is $198/month ($99 medication + $99 membership), and the ongoing refill cost is $198. Over 12 months the total is $2,316 (our calculation: $138 first month + $198 × 11). Injectable and oral formulations are available; route is clinician-dependent. Billing is monthly (pricing captured September 4, 2026).

Eden holds a 4.5-star rating across approximately 5,000 reviews on Trustpilot. One captured one-star review reports an 11-day order delay and repeated requests for medical records that Eden had previously issued (Trustpilot, captured September 4, 2026).

MEDVi: $179 first month / $299 refill, $3,468 over 12 months

MEDVi advertises a $179 first-month introductory rate for compounded semaglutide injection, verified at checkout (captured September 4, 2026). Refills are billed at $299/month. Semaglutide tablets add $70. Over 12 months the total is $3,468 (our calculation: $179 + $299 × 11). Tirzepatide injection is $279 first month and $399 per refill. Medication, clinician care, and shipping are included; there is no separate membership fee. Billing is monthly with no contract, and you may cancel anytime (pricing captured September 4, 2026).

MEDVi also offers branded Wegovy and Zepbound pathways at $99/month membership plus medication cost. MEDVi holds a 4.3-star rating across approximately 15,000 reviews on Trustpilot (captured September 4, 2026).

Mochi Health: advertised first-month rate $99, varies by prescribed dose

Mochi Health uses per-dose pricing. The advertised first-month rate for the starting dose is $60/month medication plus $39/month membership, for a total of $99/month. Ongoing membership remains $39/month, separate from medication. Higher doses carry higher medication costs, so your effective monthly rate will change if your provider titrates your dose upward. We cannot calculate a fixed 12-month total without knowing your prescribed dose progression. Injectable semaglutide and tirzepatide and branded options are available (pricing captured September 4, 2026).

Mochi Health holds a 4.5-star rating across approximately 18,000 reviews on Trustpilot. One captured example reports a provider appearing late to a video visit and not engaging during the consultation (Trustpilot, captured September 4, 2026).

Peak Wellness: $249/month, $2,988 over 12 months

Peak Wellness charges one ongoing monthly rate of $249 for compounded semaglutide with no separate membership fee. Over 12 months the total is $2,988 (our calculation: $249 × 12). Multi-month prepaid plans offer lower per-month rates. Month-to-month or prepaid billing is available (pricing captured July 23, 2026).

Henry Meds: $297/month, $3,564 over 12 months

Henry Meds charges $297/month for compounded semaglutide injection on a month-to-month plan. Over 12 months the total is $3,564 (our calculation: $297 × 12). Six-month plans are $1,782 (effective $297/month) or $1,482 prepaid-in-full; 12-month plans are $3,564 (effective $297/month) or $2,364 prepaid-in-full. Sublingual semaglutide tablets are $249/month month-to-month; premium tablets or drops are $179/month month-to-month. No separate membership fee is charged; medication, provider access, and shipping are included. Tirzepatide is offered as an oral dissolving tablet only, not an injection (pricing captured September 4, 2026; July 23, 2026).

Henry Meds holds a 4.4-star rating across approximately 13,000 reviews on Trustpilot (captured September 4, 2026).

Decision factors beyond the monthly rate

First-month promotions versus ongoing refills

MEDVi and Eden both advertise reduced first-month rates. MEDVi's $179 introductory price rises to $299 per refill, adding $1,320 over the remaining 11 months compared to a flat $179 rate (our calculation). Eden's $39 first-month membership becomes $99/month, adding $660 over 11 months compared to a flat $39 membership (our calculation). OrderlyMeds offers a two-month $149 starter then bills $149/month, so the per-month cost remains consistent after the starter period. PlexusDx, Peak Wellness, and Henry Meds charge one flat rate every month with no introductory discount or refill increase.

Membership fees

Eden and Mochi Health separate membership from medication cost. Eden membership is $99/month ongoing (after $39 in month one), so the effective all-in rate for semaglutide is $198/month. Mochi membership is $39/month, and medication cost varies by dose. PlexusDx, OrderlyMeds, MEDVi, Peak Wellness, and Henry Meds bundle everything into one monthly price with no separate membership line item.

Dose-based versus flat pricing

Mochi Health charges per dose; as your provider titrates upward, your medication cost rises. PlexusDx, MEDVi, Peak Wellness, and Henry Meds charge the same monthly rate at every dose. OrderlyMeds and Eden do not specify per-dose variation in captured pricing.

Cancellation and commitment

All seven providers in this comparison offer month-to-month billing with no long-term contract. PlexusDx, OrderlyMeds, MEDVi, Eden, Mochi Health, Peak Wellness, and Henry Meds state you may cancel anytime. No early-termination fees are advertised for month-to-month plans.

Choose OrderlyMeds if…

• You want the lowest effective 12-month cost ($1,639) and are comfortable with the two-month starter structure.
• You accept the 3.6-star Trustpilot rating and are prepared to monitor order fulfillment and support responsiveness closely.
• You prefer no separate membership fee.

Choose Eden if…

• You value the 4.5-star Trustpilot rating across approximately 5,000 reviews.
• You want access to both injectable and oral formulations, with route determined by your clinician.
• You are comfortable separating membership ($99/month ongoing) and medication ($99/month semaglutide) into two line items.
• The $2,316 effective 12-month cost fits your budget.

Choose MEDVi if…

• You want a lower first month ($179) to test the service before committing to the $299 refill rate.
• You value the option to add semaglutide tablets for $70.
• You accept the higher 12-month total ($3,468) in exchange for month-to-month flexibility and the 4.3-star Trustpilot rating.

Choose Mochi Health if…

• You are starting at a low dose and want an advertised first-month rate of $99 ($60 medication + $39 membership).
• You understand that your medication cost will rise as your provider increases your dose.
• You value the 4.5-star Trustpilot rating across approximately 18,000 reviews and are comfortable with the per-dose pricing model.

Choose Peak Wellness if…

• You want a single flat rate ($249/month) with no membership fee and no first-month-versus-refill complexity.
• You may consider a multi-month prepaid plan later to lower the per-month rate.

Choose Henry Meds if…

• You value the 4.4-star Trustpilot rating across approximately 13,000 reviews.
• You want access to sublingual tablets ($249/month) or premium tablets/drops ($179/month) in addition to injectable semaglutide.
• You accept the higher month-to-month rate ($297) for the no-membership, medication-provider-shipping-included structure.

Where PlexusDx fits

PlexusDx charges $189/month for compounded semaglutide injection with month-to-month billing, no separate membership fee, and the same price at every dose. Over 12 months the total is $2,268—higher than OrderlyMeds ($1,639) but lower than the advertised first-month total for Eden ($2,316, with a first-month rate of $138 and ongoing refill cost of $198), Peak Wellness ($2,988), Henry Meds ($3,564), and MEDVi ($3,468). Medication, clinician review, unlimited support, and shipping are included. You may cancel anytime. PlexusDx works with licensed 503A compounding pharmacies and holds a 4.3-star rating on Trustpilot, with 79% of reviews at five stars and 83% at four stars or higher (captured September 9, 2026). If you want transparent flat-rate pricing, no membership complexity, and a mid-range 12-month cost with solid review performance, PlexusDx is a practical choice.

Methodology and freshness

We captured publicly displayed pricing from each provider's website and verified figures at checkout where possible between July 20 and September 8, 2026. All 12-month cost calculations are our own, derived by summing advertised monthly rates and any introductory discounts over a 12-month period. Review ratings and volume are captured from Trustpilot on September 4, 2026. Individual review examples are paraphrased allegations reported by users on that platform; they do not represent verified facts or typical outcomes. Pricing may change; confirm at checkout before purchase. We do not guarantee eligibility, prescribed medication, dose, or treatment outcomes.

Frequently Asked Questions

What is the cheapest month-to-month semaglutide provider?

OrderlyMeds offers the lowest effective 12-month cost at $1,639 ($149 two-month starter, then $149/month ongoing), based on publicly displayed pricing captured September 4, 2026. PlexusDx is second at $2,268 ($189/month flat). Mochi Health has an advertised first-month rate of $99 for the starting dose but uses per-dose pricing, so total cost varies.

Do all month-to-month plans let me cancel anytime?

Yes. PlexusDx, OrderlyMeds, Eden, MEDVi, Mochi Health, Peak Wellness, and Henry Meds all advertise month-to-month billing with no long-term contract and no early-termination fees. Confirm cancellation terms at enrollment.

Which providers charge a separate membership fee?

Eden charges $39 first month, then $99/month ongoing membership, in addition to medication cost. Mochi Health charges $39/month membership in addition to per-dose medication cost. PlexusDx, OrderlyMeds, MEDVi, Peak Wellness, and Henry Meds bundle everything into one monthly rate with no separate membership line item.

Does the price change as my dose increases?

Mochi Health uses per-dose pricing, so your medication cost rises when your provider increases your dose. PlexusDx, MEDVi, Peak Wellness, and Henry Meds charge the same monthly rate at every dose. OrderlyMeds and Eden pricing does not specify per-dose variation in captured evidence.

Are compounded semaglutide providers FDA-approved?

No. Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. PlexusDx works with licensed 503A compounding pharmacies.

Sources

• PlexusDx pricing and program details (plexusdx.com, captured September 8, 2026; September 4, 2026)
• OrderlyMeds pricing and program details (orderlymeds.com, captured September 4, 2026)
• Eden pricing and program details (captured September 4, 2026; July 23, 2026)
• MEDVi pricing and program details (captured September 4, 2026; July 23, 2026)
• Mochi Health pricing and program details (captured September 4, 2026)
• Peak Wellness pricing (captured July 23, 2026)
• Henry Meds pricing and program details (captured September 4, 2026; July 23, 2026)
• Trustpilot review data for PlexusDx, OrderlyMeds, Eden, MEDVi, Mochi Health, and Henry Meds (captured September 4, 2026)

Compounded medication disclosure: Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. PlexusDx works with licensed 503A compounding pharmacies.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.