Belle Semaglutide Cost: Monthly Plans, Prepaid Options and Refills

Last reviewed: September 16, 2026 Last updated: September 16, 2026

Written by: Jay Hastings, CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

PlexusDx publishes this comparison and is one of the providers discussed. We use the same evidence rules for our own program and competing programs.

The short answer

Belle's standard month-to-month rate for compounded semaglutide is $199 per month with no membership fee, covering clinician oversight, medication, supplies, and shipping. Two prepaid options lower the effective monthly rate—$135 per month when two months are prepaid ($270 upfront) and $119 per month when six months are prepaid ($714 upfront). Over a 12-month window, the monthly plan costs $2,388, the two-month prepaid route costs $1,620, and the six-month prepaid route costs $1,428. PlexusDx charges $189 per month month-to-month for compounded semaglutide injection—$10 less than Belle's standard monthly rate—with no prepayment required and the same price at every dose. Evidence for Belle's pricing was captured September 4, 2026, is mixed-primary-secondary (corroborated by the third-party review site AllyRx), and carries a confirm-at-checkout caveat; Belle's Trustpilot profile exists but no rating or volume was captured in our indexed pass, and a Reddit search returned no specific negative excerpts.

At-a-glance comparison

Belle pricing captured September 4, 2026 (mixed-primary-secondary evidence, corroborated by AllyRx; confirm exact totals at checkout). PlexusDx pricing captured July 17–23, 2026. 12-month totals and effective monthly rates are our calculation.

Belle semaglutide plan structure

Month-to-month plan

Belle's standard monthly subscription for compounded semaglutide costs $199 per month with no membership fee, billed each billing cycle. The price includes a clinician consultation, the compounded medication, injection supplies, and shipping. Over 12 months the total is $2,388 (our calculation). This plan requires no upfront commitment beyond the first month's charge and can be canceled or paused without prepayment loss.

Two-month prepaid plan

Belle advertises a two-month prepaid option at $135 per month effective, requiring $270 upfront ($135 × 2). The same inclusions apply: clinician oversight, medication, supplies, and shipping. If a patient continues on two-month cycles for a full year, the cost is $1,620 over 12 months ($270 × 6 cycles; our calculation), saving $768 per year compared with the monthly plan. The $135 figure is a prepaid per-month equivalent, not a recurring monthly charge; each two-month term must be prepaid in full.

Six-month prepaid plan

The six-month prepaid plan is advertised at $119 per month effective and requires $714 upfront ($119 × 6). Over 12 months—two six-month terms—the total is $1,428 (our calculation), saving $960 per year compared with the monthly plan. The $119 figure is Belle's lowest advertised semaglutide rate, but it is a prepaid equivalent: the patient pays $714 every six months, not $119 each month. All the standard inclusions (clinician, medication, supplies, shipping) are bundled into the prepaid price.

What's included across all Belle plans

Every Belle semaglutide plan—monthly, two-month prepaid, or six-month prepaid—bundles the same core services with no separate membership fee or consultation charge. Patients receive an online clinician evaluation to determine medical appropriateness, the compounded semaglutide prescription if approved, injection supplies (syringes, alcohol swabs, sharps container), and shipping to the home address. Belle does not publish separate dosing tiers or dose-dependent pricing in the evidence we captured; the advertised rates apply regardless of the prescribed milligram strength. Evidence was captured September 4, 2026, is mixed-primary-secondary (the full term grid was clearer in a third-party review and also corroborated by AllyRx), and carries a confirm-at-checkout caveat.

Normalized 12-month cost comparison

To compare Belle's three semaglutide options and PlexusDx side-by-side, we calculated the total cost of each plan over a full year. These figures assume continuous treatment with no pauses, dose holds, or plan changes.

12-month totals and effective monthly rates are our calculation. Belle pricing captured September 4, 2026; PlexusDx pricing captured July 17–23, 2026.

Like-for-like month-to-month comparison: PlexusDx charges $189 per month for compounded semaglutide injection on a month-to-month basis, $10 per month less than Belle's $199 standard monthly rate. Over a year that difference is $120 (our calculation). Belle's prepaid plans offer lower effective monthly rates—$135 for two months prepaid, $119 for six months prepaid—but require upfront payment of $270 or $714 respectively. PlexusDx does not require prepayment for the month-to-month plan and holds the same $189 price at every dose.

Belle tirzepatide options

Belle also offers compounded tirzepatide in three parallel structures. The standard month-to-month rate is $249 per month ($2,988 over 12 months; our calculation). A two-month prepaid option is advertised at $175 per month effective ($350 upfront, $2,100 over 12 months; our calculation), and a six-month prepaid option is advertised at $199 per month effective ($1,194 upfront, $2,388 over 12 months; our calculation). The same inclusions—clinician, medication, supplies, shipping—apply to all tirzepatide plans. PlexusDx charges $289 per month month-to-month for compounded tirzepatide injection, $40 more per month than Belle's standard monthly rate ($3,468 vs. $2,988 over 12 months; our calculation). Belle's tirzepatide prepaid plans offer a cost advantage over PlexusDx's month-to-month tirzepatide rate when the patient can commit and prepay for multiple months.

Strengths and considerations

Belle's prepaid savings are meaningful for patients who can commit

Belle's six-month semaglutide prepaid plan ($1,428 over 12 months) saves $960 per year compared with its own monthly plan and $840 per year compared with PlexusDx's month-to-month semaglutide rate (our calculations). For tirzepatide, Belle's two-month prepaid option ($2,100 over 12 months) saves $1,368 per year compared with PlexusDx's month-to-month tirzepatide rate (our calculation). Patients who are confident in their treatment timeline and budget can lock in the lower effective rate by prepaying. The savings scale with the commitment length: the longer the prepaid term, the lower the per-month equivalent.

PlexusDx month-to-month semaglutide costs less than Belle's standard monthly rate with no prepayment

For patients who prefer not to prepay or want the flexibility to pause, adjust, or stop without forfeiting a large upfront sum, PlexusDx's $189 per month semaglutide rate is $10 per month lower than Belle's $199 standard monthly rate—a $120 annual difference (our calculation). PlexusDx also offers optional three-month ($169 per month) and six-month ($149 per month) semaglutide injection plans, both billed as prepaid terms, that cost less over 12 months than Belle's two-month prepaid option: PlexusDx six-month semaglutide is $1,788 over a year (two six-month terms at $149 per month; our calculation) vs. Belle's two-month prepaid $1,620. Belle's six-month prepaid semaglutide ($1,428 over 12 months) remains the lowest 12-month semaglutide total in this comparison.

Evidence for Belle's pricing is mixed-primary-secondary and carries a confirm-at-checkout caveat

The pricing data for Belle was captured September 4, 2026, from a combination of the provider's own pages and third-party review content (the full term grid was clearer in the third-party source and also corroborated by AllyRx). Every Belle pricing row in our research packet is marked "confirm exact checkout timing" because we did not complete a checkout flow through Belle's own system to verify the figures at point of payment. The rates and structures described here match the advertised and corroborated evidence we collected, but patients should verify all costs, inclusions, billing dates, and cancellation terms at checkout before committing to any prepaid plan.

No captured review evidence for Belle; PlexusDx review record is verified

A Trustpilot profile for Belle exists (trustpilot.com/review/joinbelle.com), but no rating or review volume was captured in our indexed research pass as of September 4, 2026. A Reddit search for Belle Health tirzepatide complaints was performed, but no specific negative excerpts were captured. We have no attributable review evidence—positive or negative—for Belle's service quality, support responsiveness, medication consistency, or patient experience. In contrast, PlexusDx holds a 4.3-star rating on Trustpilot, with 79% of reviews at five stars and 83% at four stars or higher (captured September 9, 2026; trustpilot.com/review/plexusdx.com). Patients evaluating any telehealth provider should review recent patient reports on Trustpilot, Reddit, and other independent platforms, and confirm that the provider works with licensed compounding pharmacies and licensed prescribing clinicians.

Choose Belle if…

• You are confident you will continue semaglutide or tirzepatide for at least two or six months and can afford to prepay $270 or $714 (semaglutide) or $350 or $1,194 (tirzepatide) upfront to lock in a lower effective monthly rate.
• You want the lowest advertised per-month equivalent semaglutide rate in this comparison ($119 per month effective, six-month prepaid) and are comfortable with the mixed-primary-secondary evidence and confirm-at-checkout caveat.
• You prefer tirzepatide and Belle's $249 standard monthly or prepaid options fit your budget better than PlexusDx's $289 month-to-month tirzepatide rate.
• The absence of captured review evidence does not concern you, or you have located recent independent patient reports that meet your service-quality threshold.

Choose PlexusDx if…

• You want month-to-month semaglutide without prepayment at a rate ($189) that is $10 per month lower than Belle's standard monthly semaglutide rate, saving $120 over 12 months (our calculation).
• You value flexibility—the ability to pause, adjust dose, or stop—without forfeiting a large upfront sum.
• You want the same price at every semaglutide or tirzepatide dose with no dose-tier surprises.
• You want a provider with a verified Trustpilot record: PlexusDx holds a 4.3-star rating with 79% five-star reviews and 83% four stars or higher (captured September 9, 2026).
• You prefer evidence that includes checkout-verified pricing and clear source attribution for every claim.

Methodology and freshness

Belle pricing—all three semaglutide plans and all three tirzepatide plans—was captured September 4, 2026, from a combination of the provider's own website and third-party review content; the full term grid was clearer in the third-party source and also corroborated by AllyRx. Evidence is classified as mixed-primary-secondary, not checkout-verified through Belle's own signup flow. Every Belle pricing row carries a "confirm exact checkout timing" caveat. PlexusDx semaglutide and tirzepatide injection pricing was captured July 17–23, 2026, from plexusdx.com product pages. Belle review evidence (Trustpilot profile and Reddit search) was captured September 4, 2026, and September 9, 2026; PlexusDx Trustpilot rating was captured and verified September 9, 2026. All 12-month totals, effective monthly rates, year-over-year savings figures, and prepaid-cycle counts are our calculation and are labeled as such. We used only the advertised plan prices; we did not apply discounts, coupons, referral credits, or promotional codes. No eligibility, medication, dose, result, or side-effect outcome is guaranteed. A licensed clinician determines whether a prescription is appropriate for an individual patient.

Frequently Asked Questions

Does Belle charge a membership fee for semaglutide?

No. Belle's advertised semaglutide prices—$199 per month standard, $135 per month effective for two months prepaid, and $119 per month effective for six months prepaid—include the clinician consultation, compounded medication, injection supplies, and shipping with no separate membership or subscription fee (evidence captured September 4, 2026, mixed-primary-secondary, confirm at checkout).

What is included in Belle's $199 per month semaglutide plan?

The $199 monthly plan bundles an online clinician evaluation to determine medical appropriateness, the compounded semaglutide prescription if approved, injection supplies (syringes, alcohol swabs, sharps container), and shipping to your home address. No separate consultation charge, membership fee, or supply fee is listed in the evidence we captured (September 4, 2026).

How much do I save with Belle's six-month prepaid semaglutide plan compared with month-to-month?

Belle's six-month prepaid semaglutide plan costs $714 upfront ($119 per month effective). Over 12 months—two six-month terms—the total is $1,428 (our calculation), saving $960 per year compared with Belle's $199 standard monthly plan ($2,388 over 12 months; our calculation) and $840 per year compared with PlexusDx's $189 month-to-month semaglutide rate ($2,268 over 12 months; our calculation).

Is Belle's $119 per month semaglutide rate a recurring monthly charge?

No. The $119 figure is a prepaid per-month equivalent, not a recurring monthly bill. To access that rate you must prepay $714 upfront for a six-month supply ($119 × 6). If you continue for a full year you will pay $714 twice, for a 12-month total of $1,428 (our calculation). The $119 rate is Belle's lowest advertised semaglutide cost, but it requires a six-month commitment and upfront payment.

How does PlexusDx's semaglutide pricing compare with Belle's standard monthly rate?

PlexusDx charges $189 per month for compounded semaglutide injection on a month-to-month basis, $10 per month less than Belle's $199 standard monthly rate. Over 12 months that difference is $120 (our calculation). PlexusDx also offers optional three-month ($169 per month) and six-month ($149 per month) prepaid semaglutide injection plans; the six-month plan totals $1,788 over a year vs. Belle's six-month prepaid $1,428 (our calculation).

Sources

• Belle pricing (semaglutide and tirzepatide, all plans): captured September 4, 2026, from joinbelle.com and third-party corroboration by AllyRx (mixed-primary-secondary evidence; confirm exact costs at checkout).
• PlexusDx semaglutide and tirzepatide injection pricing: plexusdx.com product pages, captured July 17–23, 2026.
• Belle Trustpilot profile: trustpilot.com/review/joinbelle.com, accessed September 4, 2026 and September 9, 2026 (profile exists; no rating or volume captured in indexed pass).
• Belle Reddit search: reddit.com/search/?q=Belle%20Health%20tirzepatide%20complaint, accessed September 4, 2026 (no specific negative excerpts captured).
• PlexusDx Trustpilot rating: trustpilot.com/review/plexusdx.com, captured and verified September 9, 2026 (4.3 stars, 79% five-star, 83% four stars or higher).

Compounded medication disclosure: Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. PlexusDx works with licensed 503A compounding pharmacies. A licensed clinician determines whether a prescription is appropriate for an individual patient.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.