The 49 Peptides Analyzed by the Precision Peptide Genetic Test

Last reviewed: May 12, 2026 Last updated: May 12, 2026

Written by: Jay Hastings , CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

This article is part of the PlexusDx Education Hub — your resource for evidence-based guidance on peptides and GLP-1. Browse all Peptides & GLP-1 education

When people see "49 unique peptides" as a panel claim, the natural follow-up is: which 49? The answer is that all 49 are organized by biological pathway and protocol family — not by compound name. The Precision Peptide Genetic Test doesn't analyze the compounds themselves; it analyzes the genes that govern the biological pathways those 49 compounds target. Understanding your FTO variant tells you something about GLP-1 receptor pathway biology. Your FOXO3 profile tells you something about longevity pathway biology. Your SHBG and CYP19A1 variants tell you something about androgen pathway biology. Each of the 14 pathways, 49 peptides, and 150+ genetic insights in the panel maps the genetics of a specific biological system — so that any protocol decision downstream is informed by your actual DNA, not by a one-size-fits-all assumption.

What "49 Unique Peptides" Actually Means

The phrase "49 unique peptides" describes the breadth of the panel — the full spectrum of protocol categories whose biological pathways the test maps genetically. Some of those 49 are classical peptides: short-chain amino acid sequences that act as signaling molecules, including growth hormone secretagogues and melanocortin pathway agents. Others are hormone replacement compounds — androgens, estrogens, and their metabolites. Others are small-molecule enzyme modulators — PDE5 pathway agents and GLP-1 receptor agonists. Others are metabolic support compounds: NAD+ precursors, antioxidants, lipotropic agents. What they all share is that each one targets a specific biological pathway, and the panel analyzes your genetic baseline in each of those pathways.

Weight Management — GLP-1 and Dual Incretin Pathways

The Weight Management family is the most insight-dense pathway in the panel: 34 genetic insights covering the full architecture of metabolic response. Six distinct compound formats span GLP-1 receptor agonist, dual GIP/GLP-1 agonist, and microdose formulation categories — the compound types that have driven the deepest clinical research into genetic predictors of metabolic response. Key variants analyzed: FTO rs9939609, MC4R rs17782313, GLP1R, TCF7L2, PPARG, and GIPR. Emerging research suggests genetic factors may influence how individuals respond to GLP-1 pathway interventions — making the 34 Weight Management insights among the most consequential in the panel for those evaluating metabolic protocols.

Longevity — NAD+ and Cellular Aging Pathways

Seven compounds in the Longevity family span four distinct cellular aging mechanisms: NAD+ pathway support, growth hormone axis and GH-releasing agents, mitochondrial function compounds, and antioxidant and lipotropic formulations including glutathione precursors. The 17 Longevity & Aging insights — FOXO3, SOD2, APOE, SIRT1, and TERT chief among them — map your genetic baseline across cellular resilience, oxidative stress defense, sirtuin pathway activity, and telomere maintenance. For the full gene-by-gene breakdown, see the Complete Guide to Genetic Longevity Testing.

Muscle Growth — Growth Hormone Axis Compounds

The Muscle Growth family centers on growth hormone secretagogue compounds — agents that stimulate pituitary GH release or enhance GH receptor sensitivity downstream. The 15 Muscle Growth insights — ACTN3, IGF1, MSTN, GHSR, and GHR — map your genetic baseline across fiber type composition, growth hormone axis responsiveness, the myostatin ceiling on muscle mass, and downstream IGF-1 production. ACTN3 R577X is the most widely searched muscle growth variant in the panel. For the full breakdown, see the Complete Guide to Genetic Muscle Growth Testing.

Men's Hormone — Androgen Pathway Compounds

Three core androgen pathway compound categories make up the Men's Hormone family: testosterone replacement formulations, GnRH-stimulating agents for HPTA axis support, and fertility-preserving androgen modulation compounds. The 6 Reproductive Health insights relevant to men — SHBG, CYP19A1, AR (CAG repeat length), SRD5A2, and LH/FSH receptor variants — map the full testosterone response architecture: binding and bioavailability, aromatization to estrogen, receptor sensitivity, and DHT conversion rate. For the full breakdown, see the Complete Guide to Genetic Men's Hormone Testing.

Women's Hormone — Estrogen Pathway Compounds

Four estrogen pathway formulations make up the Women's Hormone family — systemic estradiol compounds across multiple delivery formats and localized estrogen options. The 6 Reproductive Health insights relevant to women — COMT Val158Met, CYP1A1, CYP1B1, MTHFR, ESR1, SULT1A1, and GSTM1/GSTT1 — map the complete estrogen clearance architecture: Phase 1 metabolism, Phase 2 conjugation, methylation capacity, and receptor sensitivity. For the full breakdown, see the Complete Guide to Genetic Women's Hormone Testing.

Sexual Health — PDE5, Melanocortin, and Vascular Pathways

Seven compounds in the Sexual Health family span the four biological systems that underlie sexual response: PDE5 pathway inhibitors, combination PDE5-botanical formulations, extended-release PDE5 options, and melanocortin central nervous system pathway agents. The 6 Sexual Health insights — eNOS (NOS3), DRD2, OXTR, MTNR1B, and PDE5 gene family variants — map your genetic baseline across nitric oxide production capacity, dopamine receptor signaling, oxytocin receptor sensitivity, and circadian architecture. For the full breakdown, see the Complete Guide to Genetic Sexual Health Testing.

Beyond the Launch Families — Nine Additional Pathways

The five launch protocol families account for the majority of the 49 unique compounds — but the panel extends into nine additional pathways where peptide and compound categories also have genetic contexts worth mapping. Skin Health (14 insights), Energy Metabolism (12 insights), Immunity (11 insights), Tissue Repair (9 insights), Mood (8 insights), Cognition (6 insights), Inflammation (6 insights), Brain Health (4 insights), and Sleep (3 insights) each analyze variants relevant to compound categories in those biological systems — pathways that inform a fuller picture of how your genetics interact with the broader landscape of precision health protocols.

Genetics as a Guide, Not a Guarantee

The Precision Peptide Genetic Test maps the pathways. The provider maps the protocol. Knowing that your FOXO3 variant suggests NAD+ pathway biology is worth prioritizing, or that your GHSR profile suggests growth hormone axis compounds may have higher leverage in your biology, or that your CYP19A1 variant makes estrogen management a central feature of any hormone strategy — none of that is a prescription. It's context. A qualified healthcare provider weighs that context against clinical findings, lifestyle, current biomarkers, and medical history to make the actual protocol call. That's what testing before you invest actually delivers: better-informed conversations, not pre-made answers.

The Precision Peptide Genetic Test analyzes how your genes influence peptide-related biological pathways. It does not recommend, prescribe, or determine which peptides you should use. Consult a qualified healthcare provider before beginning any peptide protocol.

Ready to understand what your genes say about your peptide response? Take the Precision Peptide Genetic Test

Frequently Asked Questions

What are the 49 peptides in the Precision Peptide Genetic Test?

The Precision Peptide Genetic Test maps how your genes interact with pathways targeted by 49 unique compounds. The five launch protocol families — Weight Management (6), Longevity (7), Muscle Growth, Men's Hormone, Women's Hormone, and Sexual Health — account for the majority. The remaining compounds span nine additional pathways analyzed across 150+ total insights.

Does the test tell me which of the 49 peptides I should take?

No — genetic testing reveals pathway biology, not protocol prescriptions. The Precision Peptide Genetic Test shows how your FTO, FOXO3, SHBG, eNOS, and other variants interact with peptide-related pathways. A qualified healthcare provider translates that genetic context into protocol decisions based on your complete clinical picture, lifestyle, and medical history.

How many genetic insights does the test provide per protocol family?

The Precision Peptide Genetic Test delivers 150+ insights across 14 pathways: 34 for Weight Management, 17 for Longevity and Aging, 15 for Muscle Growth, 6 for Reproductive Health (men's and women's hormone), 6 for Sexual Health, and insights across 9 additional pathways including Skin Health (14), Energy Metabolism (12), and Immunity (11).

This article is part of the PlexusDx Education Hub. Browse all Peptides & GLP-1 education

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.