10Rx Quarterly Pricing Explained: What Long-Term Treatment Costs

Last reviewed: September 15, 2026 Last updated: September 15, 2026

Written by: Jay Hastings, CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

PlexusDx publishes this comparison and is one of the providers discussed. We use the same evidence rules for our own program and competing programs.

The short answer

10Rx operates on a single flat prepaid quarterly model: $299 per three-month package for compounded semaglutide with B12, $450 per three-month package for compounded tirzepatide with B12 (secondary corroboration, captured September 4, 2026). There is no introductory rate or separate refill price—the same quarterly charge applies at sign-up and at every renewal, regardless of strength. That prepaid structure yields an effective monthly cost of $99.67 for semaglutide and $150 for tirzepatide (our calculation), or $1,196 and $1,800 per year respectively. In like-for-like quarterly comparison, PlexusDx three-month prepaid plans run $507 per quarter ($169/month prepaid equivalent, $2,028/year) for semaglutide injection and $807 per quarter ($269/month prepaid equivalent, $3,228/year) for tirzepatide injection. PlexusDx month-to-month plans—which require no upfront commitment—are $189/month ($2,268/year) for semaglutide and $289/month ($3,468/year) for tirzepatide. 10Rx's quarterly prepaid rate is lower than PlexusDx quarterly or month-to-month rates for both medications. The primary 10Rx pricing page (checked September 4, 2026) confirms the quarterly structure, inclusions, and flat-strength policy but suppresses the numeric package totals; we advise confirming the $299 and $450 figures at checkout before committing to the three-month prepayment.

At-a-glance comparison

Understanding 10Rx's quarterly model

Unlike providers that advertise a low introductory month and then charge a higher refill rate, 10Rx uses the same flat prepaid quarterly price at sign-up and every subsequent renewal. The primary pricing page (https://www.take10rx.com/pricing, checked September 4, 2026) confirms that customers pay for a three-month supply at a time, that the package includes medication, clinician evaluation, next-day shipping, and support with no add-on membership or service fees, and that the price does not change by strength. The page displays the quarterly structure and inclusions but suppresses the numeric package totals. Secondary corroboration (captured September 4, 2026) reports $299 for semaglutide and $450 for tirzepatide per three-month package. We advise confirming these figures at checkout before committing to the three-month prepayment.

Dividing the quarterly total by three yields an effective monthly rate: $99.67 for semaglutide, $150 for tirzepatide (our calculation from the prepaid package). Because 10Rx does not offer a month-to-month option, every commitment is a three-month upfront charge.

12-month cost calculations

Four quarterly cycles span a year. Multiplying the per-quarter prepaid charge by four gives the annual total, and dividing by twelve returns the effective monthly cost. All derived monthly equivalents and annual totals below are our calculation from the reported quarterly rates.

10Rx semaglutide

• Per quarter: $299 prepaid (secondary corroboration, captured 9/4/26)
• 12 months: 4 × $299 = $1,196
• Effective monthly: $1,196 ÷ 12 = $99.67 (prepaid quarterly equivalent, our calculation)

10Rx tirzepatide

• Per quarter: $450 prepaid (secondary corroboration, captured 9/4/26)
• 12 months: 4 × $450 = $1,800
• Effective monthly: $1,800 ÷ 12 = $150 (prepaid quarterly equivalent, our calculation)

PlexusDx semaglutide injection (like-for-like quarterly prepaid)

• Per quarter: $169/month × 3 = $507 prepaid (our calculation)
• 12 months: 4 × $507 = $2,028
• Effective monthly: $169 (prepaid three-month plan rate)

PlexusDx tirzepatide injection (like-for-like quarterly prepaid)

• Per quarter: $269/month × 3 = $807 prepaid (our calculation)
• 12 months: 4 × $807 = $3,228
• Effective monthly: $269 (prepaid three-month plan rate)

PlexusDx semaglutide injection (month-to-month, no prepayment)

• Per month: $189
• 12 months: 12 × $189 = $2,268

PlexusDx tirzepatide injection (month-to-month, no prepayment)

• Per month: $289
• 12 months: 12 × $289 = $3,468

Like-for-like comparison: quarterly prepaid plans

When comparing three-month prepaid cycles, 10Rx's per-quarter charge is lower for both medications:

• Semaglutide: 10Rx $299/quarter vs. PlexusDx $507/quarter—a $208 difference per three-month cycle, or $832 over twelve months (our calculation).
• Tirzepatide: 10Rx $450/quarter vs. PlexusDx $807/quarter—a $357 difference per three-month cycle, or $1,428 over twelve months (our calculation).

Both programs charge the same price regardless of dose strength, and both include the clinician visit, medication, and shipping with no separate membership fee. 10Rx specifies next-day shipping and B12 co-formulation; PlexusDx standard shipping timing varies, and injectable semaglutide and tirzepatide do not include B12.

Month-to-month vs. quarterly prepaid

PlexusDx offers a month-to-month option that requires no upfront three-month commitment. The monthly rate ($189 semaglutide, $289 tirzepatide) is higher than the prepaid quarterly per-month equivalent ($169 semaglutide, $269 tirzepatide), but the first charge is one month rather than three, and you may pause or stop each month without forfeiting prepaid value. Over twelve months the month-to-month total is $2,268 for semaglutide and $3,468 for tirzepatide—still higher than 10Rx's annual prepaid total of $1,196 and $1,800 respectively (our calculation), but lower initial outlay and greater monthly flexibility.

10Rx does not publish a month-to-month alternative; every order is a three-month prepaid package. If you stop before the quarter ends, you have already paid for the full cycle.

Decision factors

10Rx advantages where evidence supports them

• Lower effective monthly cost: $99.67 for semaglutide and $150 for tirzepatide (prepaid quarterly equivalent, our calculation) versus PlexusDx quarterly ($169 semaglutide, $269 tirzepatide) or month-to-month ($189 semaglutide, $289 tirzepatide).
• Single flat rate across renewals: No introductory pricing that steps up at refill; the same per-quarter charge applies at sign-up and every renewal.
• Next-day shipping: Documented standard; PlexusDx standard shipping timing varies.
• B12 co-formulation: Injectable packages include B12; PlexusDx injectable semaglutide and tirzepatide do not.

Gaps and uncertainties

• Numeric totals are secondary corroboration: The primary pricing page (checked September 4, 2026) confirms structure and inclusions but suppresses the $299 and $450 figures; confirm at checkout before committing.
• No month-to-month option: Every commitment is a three-month prepayment; if you pause or stop early, you have already paid for the full quarter.
• No Trustpilot profile located: Trustpilot search performed September 4, 2026, returned no dedicated 10Rx review profile; PlexusDx holds a 4.3-star rating with 79% five-star reviews and 83% four stars or higher (captured September 9, 2026; trustpilot.com/review/plexusdx.com).
• Cancellation and refund terms not documented: Our research packet does not include 10Rx's policy for stopping mid-quarter or requesting a refund on prepaid unused months; review the terms of service before committing to a three-month prepayment.

Choose 10Rx if…

• You are comfortable committing to a three-month prepayment ($299 semaglutide, $450 tirzepatide) at sign-up and every renewal, and you want the lowest effective monthly cost for compounded injectable GLP-1 with B12.
• You value next-day shipping as standard and appreciate a single flat price across all available strengths.
• You confirm the numeric package totals at checkout and review the cancellation and refund terms before committing, since the primary pricing page suppresses dollar figures and our research packet does not document mid-quarter stop or refund policy.

Choose PlexusDx if…

• You prefer a month-to-month plan with no upfront quarterly commitment, accepting a higher per-month rate ($189 semaglutide, $289 tirzepatide) in exchange for the ability to pause or stop each month without forfeiting prepaid value.
• You want the option to lock in a lower per-month rate with a three- or six-month prepaid plan ($169 or $149 semaglutide, $269 or $249 tirzepatide per month) that is still higher than 10Rx's quarterly equivalent but offers a middle ground between flexibility and savings.
• You value a transparent public review record—PlexusDx holds a 4.3-star rating on Trustpilot with 79% five-star reviews and 83% four stars or higher (captured September 9, 2026)—and documented pricing that appears on the primary product pages without suppression.
• You want access to oral GLP-1 capsule options (semaglutide or tirzepatide) or a microdose maintenance protocol ($129/month) alongside standard injection plans; 10Rx offers only injectable formulations with B12.

Methodology and freshness

We captured 10Rx pricing structure, inclusions, and flat-strength policy from the primary pricing page (https://www.take10rx.com/pricing) on September 4, 2026. That page confirms the quarterly billing cycle, included services (medication, clinician evaluation, next-day shipping, support), and the absence of add-on membership fees, but suppresses the numeric package totals. We obtained the $299 semaglutide and $450 tirzepatide per-quarter figures from secondary corroboration captured the same day and label them as such throughout this article. We advise readers to confirm these figures at checkout before committing to a three-month prepayment.

All effective monthly costs derived from quarterly totals, all per-quarter costs derived from monthly rates, and all 12-month totals are our calculation. PlexusDx pricing is current as of September 15, 2026. We performed a Trustpilot search for 10Rx on September 4, 2026, and located no dedicated review profile. PlexusDx review data (4.3 stars, 79% five-star, 83% four stars or higher) was captured September 9, 2026, from trustpilot.com/review/plexusdx.com.

Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. PlexusDx works with licensed 503A compounding pharmacies.

Frequently Asked Questions

Does 10Rx charge a different price for the first three months than for refills?

No. 10Rx uses the same flat prepaid quarterly package price at sign-up and every renewal—$299 per three-month supply for semaglutide, $450 for tirzepatide (secondary corroboration, captured September 4, 2026). There is no introductory discount or step-up to a higher refill rate. The same per-quarter charge applies across all available strengths and continues for as long as you renew.

What is the effective monthly cost of 10Rx when I divide the quarterly charge by three?

Dividing the reported quarterly totals by three yields $99.67 per month for semaglutide and $150 per month for tirzepatide (our calculation from the prepaid package). These are prepaid quarterly equivalents, not month-to-month billing options; you pay the full three-month amount upfront. Confirm the $299 and $450 figures at checkout, since the primary pricing page suppresses numeric totals.

Can I pay month-to-month with 10Rx instead of prepaying three months?

Our research packet does not document a month-to-month billing option for 10Rx. The pricing page (checked September 4, 2026) describes a quarterly prepaid structure, and every commitment is a three-month upfront charge. If you prefer monthly billing with the flexibility to pause or stop each month, PlexusDx offers month-to-month plans at $189 for semaglutide injection and $289 for tirzepatide injection.

How does 10Rx's annual cost compare to PlexusDx month-to-month over twelve months?

10Rx semaglutide runs $1,196 per year and tirzepatide $1,800 per year (our calculation from four quarterly prepaid cycles). PlexusDx month-to-month plans run $2,268 per year for semaglutide and $3,468 per year for tirzepatide. The 10Rx annual total is lower, but you prepay three months at a time; PlexusDx month-to-month requires no upfront quarterly commitment and allows you to pause or stop each month without forfeiting prepaid value.

What happens if I want to stop 10Rx before the end of my three-month prepaid cycle?

Our research packet does not include 10Rx's cancellation or refund policy. Because you prepay the full three-month package at sign-up and every renewal, stopping mid-quarter may mean forfeiting the unused portion. Review 10Rx's terms of service and contact their support team before committing to understand your options if you need to pause or discontinue treatment partway through a prepaid quarter.

Sources

• 10Rx pricing page structure, inclusions, and flat-strength policy (primary verification, numeric totals suppressed): https://www.take10rx.com/pricing, accessed September 4, 2026
• 10Rx semaglutide $299 and tirzepatide $450 per-quarter figures (secondary corroboration), captured September 4, 2026
• PlexusDx pricing and plan details: https://plexusdx.com, accessed September 15, 2026
• Trustpilot 10Rx search (no profile located), performed September 4, 2026
• PlexusDx Trustpilot rating (4.3 stars, 79% five-star, 83% four stars or higher): https://www.trustpilot.com/review/plexusdx.com, accessed September 9, 2026

Compounded medication disclosure: Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. PlexusDx works with licensed 503A compounding pharmacies.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.