10Rx Pricing Explained: What Its Quarterly GLP-1 Plans Include

Last reviewed: September 5, 2026 Last updated: September 5, 2026

Written by: Jay Hastings, CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

PlexusDx publishes this comparison and is one of the providers discussed. We use the same evidence rules for our own program and competing programs.

The short answer

10Rx charges $299 per quarter for compounded semaglutide with B12 and $450 per quarter for compounded tirzepatide with B12. Both are prepaid three-month packages that include medication, clinician evaluation, next-day shipping, and support—no membership fees, no add-ons. The quarterly charge is the same regardless of dose strength. Because you pay the full quarter upfront, the effective monthly rate is $99.67 for semaglutide and $150 for tirzepatide (our calculation from the quarterly totals). Over 12 months, that structure delivers a lower total cost than many month-to-month alternatives, but you commit three months of budget at once and cannot pause mid-quarter without forfeiting prepaid medication. The quarterly totals come from secondary corroboration rather than primary checkout verification (captured September 4, 2026); confirm the figures at checkout before committing.

At a glance: 10Rx quarterly plans

What the quarterly model means in practice

10Rx structures its GLP-1 pricing around a three-month billing cycle. You pay the full quarterly total—$299 for semaglutide or $450 for tirzepatide—at the start of each quarter, and that charge covers medication, clinician oversight, next-day shipping, and support for the next 90 days. The same package price applies whether you're titrating at a lower dose or maintaining at a higher one, which simplifies budgeting across dose adjustments but offers no discount for lower-strength protocols.

The quarterly structure reduces the nominal per-month cost compared to many month-to-month programs: $99.67 per month for semaglutide and $150 per month for tirzepatide when you divide the quarterly charge evenly. Those figures are prepaid equivalents—our calculation from the quarterly totals—not separate monthly bills. You commit three months of budget at once, so if your clinical picture changes or you need to pause treatment, you cannot reclaim the unused portion of a prepaid quarter.

How 10Rx's annual cost compares to flexible month-to-month plans

Over a 12-month horizon, 10Rx's prepaid model produces a materially lower total than most flexible alternatives. For semaglutide, four quarters at $299 each sum to $1,196 per year (our calculation). For tirzepatide, four quarters at $450 each sum to $1,800 per year (our calculation).

PlexusDx offers semaglutide injection at $189 per month with no commitment (12-month total $2,268, our calculation), $169 per month on a prepaid three-month plan ($2,028 annually, our calculation), and $149 per month on a prepaid six-month plan ($1,788 annually, our calculation). Even PlexusDx's longest-commitment tier costs $592 more per year than 10Rx's quarterly model for semaglutide.

For tirzepatide injection, PlexusDx charges $289 per month with no commitment ($3,468 annually, our calculation), $269 per month on a three-month plan ($3,228 annually, our calculation), and $249 per month on a six-month plan ($2,988 annually, our calculation). 10Rx's annual tirzepatide cost is $1,188 to $1,668 lower than PlexusDx's tiers (our calculation).

All figures captured September 4, 2026. 10Rx quarterly totals are secondary corroboration; confirm at checkout. PlexusDx prices are published retail rates. Twelve-month totals and effective monthly rates are our calculations.

What the all-inclusive package covers

Both 10Rx quarterly plans bundle medication, clinical oversight, logistics, and support into a single prepaid charge. The medication is compounded semaglutide or tirzepatide with vitamin B12, dispensed as a three-month supply of pre-filled injection pens or vials (pharmacy options vary). A clinician evaluation is included at the start of each quarter to review your progress and adjust your prescription if needed. Next-day shipping brings the medication to your door, and ongoing support is available throughout the quarter—no separate membership fee or per-contact charges.

The flat quarterly price applies regardless of dose strength, so you pay the same $299 or $450 whether you're titrating at 0.25 mg semaglutide per week or maintaining at 2.4 mg. That removes one variable from budgeting but means lower-dose users pay the same absolute dollar amount as higher-dose users.

Evidence quality and limitations

The quarterly structure, inclusions, and flat-across-strengths pricing are verified from 10Rx's primary pricing page (take10rx.com/pricing, checked September 4, 2026). The specific dollar totals—$299 for semaglutide and $450 for tirzepatide—are secondary corroboration, not yet confirmed at checkout. We did not submit payment or receive a final invoice. Confirm the figures and any terms-of-service details (cancellation policy, refund eligibility, pause options) at checkout before committing a quarter's budget.

Strengths and gaps in the 10Rx model

Strengths: The prepaid quarterly model delivers a materially lower annual cost than month-to-month alternatives for both semaglutide and tirzepatide. The all-inclusive package eliminates add-on fees—no membership charge, no separate shipping or support costs—so the quarterly total is the true recurring expense. Next-day shipping and flat pricing across dose strengths simplify logistics and budgeting. For patients confident in a multi-month treatment commitment, 10Rx's pricing structure is highly competitive.

Gaps: Prepaying a full quarter sacrifices flexibility. If you experience intolerable side effects, if your clinician recommends discontinuing treatment, or if you need to pause for surgery or another medical reason, you cannot recover the unused portion of a prepaid quarter. Month-to-month plans cost more over 12 months but let you stop or pause without forfeiting future medication. 10Rx's website does not publish cancellation or refund terms, so the financial risk of an unplanned pause is unclear until you review the checkout agreement. Pharmacy options vary, which may affect fill times or customer-service consistency. We located no Trustpilot profile and minimal Reddit discussion for 10Rx (captured September 4, 2026), so independent service-quality feedback is sparse compared to more widely reviewed providers.

Choose 10Rx if…

You are confident in a sustained GLP-1 protocol and want the lowest annual cost available among the options we reviewed. You have the cash flow to prepay three months at a time—$299 for semaglutide or $450 for tirzepatide—and you are comfortable forfeiting unused medication if you need to stop mid-quarter. You value a simple, all-inclusive package with no membership fees and next-day shipping included. You have reviewed the provider's checkout terms (cancellation policy, refund eligibility, pause options) and confirmed the quarterly totals before committing your first prepaid cycle.

Where PlexusDx fits

PlexusDx costs more over 12 months but offers billing flexibility that 10Rx's prepaid model does not. The month-to-month option ($189 for semaglutide injection, $289 for tirzepatide injection) lets you pause or stop without forfeiting future medication, which matters if your treatment plan changes or if you experience side effects that require discontinuation. The three-month and six-month prepaid tiers lower the effective monthly rate while still limiting your upfront commitment to a shorter horizon than 10Rx's quarterly cycle. PlexusDx holds a 4.2-star rating on Trustpilot, with 76% of reviews at five stars and 81% at four stars or higher (captured September 4, 2026), providing independent service-quality feedback that 10Rx's minimal online review record cannot yet match. PlexusDx works with licensed 503A compounding pharmacies and offers oral capsule formulations of both semaglutide and tirzepatide for patients who prefer non-injection routes. If you value flexibility, documented service quality, and formulation choice over the lowest possible annual cost, PlexusDx's month-to-month or shorter-commitment plans may better fit your situation.

Methodology and freshness

We reviewed 10Rx's public pricing page (take10rx.com/pricing), searched for Trustpilot and Reddit reviews, and compared the quarterly prepaid structure to PlexusDx's published month-to-month, three-month, and six-month plans. The quarterly structure, inclusions (medication with B12, clinician evaluation, next-day shipping, support), and flat-across-strengths pricing are verified from the primary source, checked September 4, 2026. The specific dollar totals ($299 semaglutide quarterly, $450 tirzepatide quarterly) are secondary corroboration and were not checkout-verified; confirm the figures before committing. Twelve-month totals, effective monthly rates, and annual cost differences are our calculations from the published or corroborated quarterly and monthly figures. We located no Trustpilot profile for 10Rx and minimal Reddit discussion (captured September 4, 2026). PlexusDx prices are standing published rates; PlexusDx Trustpilot rating (4.2 stars, 76% five-star, 81% four-star or higher) captured September 4, 2026.

Frequently Asked Questions

Does 10Rx charge any fees beyond the quarterly medication price?

No. The $299 semaglutide or $450 tirzepatide quarterly charge includes medication, clinician evaluation, next-day shipping, and support. There is no separate membership fee or add-on cost (verified September 4, 2026).

Can I pause or cancel a 10Rx quarterly plan if I need to stop mid-quarter?

The provider's public website does not publish cancellation or refund terms. Because you prepay the full quarter, you may not recover unused medication if you stop early. Review the checkout agreement for pause and refund policies before committing your first payment.

Is the quarterly price the same for all dose strengths?

Yes. 10Rx charges $299 per quarter for semaglutide and $450 per quarter for tirzepatide regardless of dose strength. That simplifies budgeting across titration and maintenance phases but means lower-dose users pay the same absolute amount as higher-dose users (verified September 4, 2026).

How does 10Rx's annual cost compare to PlexusDx's flexible plans?

Over 12 months, 10Rx semaglutide costs $1,196 (our calculation: four quarters at $299 each) versus PlexusDx's $1,788 to $2,268 depending on commitment tier. 10Rx tirzepatide costs $1,800 (four quarters at $450 each) versus PlexusDx's $2,988 to $3,468. 10Rx is materially less expensive annually but requires quarterly prepayment; PlexusDx offers month-to-month flexibility at a higher total cost.

Are 10Rx's compounded medications FDA-approved?

No. Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. 10Rx dispenses compounded semaglutide and tirzepatide with B12; pharmacy options vary.

Sources

• 10Rx pricing page (take10rx.com/pricing), accessed September 4, 2026
• 10Rx secondary pricing corroboration (quarterly totals), accessed September 4, 2026
• Trustpilot search for 10Rx (no profile located), accessed September 4, 2026
• Reddit search for 10Rx GLP-1 discussions, accessed September 4, 2026
• PlexusDx published pricing and Trustpilot profile (4.2 stars, 76% five-star, 81% four-star or higher), accessed September 4, 2026

Compounded medication disclosure: Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. PlexusDx works with licensed 503A compounding pharmacies.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.