The Precision Peptide Genetic Test analyzes MTHFR C677T and A1298C — the variants that set your methylation capacity and determine how efficiently your body produces the SAMe that estrogen clearance depends on. Part of 14 pathways, 49 peptides, and 150+ genetic insights, MTHFR is the upstream genetic variable that connects the methylation cycle to women's hormone balance.

The Precision Peptide Genetic Test analyzes 6 Reproductive Health insights covering women's hormone pathways — COMT, CYP1A1, CYP1B1, MTHFR, ESR1, and Phase 2 detox genes — within a panel of 14 pathways, 49 peptides, and 150+ genetic insights. This pillar guide breaks down how you produce, clear, and respond to estrogen, and why clearance genetics matter as much as production.

Genetics shapes estrogen in men through four pathways: how much testosterone converts to estradiol (CYP19A1), how efficiently it clears (COMT, MTHFR), how sensitively tissues respond (ESR1), and how much substrate is available (SHBG, SRD5A2). The Precision Peptide Genetic Test maps all these variables across 14 pathways and 150+ genetic insights.

The Precision Peptide Genetic Test analyzes MTHFR C677T and A1298C — the variants that determine your methylation capacity and its downstream effects on estrogen clearance, homocysteine levels, and hormone metabolism. Part of 14 pathways and 150+ genetic insights across 49 peptides, MTHFR is the genetic variable connecting methylation to the male hormone system.

The Precision Peptide Genetic Test analyzes six Reproductive Health genes that directly influence testosterone levels, conversion, and signaling — including SHBG, CYP19A1, AR, SRD5A2, LHCGR, and CYP17A1. Part of 14 pathways and 150+ genetic insights across 49 peptides, these variants explain why testosterone behaves differently in different men.

The Longevity-Aging pathway in the Precision Peptide Genetic Test delivers 17 insights organized across five functional clusters — antioxidant defense, NAD+ homeostasis, methylation, longevity transcription factors, and structural aging biology. Part of 14 pathways, 49 peptides, and 150+ genetic insights, these 17 variants map biological aging as a connected system, not a list of isolated risk genes.

Yes — MTHFR C677T and A1298C connect to longevity through at least five distinct biological mechanisms, from vascular aging and epigenetic clock acceleration to glutathione substrate depletion and DNA repair impairment. The Precision Peptide Genetic Test maps MTHFR within 14 pathways, 49 peptides, and 150+ genetic insights, revealing how your methylation genetics shapes your aging biology.

MTHFR converts dietary folate into the active form the methylation cycle requires. The C677T (rs1801133) and A1298C (rs1801131) variants reduce enzyme activity by 30–65%, limiting DNA repair, homocysteine clearance, and epigenetic age regulation. The Precision Peptide Genetic Test analyzes MTHFR as part of 17 Longevity & Aging insights spanning 14 pathways, 49 peptides, and 150+ genetic insights.

Genetic peptide testing analyzes how your DNA shapes 14 biological pathways that peptide protocols target — from GLP-1 signaling to growth hormone axis to estrogen clearance. The PlexusDx Precision Peptide Genetic Test delivers 150+ insights across 49 unique peptides, turning peptide decisions from guesswork into evidence-based conversations with your healthcare provider.

The PlexusDx Precision Peptide Genetic Test analyzes 34 weight management genetic insights — including the pathways most relevant to GLP-1 receptor signaling. This article explains what the research shows about genetics and semaglutide response, why MTHFR methylation status matters in the broader metabolic picture, and how genetic testing can help inform a smarter weight management approach.

Is a genetic methylation test worth it? Here's what the science says, what your results actually reveal, and how to decide if it's right for your health goals.

Genetic methylation test pricing ranges from $99 for a basic MTHFR variant check to $298 for a comprehensive 300+ insight panel. Here's how to compare what you actually get at each price point.

MTHFR test costs range from $49 for a basic clinical variant check to $298 for a comprehensive at-home panel. Here's how LabCorp, insurance, and DTC options compare in 2026.

Your MTHFR variants, pathway function, and personalized next steps — explained. Plus how to read blood test results for homocysteine, folate, and B12.