PlexusDx vs Willow: GLP-1 Pricing, Products and Plan Terms Compared

Last reviewed: September 8, 2026 Last updated: September 8, 2026

Written by: Jay Hastings, CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

PlexusDx publishes this comparison and is one of the providers discussed. We use the same evidence rules for our own program and competing programs.

The short answer

PlexusDx offers compounded semaglutide injection at $189/month and tirzepatide injection at $289/month, month-to-month. Willow charges $299/month for semaglutide and $399/month for tirzepatide, both month-to-month. Both programs include medication, provider visits, and shipping in one all-inclusive price with no membership fee. The recurring price differential is $110/month—$1,320/year—on both medications. Willow advertises oral routes for semaglutide and tirzepatide, but route-specific pricing is not itemized in published materials (captured September 4, 2026). If lowest ongoing cost for injectable compounded GLP-1 is your priority and you prefer month-to-month flexibility, PlexusDx holds the documented advantage.

At-a-glance comparison

Like-for-like pricing: month-to-month comparison

Both PlexusDx and Willow offer month-to-month billing for compounded semaglutide and tirzepatide injections. All prices below were verified from checkout flows and pricing pages captured September 4, 2026.

Semaglutide injection (month-to-month)

• PlexusDx: $189/month → $2,268/year (our calculation)
• Willow: $299/month → $3,588/year (our calculation)
• Difference: $110/month, $1,320/year

Tirzepatide injection (month-to-month)

• PlexusDx: $289/month → $3,468/year (our calculation)
• Willow: $399/month → $4,788/year (our calculation)
• Difference: $110/month, $1,320/year

PlexusDx also offers 3-month and 6-month prepaid plans at lower per-month rates. Semaglutide injection on the 6-month plan is $149/month ($1,788/year, our calculation using the prepaid 6-month rate); tirzepatide injection on the 6-month plan is $249/month ($2,988/year, our calculation using the prepaid 6-month rate). Willow does not publish multi-month commitment pricing in captured materials.

Oral route: availability and pricing transparency

Willow advertises injectable and oral routes for both semaglutide and tirzepatide (captured September 4, 2026). However, route-specific pricing for oral formulations is not itemized in published checkout flows or pricing pages. The documented $299 semaglutide and $399 tirzepatide figures apply to injections; if oral routes carry different pricing, that information is not disclosed in materials captured September 4, 2026. Readers considering oral administration should confirm route-specific pricing at checkout.

PlexusDx publishes distinct pricing for oral capsule formulations:

• Semaglutide oral: $289/month MTM, $269/month 3-month, $249/month 6-month
• Tirzepatide oral: $349/month MTM, $299/month 3-month, $279/month 6-month

PlexusDx oral capsules are compounded sublingual formulations designed for absorption under the tongue, not swallowing. Oral-route pricing is fully itemized across all billing terms.

What is included in each program

Willow inclusions

Willow's all-inclusive pricing ($299 semaglutide, $399 tirzepatide) includes:

• Compounded GLP-1 medication
• Doctor-guided treatment and provider access
• Free 2-day shipping
• No separate membership fee
• HSA/FSA payment accepted

Cancellation and refund terms are not documented in captured materials (as of September 4, 2026).

PlexusDx inclusions

PlexusDx all-inclusive pricing includes:

• Compounded GLP-1 medication (same price at every dose)
• Online provider visit and ongoing clinical oversight
• Prescription and pharmacy fulfillment
• Shipping to your address
• No membership fee, no per-visit charges
• HSA/FSA payment accepted

PlexusDx works with licensed 503A compounding pharmacies. Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient.

Service quality and review record

PlexusDx holds a 4.3-star rating on Trustpilot, with 79% of reviews at five stars and 83% at four stars or higher (captured September 9, 2026). Willow maintains a Trustpilot profile, but rating and review volume data were not captured in indexed materials (as of September 4, 2026). Readers evaluating service quality should consult current platform reviews and confirm support responsiveness before enrollment.

Decision factors: where each option fits

Choose Willow if…

• You prefer the reassurance of 2-day expedited shipping as a standard inclusion.
• You are already familiar with Willow's provider network or have a referral from a trusted source.
• You have confirmed at checkout that the oral route you prefer is available and acceptably priced.
• The $110/month premium over PlexusDx is acceptable within your budget and you value Willow's specific service delivery model.

Choose PlexusDx if…

• Lowest ongoing monthly cost is your priority—PlexusDx semaglutide injection is $189/month MTM vs. Willow's $299, and tirzepatide injection is $289/month vs. $399.
• You want transparent oral-route pricing published upfront—semaglutide oral $289 MTM, tirzepatide oral $349 MTM.
• You value the flexibility of 3-month and 6-month prepaid plans for further per-month savings ($149/month for semaglutide, $249/month for tirzepatide on the 6-month plan).
• You want a program with a documented Trustpilot rating (4.3 stars, 83% four-star or higher) before enrollment.
• You prefer same-price-at-every-dose simplicity—no surprise cost increase when your clinician adjusts your dose upward.
• You are interested in a microdose GLP-1 protocol for maintenance or gentler initiation ($129/month MTM).

Methodology and freshness

All Willow pricing and plan terms were verified from checkout flows and published pricing pages captured September 4, 2026. PlexusDx pricing is current as of September 8, 2026, and reflects standard month-to-month, 3-month, and 6-month rates. Twelve-month cost calculations are our calculation, derived by multiplying the stated monthly rate by 12. Willow's oral-route pricing was not itemized in captured materials; readers should confirm route-specific pricing at checkout. Review data for PlexusDx (4.3 stars, 79% five-star, 83% four-star or higher) was captured from Trustpilot on September 9, 2026. Willow's Trustpilot profile exists, but rating and volume data were not captured in indexed materials as of September 4, 2026. This comparison does not guarantee medication availability, eligibility, or outcomes; a licensed clinician determines whether a prescription is appropriate for each individual patient.

Frequently Asked Questions

Does Willow charge a membership fee in addition to medication cost?

No. Willow's published pricing is all-inclusive: $299/month for compounded semaglutide and $399/month for tirzepatide include medication, provider access, and free 2-day shipping with no separate membership fee (captured September 4, 2026).

Can I use HSA or FSA funds to pay for either PlexusDx or Willow?

Yes. Both PlexusDx and Willow accept HSA and FSA payment methods. Confirm current acceptance at checkout, as policies may change.

How much does PlexusDx oral semaglutide cost compared to Willow?

PlexusDx semaglutide oral capsules are $289/month month-to-month, $269/month on a 3-month plan, and $249/month on a 6-month plan. Willow advertises oral semaglutide availability but does not itemize route-specific pricing in captured materials (September 4, 2026). Confirm Willow's oral-route price at checkout.

Are compounded semaglutide and tirzepatide FDA-approved medications?

No. Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. Both PlexusDx and Willow dispense compounded GLP-1 medications. A licensed clinician determines whether a prescription is appropriate for an individual patient.

Does the price increase when my dose goes up at PlexusDx or Willow?

PlexusDx maintains the same monthly price at every dose—$189 for semaglutide injection whether you are on 0.25 mg or 2.4 mg. Willow's dose-escalation pricing policy is not documented in captured materials (September 4, 2026); confirm whether cost changes with dose adjustments before enrollment.

Sources

• Willow pricing and plan terms (checkout verification, accessed September 4, 2026)
• Willow medication offerings and shipping policy (published pricing page, accessed September 4, 2026)
• PlexusDx pricing matrix (internal, current as of September 8, 2026)
• PlexusDx Trustpilot rating (platform data, accessed September 4, 2026)
• Willow Trustpilot profile (platform listing, accessed September 4, 2026; rating data not captured)

Compounded medication disclosure: Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. PlexusDx works with licensed 503A compounding pharmacies.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.