Hers vs Fridays: Month-to-Month vs Prepaid GLP-1 Pricing

Last reviewed: May 12, 2026 Last updated: May 12, 2026

Written by: Jay Hastings , CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

Welcome to the PlexusDx Education Hub, where we translate GLP-1 science, weight-management options, and the genetics beneath them into decisions you can actually use. Explore the full Peptides & GLP-1 library.

The following is independent editorial analysis. PlexusDx has no affiliate deal, sponsorship, or commercial relationship with Hers, Fridays, or their parent companies.

Full head-to-head: PlexusDx vs Fridays →

If you are comparing Hers and Fridays, the most useful lens is billing structure: whether you pay month to month or lock in a prepaid bundle changes the math dramatically. Fridays makes that trade-off explicit, so this page leads with how commitment shapes cost, then covers the shared drug class and the genetics both brands omit.

Month-to-month versus prepaid: the core trade-off

As of Fridays' own pricing page (joinfridays.com/pricing, verified 2026-07-20), Fridays advertises compounded semaglutide at $249/mo and compounded tirzepatide at $359/mo as ongoing month-to-month rates, with $0 membership, free shipping, and included coaching and dietitian support, and it also sells prepaid multi-month plans. The lesson is that a program's lowest quoted number often assumes a long commitment you pay for up front.

Reading Hers pricing the same way

Hers (Hims & Hers Health) runs subscription telehealth with a virtual evaluation, a provider prescription, and either brand-name FDA-approved dispensing or compounded semaglutide or tirzepatide via a licensed compounding pharmacy. It publishes weight-loss pricing that varies by medication and plan. Apply the same discipline you would to Fridays: separate the flexible month-to-month rate from any discounted prepaid tier, and verify the live figure before committing, since Fridays' own rates moved materially within a single day.

Where PlexusDx lands against Fridays

PlexusDx's month-to-month rates run roughly $60 to $70/mo below Fridays' advertised month-to-month for both compounds. In other words, if you want flexibility, the month-to-month comparison favors PlexusDx; if you are ready to prepay a longer commitment, Fridays' bundle math can win on price alone. Neither answer is universal, which is exactly why structure matters more than a single sticker.

The compound behind every plan

Whatever the billing tier, the pharmacology is constant. GLP-1 receptor agonists such as semaglutide, liraglutide, and dulaglutide, plus the GIP/GLP-1 dual agonist tirzepatide, act on appetite, satiety, and gastric emptying. The trial base is equally fixed: STEP for semaglutide (NEJM 2021), SURMOUNT for tirzepatide (NEJM 2022), and SURMOUNT-OSA for tirzepatide in obstructive sleep apnea (NEJM 2024). A pricing structure cannot change what the molecule does.

The genetic layer no price tier includes

No bundle, monthly or prepaid, accounts for your genetics. A variant in TCF7L2, tied to glucose homeostasis and GLP-1 secretion, or in FTO, GLP1R, and MC4R, maps the metabolic terrain any GLP-1 compound acts on. These are pathway-level markers and do not predict response to any specific medication. The PlexusDx Precision Peptide Genetic Test analyzes 14 pathways, 49 peptides, 150+ genetic insights, including TCF7L2, FTO, MC4R. Paired with the PlexusDx Weight Management Protocols, it is the test before you invest approach, ideally before you lock money into any prepaid plan.

No affiliation: PlexusDx has no commercial relationship with Hers or Fridays and does not represent either company.

More from the Education Hub: GLP 1 Drugs and GLP 1 Hormone.

Disclaimer: This comparison is educational. PlexusDx is not affiliated with Hers or Fridays. PlexusDx offers semaglutide and tirzepatide through its own Weight Management Protocols. The Precision Peptide Genetic Test analyzes how your genes influence peptide-related biological pathways and does not predict response to any specific medication. Consult a qualified healthcare provider before beginning any peptide protocol.

Frequently Asked Questions

Is Fridays cheaper than Hers?

It depends on the tier. Fridays' verified month-to-month rates are $249/mo semaglutide and $359/mo tirzepatide, while its prepaid annual plan works out to roughly $150 and $240 per month. Hers publishes its own plan-dependent pricing. Compare like tiers, month-to-month against month-to-month, and verify both live before deciding.

Why does prepaying lower the monthly cost so much?

Prepaid multi-month bundles trade flexibility for a lower per-month equivalent. Fridays' month-to-month semaglutide rate is $249/mo; on its separate paid-annually plan the per-month equivalent is roughly $150. The savings assume you commit and pay up front, so factor in the risk that your needs or the program change during that window.

How does PlexusDx compare on billing structure?

PlexusDx's month-to-month rates run roughly $60 to $70/mo below Fridays' month-to-month for both compounds. PlexusDx also adds pathway-level genetic context through the Precision Peptide Genetic Test, which no billing tier at either brand includes.

Keep learning at the PlexusDx Education Hub. Return to the Peptides & GLP-1 library.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.