Last reviewed: May 12, 2026
Last updated: May 12, 2026
Written by:
Jay Hastings
,
CEO of PlexusDx
Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.
Medically reviewed by:
Jayden Lee, PharmD, EMBA
Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.
This review is part of the PlexusDx Education Hub, covering GLP-1 programs, compounded-pharmacy models, pricing structures, and the genetics that shape response. Browse the Peptides & GLP-1 library.
Independent editorial review. PlexusDx has no commercial relationship with Fridays or its parent company; there are no affiliate links or sponsored terms in this article.
Full head-to-head: PlexusDx vs Fridays →
Anyone researching Fridays' GLP-1 program wants two things: to understand how the telehealth-plus-compounding model works, and to see real numbers. This review does both — it lays out Fridays' structure and eligibility flow, reports the pricing published on the brand's own page, and then turns to the genetic input that no subscription, Fridays included, reads. As of April 2026.
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What Fridays offers in the GLP-1 space
Fridays, from Fridays Health, operates as telehealth paired with a compounding pharmacy. The model follows the category shape: a licensed provider evaluates you virtually and, when appropriate, issues a prescription routed to a retail pharmacy for FDA-approved brand products or a 503A compounding pharmacy for compounded semaglutide or tirzepatide, with ongoing follow-up. Current structure and pricing live on Fridays's official website.
Inside the telehealth-plus-compounding model
Because Fridays leans on a compounding pathway, most of its GLP-1 volume runs through 503A-prepared semaglutide and tirzepatide rather than brand products. A 503A pharmacy compounds patient-specific medication under a valid prescription and applicable oversight. That pathway shapes both what is available and how the program prices it, which is why the compounded model is worth understanding before comparing headline numbers.
The eligibility and prescription pathway
The flow mirrors other programs: complete an intake covering weight, medical history, and current medications; a licensed clinician reviews eligibility; a prescription is issued if you qualify; the compounding or retail pharmacy fulfills it; and follow-up supports titration and side-effect management. Provider type and support structure vary, but the sequence from intake to shipment is consistent.
Fridays pricing in detail
As of its own pricing page (joinfridays.com/pricing, verified 2026-07-20), Fridays advertises compounded semaglutide at $249/mo and compounded tirzepatide at $359/mo as ongoing month-to-month rates, with $0 membership, free shipping, and included coaching and dietitian support. Prepaid multi-month bundles lower the per-month equivalent — a paid-annually plan works out to roughly $150/mo for semaglutide and $240/mo for tirzepatide. Fridays' rates moved materially within a single day, so verify current pricing at Fridays's official website before any commitment.
Trial evidence behind the compounds
The pharmacology comes from the compound class, not the program. GLP-1 receptor agonists (semaglutide, liraglutide, dulaglutide) and the dual agonist tirzepatide carry the evidence: STEP for semaglutide (NEJM 2021), SURMOUNT for tirzepatide (NEJM 2022), and SURMOUNT-OSA for tirzepatide in obstructive sleep apnea (NEJM 2024). Populations and endpoints differ across trials, and outcomes vary by individual.
The genetic variable no subscription reads
Here is the layer none of these telehealth workflows examine: the inherited biology that sets the stage before any GLP-1 molecule arrives. Variants across FTO (fat-mass and obesity-associated), GLP1R (the receptor targeted by every GLP-1), and MC4R map the appetite and energy-balance baseline a compounded prescription is written into. These are pathway-level markers. They do not predict how you will respond to any particular drug, but they describe the metabolic terrain a prescriber is writing into. The PlexusDx Precision Peptide Genetic Test reads 14 pathways, 49 peptides, 150+ genetic insights across that terrain, mapping appetite regulation, satiety, and energy-balance biology so a conversation with your own clinician starts from data rather than guesswork. It is not a pharmacogenomic test and never forecasts a medication's effect.
PlexusDx offers semaglutide and tirzepatide through its Weight Management Protocols — Semaglutide Injection, Semaglutide Oral, Tirzepatide Injection, and Tirzepatide Oral. On price, PlexusDx's month-to-month rates run roughly $60–$70/mo below Fridays' advertised month-to-month for both compounds, while Fridays' prepaid 3- and 6-month bundles undercut PlexusDx per month. The added layer is genetic context.
Not affiliated: PlexusDx has no affiliation and no commercial relationship with Fridays or the other programs discussed in this review.
Related reading on PlexusDx: GLP 1 Drugs, GLP 1 Hormone, What Is GLP 1, GLP 1 What Is.
Educational only. PlexusDx has no affiliation or commercial relationship with Fridays. PlexusDx offers semaglutide and tirzepatide through its own Weight Management Protocols, and this review compares GLP-1 telehealth approaches. The Precision Peptide Genetic Test analyzes gene–pathway influence and does not predict any drug's effect. Consult a qualified healthcare provider before beginning a peptide protocol.
Line up the alternative: see the PlexusDx Weight Management Protocols for semaglutide and tirzepatide, or take the Precision Peptide Genetic Test to read your pathway before you pay.
Frequently Asked Questions
How much does Fridays cost per month?
As of its own pricing page (joinfridays.com/pricing, verified 2026-07-20), Fridays advertises compounded semaglutide at $249/mo and tirzepatide at $359/mo month-to-month, with $0 membership and free shipping; prepaid multi-month bundles lower the per-month equivalent. Fridays' rates moved within a single day, so verify current pricing on the brand's own site.
Is Fridays cheaper than PlexusDx?
It depends on how you pay. PlexusDx's month-to-month rates run roughly $60–$70/mo below Fridays' advertised month-to-month for both compounds, while Fridays' prepaid 3- and 6-month bundles undercut PlexusDx per month. Compare the payment structure that matches how you intend to buy, and confirm current figures directly.
What is included in a Fridays subscription?
Per its published page, Fridays bundles the compounded medication with $0 membership, free shipping, and coaching plus dietitian support, with prepaid bundles lowering the effective monthly rate. Inclusions can change, so read the current terms on the brand's own site before committing rather than relying on any summary here.
How does genetic testing fit with a Fridays prescription?
It sits upstream of the prescription. The Precision Peptide Genetic Test maps pathway-level variants in FTO, and MC4R that describe your baseline metabolism. It does not predict how a Fridays compound will perform; it provides context to discuss with your own clinician before or alongside any program.
This article is part of the PlexusDx Education Hub. Browse all Peptides & GLP-1 education.
Medical and Editorial Standards
Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.
Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.
Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.
Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.
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