Fridays Cost: What Drives Your Monthly Total and How It Moves

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This editorial review breaks down how a Fridays monthly cost is built, what drives it up or down, and how the numbers behave over time. Fair-balance editorial framing, not a buying recommendation. As of April 2026.

Full head-to-head: PlexusDx vs Fridays →

This is an independent editorial review. PlexusDx holds no commercial relationship with Fridays, earns no affiliate commission, and was not compensated to publish it.

Fridays at a glance: a telehealth and compounding model

Fridays (Fridays Health) pairs virtual care with a compounding pharmacy. A licensed provider reviews an online intake, and, if you qualify, writes a prescription routed either to a retail pharmacy for FDA-approved brand products or to a 503A compounding pharmacy for compounded semaglutide or tirzepatide. Cost follows directly from which of those routes you land on. See Fridays' own website for the current program layout.

The building blocks of a Fridays monthly bill

Rather than one flat number, a Fridays bill assembles from a few parts: the compound itself, any program or membership fee, shipping, and the clinical follow-up that supports dose titration. On its own pricing page (joinfridays.com/pricing, verified 2026-07-20), Fridays shows compounded semaglutide at $249 per month and compounded tirzepatide at $359 per month as month-to-month rates, with $0 membership, free shipping, and coaching plus dietitian support folded in rather than billed separately.

Compound choice is the largest lever

Semaglutide and tirzepatide are priced differently because they are different molecules with different supply dynamics. Switching between them, or moving from a compounded version to an FDA-approved brand filled at retail, is usually the single biggest swing in a monthly total.

Month-to-month versus prepaid: how the math changes

The headline rate assumes you pay each month. Prepaid bundles rearrange the math: Fridays states that a paid-annually plan works out to roughly $150 per month for semaglutide and $240 per month for tirzepatide. For context, PlexusDx month-to-month rates run about $60 to $70 below Fridays month-to-month for both compounds, and Fridays also sells prepaid three- and six-month bundles. The right comparison depends on how long you expect to stay on therapy.

Why cash-pay pricing moves so often

Because compounded GLP-1 therapy is cash-pay and not tied to insurance contracts, the posted number can shift with supply and demand. Fridays rates moved materially within a single day during our check. Treat any quoted figure, including the ones here, as a point-in-time reading and verify the live rate at Fridays' own website before committing.

The cost variable that no pricing page lists

Every line item on a telehealth invoice sits downstream of biology the invoice never mentions. A variant in FTO, the fat-mass and obesity-associated gene, or in MC4R, a melanocortin receptor tied to satiety, shapes how a body arrives at a GLP-1 program in the first place. These pathway-level markers do not predict what any compound will cost or do, but they describe the metabolic terrain a clinician is prescribing into. The PlexusDx Precision Peptide Genetic Test reads 14 pathways, 49 peptides, 150+ genetic insights, including FTO, MC4R, and TCF7L2, so the money you spend on a protocol is spent with context rather than guesswork.

How PlexusDx structures the same category

PlexusDx sells semaglutide and tirzepatide directly through its Weight Management Protocols, available as Semaglutide Injection, Tirzepatide Injection, and oral formats, led by transparent month-to-month rates rather than a long prepaid floor. Pairing that with the genetic test is the test-before-you-invest idea: understand the pathway, then decide where your dollars go.

No affiliation: PlexusDx is independent of Fridays and has no commercial ties to the brands discussed in this review.

More from the PlexusDx library: GLP-1: What Is It, GLP-1 Drugs.

Disclaimer: this article is educational. PlexusDx is not affiliated with Fridays and has no commercial relationship with the brands reviewed. PlexusDx offers semaglutide and tirzepatide through its own Weight Management Protocols, and this piece compares approaches within the GLP-1 telehealth space. The Precision Peptide Genetic Test analyzes how your genes influence peptide-related biological pathways; it does not predict response to any specific medication and is not a pharmacogenomic test. Speak with a qualified healthcare provider before beginning any peptide protocol.

Frequently Asked Questions About Fridays Cost

What determines a Fridays monthly cost?

Your monthly total reflects which compound you choose, whether it is compounded or brand, and whether you pay month-to-month or prepay. Fridays lists compounded semaglutide at $249 and compounded tirzepatide at $359 monthly, with no membership fee and free shipping bundled in.

Does prepaying really lower the Fridays cost?

Yes. Fridays advertises $249 monthly for semaglutide and $359 for tirzepatide month-to-month; separately, its paid-annually plan works out to roughly $150 and $240 per month. The trade is commitment and cash up front in exchange for a lower per-month equivalent across the term.

Why do the numbers change so quickly?

Compounded cash-pay pricing is not fixed like insurance formularies. Fridays rates moved materially within a single day during our review on 2026-07-20, so any figure here is a snapshot. Confirm the live number on the brand site before you commit to a plan.

Does the genetic test factor into cost decisions?

It does not change any program price, and it never predicts drug response. The Precision Peptide Genetic Test maps pathway variants such as FTO so you understand your baseline metabolism before spending on a protocol, turning a cost decision into an informed one.

This article is part of the PlexusDx Education Hub. Browse all Peptides & GLP-1 education