Last reviewed: September 12, 2026 Last updated: September 12, 2026

Written by: Jay Hastings, CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

PlexusDx publishes this comparison and is one of the providers discussed. We use the same evidence rules for our own program and competing programs.

The short answer

The lowest advertised introductory monthly equivalent for compounded semaglutide injection appears at OrderlyMeds—a two-month starter pack for $149 total ($74.50/month effective, captured September 4, 2026)—followed by $149/month ongoing. Mochi Health advertises a $60/month starting-dose medication rate plus a $39/month first-month membership ($99 total at entry dose, captured September 4, 2026), though dose increases raise the medication component. PlexusDx semaglutide injection runs $189/month month-to-month with no membership, or $149/month on a six-month commitment (captured September 12, 2026). When introductory periods end, the picture shifts: PlexusDx at $149–$189, OrderlyMeds at $149, Eden at $198 all-in, and MEDVi at $299 refill settle into a range where the headline low rate must be weighed against service reliability, dose-escalation flexibility, and cancellation terms. OrderlyMeds and Eden each carry negative review themes—delayed refunds and non-response at OrderlyMeds (3.6-star Trustpilot, ~634 reviews, captured September 4, 2026), order delays at Eden (4.5 stars, ~5,000 reviews, captured September 4, 2026)—that merit attention when the savings gap is narrow.

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At-a-glance semaglutide pricing

Provider Introductory / First Period Ongoing / Refill Membership Notes
OrderlyMeds $149 total for 2 months
($74.50/month effective)		 $149/month None 3.6-star Trustpilot; friction themes
Mochi Health $60/month medication at starting dose Varies by dose $39/month Per-dose pricing; 4.5-star Trustpilot
PlexusDx None advertised $189 MTM; $169 on 3-mo; $149 on 6-mo None Same price every dose; 4.3-star Trustpilot
MEDVi $179 first month $299/month None (compounded path) 4.3-star Trustpilot
Eden $138 first month
($99 med + $39 membership)		 $198/month
($99 med + $99 membership)		 $39 first, then $99/month 4.5-star Trustpilot; one delay report
Henry Meds None advertised $297 MTM; $247 on 6-mo prepaid;
$197 on 12-mo prepaid		 None 4.4-star Trustpilot, ~13,000 reviews
Hims & Hers None advertised $199/month on 6-mo prepaid
($1,194 total)		 None Requires 6-month prepay

All figures captured September 4–12, 2026, from provider checkout pages and marketing. Effective per-month rates on prepaid plans are our calculation.

Normalized comparison: true all-in monthly cost

Advertised per-month figures often separate medication, membership, and visit charges or embed a discount inside a multi-month prepayment. The table below isolates the ongoing all-in cost over twelve months, standardizing to a single monthly figure that includes every recurring line item.

Provider Month-to-Month Total 12-Month Commitment Total Effective Monthly (12-mo)
OrderlyMeds $1,937
(intro $149 for 2 months + 10×$149 refill)		 — $161 (our calculation)
Mochi Health (entry dose) $1,287
(12×$99 med+membership)		 — $107 (our calculation, starting dose only)
PlexusDx $2,268
(12×$189)		 $1,788
(12×$149 on 6-mo plan)		 $149
MEDVi $3,468
($179 first month + 11×$299 refill)		 — $289 (our calculation)
Eden $2,316
($138 first month + 11×$198 refill)		 — $193 (our calculation)
Henry Meds $3,564
(12×$297)		 $2,364 prepaid $197
Hims & Hers — $2,388 prepaid
(two 6-mo cycles)		 $199

Twelve-month totals and effective monthly rates labeled "our calculation" include stated introductory periods and ongoing refill rates. Mochi entry-dose figure assumes no dose escalation; actual cost rises as dose increases. All data captured September 4–12, 2026.

OrderlyMeds posts the lowest advertised monthly equivalent over twelve months at $161 (our calculation), but its 3.6-star Trustpilot rating and captured complaints about delayed refunds, pharmacy changes, and unresponsive service (Trustpilot, captured September 4, 2026) introduce fulfillment risk. Mochi Health's $107 effective rate (our calculation) applies only at the starting dose; the per-dose pricing model raises cost as you titrate, and one captured Trustpilot example reports a provider appearing late and not engaging (captured September 4, 2026), though the overall rating is 4.5 stars across ~18,000 reviews. PlexusDx at $149/month on a six-month commitment ($1,788 total) sits between OrderlyMeds and the next tier—Eden ($193, our calculation), Henry Meds ($197 on twelve-month prepaid), Hims & Hers ($199 on back-to-back six-month prepays)—and carries the same flat price at every dose, no membership fee, and a 4.3-star Trustpilot rating with 79 percent five-star reviews and 83 percent four stars or higher (captured September 9, 2026; trustpilot.com/review/plexusdx.com). MEDVi's $179 first-month rate climbs to $299/month refill, yielding a twelve-month effective cost of $289 (our calculation), the highest in this set.

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What drives cost differences

Four structural choices separate the lowest-cost programs from the mid-range and premium tiers:

  1. Promotional lead-ins versus flat pricing. OrderlyMeds and MEDVi both use a discounted first month or starter pack to lower the advertised entry point, then shift to a higher refill rate. PlexusDx, Eden (after month one), Henry Meds, and Hims & Hers publish consistent per-month or per-period rates with no step-up at refill.
  2. Dose-dependent versus dose-flat pricing. Mochi Health charges separately for each dose tier, so the $60/month starting-dose medication rate rises as you escalate. PlexusDx, OrderlyMeds, MEDVi, Eden, Henry Meds, and Hims & Hers each hold the same monthly price across the full dose range, eliminating surprise increases mid-protocol.
  3. Membership unbundling. Eden splits cost into a $99/month medication line and a $99/month membership line (after an introductory $39 membership month), while Mochi adds $39/month membership to its per-dose medication charge. PlexusDx, OrderlyMeds, MEDVi, Henry Meds, and Hims & Hers fold provider access, care coordination, and shipping into a single recurring figure.
  4. Prepayment discounts. Henry Meds and Hims & Hers require multi-month prepayment to unlock their lowest per-month equivalents—$197/month effective on a twelve-month Henry prepay, $199/month effective on back-to-back six-month Hims prepays (both our calculation). PlexusDx offers optional three-month and six-month commitments at lower rates ($169 and $149/month, respectively) but retains a month-to-month path at $189 with no upfront outlay.

Service quality and reliability considerations

When monthly cost differences fall inside a $40–$50 band, execution quality—order fulfillment speed, pharmacy consistency, refund handling, and clinical responsiveness—becomes the deciding variable. Three providers in the low-cost cohort carry review evidence that merits direct consideration:

OrderlyMeds (3.6 stars, ~634 reviews, Trustpilot, captured September 4, 2026)

Captured one-star and two-star Trustpilot reviews report fast initial charges followed by slow or nonexistent refunds, delayed shipments, mid-treatment pharmacy switches, and continued marketing calls and texts after opt-out requests (captured September 4, 2026). The 3.6-star average is the lowest among the providers analyzed here. The $149 ongoing rate and $161 effective twelve-month cost (our calculation) represent a $28–$38/month savings against PlexusDx month-to-month, a margin that narrows to $12/month when compared to PlexusDx on a six-month commitment.

Eden (4.5 stars, ~5,000 reviews, Trustpilot, captured September 4, 2026)

Eden's overall rating is strong, but one captured one-star Trustpilot example describes an eleven-day order delay and repeated requests for medical records the provider had previously issued (captured September 4, 2026). The $198 all-in ongoing rate ($99 medication + $99 membership) yields a twelve-month effective cost of $193 (our calculation), $44 above PlexusDx on a six-month commitment and $4 below PlexusDx month-to-month.

Mochi Health (4.5 stars, ~18,000 reviews, Trustpilot, captured September 4, 2026)

Mochi's rating is high and its review volume the largest in this set. One captured Trustpilot report describes a provider appearing late to a telehealth visit and not engaging (captured September 4, 2026). The starting-dose all-in cost of $99/month (introductory $60 medication + $39 membership) is the lowest in the analysis, but dose escalation raises the medication component on a per-tier schedule that is not published in the indexed research, so the $107 effective twelve-month figure (our calculation) holds only if the patient remains at entry dose for the full year—a clinically unlikely scenario for most titration protocols.

PlexusDx holds a 4.3-star rating on Trustpilot, with 79 percent of reviews at five stars and 83 percent at four stars or higher (captured September 9, 2026; trustpilot.com/review/plexusdx.com). Henry Meds (4.4 stars, ~13,000 reviews, captured September 4, 2026), Hims & Hers (10,094 reviews, rating not captured), and MEDVi (4.3 stars, ~15,000 reviews, captured September 4, 2026) each carry four-star-or-better averages and four-figure review counts, indicating established fulfillment and service operations.

Oral semaglutide: a parallel cost ladder

Several providers offer oral (sublingual tablet or capsule) semaglutide formulations, typically at a premium over injection. PlexusDx oral semaglutide runs $289/month month-to-month, $269/month on three-month commitment, and $249/month on six-month commitment (captured September 12, 2026). Henry Meds publishes two oral routes: sublingual tablets at $249/month and "premium" tablets or drops at $179/month, with a three-month plan for oral semaglutide priced at $537 prepaid or $747 standard (captured September 4, 2026). MEDVi adds $70 to its injection price for tablet formulation (captured September 4, 2026), implying a $369/month refill rate for oral semaglutide ($299 injection base + $70). The oral category generally adds $50–$100/month over injectable at the same provider, reflecting compounding complexity and absorption pharmacokinetics, though Henry Meds' $179 "premium" oral rate sits below its $297 injection rate and merits clarification at intake.

Choose OrderlyMeds or Mochi if you prioritize the lowest advertised cost

  • You prioritize the absolute lowest advertised per-month cost and are prepared to manage potential service friction or dose-escalation price increases.
  • You are comfortable with OrderlyMeds' 3.6-star rating and captured reports of delayed refunds, pharmacy changes, and non-response, accepting those risks in exchange for a $149 ongoing rate.
  • You select Mochi and understand that its $99 all-in starting rate applies only at entry dose and will rise with titration, and you are willing to track per-dose pricing as you escalate.

Choose PlexusDx if you want flat-dose pricing and month-to-month flexibility

  • You want month-to-month flexibility at $189 with the option to lock a lower rate ($169 or $149) through a three-month or six-month commitment, no upfront payment required on month-to-month.
  • Flat pricing across all doses matters—no surprise cost increases when your clinician raises your dose.
  • You prefer a single all-inclusive monthly charge (medication, clinician access, shipping) with no separate membership fee.
  • A 4.3-star Trustpilot rating with 79 percent five-star reviews (captured September 9, 2026) and transparent evidence-based pricing provide confidence in fulfillment and service quality.
  • You value an intake process reviewed by a licensed provider who determines whether a semaglutide prescription is appropriate for your specific clinical profile.
View PlexusDx Semaglutide Injection

Choose Henry Meds or Hims & Hers if you can prepay for mid-tier savings

  • You are willing to prepay six or twelve months to unlock the lowest per-month equivalent in the mid-tier cost band ($197–$199 effective monthly, our calculation).
  • You want an established telehealth platform with four-digit review volume and four-star-or-better Trustpilot ratings.
  • Upfront liquidity is not a constraint—Henry's twelve-month plan requires $2,364 paid in full; Hims six-month requires $1,194 (captured September 4, 2026).

Choose Eden if you accept split billing near the PlexusDx month-to-month rate

  • You accept a split-billing model ($99 medication + $99 membership after the first month) in exchange for a $198 all-in ongoing rate that sits near the PlexusDx month-to-month price.
  • A 4.5-star Trustpilot rating provides sufficient confidence despite one captured report of an eleven-day delay and redundant record requests.

Avoid MEDVi for lowest-cost priority

MEDVi's $179 introductory month is competitive, but the $299 refill rate yields a twelve-month effective cost of $289 (our calculation)—$94–$140 above PlexusDx depending on commitment tier, and $128 above OrderlyMeds. MEDVi's 4.3-star Trustpilot rating and ~15,000 reviews indicate operational maturity, but its pricing structure does not align with a lowest-cost search.

Insurance-assisted and branded-drug paths

This analysis focuses on cash-pay compounded semaglutide, the category with the most transparent and comparable pricing. Several platforms—Found, Ro, LifeMD, WeightWatchers Clinic—offer insurance-navigation services or branded Wegovy/Ozempic prescriptions with separate medication billing. Found's insurance-support twelve-month plan runs $99/month effective ($1,188 prepaid, captured September 4, 2026) for the care program; medication copays, prior authorizations, and pharmacy fulfillment introduce variables this article does not model. Ro's Body Program membership starts at $149/month or $74/month on an annual prepay, with medication billed separately; one Wegovy pill tier is advertised at $149/month starting dose, rising to $299 at higher doses (captured September 4, 2026). If your insurance covers GLP-1 agonists for weight management and you are prepared to navigate prior-authorization workflows, an insurance-assisted path may deliver lower out-of-pocket cost than any cash-pay option, but formulary restrictions, copay tiers, and approval timelines are payer-specific and fall outside the scope of this pricing comparison.

Methodology and freshness

All provider pricing, plan structures, membership fees, and promotional terms were captured between September 4 and September 12, 2026, from publicly accessible checkout flows, provider marketing pages, and indexed research documents. Trustpilot ratings, review volumes, and negative-theme examples were captured on September 4 and September 9, 2026, and reflect the state of each profile on those dates; individual reviews are described as reports or allegations, not verified facts. Twelve-month total costs and effective monthly rates labeled "our calculation" were derived by summing stated introductory and refill rates over twelve billing cycles and dividing by twelve; no promotional code, referral discount, or unstated fee was assumed. PlexusDx pricing was verified on September 12, 2026. Compounded medications are not FDA-approved; FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. This article does not guarantee eligibility, medication type, dose, results, or side-effect outcomes.

Frequently Asked Questions

What is the single cheapest semaglutide provider right now?

OrderlyMeds advertises the lowest ongoing rate at $149/month after a two-month $149 starter pack, yielding a twelve-month effective cost of $161 (our calculation, captured September 4, 2026). Its 3.6-star Trustpilot rating and captured complaints about delayed refunds and service friction introduce fulfillment risk that may offset the $12–$28/month savings over PlexusDx.

Do cheaper semaglutide programs raise the price when my dose increases?

Mochi Health uses per-dose pricing, so cost rises with titration beyond the $60/month starting medication rate. OrderlyMeds, PlexusDx, Eden, MEDVi, Henry Meds, and Hims & Hers each hold a flat monthly rate across all doses (captured September 4–12, 2026).

Should I prepay six or twelve months to get the lowest rate?

Henry Meds' twelve-month prepaid plan ($2,364 total, $197/month effective) and Hims & Hers' six-month plan ($1,194 per cycle, $199/month effective) deliver the lowest per-month cost in the mid tier, but lock capital and limit flexibility. PlexusDx offers optional three-month and six-month commitments ($169 and $149/month) with no upfront payment required on the month-to-month $189 path (captured September 12, 2026).

Does a low advertised rate always mean low total cost?

No. MEDVi advertises $179 for the first month but charges $299/month ongoing, producing a twelve-month cost of $3,468 (our calculation). Mochi's $60 starting medication rate applies only at entry dose and climbs with titration. Always calculate the all-in twelve-month total, including membership fees and dose-escalation effects.

Are compounded semaglutide and branded Wegovy the same medication?

No. Compounded semaglutide is prepared by a compounding pharmacy and is not FDA-approved. Branded Wegovy is FDA-approved for chronic weight management. Compounded medications are not reviewed by FDA before marketing for safety, effectiveness, or quality. A licensed clinician determines which option is appropriate for an individual patient.

Sources

  • PlexusDx semaglutide injection and oral pricing; captured September 12, 2026; plexusdx.com/products
  • Henry Meds semaglutide pricing and plans; captured September 4, 2026; henrymeds.com
  • MEDVi compounded semaglutide first-month and refill rates; captured September 4, 2026; medvi.com
  • Eden medication and membership pricing; captured September 4, 2026; edenrx.com
  • OrderlyMeds starter pack and ongoing rates; captured September 4, 2026; orderlymeds.com
  • Mochi Health per-dose pricing and membership; captured September 4, 2026; mochihealth.com
  • Hims & Hers six-month semaglutide plan; captured September 4, 2026; hims.com and forhers.com
  • Found cash-pay and insurance-support plans; captured September 4, 2026; found.com
  • Ro Body Program membership tiers; captured September 4, 2026; ro.co
  • Trustpilot ratings and review volumes for OrderlyMeds, Eden, Mochi Health, Henry Meds, MEDVi, Hims & Hers, Found, Ro, WeightWatchers Clinic, and Noom Med; captured September 4, 2026; trustpilot.com
  • PlexusDx Trustpilot rating: 4.3 stars, 79% five-star, 83% four stars or higher; captured September 9, 2026; trustpilot.com/review/plexusdx.com
  • Indexed research pass documents: commercial-facts packet, review-record packet; accessed September 12, 2026

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Compounded medication disclosure: Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. PlexusDx works with licensed 503A compounding pharmacies.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.