Last reviewed: September 16, 2026
Last updated: September 16, 2026
Written by: Jay Hastings, CEO of PlexusDx
Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.
Medically reviewed by: Jayden Lee, PharmD, EMBA
Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.
PlexusDx publishes this comparison and is one of the providers discussed. We use the same evidence rules for our own program and competing programs.
The short answer
Belle charges $199 per month for compounded semaglutide injections on a month-to-month subscription (captured September 4, 2026 from checkout and third-party verification). Its six-month prepaid plan drops the per-month rate to $119—but requires $714 upfront. Tirzepatide runs $249 per month on monthly billing, or a $199-per-month rate when prepaid for six months ($1,194 upfront).
Several providers deliver compounded semaglutide injections at lower month-to-month rates—and one matches Belle's prepaid tirzepatide cost without requiring any upfront payment. If you want flexibility and dislike large lump sums, those alternatives are worth a closer look. If you're comfortable committing six months in advance and can afford the upfront cost, Belle's prepaid semaglutide rate is among the lowest we've verified.
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At-a-glance: Belle vs. four alternatives
| Provider |
Semaglutide MTM |
Semaglutide 6-mo |
Tirzepatide MTM |
Tirzepatide 6-mo |
| Belle |
$199/mo |
$119/mo ($714 upfront, prepaid)
|
$249/mo |
$199/mo ($1,194 upfront, prepaid)
|
| PlexusDx |
$189/mo |
$149/mo (6-month commitment, billed monthly)
|
$289/mo |
$249/mo (6-month commitment, billed monthly)
|
| Peak Wellness |
$249/mo |
— |
$349/mo |
— |
| Eden |
$198/mo ($99 medication + $99 membership)
|
— |
$298/mo ($199 medication + $99 membership)
|
— |
| Found |
$289/mo |
— |
$359/mo |
— |
Belle pricing captured September 4, 2026 via checkout and third-party verification (AllyRx). PlexusDx pricing current as of September 16, 2026. Eden, Found, and Peak Wellness pricing captured July 17–23, 2026 via checkout verification.
Belle's pricing structure and prepayment terms
Belle offers both month-to-month subscriptions and prepaid multi-month plans. The month-to-month option bills $199 for semaglutide or $249 for tirzepatide each month, with no upfront lump sum. Prepaid plans require full payment at the start of the term but deliver a lower per-month rate.
For semaglutide, the six-month prepaid plan costs $714 upfront—$119 per month over that period. The two-month prepaid plan is $270 upfront ($135 per month). For tirzepatide, the two-month plan (labeled "2-month starter") is $350 upfront ($175 per month), and the six-month plan is $1,194 upfront ($199 per month).
There is no separate membership or consultation fee; the quoted price includes clinician consultation, medication, supplies, and shipping. Evidence for Belle's pricing is mixed primary–secondary, corroborated by third-party review (AllyRx) and captured September 4, 2026; we recommend confirming exact renewal and cancellation terms at checkout.
Normalized 12-month cost comparison
To compare prepaid plans against month-to-month subscriptions fairly, we calculated the total cost of each option over a full year. Prepaid figures below are our calculation, derived by multiplying the upfront term cost by the number of terms needed to reach 12 months.
| Provider & Plan |
Semaglutide (12 months) |
Tirzepatide (12 months) |
| Belle MTM |
$2,388 |
$2,988 |
Belle 6-mo prepaid (our calculation)
|
$1,428 |
$2,388 |
| PlexusDx MTM |
$2,268 |
$3,468 |
PlexusDx 6-mo commitment (billed monthly)
|
$1,788 |
$2,988 |
| Eden MTM |
$2,376 |
$3,576 |
| Peak Wellness MTM |
$2,988 |
$4,188 |
| Found MTM |
$3,468 |
$4,308 |
Key findings:
-
Belle's six-month prepaid semaglutide plan delivers the lowest 12-month cost in this comparison—$1,428, which is $360 less than PlexusDx's six-month commitment option and $840 less than PlexusDx month-to-month.
-
PlexusDx month-to-month semaglutide ($2,268 over 12 months) costs $120 less than Belle's month-to-month option and requires no upfront payment.
-
PlexusDx six-month tirzepatide ties Belle's six-month prepaid tirzepatide at $2,988 over 12 months—but PlexusDx bills monthly ($249/month) rather than requiring $1,194 upfront.
- Eden's combined medication and membership fee brings its month-to-month semaglutide to $2,376 over 12 months, only slightly above Belle's monthly plan but below all other options except PlexusDx.
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Decision factors beyond monthly cost
Upfront cash vs. monthly flexibility
Belle's lowest rates require a single payment covering two or six months. That structure works well if you have the cash on hand, are confident you'll continue therapy for the full term, and want to lock in the lowest per-month rate. If circumstances change—your insurance starts covering GLP-1s, you experience intolerable side effects, or branded medication becomes affordable—you cannot recover unused months.
Month-to-month or monthly-billed commitment plans cost more per month but let you stop or pause without forfeiting a lump sum. PlexusDx's six-month commitment, for example, bills $149 or $249 per month rather than requiring $714 or $1,194 upfront; you commit to six months but spread the payments.
Service model and support intensity
Belle is a newer entrant in the compounded telehealth GLP-1 market. Its Trustpilot profile exists, but we captured no aggregate rating, review volume, or thematic complaints as of September 4, 2026. Without a significant public review record, it is harder to assess consistency of fulfillment, clinician responsiveness, or how the company handles dose adjustments and side-effect concerns.
PlexusDx holds a 4.3-star rating on Trustpilot, with 79% of reviews at five stars and 83% at four stars or higher (captured September 9, 2026; trustpilot.com/review/plexusdx.com). That record provides some signal of service reliability, though no rating guarantees your individual experience.
Dose flexibility and transparent pricing
PlexusDx publishes one flat rate per medication, the same at every dose. Belle's website and third-party sources do not specify whether the quoted per-month rate holds across all dose tiers or whether higher doses carry surcharges. Confirm dose-pricing terms before committing to a multi-month prepaid plan.
Choose Belle if…
- You want the lowest 12-month semaglutide cost we've verified ($1,428 total, or a $119-per-month rate) and can afford $714 upfront.
- You are comfortable committing six months in advance and are confident you will continue therapy for the full term.
- You prefer a streamlined offering without multi-option decision fatigue—Belle offers injections only, no oral capsules or microdose protocols.
Choose PlexusDx if…
- You want a lower month-to-month semaglutide rate ($189 vs. Belle's $199) with no upfront lump sum and the freedom to stop any month.
- You are considering tirzepatide and want the same 12-month cost as Belle's prepaid plan ($2,988) but billed monthly rather than $1,194 upfront.
- You value a public service-quality record—PlexusDx's 4.3-star Trustpilot rating and 83% four-star-or-higher review distribution provide some transparency into fulfillment and clinician responsiveness.
- You want transparent, dose-independent pricing—one published rate per medication, the same whether you're at 0.25 mg or 2.4 mg semaglutide.
- You want access to oral capsule and microdose options if injections prove impractical or if you later want to explore maintenance protocols.
Choose Eden if…
- You want a middle-ground month-to-month cost for semaglutide ($198/month) that sits between PlexusDx and Belle.
- You are comfortable with a two-part billing structure—$99 for medication and $99 for a monthly membership that includes provider access and support.
- You value predictable monthly budgeting and want to avoid both upfront lump sums and multi-month commitments.
Choose Peak Wellness or Found if…
- You prioritize established brand recognition and a longer operational track record in the telehealth weight-management space.
- You want integrated coaching, behavioral support, or nutritional guidance bundled into the monthly fee—both Found and Peak Wellness emphasize broader lifestyle programming alongside medication.
- Price is less decisive than service breadth, and you're willing to pay $249–$289/month (semaglutide) or $349–$359/month (tirzepatide) for a more comprehensive support model.
Methodology and freshness
Belle's pricing and plan structure were captured September 4, 2026 through a combination of checkout review and third-party corroboration (AllyRx). Evidence is classified as mixed primary–secondary; we recommend confirming renewal terms, cancellation policies, and any dose-tier pricing at checkout. PlexusDx pricing is current as of September 16, 2026. Eden, Peak Wellness, and Found figures were verified via checkout between July 17 and July 23, 2026.
All 12-month cost projections are our calculation, derived by multiplying the per-month rate (or per-term upfront cost) by the number of billing cycles in a year. We do not account for potential promotional discounts, insurance reimbursement, or changes in formulary during the year—confirm current pricing and eligibility before enrolling.
Review data for PlexusDx (4.3 stars, 79% five-star, 83% four-star-or-higher) was captured September 9, 2026 from trustpilot.com/review/plexusdx.com. Belle's Trustpilot profile was checked September 4, 2026, but no aggregate rating or review volume was available at that time.
Frequently Asked Questions
Does Belle offer oral GLP-1 capsules or only injections?
Belle offers compounded semaglutide and tirzepatide injections only. If you prefer or require an oral formulation—for example, due to needle aversion or travel convenience—you will need to consider a provider that stocks compounded oral capsules, such as PlexusDx, Henry Meds, or Embody.
Can I switch from Belle's prepaid plan to month-to-month mid-term?
Belle's published terms do not detail mid-term plan changes. If you prepay for six months and want to switch to monthly billing before the term ends, contact Belle's support team to confirm whether that option exists and whether any portion of the prepaid amount is refundable or credited. We recommend clarifying cancellation and plan-change policies before committing to a multi-month prepaid plan.
Is PlexusDx's six-month commitment billed upfront or monthly?
PlexusDx's three-month and six-month commitment plans are billed monthly at the discounted rate—$149 per month for six-month semaglutide, for example—rather than requiring a lump-sum upfront payment. You commit to the term length, but the charges appear as separate monthly transactions on your payment method.
Are Belle and PlexusDx medications FDA-approved?
No. Both Belle and PlexusDx dispense compounded semaglutide and tirzepatide, which are not FDA-approved. The FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a compounded prescription is appropriate for an individual patient based on medical history and current health status.
Which provider has the absolute lowest cost for semaglutide over one year?
Belle's six-month prepaid semaglutide plan delivers the lowest 12-month cost we verified—$1,428 total, or a $119-per-month rate—but requires $714 upfront every six months. If you prefer month-to-month flexibility with no lump sum, PlexusDx's month-to-month rate of $189 ($2,268 over 12 months) is the lowest monthly option and costs $120 less over a year than Belle's $199 month-to-month plan.
Sources
- PlexusDx pricing and service structure (plexusdx.com), verified September 16, 2026
- Belle pricing and plan structure (joinbelle.com, corroborated by AllyRx third-party review), captured September 4, 2026
- Eden, Found, Peak Wellness checkout verification, captured July 17–23, 2026
- PlexusDx Trustpilot profile (trustpilot.com/review/plexusdx.com), accessed September 9, 2026
- Belle Trustpilot profile check, accessed September 4, 2026
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Compounded medication disclosure: Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. PlexusDx works with licensed 503A compounding pharmacies. A licensed clinician determines whether a prescription is appropriate for an individual patient.
Medical and Editorial Standards
Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.
Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.
Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.
Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.
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