10Rx Pricing (2026): Quarterly Packages, Refills and Total Annual Cost

Last reviewed: September 10, 2026 Last updated: September 10, 2026

Written by: Jay Hastings, CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

PlexusDx publishes this comparison and is one of the providers discussed. We use the same evidence rules for our own program and competing programs.

The short answer

10Rx sells compounded semaglutide and tirzepatide exclusively in quarterly prepaid packages: $299 every three months for semaglutide with B12 ($99.67 per month when paying quarterly upfront), and $450 every three months for tirzepatide with B12 ($150 per month when paying quarterly upfront), both captured September 4, 2026. No membership fees, no separate consultation charges, and next-day shipping included. The quarterly prepayment model delivers a lower 12-month total cost than many month-to-month alternatives—$1,196 annually for semaglutide versus $2,268 for PlexusDx month-to-month semaglutide, for example—but requires upfront commitment every three months and offers no pay-as-you-go flexibility. 10Rx's pricing page (checked September 4, 2026) describes the quarterly structure and inclusions; the $299 semaglutide and $450 tirzepatide quarterly totals were corroborated through secondary checkout data and should be confirmed at checkout.

10Rx pricing at a glance

Understanding the quarterly prepaid model

10Rx does not offer month-to-month billing. Every purchase is a three-month supply paid upfront: $299 for semaglutide with B12, or $450 for tirzepatide with B12. To continue treatment, you pay the same amount every three months. The per-month equivalent—$99.67 for semaglutide, $150 for tirzepatide—is our calculation; 10Rx bills and ships quarterly.

This prepayment structure lowers the per-month arithmetic but removes the option to pause or pay one month at a time. If cash flow or medication tolerance is uncertain, a quarterly commitment may feel less flexible than a true month-to-month plan.

12-month total cost comparison

We calculated the total outlay over one year for 10Rx's quarterly packages and compared it to PlexusDx month-to-month and multi-month plans. All figures below are our calculations based on the stated per-cycle or per-month rates.

Key observations:

• 10Rx's quarterly semaglutide package costs $1,196 over 12 months, $1,072 less than PlexusDx month-to-month semaglutide ($2,268) and $592 less than PlexusDx's 6-month semaglutide plan ($1,788).
• 10Rx's quarterly tirzepatide package costs $1,800 over 12 months, $1,668 less than PlexusDx month-to-month tirzepatide ($3,468) and $1,188 less than PlexusDx's 6-month tirzepatide plan ($2,988).
• 10Rx requires $299 or $450 upfront every three months; PlexusDx month-to-month requires no prepayment, and PlexusDx's 6-month plan requires six months upfront.
• PlexusDx offers a 3-month plan for both medications (semaglutide $169/month, tirzepatide $269/month), but those rates still result in higher 12-month totals than 10Rx's quarterly packages: $2,028 for semaglutide, $3,228 for tirzepatide (our calculation).

No like-for-like quarterly-versus-quarterly comparison is available because PlexusDx does not sell a standalone 3-month prepaid package at the same cycle length as 10Rx.

What's included in the 10Rx package

Both the semaglutide and tirzepatide quarterly packages include:

• Three-month supply of compounded medication with B12
• Clinician evaluation and consultation
• Next-day shipping
• Ongoing support

10Rx uses flat dose pricing: the same quarterly rate applies across all available strengths. Dose adjustments do not change your bill within a given medication. The range of available strengths is not enumerated in the evidence we reviewed (September 4, 2026).

How refills and dose changes work

Because 10Rx ships a three-month supply, your next refill arrives every 90 days at the same $299 or $450 rate. If your clinician increases your dose mid-cycle, the evidence does not describe whether you receive a partial refund, a credit, or an adjusted shipment schedule. Confirm the dose-change protocol during your consultation or before your first order.

Cancellation and refund terms were not documented in the sources we reviewed. Ask 10Rx directly whether you can cancel mid-quarter and receive a prorated refund, or whether the full quarterly charge is non-refundable once processed.

Comparing quarterly prepayment to month-to-month flexibility

10Rx's prepaid model works well when:

• You are confident in medication tolerance and plan to stay on therapy for at least three months.
• You want the lowest total annual cost and can front $299 or $450 every quarter.
• You prefer fewer billing transactions—four per year instead of twelve.

Month-to-month billing (PlexusDx and others) works better when:

• You want to pause or stop without forfeiting prepaid months.
• You prefer spreading cost evenly across the year without upfront cycles.
• You are trialing GLP-1 therapy and uncertain about side effects or long-term commitment.

The 12-month totals show that 10Rx's prepaid structure delivers significant savings if you complete the full year, but the model offers no month-to-month exit flexibility.

Medication availability and regulatory status

10Rx dispenses compounded semaglutide and tirzepatide injections, both formulated with vitamin B12. Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. 10Rx works with licensed 503A compounding pharmacies.

Pharmacy options vary. The evidence does not specify which 503A pharmacies 10Rx partners with or whether you can request a particular compounder. If pharmacy preference matters to you, ask before ordering.

Service quality and review record

We searched Trustpilot on September 4, 2026, and found no profile for 10Rx. A Reddit search was performed but yielded no specific attributable complaints or negative themes in the indexed data. The absence of a public review footprint does not indicate poor service, but it does mean prospective patients have less independent feedback to inform their decision.

For comparison, PlexusDx holds a 4.3-star rating on Trustpilot, with 79% of reviews at five stars and 83% at four stars or higher (captured September 9, 2026; trustpilot.com/review/plexusdx.com).

Choose 10Rx if…

• You want the lowest 12-month total cost for compounded semaglutide or tirzepatide and can prepay quarterly.
• You are confident in your medication tolerance and plan to continue therapy for at least one year.
• You prefer fewer billing events and are comfortable with a three-month supply commitment every 90 days.
• You value flat dose pricing and want no membership or consultation fees layered onto your medication cost.

Where PlexusDx fits

PlexusDx offers month-to-month, 3-month, and 6-month plans for compounded semaglutide and tirzepatide injections. Month-to-month semaglutide is $189, tirzepatide $289; 6-month semaglutide is $149 per month, tirzepatide $249 per month. All plans include the prescription, medication, provider visit, and shipping in one price—no membership fees.

PlexusDx costs more over 12 months than 10Rx's quarterly packages ($1,788 versus $1,196 for semaglutide on the 6-month plan, $2,988 versus $1,800 for tirzepatide), but month-to-month billing lets you pause or stop without forfeiting prepaid months, and the 6-month plan still avoids quarterly cycle commitment while lowering the per-month rate. If you want pay-as-you-go flexibility or are trialing therapy, PlexusDx's month-to-month structure may justify the higher annual total. If you are certain about long-term treatment and prioritize lowest cost, 10Rx's prepaid model wins on price.

Methodology and freshness

10Rx pricing and package details were captured September 4, 2026, from the company's pricing page and corroborated through secondary checkout data. The primary page (take10rx.com/pricing) confirms quarterly structure, flat dose pricing, and all inclusions but suppresses numeric package totals; the $299 semaglutide and $450 tirzepatide figures are secondary corroboration and should be confirmed at checkout. PlexusDx pricing was captured July 17–23, 2026, from internal product pages. Trustpilot and Reddit searches were performed September 4, 2026. PlexusDx Trustpilot rating (4.3 stars, 79% five-star, 83% four stars or higher) was captured September 9, 2026, from trustpilot.com/review/plexusdx.com. All 12-month cost totals and per-month equivalents are our calculations based on stated per-cycle or per-month rates. No payment was submitted to 10Rx during verification. We will update this analysis when new package pricing, billing options, or cancellation terms become available.

Frequently Asked Questions

Does 10Rx charge a membership or consultation fee?

No. The $299 semaglutide and $450 tirzepatide quarterly packages include the medication, clinician evaluation, next-day shipping, and ongoing support with no separate membership or service fee.

Can I pay month-to-month with 10Rx?

No documented month-to-month option exists. 10Rx sells three-month prepaid packages exclusively: $299 for semaglutide or $450 for tirzepatide every quarter. If a pay-per-month plan is available, it was not documented in the evidence we reviewed as of September 4, 2026.

What happens if I want to cancel mid-quarter?

Cancellation and refund terms were not documented in the sources reviewed. Contact 10Rx directly to confirm whether you can cancel partway through a three-month cycle and receive a prorated refund, or whether the quarterly charge is non-refundable once processed.

Does the price change when my dose increases?

10Rx uses flat dose pricing—the same quarterly rate applies across all available strengths of a given medication. A dose increase does not change your $299 semaglutide or $450 tirzepatide bill, but the evidence does not describe how mid-cycle dose adjustments affect shipment schedules or credits.

How does 10Rx's total annual cost compare to PlexusDx?

10Rx semaglutide costs $1,196 over 12 months (four quarterly $299 payments), versus $2,268 for PlexusDx month-to-month semaglutide and $1,788 for PlexusDx 6-month semaglutide (our calculations). 10Rx tirzepatide costs $1,800 annually, versus $3,468 PlexusDx month-to-month and $2,988 PlexusDx 6-month. 10Rx is cheaper if you prepay quarterly and complete the year; PlexusDx month-to-month offers pause-and-resume flexibility at a higher total cost.

Sources

• PlexusDx product pages (plexusdx.com, pricing captured July 17–23, 2026)
• 10Rx pricing page and secondary checkout corroboration (take10rx.com/pricing, captured September 4, 2026, 13:49:55 UTC)
• Trustpilot: 10Rx search and PlexusDx profile (trustpilot.com/review/plexusdx.com, PlexusDx rating captured September 9, 2026; 10Rx search September 4, 2026)
• Reddit search for 10Rx reports (performed September 4, 2026)

Compounded medication disclosure: Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. PlexusDx works with licensed 503A compounding pharmacies.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.