Depression Support Diet (Plant-Based)
This primarily plant-based plan is designed to nourish your brain and body with essential nutrients known to support mental well-being while adhering to your specific dietary needs. By focusing on whole, unprocessed foods, this Depression Support Diet naturally excludes corn, dairy, and eggs, making it a seamless fit for vegan, vegetarian, and pescatarian lifestyles. Beyond simply avoiding restricted ingredients, this plan actively enhances your intake of mood-supportive nutrients—such as antioxidants, fiber, and healthy fats—while minimizing sugars that can disrupt energy levels. This approach aligns with insights from your PlexusDx genetic report, which analyzes genes like MTHFR, MTRR, and PEMT that influence how your body processes folate, recycles B vitamins, and utilizes choline for neurotransmitter synthesis and brain health. By targeting these biological pathways with nutrient-dense foods, this meal plan aims to bridge potential genetic gaps and support a balanced, resilient mood.
The strategies in this program are grounded in research linking nutrition to mental health, specifically how certain vitamins and minerals can influence depressive symptoms. A balanced diet that prevents common nutrient deficiencies while enhancing specific compounds may help improve mood regulation and cognitive function. Key evidence-backed pillars of this plan include:
- Zinc & Selenium: Essential minerals that may be lower in individuals with depression and can support mood stability. Your plan includes sources like tofu, fortified granola, sunflower seed butter, pumpkin seeds, and chia seeds.
- Folate (Vitamin B9): Critical for nervous system health and often linked to improved symptoms in mood disorders. We emphasize folate-rich foods such as soy milk, edamame, tofu, spinach, Brussels sprouts, and broccoli.
- Omega-3 Fats: Fatty acids that play a vital role in brain function and managing inflammation. Your meals incorporate plant-based omega-3s from chia seeds and flax seeds.
- Probiotics: Fermented foods that support a healthy gut microbiome, which is increasingly linked to mental well-being. You will find gut-friendly additions like sauerkraut and kimchi in your plan.
- Protein: Provides amino acids like tryptophan, a precursor to the "feel-good" hormone serotonin. We focus on high-quality plant proteins including legumes, soy foods, nuts, and seeds.
Ready to get started? Click the button below to access your personalized PlexusDx meal planning tool, where you can view your full weekly schedule and shopping list. If you see a meal that doesn't fit your preferences or current cravings, you can easily find a delicious alternative that still matches your genetic profile. Just follow these steps:
- Locate the meal you want to change on your planner.
- Click the three dots next to the meal name.
- Select “Swap recipe” from the menu.
- Choose “Swap” to change just that meal, or “Swap all” to replace it everywhere it appears.
- Keep clicking “Swap” to browse through other corn-free, dairy-free, and egg-free alternatives that fit your plan.
PlexusDx provides educational information about genetic predispositions only. This content is not medical advice. Always discuss genetic findings, test results, symptoms, and treatment decisions with your healthcare provider or an allergist to determine appropriate care for your situation.

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Depression Support Diet
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